期刊
ACS CATALYSIS
卷 9, 期 9, 页码 8153-8158出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.9b02536
关键词
iridium; C-H activation; benzoic acids; substituted indanones; diketo compounds
资金
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy (EXC-2033) [390677874, SFB-TRR 88, GO 853/12-1]
- BMBF
- state of NRW (Center of Solvation Science ZEMOS)
- CSC
A catalytic annulation is presented that provides straightforward, modular synthetic access to 3-substituted indanones from benzoic acids and alpha,beta-unsaturated ketones. It is catalyzed by a bimetallic Ir/In system and proceeds via hydroarylation followed by Claisen condensation and optional retro-Claisen deacylation. The annulation may be combined into a one-pot procedure with the synthesis of the unsaturated ketone substrates from aldehydes and acetone. Two complementary reaction protocols are provided that are applicable to diversely functionalized electron-rich and electron-poor substrates.
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