期刊
ACS CATALYSIS
卷 9, 期 10, 页码 9285-9291出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.9b03352
关键词
C(sp(3))-C(sp(3)) Cross-Coupling; nickel catalyst; cobalt catalyst; alkyl tosylate; alkyl halide
资金
- JSPS KAKENHI [JP18K05106]
The C(sp(3))-C(sp3) Cross-Coupling of alkyl halides with alkyl tosylates has been developed by employing a combination of nickel and nucleophilic cobalt catalysts in the presence of a manganese reductant. This method provides a straightforward route to a diverse set of not only secondary-primary but also primary-primary C(sp(3))-C(sp(3)) linkages under mild conditions without using alkyl-metallic reagents. Mechanistic studies suggest the formation of alkyl radicals from both alkyl halides and alkyl tosylates. Additionally, cross-coupling could be applied to the short-step synthesis of a histone deacetylase inhibitor, Vorinostat.
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