Review
Oncology
Angela Liu, Leonard Naymagon, Douglas Tremblay
Summary: This review explores the treatment considerations of splanchnic vein thromboses (SVTs) associated with myeloproliferative neoplasms (MPNs). Anticoagulation is the mainstay of therapy, and cytoreductive therapy is recommended according to MPN treatment guidelines. Endovascular intervention may be considered in the acute setting to prevent or mitigate potential portal hypertensive complications in patients with occlusive or extensive clot burden.
Review
Oncology
Elizabeth A. Connolly, Peter S. Grimison, Lisa G. Horvath, Phillip J. Robinson, Roger R. Reddel
Summary: Sarcoma, a rare and complex disease, faces challenges in diagnosis, disease classification, lack of effective treatment options, and identification of biomarkers and drug targets. Proteomics, the study of proteins, offers insights into cancer biology. This review discusses quantitative proteomic studies in sarcoma, highlighting the potential for diagnostic, prognostic, and therapeutic biomarkers. The application of proteomic methodologies in various sarcoma subtypes is described, with a focus on histological classification and understanding disease heterogeneity. The importance of proteomic research in addressing unmet needs in sarcoma is outlined.
FRONTIERS IN ONCOLOGY
(2023)
Article
Hematology
Asim Cengiz Akbulut, Ryanne A. Arisz, Constance C. F. M. J. Baaten, Gaukhar Baidildinova, Aarazo Barakzie, Rupert Bauersachs, Jur Ten Berg, Wout W. A. van den Broek, H. C. de Boer, Amandine Bonifay, Vanessa Broker, Richard J. Buka, Hugo ten Cate, Arina J. ten Cate-Hoek, S. Cointe, Ciro De Luca, Ilaria De Simone, Rocio Vacik Diaz, Francoise Dignat-George, Kathleen Freson, Giulia Gazzaniga, Eric C. M. van Gorp, Anxhela Habibi, Yvonne M. C. Henskens, Aaron F. J. Iding, Abdullah Khan, Gijsje H. Koenderink, Akhil Konkoth, Romaric Lacroix, Trisha Lahiri, Wilbur Lam, Rachel E. Lamerton, Roberto Lorusso, Qi Luo, Coen Maas, Owen J. T. McCarty, Paola E. J. van der Meijden, Joost C. M. Meijers, Adarsh K. Mohapatra, Neta Nevo, Alejandro Pallares Robles, Philippe Poncelet, Christoph Reinhardt, Wolfram Ruf, Ronald Saraswat, Claudia Schonichen, Roger Schutgens, Paolo Simioni, Stefano Spada, Henri M. H. Spronk, Karlygash Tazhibayeva, Jecko Thachil, Rocio Vacik Diaz, L. Vallier, Alicia Veninga, Peter Verhamme, Chantal Visser, Steve P. Watson, Philip Wenzel, Ruth A. L. Willems, Anne Willers, Pengyu Zhang, Konstantinos Zifkos, Anton Jan van Zonneveld
Summary: The Fourth Maastricht Consensus Conference on Thrombosis covered a wide range of topics, including the role of coagulation proteins in cardiovascular disease, novel mechanisms of thrombosis, strategies to limit bleeding risks, hemostasis in extracorporeal systems, and clinical dilemmas in thrombosis and antithrombotic management. The conference also revisited the coagulopathy associated with COVID-19.
THROMBOSIS AND HAEMOSTASIS
(2023)
Review
Hematology
Alberto Alvarez-Larran, Emanuela Sant'Antonio, Claire Harrison, Jean-Jacques Kiladjian, Martin Griesshammer, Ruben Mesa, Jean Christophe Ianotto, Francesca Palandri, Juan Carlos Hernandez-Boluda, Gunnar Birgegard, Jyoti Nangalia, Steffen Koschmieder, Elisa Rumi, Tiziano Barbui
Summary: The European LeukemiaNet identified unmet clinical needs in the management of CALR-mutated essential thrombocythaemia and proposed 14 recommendations and 6 solution proposals. The experts highlighted potential areas of concern, including antiplatelet therapy, platelet count definition, treatment targets, and management in different patient populations. By consensus-based approaches, the network aimed to address uncertainties and improve patient care in this specific subset of myeloproliferative neoplasms.
