Article
Cell Biology
Tian Xia, Zhiyong Zhang, Xin Zhang, Quanfu Li
Summary: This study aimed to determine the effect of the interaction between miR-186-3p and KRT18 on the biological behavior of colon cancer cells. The results showed that miR-186-3p suppresses proliferation and viability, but facilitates apoptosis in colon cancer cells by targeting KRT18 and negatively regulating the MAPK signaling pathway.
Article
Cell Biology
Bang Liu, Yinghong Cui, Wei Chen, Li Du, Chunyun Li, Cailin Wan, Zuping He
Summary: In this study, miR-100-3p was shown to regulate the proliferation and apoptosis of human Sertoli cells by targeting SGK3 gene. This finding provides a novel epigenetic regulator and potential target for gene therapy of male infertility.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Clinical Neurology
Michela Ferraldeschi, Silvia Romano, Simona Giglio, Carmela Romano, Emanuele Morena, Rosella Mechelli, Viviana Annibali, Martina Ubaldi, Maria Chiara Buscarinu, Renato Umeton, Gabriele Sani, Andrea Vecchione, Marco Salvetti, Giovanni Ristori
Summary: The study identified specific plasma miRNA markers in HD patients, suggesting their potential role in characterizing the disease and determining therapeutic targets. Molecular and bioinformatic analyses revealed an interaction between these miRNAs and the HTT protein, indicating their biological plausibility in HD pathophysiology.
FRONTIERS IN NEUROLOGY
(2021)
Article
Oncology
Sofia Elena Tesolato, Daniel Gonzalez-Gamo, Ana Barabash, Paula Claver, Sofia Cristina de la Serna, Inmaculada Dominguez-Serrano, Jana Dziakova, Carmen de Juan, Antonio Jose Torres, Pilar Iniesta
Summary: This study aims to analyze and correlate the expression levels of four miRNAs associated with cancer and obesity in colorectal cancer (CRC) patients and a control group. The results indicate the significance of hsa-miR-143-3p and hsa-miR-181a-5p in the clinical management of CRC.
Article
Biochemistry & Molecular Biology
Jiancong Lu, Junhong Lin, Yu Zhou, Kai Ye, Changquan Fang
Summary: In NSCLC, the majority of patients have lung adenocarcinoma (LA) with varying survival rates. PYCR1 gene and miR-328-3p are associated with cancer development, with miR-328-3p targeting PYCR1 to suppress LA cell malignancy by inhibiting cell proliferation and migration while promoting apoptosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Jieli Pan, Meiya Li, Fenglin Yu, Feiye Zhu, Linyan Wang, Dandan Ning, Xiaoli Hou, Fusheng Jiang
Summary: Shikonin can inhibit the growth and induce apoptosis of non-small cell lung cancer cells by up-regulating miR-628-3p, which involves promoting the expression of p53 and miR-628-3p, and direct interaction between p53 and the promoter of miR-628-3p.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Kun Zhou, Dachun Cao, Yu Wang, Lei Wang, Xiangjun Meng
Summary: High expression of APBB2 was detected in gastric adenocarcinoma patients, indicating a potential predictive biomarker for poor prognosis. Silencing APBB2 inhibited the functions of gastric adenocarcinoma cells, including proliferation, cell cycle progression, migration, and invasion. The binding sites between hsa-mir-30a and the 3'-UTR of APBB2 suggest a regulatory role of hsa-mir-30a in APBB2 expression.
Article
Genetics & Heredity
Linxiang Feng, Zian Feng, Jie Hu, Jiahui Gao, Ang Li, Xiaodong He, Liu Liu, Zuojun Shen
Summary: In this study, high-throughput sequencing of miRNAs in plasma exosomes from lung adenocarcinoma patients and healthy individuals was performed. The results identified hsa-miR-4454 and hsa-miR-619-5p as potential biomarkers for the early diagnosis of lung adenocarcinoma.
FRONTIERS IN GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Jing Sui, Qun Zhao, Yanqiu Zhang, Geyu Liang
Summary: The study found that LINC00961 is significantly downregulated in non-small cell lung cancer (NSCLC) tissues, and it inhibits the expression of miR-19a-3p/miR-19b-3p/miR-125b-5p through the PI3K-AKT/MAPK/mTOR signaling pathway, thereby suppressing tumor cell proliferation and migration while promoting apoptosis. This may provide potential biomarkers for the diagnosis and treatment of NSCLC.
