Article
Biochemistry & Molecular Biology
Larisa N. Ilina, Olga Afanasieva, Andrey A. Shiryaev, Elina E. Vlasova, Said K. Kurbanov, Marina Afanasieva, Marat Ezhov, Vladislav P. Vasiliev, Damir M. Galyautdinov, Sergey N. Pokrovsky, Renat S. Akchurin
Summary: This study compares demographic indicators, lipids, and clinical outcomes in patients with different phenotypes of coronary artery disease after coronary artery bypass grafting (CABG). The results show that diffuse atherosclerosis and coronary calcinosis are associated with elevated levels of lipoprotein(a) (Lp(a)), and patients with these conditions have a higher risk of major adverse cardiovascular events (MACE) within one year after surgery.
Article
Medicine, General & Internal
Xingzhu Liu, Yanfei Chen, Yanfei Yang, Zhongjian Su, Feng Wang, Chenghao Zhanghuang, Yuqin Wu, Xing Zhang
Summary: This study investigated the correlation between FGA gene polymorphisms and coronary artery lesion in Kawasaki disease. The concentrations of serum MMPs and FG-α were significantly higher in KD patients, suggesting that FGA gene polymorphisms affect coronary artery lesion in children with KD.
FRONTIERS IN MEDICINE
(2023)
Article
Pediatrics
Fang Tian, Linxi Ma, Renbing Zhao, Lijuan Ji, Xiufen Wang, Wenli Sun, Yu Jiang
Summary: This study aimed to investigate the role of matrix metalloproteinases (MMPs) in coronary artery lesions (CAL) and found a significant correlation between the levels of MMP-2 and MMP-9 and the occurrence of CAL in Kawasaki disease patients. Intravenous immunoglobulin treatment effectively reduced the levels of MMPs, particularly in patients with CAL.
FRONTIERS IN PEDIATRICS
(2022)
Article
Biochemistry & Molecular Biology
David G. Thomas, Ying Wei, Alan R. Tall
Summary: The study assessed the pleiotropic effects of lipid trait genetic variants and conducted multivariable Mendelian randomization (MR) analysis in coronary artery disease. Results indicated that 30% of lipid trait genetic variants have effects on metabolic syndrome traits, yet the associations of LDL-C, HDL-C, TGs, BMI, T2D, and SBP with CAD remained independent and robust to adjustment for directional pleiotropy. MR at loci linked to direct effects on HDL-C and TGs suggested specific causal effects of these factors on CAD.
JOURNAL OF LIPID RESEARCH
(2021)
Article
Endocrinology & Metabolism
Shuran Shao, Kaiyu Zhou, Xiaoliang Liu, Lei Liu, Mei Wu, Yuxin Deng, Hongyu Duan, Yifei Li, Yimin Hua, Chuan Wang
Summary: This study found that lipid profiles were significantly dysregulated in KD patients with IVIG resistance and CALs. Some of them, such as LDL-C and Apo A, could serve as complementary laboratory markers for predicting both IVIG resistance and CALs.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Immunology
Xiaoxuan Ma, Meiming Su, Qingze He, Zhidan Zhang, Fanshun Zhang, Zhenghong Liu, Lu Sun, Jianping Weng, Suowen Xu
Summary: By analyzing human plaque tissue data and conducting experiments on mice, this study identifies PHACTR1 as being associated with endothelial dysfunction, which it regulates through inflammation response and NO production, and finds that its expression can be reduced by certain drugs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jie Gao, Jun Lu, Wenjun Sha, Bilin Xu, Cuiping Zhang, Hongping Wang, Juan Xia, Hong Zhang, Wenjun Tang, Tao Lei
Summary: This study evaluated the association between the neutrophil to HDL-C ratio (NHR) and the degree of coronary stenosis in patients with stable coronary artery disease (CAD). The results showed that NHR was not only associated with the occurrence and seriousness of CAD, but also a better predictor of severe CAD than neutrophil, HDL-C or LDL-C/HDL-C.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ken-Pen Weng, Kuang-Jen Chien, Shih-Hui Huang, Lien-Hung Huang, Pei-Hsien Lin, Yuyu Lin, Wei-Hsiang Chang, Chun-Yu Chen, Sung-Chou Li
