Article
Cell Biology
Ziming Jiang, Yiming Zhang, Yu Zhang, Zhankui Jia, Zhengguo Zhang, Jinjian Yang
Summary: The study revealed that exosomes released by bladder cancer cells can promote the immunosuppressive polarization of macrophages, facilitating tumor growth. This process is mediated by down-regulation of PTEN and activation of AKT/STAT3/6 signaling. Inhibiting the generation or secretion of exosomes can suppress the immunosuppressive transformation of macrophages, thereby inhibiting tumor growth.
CELL COMMUNICATION AND SIGNALING
(2021)
Review
Cell Biology
Sebastian Lillo, Maya Saleh
Summary: Inflammasomes are critical regulators of innate immunity, inflammation and cell death, and have emerged as important regulators of cancer development and control. The roles of inflammasomes in different cancers vary greatly, with both stimulating anti-tumor immunity and promoting tumor growth. A better understanding of inflammasome functions in different cancers is critical for the design of novel cancer immunotherapies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Zixiang Wang, Shourong Wang, Junchao Qin, Xiyu Zhang, Gang Lu, Hongbin Liu, Haiyang Guo, Ligang Wu, Victoria O. Shender, Changshun Shao, Beihua Kong, Zhaojian Liu
Summary: This study reveals that altered expression of splicing factor BUD31 can enhance ovarian cancer progression by promoting exon inclusion in the anti-apoptotic BCL2 family member, BCL2L12. The findings highlight the critical role of BUD31-regulated exon inclusion in ovarian cancer cell survival and cancer progression.
NATURE COMMUNICATIONS
(2022)
Article
Genetics & Heredity
Bitian Liu, Shen Pan, Junlong Liu, Chuize Kong
Summary: Research indicates that high infiltration of CAFs is associated with tumor progression and poor prognosis in BLCA. RUNX2, an overexpressed transcription factor in bladder cancer, is related to CAFs and affects prognosis. Therefore, RUNX2 may serve as a potential marker related to CAFs and a therapeutic target in BLCA.
Review
Biochemistry & Molecular Biology
Magdalena Wilczak, Magdalena Surman, Malgorzata Przybylo
Summary: Bladder cancer is the 10th most common malignancy worldwide, with a high mortality rate. Altered glycosylation of bladder cancer cells plays a crucial role in disease progression and could be used for diagnostic and therapeutic purposes.
Article
Oncology
Le Tao, Xingyu Mu, Haige Chen, Di Jin, Ruiyun Zhang, Yuyang Zhao, Jie Fan, Ming Cao, Zhihua Zhou
Summary: The study found that increased FTO expression in bladder tumor tissues correlated with clinical prognosis and outcomes of bladder cancer. FTO facilitates tumor growth in bladder cancer by regulating the MALAT/miR-384/MAL2 axis in m6A RNA modification manner.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Huimin Xu, Lingao Ju, Yaoyi Xiong, Mengxue Yu, Fenfang Zhou, Kaiyu Qian, Gang Wang, Yu Xiao, Xinghuan Wang
Summary: RNF126 is highly expressed in various cancers and acts as an oncogene in bladder cancer by promoting cell proliferation and metastasis through the EGFR/PI3K/AKT signaling pathway. It directly interacts with and regulates the stability of PTEN, an inhibitor of the PI3K/AKT pathway, through poly-ubiquitination. Knockdown of PTEN restores the effects of RNF126 silencing on cell proliferation, metastasis, and tumor formation in bladder cancer cells.
CELL DEATH & DISEASE
(2021)
Article
Biotechnology & Applied Microbiology
Weiyun Pan, Jun Han, Na Wei, Hui Wu, Yizhuo Wang, Jingnan Sun
Summary: The study found that LINC00702 can promote DUSP1 by recruiting JUND to inhibit the proliferation of bladder cancer cells and the secretion of inflammatory factors by M2-TAMs. The anti-tumor activity of LINC00702 was ultimately validated in vivo.
Article
Oncology
Prasanna Vasudevan Iyengar, Dieuwke Louise Marvin, Dilraj Lama, Tuan Zea Tan, Sudha Suriyamurthy, Feng Xie, Maarten van Dinther, Hailiang Mei, Chandra Shekhar Verma, Long Zhang, Laila Ritsma, Peter ten Dijke
Summary: TRAF4 is a molecule associated with the prognosis of bladder cancer. The study found that low TRAF4 expression is correlated with poor overall survival in patients with bladder cancer. TRAF4 affects bladder cancer cells by regulating EMT genes and epithelial/invasive properties.