LANCET HAEMATOLOGY
(2021)
Article
Allergy
Ioana Agache, Dario Antolin-Amerigo, Frederic de Blay, Cristina Boccabella, Cristiano Caruso, Pascal Chanez, Mariana Couto, Ronina Covar, Serge Doan, Jean-Luc Fauquert, Gail Gauvreau, Alina Gherasim, Ludger Klimek, Catherine Lemiere, Parameswaran Nair, Inigo Ojanguren, David Peden, Luis Perez-de-Llano, Oliver Pfaar, Carmen Rondon, Maia Rukhazde, Joaquin Sastre, Johannes Schulze, Diana Silva, Susan Tarlo, Sanna Toppila-Salmi, Jolanta Walusiak-Skorupa, Stefan Zielen, Ibon Eguiluz-Gracia
Summary: Allergic asthma is a common asthma phenotype that requires IgE sensitization to aeroallergens for diagnosis. However, current protocols for bronchial allergen challenge are not suitable for moderate-to-severe asthmatics or clinical practice. Correct diagnosis of allergic asthma can aid in selecting patients for immunomodulatory therapies, such as allergen sublingual immunotherapy.
Article
Oncology
Pietro Quaglino, Nicola Pimpinelli, Pier Luigi Zinzani, Marco Paulli, Stefano Pileri, Emilio Berti, Lorenzo Cerroni, Joan Guitart, Youn H. Kim, Serena Rupoli, Marco Santucci, Gabriele Simontacchi, Maarten Vermeer, Richard Hoppe, Barbara Pro, Steven H. Swerdlow, Giovanni Barosi
Summary: This article presents major unmet clinical needs in the management of primary cutaneous B-cell lymphomas (PCBCLs) and proposes recommendations and research directions to address these needs. These recommendations and research directions will help improve the diagnosis and treatment of PCBCLs.
HEMATOLOGICAL ONCOLOGY
(2023)
Review
Rheumatology
Nihal Sahin, Hafize Emine Sonmez, Nuray Aktay Ayaz, Betul Sozeri
Summary: This study conducted a systematic review of the literature on transitional care for patients with JIA. The findings highlighted the importance of transitioning children with rheumatic diseases to adult rheumatology services, but the absence of established guidelines posed challenges. The study also identified the major areas of research in this field, including assessing readiness, evaluating structured transition programs, and investigating disease-related outcomes.
Review
Biochemistry & Molecular Biology
Aleksandra H. Opinc, Joanna S. Makowska
Summary: This article summarizes the latest research on the association between idiopathic inflammatory myopathies and malignancy, the understanding of its pathogenesis. It analyzes the potential risk and protective factors for developing cancer-associated myositis (CAM), and proposes management recommendations and a new cancer screening scheme.
Review
Medicine, Research & Experimental
Harinder Gill, Garret M. K. Leung, Melissa G. M. Ooi, Winnie Z. Y. Teo, Chieh-Lee Wong, Chul Won Choi, Gee-Chuan Wong, Zhentang Lao, Ponlapat Rojnuckarin, Ma. Rosario Irene D. Castillo, Zhijian Xiao, Hsin-An Hou, Ming-Chung Kuo, Lee-Yung Shih, Gin-Gin Gan, Chien-Chin Lin, Wee-Joo Chng, Yok-Lam Kwong
Summary: Myeloproliferative neoplasms (MPN) are a group of heterogeneous hematopoietic stem cell disorders. The Asian Myeloid Working Group (AMWG) aims to review the evidence and provide pragmatic approaches for treatment. Treatment should be patient-specific and based on accurate diagnosis and risk stratification.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Medicine, General & Internal
Maurizio Scarpa, Antonio Barbato, Annalisa Bisconti, Alberto Burlina, Daniela Concolino, Federica Deodato, Maja Di Rocco, Carlo Dionisi-Vici, Maria Alice Donati, Simona Fecarotta, Agata Fiumara, Carlotta Galeone, Fiorina Giona, Gaetano Giuffrida, Raffaele Manna, Paolo Mariani, Andrea Pession, Annalisa Scopinaro, Marco Spada, Federico Spandonaro, Gianluca Trifiro, Francesca Carubbi, Maria Domenica Cappellini
Summary: This study conducted a Delphi consensus of experts in Italy on infantile neurovisceral ASMD, chronic neurovisceral ASMD, and chronic visceral ASMD. The findings showed a high agreement on various topics related to ASMD characteristics, diagnosis, treatment, and disease burden. These results provide valuable indications for the management of ASMD at a public health level in Italy.
