期刊
EPIGENOMICS
卷 11, 期 12, 页码 1413-1427出版社
FUTURE MEDICINE LTD
DOI: 10.2217/epi-2019-0040
关键词
developmental origins of health and disease; DNA methylation; epigenome-wide association study; pediatric cohort; socioeconomic status
资金
- NIH [R01 HD034568, R01 HL111108, R01 NR013945, UH3 OD023286]
Aim: We investigated associations of prenatal socioeconomic status (SES) with DNA methylation at birth, and to explore persistence of associations into early (similar to 3 years) and mid-childhood (similar to 7 years) among 609 mother-child pairs in a Boston-area prebirth cohort. Materials & methods: First, we created a prenatal SES index comprising individual- and neighborhood-level metrics and examined associations of low (lowest 10%) versus high (upper 90%) SES with genome-wide DNA methylation in cord blood via the Infinium HumanMethylation450 BeadChip. Next, we evaluated persistence of associations detected in cord blood with DNA methylation of the same CpG sites measured in peripheral leukocytes in early- and mid-childhood. Results & conclusion: Low prenatal SES was associated with methylation at CpG sites near ACSF3, TNRC6-CAS1, MTMR4 and LRRN4. The relationship with LRRN4 persisted into early childhood.
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