DNA AND CELL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Genxi Zhang, Xinchao Zhang, Kaizhi Zhou, Xuanze Ling, Jin Zhang, Pengfei Wu, Tao Zhang, Kaizhou Xie, Guojun Dai
Summary: This study has revealed the regulatory role of miRNA-10a-5p in the proliferation, differentiation, and apoptosis of chicken myoblasts by targeting the BCL6 gene. The findings highlight the significance of miRNA-10a-5p and BCL6 in skeletal muscle growth, development, and autophagy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Developmental Biology
Xin Chen, Qian Lin Song, Rui Ji, Jia Yu Wang, Ze Hong Li, DuanYing Guo, Tai Lang Yin, Shao Juan Wang, Jing Yang
Summary: This study demonstrates that miR-187 plays an important role in recurrent miscarriage by inhibiting the proliferation, migration, and invasion of trophoblasts through regulation of BCL6. These findings provide new insights into the pathogenesis of recurrent miscarriage.
Article
Cell Biology
Ying Liu, Lei Li, Xiang Song
Summary: This study reveals the mechanism by which circPVT1 in lung cancer-derived exosomes promotes proliferation, invasion, and migration of lung cancer cells. It demonstrates that circPVT1 regulates macrophage polarization through the miR-124-3p/EZH2 axis, leading to enhanced biological functions of lung cancer cells.
Article
Biochemistry & Molecular Biology
Marta Gil-Martinez, Clara Lorente-Sorolla, Jose M. Rodrigo-Munoz, Sara Naharro, Zahara Garcia-de Castro, Joaquin Sastre, Marcela Valverde-Monge, Santiago Quirce, Maria L. Caballero, Jose M. Olaguibel, Victoria del Pozo
Summary: Clarifying inflammatory processes and categorising asthma into phenotypes and endotypes improves asthma management. Obesity worsens severe asthma and reduces quality of life, although its specific molecular impact remains unclear. We aimed to study hsa-miR-26a-1-3p, hsa-miR-376a-3p, and their target genes in asthmatic subjects with or without obesity to find biomarkers and comprehend obese asthma mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Chenchen Han, Huilin Zheng, Die Hu, Maiqiu Wang, Hongpeng Wang, Lei Zhang
Summary: This study utilized gene expression data from databases to identify differential circRNA, miRNA, and mRNA associated with drug resistance in pancreatic cancer. Through the use of multiple databases, a negative regulatory mechanism was identified, and differential circRNA, miRNA, and mRNA consistent with this mechanism were validated using clinical data.
Article
Biochemistry & Molecular Biology
Zahra Mohamadzade, Bahram M. Soltani, Zahra Ghaemi, Parisa Hoseinpour
Summary: This study identified miR-1226-3p as a tumor suppressor in SKBR3 cells, exerting its inhibitory effect by targeting HER2, PIK3R2, and AKT1 genes and downregulating the PI3K/AKT pathway.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)
Review
Medical Laboratory Technology
Qun Zhou, Wei Hu, Wei Zhu, Feng Zhang, Li Lin-lin, Cong Liu, Yi-yan Songyang, Cheng-cao Sun, Dejia Li
CLINICA CHIMICA ACTA
(2018)
Article
Oncology
Cheng-Cao Sun, Shu-Jun Li, Zhen-Long Chen, Guang Li, Qian Zhang, De-Jia Li
MOLECULAR THERAPY-ONCOLYTICS
(2019)
Article
Biotechnology & Applied Microbiology
Cheng-Cao Sun, Shu-Jun Li, Wei Hu, Jian Zhang, Qun Zhou, Cong Liu, Lin-Lin Li, Yi-Yan Songyang, Feng Zhang, Zhen-Long Chen, Guang Li, Zhuo-Yue Bi, Yong-Yi Bi, Feng-Yun Gong, Tao Bo, Zhan-Peng Yuan, Wei-Dong Hu, Bo-Tao Zhan, Qian Zhang, Qi-Qiang He, De-Jia Li
Article
Biochemistry & Molecular Biology
Yan Xu, Yuan Li, Jiankang Jin, Guangchun Han, Chengcao Sun, Melissa Pool Pizzi, Longfei Huo, Ailing Scott, Ying Wang, Lang Ma, Jeffrey H. Lee, Manoop S. Bhutani, Brian Weston, Christopher Vellano, Liuqing Yang, Chunru Lin, Youngsoo Kim, A. Robert MacLeod, Linghua Wang, Zhenning Wang, Shumei Song, Jaffer A. Ajani
Review
Biochemistry & Molecular Biology
Wei Hu, Cong Liu, Zhuo-Yue Bi, Qun Zhou, Han Zhang, Lin-Lin Li, Jian Zhang, Wei Zhu, Yang-Yi-Yan Song, Feng Zhang, Hui-Min Yang, Yong-Yi Bi, Qi-Qiang He, Gong-Jun Tan, Cheng-Cao Sun, De-Jia Li