INTERNAL AND EMERGENCY MEDICINE
(2023)
Article
Hematology
Pier Luigi Zinzani, Marco Paulli, Luca Arcaini, Emanuel Della Torre, Simone Ferrero, Amalia Figuera, Ferdinando Frigeri, Maurizio Martelli, Elena Sabattini, Riccardo Scarpa, Giovanni Barosi
Summary: This article presents the results of a discussion among Italian experts regarding the clinical needs in managing idiopathic multicentric Castleman disease (iMCD). They issued recommendations for clinical decisions and proposed new research in areas such as diagnostic certainty, siltuximab therapy, and alternatives for patients resistant/intolerant to siltuximab therapy. The article aims to improve the practice of iMCD and inform future studies in the field.
Editorial Material
Urology & Nephrology
Catalina Martin-Cleary, Ana Belen Sanz, Alejandro Avello, Maria Dolores Sanchez-Nino, Alberto Ortiz
Summary: The current diagnosis of acute kidney injury (AKI) relies on markers of decreased kidney function rather than markers of injury, resulting in a delayed diagnosis. Biomarkers of injury are needed for early diagnosis and prediction of AKI. Several commercially available immunoassays have shown promising data, but their performance may vary depending on the clinical context. A recent study has reported a urinary peptidomics classifier that predicts AKI better than current biomarkers.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Hematology
Snjezana Janjetovic, Lennart Beckmann, Katharina Holstein, Christina Rolling, Benjamin Thiele, Philippe Schafhausen, Gerhard Schoen, Carsten Bokemeyer, Florian Langer, Minna Voigtlaender
Summary: The study identified a significant association between JAK2V617F-positive MPN and definite APS, with patients with APS potentially experiencing earlier onset of thrombotic events, necessitating more aggressive antithrombotic treatment strategies.
THROMBOSIS RESEARCH
(2021)
Article
Oncology
Mohamed Hussam Aswad, Jarmila Kissova, Petra Ovesna, Miroslav Penka
Summary: This study found that factors such as JAK2V617F mutation, age, history of thrombosis, and smoking are key determinants of thrombosis risk in MPN patients. The multifactorial mechanism of thrombosis in patients supports the need for individualized and complex management.
Article
Hematology
Hui Yin Lim, Prahlad Ho
Summary: Philadelphia chromosome-negative myeloproliferative neoplasms are associated with increased thrombotic events. Current laboratory investigations are not accurate enough to assess the underlying procoagulant state and predict thrombotic risks. Viscoelastic testing may provide a more comprehensive assessment of hemostatic function in these neoplasms, but its role in thrombosis is not well defined.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2023)
Article
Hematology
Francesco Mannelli, Francesca Gesullo, Carmela Mannarelli, Fiorenza Vanderwert, Stefano Lazzi, Francesco Mungai, Valentina Berti, Raffaella Santi, Paola Guglielmelli, Alessandro M. Vannucchi
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Oncology
Francesco Mannelli, Paola Guglielmelli, Paola Fazi, Enrico Crea, Alfonso Piciocchi, Marco Vignetti, Sergio Amadori, Fabrizio Pane, Adriano Venditti, Alessandro M. Vannucchi
Summary: The evolution into a blast phase is a fatal event in myeloproliferative neoplasms, with a median survival of 3-6 months. Clinical trials with innovative approaches are needed for this category of patients. The ENABLE trial aims to test the combination of venetoclax and decitabine in patients with post-MPN blast phase, who have a poor prognosis.
