Article
Infectious Diseases
Taylor J. Van Gundy, Amy J. Ullmann, Kevin S. Brandt, Robert D. Gilmore
Summary: A novel transwell assay was developed to assess the migration of Borrelia burgdorferi s.s. towards Ixodes scapularis salivary gland proteins. Specific proteins in tick saliva gland extract were found to have chemoattractant activity for B. burgdorferi s.s. These findings suggest that further research on tick saliva components may lead to a better understanding of the chemotaxis of B. burgdorferi s.s.
TICKS AND TICK-BORNE DISEASES
(2021)
Article
Infectious Diseases
Alynn M. Martin, Danielle Buttke, Jordan Raphael, Kelsey Taylor, Sarah Maes, Christina M. Parise, Howard S. Ginsberg, Paul C. Cross
Summary: Lyme disease, the most common vector-borne disease in the United States, is primarily caused by the bacterium Borrelia burgdorferi s.s. Research has focused on reducing tick densities to mitigate the risk, with white-tailed deer management considered a potential method. However, the impact of deer management on the density of infected ticks and prevalence of infection is unclear.
TICKS AND TICK-BORNE DISEASES
(2023)
Article
Infectious Diseases
Erik Foster, James Burtis, Jennifer L. Sidge, Jean Tsao, Jenna Bjork, Gongping Liu, David F. Neitzel, Xia Lee, Susan Paskewitz, Diane Caporale, Rebecca J. Eisen
Summary: The geographic range of the blacklegged tick and its associated human pathogens has expanded, increasing the risk for tick-borne diseases. Understanding the time and location of potential exposure to infected ticks is crucial for prevention and diagnosis. Monitoring infection prevalence in ticks aids in assessing risk, but setting a fixed threshold is not feasible due to variability. Reducing repeated sampling does not significantly impact estimates of average infection prevalence.
TICKS AND TICK-BORNE DISEASES
(2022)
Article
Biology
Anne L. Sapiro, Beth M. Hayes, Regan F. Volk, Jenny Y. Zhang, Diane M. Brooks, Calla Martyn, Atanas Radkov, Ziyi Zhao, Margie Kinnersley, Patrick R. Secor, Balyn W. Zaro, Seemay Chou
Summary: This study longitudinally defined the global transcriptomic landscape of Bb inside nymphal Ixodes scapularis ticks during a transmitting bloodmeal. It identified 192 Bb genes that substantially change expression during the bloodmeal, many of which encode proteins located in the cell envelope or proteins of unknown function. Mass spectrometry was used to identify candidate tick proteins that physically interact with Bb.
Article
Infectious Diseases
Alexandra N. Cumbie, Erin L. Heller, Zachary J. Bement, Anna Phan, Eric L. Walters, Wayne L. Hynes, Holly D. Gaff
Summary: The interaction between hosts and ticks plays a crucial role in the ecology of vector-borne diseases, with birds potentially playing a role in the maintenance and dispersal of Borrelia burgdorferi s.s., the main causative agent of Lyme disease in the southeastern United States.
TICKS AND TICK-BORNE DISEASES
(2021)
Article
Infectious Diseases
Vardayani Ratti, Jonathan M. Winter, Dorothy Wallace
Summary: The literature on Lyme disease debates the impact of changing deer populations, which can both decrease and increase disease incidence. The balance of these effects depends on the relative population sizes of different host types and host preferences. Simulation results suggest that removing reservoir-incompetent hosts may reduce tick populations, with dilution effects at low reservoir-competent host populations and amplification effects at high reservoir-competent host populations.
TICKS AND TICK-BORNE DISEASES
(2021)
Article
Parasitology
Djamel Tahir, Btissam Asri, Leon Nicolaas Meyer, Alec Evans, Thomas Mather, Byron Blagburn, Reinhard K. Straubinger, Valerie Choumet, Frans Jongejan, Marie Varloud
Summary: The ex vivo feeding technique using DPP showed high efficacy in blocking the acquisition of Borrelia burgdorferi and killing ticks, without exposing animals to pathogens or vectors. This method could be a promising approach for tick control and disease prevention.