MOLECULAR CANCER RESEARCH
(2022)
Article
Multidisciplinary Sciences
Paulina Wigner, Beata Szymanska, Michal Bijak, Ewa Sawicka, Pawel Kowal, Zofia Marchewka, Joanna Saluk-Bijak
Summary: Epidemiological studies confirm the importance of free radical overproduction in cancer induction and development, while a decrease in antioxidant systems efficiency increases the risk of carcinogenesis. Our study investigated plasma levels of oxidative/nitrative stress markers in bladder cancer patients, finding higher levels compared to healthy individuals. The positive correlation between bladder cancer progression and oxidative stress levels highlights the role of oxidative stress in cancer development, emphasizing the importance of proper antioxidant protection.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Kirsteen J. Campbell, Susan M. Mason, Matthew L. Winder, Rosalie B. E. Willemsen, Catherine Cloix, Hannah Lawson, Nicholas Rooney, Sandeep Dhayade, Andrew H. Sims, Karen Blyth, Stephen W. G. Tait
Summary: MCL-1 plays a crucial role in breast cancer, with its anti-apoptotic function being key. Deletion or inhibition of MCL-1 relies on pro-apoptotic proteins BAX/BAK for its anti-tumor effects, and it also influences stem cell activity in breast cancer cells.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Cell Biology
Yi-Hsiang Wang, Chia-Yi Shen, Sheng-Chieh Lin, Wen-Hung Kuo, Yuan-Ting Kuo, Yu-Ling Hsu, Wen-Ching Wang, Kai-Ti Lin, Lu-Hai Wang
Summary: This study identified an important immune cytokine, CXCL7, secreted by tumor infiltrating monocytes, to stimulate cancer cell migration, invasion, and metastasis, contributing to the promotion of breast cancer progression.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Ganping Wang, Yarong Dai, Kang Li, Maosheng Cheng, Gan Xiong, Xiaochen Wang, Shuang Chen, Zhi Chen, Jianwen Chen, Xiuyun Xu, Rong-song Ling, Liang Peng, Demeng Chen
Summary: The study demonstrates that Mettl3-mediated m(6)A modification is crucial for the activation of TEK-VEGF-A-mediated tumor progression and angiogenesis in bladder cancer. Experimental results using transgenic mouse models and bladder cancer stem cell populations showed that depletion of Mettl3 inhibits tumor oncogenesis and progression in bladder cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yeong-Chin Jou, Shou-Chieh Wang, Yuan-Chang Dia, Shou-Tsung Wang, Min-Hua Yu, Hsin-Yi Yang, Lei-Chin Chen, Cheng-Huang Shen, Yi-Wen Liu
Summary: The study demonstrated that GSTM5 acts as a tumor suppressor in bladder cancer cells without significantly affecting chemoresistance to cisplatin and mitomycin C, and the cellular levels of GSH are key mechanisms underlying the anticancer effect of GSTM5. Low gene expression and high DNA methylation levels of GSTM5 may serve as tumor markers for bladder cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Bo Xie, Juntao Lin, Xianwu Chen, Xuejian Zhou, Yan Zhang, Mengjing Fan, Jiayong Xiang, Ning He, Zhenghui Hu, Feifan Wang
Summary: In this study, it was found that circular RNA circXRN2 suppresses tumor progression driven by H3K18 lactylation by activating the Hippo signaling pathway in human bladder cancer. CircXRN2 is downregulated in bladder cancer tissues and cells, and it exerts its biological functions by preventing the degradation of LATS1 and activating the Hippo pathway.
