Article
Engineering, Electrical & Electronic
Sanjeet Kumar, Jaligam Murali Mohan, Khairunnisa Amreen, Satish Kumar Dubey, Sanket Goel
Summary: Continuous monitoring of antipsychotic drug release is important for dose monitoring in patients undergoing treatment. A miniaturized electrochemical sensing device based on paper was developed for the detection of the antipsychotic drug Clozapine. The device showed promising analytical performance and could be applied in point-of-care testing for drug sensing in biomedical applications.
SENSORS AND ACTUATORS A-PHYSICAL
(2023)
Article
Chemistry, Analytical
Tania Pomili, Paolo Donati, Pier Paolo Pompa
Summary: The study presents a monolithic and fully integrated paper-based device for the simultaneous detection of three prognostic biomarkers in saliva. The device features a unique design and simple fabrication process, with particles exhibiting visible color changes at non-physiological concentrations.
Article
Materials Science, Multidisciplinary
Ruihua Tang, Ming Yue Xie, Min Li, Lei Cao, Shangsheng Feng, Zedong Li, Feng Xu
Summary: Biosensors play an important role in the earlier diagnosis of diseases, food safety, and environment monitoring in resource-limited settings. Paper-based biosensors, utilizing the green and porous material properties of paper, provide a cost-effective, degradable, portable, and flexible platform for various applications. Nitrocellulose membrane, as a promising substrate material, has been extensively used due to its easy protein binding and high efficiency. However, there is a need for a deeper understanding of the research advances and broader applications of nitrocellulose membrane in paper-based biosensors.
APPLIED MATERIALS TODAY
(2022)
Article
Chemistry, Analytical
M. Jalal Uddin, Nabil H. Bhuiyan, Jun H. Hong, Joon S. Shim
Summary: A fully automated optofluidic device was developed for enzyme-linked immunosorbent assay using a smartphone-based optical platform. The platform successfully monitored liquid movement in the reaction chamber by measuring changes in light intensity, achieving a low detection limit for human cardiac biomarker detection.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Manuel Gutierrez-Capitan, Ana Sanchis, Estela O. Carvalho, Antonio Baldi, Lluisa Vilaplana, Vanessa F. Cardoso, Alvaro Calleja, Mingxing Wei, Roberto de la Rica, Javier Hoyo, Arnau Bassegoda, Tzanko Tzanov, Maria-Pilar Marco, Senentxu Lanceros-Mendez, Cesar Fernandez-Sanchez
Summary: This study demonstrates a unique and easily deployable multiplex device that can simultaneously measure interleukin-8, tumor necrosis factor-α, and myeloperoxidase biomarkers in sputum, aiming to facilitate the timely detection of acute exacerbations of chronic obstructive pulmonary disease.
Article
Chemistry, Multidisciplinary
Brittany AuYoung, Akshay Gutha Ravichandran, Divykumar Patel, Nisarg Dave, Achal Shah, Brianna Wronko-Stevens, Franklin Bettencourt, Reshma Rajan, Nidhi Menon
Summary: This article introduces a device called the KromaHealth Kit, which utilizes image processing and machine learning technology to quantitatively measure total bilirubin in human serum. By depositing biochemical assays on absorbent paper pads and using a dedicated smartphone app to capture images of colorimetric changes, the device can convert them into quantitative values of bilirubin. The research indicates that the KromaHealth Kit can serve as an inexpensive alternative to traditional bilirubin testing in clinical settings, offering high precision, ease-of-use, long shelf-life, and short turnaround time.
FRONTIERS IN CHEMISTRY
(2022)
Review
Chemistry, Analytical
Lauren S. Puumala, Samantha M. Grist, Jennifer M. Morales, Justin R. Bickford, Lukas Chrostowski, Sudip Shekhar, Karen C. Cheung
Summary: Silicon photonic (SiP) sensors are a promising platform for decentralized diagnostics due to their scalability, low limit of detection, and ability to integrate multiple sensors. Biofunctionalization plays a critical role in sensor performance. This review evaluates biofunctionalization strategies for SiP sensors, focusing on bioreceptor selection, immobilization strategies, and patterning techniques.