PARASITES & VECTORS
(2021)
Article
Infectious Diseases
Lucas Schorter, Reinhard K. Straubinger
Summary: The study found that local anaesthetics like lidocaine, procaine, and ropivacaine can inhibit the growth of Borrelia spp., with differences in sensitivity among the different Borrelia species. The impact on growth inhibition varied depending on the concentration and exposure time of the anaesthetics, suggesting potential use of these drugs in controlling Borrelia infections.
TICKS AND TICK-BORNE DISEASES
(2021)
Article
Chemistry, Medicinal
Weronika Grazlewska, Lucyna Holec-Gasior, Karolina Solowinska, Tomasz Chmielewski, Beata Fiecek, Marinela Contreras
Summary: In this study, specific epitopes of two B. burgdorferi antigens were identified and used to create chimeric proteins for Lyme disease serodiagnosis.
ACS INFECTIOUS DISEASES
(2023)
Article
Parasitology
Zsuzsa Kalmar, Violeta Briciu, Mircea Coroian, Mirela Flonta, Amanda-Lelia Radulescu, Adriana Topan, Andrei Daniel Mihalca, Mihaela Lupse
Summary: The study in Romania found specific IgG and IgM antibodies to Borrelia burgdorferi s.l. among healthy blood donors. Higher seroprevalence was observed in men, older individuals, and those engaged in outdoor work.
PARASITES & VECTORS
(2021)
Article
Public, Environmental & Occupational Health
Jeff Hamik, Travis J. J. Bourret, Halie Smith, Molly Herman, Rachael Birn, Tammy Dawdy, Mona J. J. Zuffante, Matthew A. A. Donahue
Summary: In August 2021, two cases of Lyme disease were reported in Nebraska, with patients having local exposure to wooded areas. Epidemiological investigations confirmed that the two patients were exposed to ticks in adjacent wooded sites. Environmental investigations collected 12 ticks, identified as black-legged ticks, and found that 58.3% of them tested positive for Borrelia burgdorferi s.s., the bacterium causing Lyme disease. This study documents the presence of I. scapularis ticks and the occurrence of local transmission of Lyme disease in Nebraska for the first time, highlighting the need for continued surveillance and monitoring.
ZOONOSES AND PUBLIC HEALTH
(2023)
Article
Infectious Diseases
Mateusz Markowicz, Michael Kundi, Gerold Stanek, Hannes Stockinger
Summary: The relationship between infection with Borrelia burgdorferi sensu lato and nonspecific symptoms is controversial. This study found that individuals infected with B. burgdorferi sl did not develop nonspecific symptoms more frequently compared to non-infected controls.
TICKS AND TICK-BORNE DISEASES
(2022)
Article
Immunology
Marta Wozinska, Kacper Toczylowski, Dawid Lewandowski, Ewa Bojkiewicz, Artur Sulik
Summary: This study assessed the knowledge, attitudes, and preventive practices against tick-borne diseases (TBDs) among residents in northeastern Poland. The results showed that the internet and doctors were the main sources of knowledge, and participants had moderate knowledge and attitudes towards TBDs. However, there were misconceptions regarding Lyme borreliosis (LB) transmission, symptoms, and management. Higher risk perceptions were associated with the adoption of preventive behaviors. Healthcare professionals played a crucial role in communicating knowledge about TBDs.