Review
Pathology
Umberto Gianelli, Juergen Thiele, Attilio Orazi, Naseema Gangat, Alessandro M. Vannucchi, Ayalew Tefferi, Hans Michael Kvasnicka
Summary: The International Consensus Classification (ICC) of myeloid neoplasms, which was based on the efforts of pathologists, oncologists, and geneticists, aimed to update the 2017 World Health Organization classification system for hematopoietic tumors. The classification of myeloproliferative neoplasms (MPNs) underwent significant modifications, especially in terms of diagnostic methods and criteria.
Article
Oncology
Giacomo Coltro, Emanuela Sant'Antonio, Giuseppe A. Palumbo, Francesco Mannelli, Valerio De Stefano, Marco Ruggeri, Elena M. Elli, Roberta Zanotti, Oscar Borsani, Irene Bertozzi, Andrea Duminuco, Silvia Betti, Giuseppe Carli, Fabrizio Cavalca, Ilaria Tanasi, Elisa Rumi, Maria L. Randi, Bruno Garibaldi, Giuseppe G. Loscocco, Paola Guglielmelli, Alessandro M. Vannucchi
Summary: This study provides valuable insights into the efficacy and safety of ruxolitinib in a real-world cohort of Italian patients with myelofibrosis. The results highlight the importance of drug exposure, side effects, and treatment response in determining patient outcomes.
Editorial Material
Oncology
William Shomali, Philomena Colucci, Tracy I. George, Jean-Jacques Kiladjian, Cheryl Langford, Jay L. Patel, Andreas Reiter, Alessandro M. Vannucchi, Jason Gotlib
Article
Oncology
Elisa Bianchi, Sebastiano Rontauroli, Lara Tavernari, Margherita Mirabile, Francesca Pedrazzi, Elena Genovese, Stefano Sartini, Massimiliano Dall'Ora, Giulia Grisendi, Luca Fabbiani, Monica Maccaferri, Chiara Carretta, Sandra Parenti, Sebastian Fantini, Niccolo Bartalucci, Laura Calabresi, Manjola Balliu, Paola Guglielmelli, Leonardo Potenza, Enrico Tagliafico, Lorena Losi, Massimo Dominici, Mario Luppi, Alessandro Maria Vannucchi, Rossella Manfredini
Summary: BM fibrosis is a major pathology in myelofibrosis and is associated with overexpression of OPN protein. ERK1/2 is a key regulator of OPN production, and inhibiting ERK1/2 activity can reduce OPN production and hinder the development of BM fibrosis. Targeting OPN and ERK1/2 could be potential therapeutic strategies for myelofibrosis.
Article
Oncology
Elisabetta Maria Abenavoli, Matteo Barbetti, Flavia Linguanti, Francesco Mungai, Luca Nassi, Benedetta Puccini, Ilaria Romano, Benedetta Sordi, Raffaella Santi, Alessandro Passeri, Roberto Sciagra, Cinzia Talamonti, Angelina Cistaro, Alessandro Maria Vannucchi, Valentina Berti
Summary: This study tested the diagnostic value of 18F-FDG PET/CT volumetric and texture parameters in the histological differentiation of mediastinal bulky lymphoma. The results support the use of metabolic heterogeneity as an imaging biomarker and the use of radiomic features for early characterization of mediastinal bulky lymphoma.
Article
Hematology
Riccardo Paggi, Francesca Mariotti, Jessica Mencarini, Silvia Bresci, Irene Campolmi, Filippo Bartalesi, Beatrice Borchi, Luca Nassi, Benedetta Sordi, Alessandro Maria Vannucchi, Alessandro Bartoloni
Summary: The use of specific inhibitory drugs for intracellular signalling pathways is a risk factor for Aspergillus spp. infections in patients with Waldenstrom's macroglobulinaemia. The overlapping clinical manifestations of the two diseases may require different medical specialties.
MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES
(2023)
Article
Hematology
Agnerys Lopez Sacerio, Mara Caridad Tejeda Ramon, Aliuska Morales Helguera, Yunierkis Perez Castillo, Javier Cruz Rodriguez, Jorge Felix Guerra Rodriguez, Anna Falanga
Summary: This study developed a logistic regression model to predict VTE risk in hospitalized HM patients and validated it both internally and externally. The model includes 5 predictive factors and showed good accuracy and discrimination in predicting VTE risk.
ANNALS OF HEMATOLOGY
(2023)
Article
Oncology
Francesca Palandri, Elena Rossi, Giuseppe Auteri, Massimo Breccia, Simona Paglia, Giulia Benevolo, Elena M. Elli, Francesco Cavazzini, Gianni Binotto, Alessia Tieghi, Mario Tiribelli, Florian H. Heidel, Massimiliano Bonifacio, Novella Pugliese, Giovanni Caocci, Monica Crugnola, Francesco Mendicino, Alessandra D'Addio, Simona Tomassetti, Bruno Martino, Nicola Polverelli, Sara Ceglie, Camilla Mazzoni, Rikard Mullai, Alessia Ripamonti, Bruno Garibaldi, Fabrizio Pane, Antonio Cuneo, Mauro Krampera, Gianpietro Semenzato, Roberto M. Lemoli, Nicola Vianelli, Giuseppe A. Palumbo, Alessandro Andriani, Michele Cavo, Roberto Latagliata, Valerio De Stefano
Summary: The prognostic relevance of complete response to hydroxyurea, predictors of response, and patients' triggers for switching to ruxolitinib in polycythemia vera are uncertain. Many PV patients receive underdosed hydroxyurea, leading to lower response and toxicity rates. Splenomegaly and other symptoms are the main drivers for early switch to ruxolitinib despite poor response to hydroxyurea.
Article
Oncology
Patricia Gomez-Rosas, Cinzia Giaccherini, Laura Russo, Cristina Verzeroli, Sara Gamba, Carmen Julia Tartari, Silvia Bolognini, Chiara Ticozzi, Francesca Schieppati, Luca Barcella, Roberta Sarmiento, Giovanna Masci, Carlo Tondini, Fausto Petrelli, Francesco Giuliani, Andrea D'Alessio, Mauro Minelli, Filippo De Braud, Armando Santoro, Roberto Labianca, Giampietro Gasparini, Marina Marchetti, Anna Falanga, H. Y. P. E. R. C. A. N. Investigators HYPERCAN Investigators
Summary: This study found that VTE is a common complication in lung cancer patients during chemotherapy and is associated with increased mortality. A new prediction model was developed to stratify the risk of VTE and mortality in lung cancer patients, which showed higher accuracy compared to other existing models.
Article
Medicine, Research & Experimental
Oluwatoyosi Muse, Rushad Patell, Christian G. Peters, Moua Yang, Emale El-Darzi, Sol Schulman, Anna Falanga, Marina Marchetti, Laura Russo, Jeffrey I. Zwicker, Robert Flaumenhaft
Summary: Thrombosis is a common complication of advanced cancer, and our study reveals that activation of the unfolded protein response (UPR) in cancer cells can lead to increased release of prothrombotic particles, providing a mechanistic link between ER stress and cancer-associated thrombosis.
Article
Biochemistry & Molecular Biology
Srdan Verstovsek, Ivan Krecak, Florian H. Heidel, Valerio De Stefano, Kenneth Bryan, Mike W. Zuurman, Michael Zaiac, Mara Morelli, Aoife Smyth, Santiago Redondo, Erwan Bigan, Michael Ruhl, Christoph Meier, Magali Beffy, Jean-Jacques Kiladjian
Summary: The PV-AIM study used machine learning to identify markers of thromboembolic events (TE) in patients with polycythemia vera (PV). The study found that lymphocyte percentage (LYP), neutrophil percentage (NEP), and red cell distribution width (RDW) are closely associated with TE risk, and can be used to identify high-risk patients.
Correction
Medicine, General & Internal
S. Verstovsek, A. T. Gerds, A. M. Vannucchi
Correction
Medicine, General & Internal
S. Verstovsek, A. T. Gerds, A. M. Vannucchi