Article
Cell Biology
Yaohua Zhang, Yajuan Li, Qingsong Hu, Yutao Xi, Zhen Xing, Zhao Zhang, Lisa Huang, Jianbo Wu, Ke Liang, Tina K. Nguyen, Sergey D. Egranov, Chengcao Sun, Zilong Zhao, David H. Hawke, Jin Li, Deqiang Sun, Jean J. Kim, Ping Zhang, Jie Cheng, Abid Farida, Mien-Chie Hung, Leng Han, Radbod Darabi, Chunru Lin, Liuqing Yang
NATURE CELL BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Roopa Thapar, Jing L. Wang, Michal Hammel, Ruiqiong Ye, Ke Liang, Chengcao Sun, Ales Hnizda, Shikang Liang, Su S. Maw, Linda Lee, Heather Villarreal, Isaac Forrester, Shujuan Fang, Miaw-Sheue Tsai, Tom L. Blundell, Anthony J. Davis, Chunru Lin, Susan P. Lees-Miller, Terence R. Strick, John A. Tainer
NUCLEIC ACIDS RESEARCH
(2020)
Article
Genetics & Heredity
Cheng-Cao Sun, Wei Zhu, Shu-Jun Li, Wei Hu, Jian Zhang, Yue Zhuo, Han Zhang, Juan Wang, Yu Zhang, Shao-Xin Huang, Qi-Qiang He, De-Jia Li
Correction
Biochemistry & Molecular Biology
Roopa Thapar, Jing L. Wang, Michal Hammel, Ruiqiong Ye, Ke Liang, Chengcao Sun, Ales Hnizda, Shikang Liang, Su S. Maw, Linda Lee, Heather Villarreal, Isaac Forrester, Shujuan Fang, Miaw-Sheue Tsai, Tom L. Blundell, Anthony J. Davis, Chunru Lin, Susan P. Lees-Miller, Terence R. Strick, John A. Tainer
NUCLEIC ACIDS RESEARCH
(2021)
Correction
Genetics & Heredity
Cheng-Cao Sun, Wei Zhu, Shu-Jun Li, Wei Hu, Jian Zhang, Yue Zhuo, Han Zhang, Juan Wang, Yu Zhang, Shao-Xin Huang, Qi-Qiang He, De-Jia Li
Summary: The paper has been amended and the updated version can be found in the original article.
Correction
Biochemistry & Molecular Biology
Yan Xu, Yuan Li, Jiankang Jin, Guangchun Han, Chengcao Sun, Melissa Pool Pizzi, Longfei Huo, Ailing Scott, Ying Wang, Lang Ma, Jeffrey H. Lee, Manoop S. Bhutani, Brian Weston, Christopher Vellano, Liuqing Yang, Chunru Lin, Youngsoo Kim, A. Robert MacLeod, Linghua Wang, Zhenning Wang, Shumei Song, Jaffer A. Ajani
Article
Oncology
Yue Zhuo, Shujun Li, Wei Hu, Yu Zhang, Yufan Shi, Faxue Zhang, Jian Zhang, Juan Wang, Meijuan Liao, Jiahao Chen, Huiling Qian, Dejia Li, Chengcao Sun
Summary: SNORA38B is highly expressed in non-small cell lung cancer (NSCLC) and associated with worse prognosis. It promotes tumor progression through various mechanisms, including cell proliferation, migration, invasion, and inhibition of apoptosis. SNORA38B also affects the tumor immune microenvironment, reducing immune efficacy and favoring tumor progression.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Cell Biology
Yaohua Zhang, Chengcao Sun, Yajuan Li, Juan Qin, Kaushik Amancherla, Ying Jing, Qingsong Hu, Ke Liang, Zhao Zhang, Youqiong Ye, Lisa A. Huang, Tina K. Nguyen, Sergey D. Egranov, Zilong Zhao, Andrew Wu, Yutao Xi, Jun Yao, Mien-Chie Hung, George A. Calin, Jie Cheng, Bora Lim, Lorenz H. Lehmann, Joe-Elie Salem, Douglas B. Johnson, Michael A. Curran, Dihua Yu, Leng Han, Radbod Darabi, Liuqing Yang, Javid J. Moslehi, Chunru Lin
Summary: This study found that tumor-bearing mice treated with immune checkpoint inhibitors (ICIs) for cancer showed cardiovascular toxicities, including myocarditis and arrhythmia. Female mice were more susceptible to myocarditis. The down-regulation of MANF and HSPA5 in the heart tissue was associated with these cardiac effects.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Meeting Abstract
Biotechnology & Applied Microbiology
Chengcao Sun
Article
Pharmacology & Pharmacy
Yue Zhuo, Wei Hu, Mei-Juan Liao, Jia-Hao Chen, Jian Zhang, Juan Wang, Yu Zhang, Fa-Xue Zhang, Yu-Fan Shi, Hui-Ling Qian, Shu-Jun Li, Cheng-Cao Sun
Summary: Long noncoding RNAs (lncRNAs) play essential roles in non-small cell lung cancer (NSCLC), with lncRNA PP7080 regulating DNA methylation and interacting with TFAP2C and PDCD6 to affect cell proliferation, migration, invasion, tumor growth, and immune resistant tumor microenvironment (TME) in NSCLC.
ADVANCED THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)