期刊
WORLD JOURNAL OF GASTROENTEROLOGY
卷 25, 期 31, 页码 4383-4404出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v25.i31.4383
关键词
Colorectal cancer; Inflammation; Prognosis; Cytokine; Chemokine; C-reactive protein; Glasgow prognostic score; Cachexia; Metastasis
Systemic inflammation is a marker of poor prognosis preoperatively present in around 20%-40% of colorectal cancer patients. The hallmarks of systemic inflammation include an increased production of proinflammatory cytokines and acute phase proteins that enter the circulation. While the low-level systemic inflammation is often clinically silent, its consequences are many and may ultimately lead to chronic cancer-associated wasting, cachexia. In this review, we discuss the pathogenesis of cancer-related systemic inflammation, explore the role of systemic inflammation in promoting cancer growth, escaping antitumor defense, and shifting metabolic pathways, and how these changes are related to less favorable outcome.
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