Article
Biochemical Research Methods
Azim Parandakh, Oriol Ymbern, William Jogia, Johan Renault, Andy Ng, David Juncker
Summary: Researchers have developed a novel chip-based ELISA technology that enables rapid and highly sensitive antibody detection. The chip simplifies chip loading and pipetting through autonomous aliquoting functionality, and can accommodate higher surfactant concentrations. The ELISA chip can complete the assay in 1.5 hours and exhibits comparable accuracy and performance to central laboratory ELISA.
Article
Chemistry, Analytical
Suchanat Boonkaew, Ilhoon Jang, Eka Noviana, Weena Siangproh, Orawon Chailapakul, Charles S. Henry
Summary: The study demonstrated an electrochemical paper-based analytical device (ePAD) combined with a label-free immunoassay for the simultaneous determination of three important cardiovascular disease biomarkers. The ePAD showed good linearity, low detection limits, and good reproducibility, enabling the simultaneous detection of the three biomarkers in serum samples. The proposed immunosensor can be a great alternative for the early detection of cardiovascular diseases at the point-of-care.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Multidisciplinary
David S. Kinnamon, Jacob T. Heggestad, Jason Liu, Thu Nguyen, Vo Ly, Angus M. Hucknall, Cassio M. Fontes, Rhett J. Britton, Jian-Piao Cai, Jasper Fuk-Woo Chan, Kwok-Yung Yuen, Thuy Le, Ashutosh Chilkoti
Summary: We developed a self-contained immunoassay platform that can be used in field settings with varied temperature, humidity, and blood samples. The platform has high sensitivity and accuracy in detecting analyte concentration, and a portable detection device. We also improved the microfluidic cassette for better usability and faster results. By using this platform, we successfully conducted a rapid diagnostic test for talaromycosis infection in patients, showing comparable sensitivity and specificity to laboratory tests.
Article
Biophysics
Bowen Shu, Ling Lin, Bin Wu, Enqi Huang, Yu Wang, Zhujun Li, Haoyan He, Xiuxia Lei, Banglao Xu, Dayu Liu
Summary: An ultraportable RNA amplification testing device is introduced for rapid screening of infectious pathogens, utilizing 3D-printed structural parts and off-the-shelf mechanical/electronic components. By preloading necessary reagents in a multi-channel droplet array chip, the device enables seamless integration of bacteria lysis, RNA extraction, and amplification, while providing visual readout and geometrically-multiplexed quantitative detection through an integrated wireless video camera.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Multidisciplinary
Bolin Chen, Zachary T. Johnson, Delaney Sanborn, Robert G. Hjort, Nate T. Garland, Raquel R. A. Soares, Bryan Van Belle, Nathan Jared, Jingzhe Li, Dapeng Jing, Emily A. Smith, Carmen L. Gomes, Jonathan C. Claussen
Summary: The study presents a scalable fabrication approach to create laser-induced graphene (LIG) with different electrical conductivity, surface morphology, and surface wettability. The LIG-based integrated microfluidics and electrochemical sensors demonstrated high sensitivities and low limits of detection for various ions and a pesticide. LIG was also used to create a high-performance micro supercapacitor with improved power density and energy density. This tunable fabrication approach is expected to have a wide range of applications in real-time health and environmental sensors as well as energy storage/harvesting modules.
Article
Engineering, Electrical & Electronic
Jaligam Murali Mohan, Sanjeet Kumar, Khairunnisa Amreen, Arshad Javed, Satish Kumar Dubey, Sanket Goel
Summary: One of the most common plasticizers that can cause endocrine disruption is phthalates, which are widely used in the production of consumer plastic items. This increases the risk of exposure to phthalates in items stored in water bottles, beverage drinks, and food. The detection of phthalates is crucial for food safety and quality. A point-of-care, screen-printed, disposable paper device was developed for the detection of phthalates, integrated with buckypaper for efficient detection. The device showed promising results and has the potential to be used as a point-of-care testing platform.