Summary: This study identified that the levels of S100A4 and CAT were associated with the risk of CAL in KD patients. Furthermore, S100A4 treatment was found to disrupt the endothelial layer, promoting cell migration and increasing permeability. These findings suggest that S100A4 could potentially be targeted for the treatment of CAL in KD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sivanan Sivasinprasasn, Naruemon Wikan, Jiraporn Tocharus, Waraluck Chaichompoo, Apichart Suksamrarn, Chainarong Tocharus
Summary: The study revealed that the combined application of PAVA and RSV can inhibit ox-LDL-induced inflammatory responses, decrease activation of NF-KB/NLRP3 pathway, reduce recruitment of monocytes, and ameliorate impairment of cell-cell junctions, offering a novel mechanism for the treatment of cardiovascular diseases.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Younan Yao, Jin Liu, Bo Wang, Ziyou Zhou, Xiaozhao Lu, Zhidong Huang, Jingru Deng, Yongquan Yang, Ning Tan, Shiqun Chen, Jiyan Chen, Yong Liu
Summary: This study reveals that the association between elevated Lp(a) and increased risk of all-cause death may vary at different baseline LDL-C levels.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Konstantinos Mourouzis, Gerasimos Siasos, Evangelos Oikonomou, Marina Zaromitidou, Vicky Tsigkou, Alexis Antonopoulos, Evanthia Bletsa, Panagiota Stampouloglou, Konstantinos Vlasis, Manolis Vavuranakis, Dimitris Tousoulis
Summary: The study found that elevated Lp-PLA2 levels are significantly associated with endothelial dysfunction and arterial stiffness in patients with stable coronary artery disease, independently of classical risk factors and medication.
LIPIDS IN HEALTH AND DISEASE
(2021)
Article
Cardiac & Cardiovascular Systems
Sara N. Koenig, Holly C. Sucharski, Elizabeth M. Jose, Emma K. Dudley, Francesca Madiai, Omer Cavus, Aaron D. Argall, Jordan L. Williams, Nathaniel P. Murphy, Caullin B. R. Keith, Mona El Refaey, Richard J. Gumina, Konstantinos D. Boudoulas, M. Wesley Milks, Gbemiga Sofowora, Sakima A. Smith, Thomas J. Hund, Nathan T. Wright, Elisa A. Bradley, Karolina M. Zareba, Loren E. Wold, Ernest L. Mazzaferri, Peter J. Mohler
Summary: Elevated HDL-C is associated with improved cardiovascular outcomes, but clinical trials targeting HDL-C have not been successful. Rare compound heterozygous variants in SCARB1 have been found to cause severe CAD through Mendelian inheritance. These findings support the disease-contributing capability of loss-of-function SCARB1 variants.
CIRCULATION RESEARCH
(2021)
Article
Immunology
Kazuki Iio, Yoshihiko Morikawa, Koichi Miyata, Tetsuji Kaneko, Masahiro Misawa, Hiroyuki Yamagishi, Masaru Miura
Summary: This study aimed to identify the characteristics of Kawasaki disease patients with a low risk of coronary artery aneurysm (CAA) development. Using multivariable logistic regression analysis and decision tree creation, a subgroup of KD patients with a low CAA risk was identified. This subgroup accounted for approximately one quarter of the entire study cohort.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Weiqian E. Lee, Elijah Genetzakis, Gemma A. Figtree
Summary: Although recognized cardiovascular risk factors play a role in the development of coronary artery disease (CAD) and heart attack, the susceptibility of humans to this process is different from other animals. Mitochondrial dysfunction, particularly in the endothelial cells, has been found to be strongly associated with CAD. In this review, we explore the potential opportunities in analyzing mitochondrial function using patient-derived cells, such as endothelial colony-forming cells cultured from venous blood. We discuss how this analysis may serve as a biomarker for diagnosis and risk management, and how patient-derived cell models can aid in the development of novel therapies for humans.
Article
Rheumatology
Ricardo Rodriguez-Calvo, Montse Guardiola, Iris Oliva, Hugo Arrando, Idoia Arranz, Anna Ferre, Paula Pellicer, Sandra Parra, Josep Ribalta, Antoni Castro
Summary: The study found that LDL from active SLE patients had greater proatherogenic effects on endothelial cells compared to LDL from inactive SLE patients at the same LDL concentration.