Article
Immunology
Yohko Kitagawa, Naganari Ohkura, Yujiro Kidani, Alexis Vandenbon, Keiji Hirota, Ryoji Kawakami, Keiko Yasuda, Daisuke Motooka, Shota Nakamura, Motonari Kondo, Ichiro Taniuchi, Terumi Kohwi-Shigematsu, Shimon Sakaguchi
Article
Cell Biology
Kazuhiro Takara, Daisuke Eino, Koji Ando, Daisuke Yasuda, Hisamichi Naito, Yohei Tsukada, Tomohiro Iba, Taku Wakabayashi, Fumitaka Muramatsu, Hiroyasu Kidoya, Shigetomo Fukuhara, Naoki Mochizuki, Satoshi Ishii, Haruhiko Kishima, Nobuyuki Takakura
Article
Oncology
Kentaro Jingushi, Yuko Ueda, Kaori Kitae, Hiroaki Hase, Hiroshi Egawa, Ikumi Ohshio, Ryoji Kawakami, Yuri Kashiwagi, Yohei Tsukada, Takumi Kobayashi, Wataru Nakata, Kazutoshi Fujita, Motohide Uemura, Norio Nonomura, Kazutake Tsujikawa
MOLECULAR CANCER RESEARCH
(2015)
Article
Pathology
Yumiko Hayashi, Weizhen Jia, Hiroyasu Kidoya, Fumitaka Muramatsu, Yohei Tsukada, Nobuyuki Takakura
AMERICAN JOURNAL OF PATHOLOGY
(2019)
Article
Oncology
Daisuke Eino, Yohei Tsukada, Hisamichi Naito, Yonehiro Kanemura, Tomohiro Iba, Taku Wakabayashi, Fumitaka Muramatsu, Hiroyasu Kidoya, Hideyuki Arita, Naoki Kagawa, Yasunori Fujimoto, Kazuhiro Takara, Haruhiko Kishima, Nobuyuki Takakura
Article
Multidisciplinary Sciences
Keiko Yasuda, Yohko Kitagawa, Ryoji Kawakami, Yoshitaka Isaka, Hitomi Watanabe, Gen Kondoh, Terumi Kohwi-Shigematsu, Shimon Sakaguchi, Keiji Hirota
NATURE COMMUNICATIONS
(2019)
Article
Immunology
Masahiko Akamatsu, Norihisa Mikami, Naganari Ohkura, Ryoji Kawakami, Yohko Kitagawa, Atsushi Sugimoto, Keiji Hirota, Naoto Nakamura, Satoru Ujihara, Toshio Kurosaki, Hisao Hamaguchi, Hironori Harada, Guliang Xia, Yoshiaki Morita, Ichiro Aramori, Shuh Narumiya, Shimon Sakaguchi
SCIENCE IMMUNOLOGY
(2019)
Article
Multidisciplinary Sciences
Yohei Tsukada, Fumitaka Muramatsu, Yumiko Hayashi, Chiaki Inagaki, Hang Su, Tomohiro Iba, Hiroyasu Kidoya, Nobuyuki Takakura
Summary: This study demonstrates the engraftment of human blood vessels in mice by transplanting human tumor tissue into a cranial window, providing a new method to study human vascular biology. An in vivo imaging technique using two-photon microscopy allows continuous observation of human blood vessels, showing connections with mouse blood vessels and dependence on VEGFR2 signaling.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Ryoji Kawakami, Yohko Kitagawa, Kelvin Y. Chen, Masaya Arai, Daiya Ohara, Yamami Nakamura, Keiko Yasuda, Motonao Osaki, Norihisa Mikami, Caleb A. Lareau, Hitomi Watanabe, Gen Kondoh, Keiji Hirota, Naganari Ohkura, Shimon Sakaguchi
Summary: The transcription factor Foxp3 plays crucial roles in Treg cell development and function by controlling Foxp3 transcription. Deletion of CNS0 and CNS3 completely abrogates Treg cell generation and impairs Foxp3 expression stability in residual Treg cells, leading to lethal systemic autoimmunity and inflammation. Hierarchical and coordinated activation of Foxp3 CNS0 and CNS3 initiates and stabilizes Foxp3 gene expression, crucially controlling Treg cell development and self-tolerance.
Article
Food Science & Technology
Norihisa Mikami, Hiroko Tani, Ryoji Kawakami, Atsushi Sugimoto, Shimon Sakaguchi, Tomoki Ikuta
Summary: Research shows that Brazilian green propolis increases TNFR2 expression in Tregs via the IRF4/cMyc axis, with artepillin C being a major effective component. These findings suggest that propolis and artepillin C have the potential to activate Tregs through TNFR2 expression, and may be beneficial for the prevention and treatment of autoimmune or inflammatory diseases.
FOOD SCIENCE & NUTRITION
(2021)
Review
Immunology
Shimon Sakaguchi, Ryoji Kawakami, Norihisa Mikami
Summary: FoxP3-expressing regulatory T cells (Tregs) are valuable in treating immunological diseases and establishing transplantation tolerance. They can be expanded in vivo or in vitro for immune suppression and suppression of specific targets.
IMMUNOTHERAPY ADVANCES
(2023)
Article
Multidisciplinary Sciences
Norihisa Mikami, Ryoji Kawakami, Kelvin Y. Chen, Atsushi Sugimoto, Naganari Ohkura, Shimon Sakaguchi
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)