IEEE SENSORS JOURNAL
(2023)
Article
Chemistry, Analytical
Amer Charbaji, Hojat Heidari-Bafroui, Constantine Anagnostopoulos, Mohammad Faghri
Summary: The paper presents a simple and cost-effective paper-based microfluidic device for detecting nitrate in water. By incorporating recent advancements in paper-based technology suitable for nitrate detection, the device achieved significant improvement in nitrate detection compared to previous methods.
Article
Chemistry, Analytical
Nachiket Kelkar, Akshata Prabhu, Anusha Prabhu, M. S. Giri Nandagopal, Naresh Kumar Mani
Summary: Paper has long been used for testing analytes, but with the rapid growth of populations in isolated areas, there is now demand for easy-to-transport, low-cost, and rapid diagnostic methods. Hormones serve as crucial biomarkers in detecting specific physiological conditions, holding great potential for detection using paper-based devices.
MICROCHEMICAL JOURNAL
(2022)
Review
Chemistry, Multidisciplinary
Hui Zhang, Yufei Ma, Yijie Wang, Lin Niu, Rui Zou, Min Zhang, Hao Liu, Guy M. Genin, Ang Li, Feng Xu
Summary: This article reviews the soft-hard tissue interfaces found in the body and their application in bioinspired engineering materials. It also describes a range of manufacturing technologies related to interfacial tissue engineering, hydrogel bioadhesion, and healthcare and medical devices.
Article
Chemistry, Analytical
Yuxiang Zhao, Yabei Li, Shuake Kuermanbayi, Yulin Liu, Junjie Zhang, Zhaoyang Ye, Hui Guo, Kai Qu, Feng Xu, Fei Li
Summary: Ferroptosis, a promising therapeutic strategy for cancers, has attracted great interest. Monitoring the dynamic changes in key parameters during the early course of ferroptosis can provide insights for understanding the underlying mechanisms and developing targeted therapies.
ANALYTICAL CHEMISTRY
(2023)
Article
Engineering, Biomedical
Jinbin Qiu, Guorui Jin, Guoyou Huang, Haishui Huang, Feng Xu
Summary: In this study, an in vitro astrocyte culture system capable of precisely controlling culture temperature was developed to investigate the effects of clinically-relevant hyperthermic temperatures on astrocyte viability, morphology, and functions. It was found that high hyperthermia caused irreversible and permanent damages to astrocytes, while mild hyperthermia induced astrocyte activation and cytokine secretion without significant decreases in cell viability. This study provides new insights into fever-related symptoms and opens up possibilities for astrocyte-targeted therapy to treat brain diseases via hyperthermia.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Engineering, Biomedical
Yan Hu, Yuanbo Jia, Siwei Wang, Yufei Ma, Guoyou Huang, Tan Ding, Dayun Feng, Guy M. Genin, Zhao Wei, Feng Xu
Summary: Injectable hydrogels have the potential to promote healing of brain lesions, but current challenges arise from the mismatch between the hydrogel and the brain tissue. This study develops a self-healing hydrogel that mimics the composition, stiffness, and viscoelasticity of native brain tissue, and shows promising results in an in vivo mouse model of brain lesions.
ADVANCED HEALTHCARE MATERIALS
(2023)
Correction
Chemistry, Analytical
Zhaoyang Ye, Yabei Li, Yuxiang Zhao, Junjie Zhang, Tong Zhu, Feng Xu, Fei Li
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Zhaoyang Ye, Yabei Li, Yuxiang Zhao, Junjie Zhang, Tong Zhu, Feng Xu, Fei Li
Summary: This study constructed an in vitro cardiac tissue model and established a thermal-electric coupled theoretical model to simulate the electric field and temperature distributions around the cardiac tissue. Scanning electrochemical microscopy (SECM) was used to in situ and quantitatively monitor the dynamic changes in the key parameters of the cardiac tissue function after electric field stimulations. The results showed that the oxygen consumption, cell membrane permeability coefficient, and contraction frequency of the cardiac tissue were strongly dependent on electrical energy, especially when the electrical energy was higher than 0.001 J.