Review
Immunology
Jannelle Couret, Samantha Schofield, Sukanya Narasimhan
Summary: This review focuses on environmental factors that influence tick biology and tick-pathogen interactions, highlighting the impact of temperature, humidity, and environmental microbiota on tick parasitism and the transmission of tick-borne diseases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Jamil N. Kanji, Abraam Isaac, Daniel Gregson, Monika Mierzejewski, Danny Shpeley, Pauline Tomlin, Michael Groeschel, L. Robbin Lindsay, Lisa Lachance, Kinga Kowalewska-Grochowska
Summary: This study retrospectively analyzed tick species and quantity recovered from humans in Alberta over a 19-year period, and conducted molecular testing for pathogens associated with Ixodes scapularis and I. pacificus. Dermacentor ticks were the most common, followed by Ixodes and Amblyomma. The risk of tick-borne pathogen exposure, such as Lyme disease, in Alberta remains low.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Medical Laboratory Technology
Faruk Karakecili, Aytekin Cikman, Merve Aydin, Bans Gulhan
ANNALS OF LABORATORY MEDICINE
(2018)
Article
Medicine, Research & Experimental
Senol Bicer, Cebrail Gursul, Ilyas Sayar, Orhan Akman, Secil Cakarli, Merve Aydin
MEDICAL SCIENCE MONITOR
(2018)
Article
Public, Environmental & Occupational Health
Aytekin Cikman, Merve Aydin, Baris Gulhan, Faruk Karakecili, Muhammet G. Kurtoglu, Serife Yuksekkaya, Mehmet Parlak, Bilge S. Gultepe, Aysegul C. Cicek, Fulya B. Bilman, Ihsan H. Ciftci, Murat Kara, Selahattin Atmaca, Tuncer Ozekinci
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2019)
Article
Endocrinology & Metabolism
Nur Gozde Kulhan, Mehmet Kulhan, Merve Aydin, Umit Nayki, Cenk Nayki, Pasa Ulug, Nahit Ata, Cuma Mertoglu, Aytekin Cikman, Ilyas Sayar, Can Turkler
GYNECOLOGICAL ENDOCRINOLOGY
(2019)
Article
Infectious Diseases
Baris Gulhan, Merve Aydin, Mehtap Demirkazik, Ismail Soner Koltas, Aytekin Cikman, Kultigin Turkmen, Tugce Duran
JOURNAL OF INFECTION IN DEVELOPING COUNTRIES
(2020)
Article
Microbiology
Hanife Nur Karakoc, Selcuk Kaya, Merve Aydin, Iftihar Koksal
Summary: This study examined the adherence rate of HIV patients to high-efficacy ART, and found that factors such as patients' age, disease duration, follow-up frequency, depressive mood, substance use, and HIV positivity in partners had an impact on treatment adherence.
FLORA INFEKSIYON HASTALIKLARI VE KLINIK MIKROBIYOLOJI DERGISI
(2021)
Article
Mycology
Merve Aydin, Ali Ozturk, Tugce Duran, Ummuhan Ozdemir Ozmen, Esra Sumlu, Esra Bilen Ayan, Emine Nedime Korucu
Summary: This study synthesized a series of new sulfo-nyl hydrazones compound and demonstrated their antifungal and biofilm inhibitory activity. The results suggest that Anaf compounds may have potential therapeutic applications in the treatment and prevention of biofilm-associated Candida infections.
JOURNAL DE MYCOLOGIE MEDICALE
(2023)
Article
Public, Environmental & Occupational Health
Hanife Nur Karakoc, Aysun Aksoy, Merve Aydin, Safiye Nur Ozcan, Gulcin Zengin, Hacer Aksit Yasar
Summary: By evaluating the effectiveness of high-dose corticosteroid pulse therapy in hospitalized patients with severe COVID-19 pneumonia, it was found that the CRP response, oxygen requirement, and OSCI scores can be used as prognostic factors to select patients who will benefit from this therapy.
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Bahriye Horasanli, Merve Aydin, Esra Sumlu, Zeynep Caliskan Sak, Aysun Ozsahin, Esra Firat Oguz, Ozcan Erel
Summary: This study investigated thiol-disulfide hemostasis in patients with migraine and found evidence of oxidative stress in migraine patients. However, further large-scale studies are needed to support these findings.
ANNALS OF CLINICAL AND ANALYTICAL MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Merve Aydin, Mustafa Yazici, Mehtap Demirkazik, Ismail Soner Koltas, Aytekin Cikman, Baris Gulhan, Tugce Duran, Aysun Yilmaz, Murat Kara
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE
(2019)
Article
Mycology
Merve Aydin, Semra Kustimur, Ayse Kalkanci, Tugce Duran
REVISTA IBEROAMERICANA DE MICOLOGIA
(2019)
Article
Medicine, Research & Experimental
Aylin Altay Kocak, Merve Aydin, Takashi Matsumoto, Takaaki Yahiro, Buket Dalgic, Gulendam Bozdayi, Kamruddin Ahmed
REVISTA ROMANA DE MEDICINA DE LABORATOR
(2019)
Article
Medicine, General & Internal
Canan Dizili-Yelgin, Aytekin Cikman, Faruk Karakecili, Baris Gulhan, Merve Aydin
Article
Microbiology
Sevgi Ozyegen Arslan, Merve Aydin, Israa Ibrahim Khalil Jabban, Ayse Seyer, Ali Adil Fouad, Burce Yalcin, Feyza Demir, Gulsah Biter, Ayse Kalkanci, Semra Kustimur
FLORA INFEKSIYON HASTALIKLARI VE KLINIK MIKROBIYOLOJI DERGISI
(2018)
Article
Infectious Diseases
Harold Salant, Yaarit Nachum-Biala, Doni Zivotofsky, Tsachi Even Tzur, Gad Baneth
Summary: This study describes the presentation, clinical signs, parasitemia levels, laboratory findings and treatment of dogs infected with B. negevi. Treatment with imidocarb dipropionate was helpful for recovery from clinical disease but did not facilitate parasite elimination, and it is therefore recommended to treat canine B. negevi infection with the combination of atovaquone and azithromycin.
TICKS AND TICK-BORNE DISEASES
(2024)
Article
Infectious Diseases
Gervillien Arnold Malonga, Almoustapha Issiaka Maiga, Dimitry Moudiongui Mboungou Malanda, Mahamadou Saliou, Juth ece Private Malanda-Kiminou, Oumar Dolo, Anicet Luc Magloire Boumba, Alhassane Ba, Robert Murphy, Jean Felix Peko, Anne-Genevieve Marcelin, Vincent Calvez, Stephane Marot
Summary: A serological survey in sub-urban areas of the capital cities of Congo and Mali reveals human contact with Crimean-Congo hemorrhagic fever virus (CCHFV) associated with previously described CCHFV risk factors.
TICKS AND TICK-BORNE DISEASES
(2024)
Article
Infectious Diseases
Aleksander Wymazal, Sabina Nowak, Robert W. Myslajek, Anna Bajer, Renata Welc-Faleciak, Maciej Szewczyk, Iga Kwiatkowska, Kinga M. Stepniak, Michal Figura, Agnieszka Kloch
Summary: The wolf population in Central and Eastern Europe has been increasing, but their frequent contacts with humans make them a potential zoonotic reservoir. This study found a high prevalence of tick-borne pathogens in free-ranging wolves from Poland.
TICKS AND TICK-BORNE DISEASES
(2024)
Article
Infectious Diseases
Nannet D. Fabri, Hans Heesterbeek, Joris P. G. M. Cromsigt, Frauke Ecke, Hein Sprong, Lonneke Nijhuis, Tim R. Hofmeester, Nienke Hartemink
Summary: In many parts of the northern hemisphere, different species of deer, small mammals, and birds coexist and their composition can strongly influence the outbreak potential of tick-borne pathogens. This study investigates how the abundance and composition of vertebrate communities affect the basic reproduction number R0 of tick-borne pathogens, and shows that species composition plays a substantial role in the outbreak potential of tick-borne diseases.
TICKS AND TICK-BORNE DISEASES
(2024)
Article
Infectious Diseases
Lynn M. Osikowicz, Maria R. Rizzo, Andrias Hojgaard, Sarah E. Maes, Rebecca J. Eisen
Summary: This article describes the prevalence and diversity of Lyme disease in the United States. By using different detection methods, the authors found various species of spirochetes present in specific tick species, revealing the potential transmission of pathogens among ticks.
TICKS AND TICK-BORNE DISEASES
(2024)
Review
Infectious Diseases
El-Sayed El-Alfy, Ibrahim Abbas, Somaya Saleh, Rana Elseadawy, Ragab M. Fereig, Mohamed Abdo Rizk, Xuenan Xuan
Summary: Published data on tick-borne pathogens in camels worldwide have been collected, providing an overview of their global prevalence and species diversity. Evidence of natural infection of camels with certain tick-borne pathogens is limited, particularly because most of the camels were considered healthy at the time of sampling. More research is needed to understand the role of camels in maintaining and transmitting these pathogens.
TICKS AND TICK-BORNE DISEASES
(2024)
Article
Infectious Diseases
Saana Sipari, Mikko Kiljunen, Minna Nylund, Eva R. Kallio
Summary: This study introduces a stable isotope analysis method to directly identify tick breeding hosts by sampling field collected larvae. The results show that stable isotope signatures can reflect the diet of the breeding host of the mother tick.
TICKS AND TICK-BORNE DISEASES
(2024)