ANALYTICAL CHEMISTRY
(2023)
Article
Thermodynamics
Pengpeng Jia, Zedong Li, Xuefeng Wang, Feng Xu, Minli You, Shangsheng Feng
Summary: A mathematical model was developed to study the methods for improving the detection sensitivity of portable diagnostic devices. By simulating capillary flow and binding reactions on the internal pore surface, the effect of different specifications of nitrocellulose membranes on detection performance was investigated. The simulated results showed that selecting a membrane with an optimal average pore size can achieve the highest detection sensitivity, and a heterogeneous pore distribution design was proposed to improve detection speed and sensitivity.
INTERNATIONAL COMMUNICATIONS IN HEAT AND MASS TRANSFER
(2023)
Article
Multidisciplinary Sciences
Yuanbo Jia, Jiahui Hu, Keli An, Qiang Zhao, Yang Dang, Hao Liu, Zhao Wei, Songmei Geng, Feng Xu
Summary: In this study, enhanced phosphorylation of focal adhesion kinase (FAK) was found to be associated with scratch-exacerbated atopic dermatitis (AD). The researchers developed a multifunctional hydrogel dressing that integrates oxidative stress modulation with FAK inhibition to synergistically treat AD. The results showed that the hydrogel can scavenge reactive oxygen species, reduce intercellular junction deficiency, and alleviate inflammation in mouse AD models with controlled scratching.
NATURE COMMUNICATIONS
(2023)
Article
Engineering, Biomedical
Shanshan Zhu, Tian Zhang, Huan Gao, Guorui Jin, Jin Yang, Xiaocong He, Hui Guo, Feng Xu
Summary: Chemotherapy for breast cancer treatment is commonly used in clinics but has limited efficacy due to poor specificity and tumor microenvironment-induced diffusion barrier. A combination therapy strategy based on an extracellular matrix modulator and tumor microenvironment-responsive drug is developed, demonstrating outstanding therapeutic efficacy in vitro and in vivo. This mechanochemical approach provides a promising approach for breast cancer therapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Analytical
Gilberto Henao-Pabon, Ning Gao, K. Sudhakara Prasad, XiuJun Li
Summary: A disposable paper-based glucose biosensor with direct electron transfer of glucose oxidase was developed using simple covalent immobilization. It exhibited high electron transfer rate and good affinity for glucose oxidase, while maintaining enzymatic activities. This low-cost glucose biosensor achieved a wide glucose detection range and remarkable selectivity, making it suitable for monitoring different stages of diabetes.
Article
Nanoscience & Nanotechnology
Jinbin Qiu, Zhijie Li, Keli An, Lele Niu, Haishui Huang, Feng Xu
Summary: This study constructed 3D culture models to investigate the thermal response of glioma cells under different hyperthermic temperatures. It was found that the high energy level of cells in 3D glioma spheres enables them to maintain cellular viability and respond promptly to thermal stimulation. Additionally, 3D glioma spheres exhibit strong drug resistance to thermo-chemical combination therapy.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Multidisciplinary Sciences
Jicheng Niu, Wenjing Liu, Jasmine Xinze Li, Xianglong Pang, Yulin Liu, Chao Zhang, Keyang Yue, Yulin Zhou, Feng Xu, Xiaoguang Li, Fei Li
Summary: The authors report a strategy for laser cutting machining of nanoparticle encased water pancakes with sub-millimeter depth. They verified and elucidated the process of nanoparticle-encased water pancake laser cutting and the parameters that affect cutting accuracy through theoretical analysis, numerical simulation, and experimental studies. Laser-fabricated water patterns with diverse properties were demonstrated and their applications in various fields were conceptually demonstrated.
NATURE COMMUNICATIONS
(2023)
Article
Computer Science, Information Systems
Bin Li, Wei Zhang, Hong Fu, Hao Liu, Feng Xu
Summary: This article proposes an end-to-end multi-level constrained spatiotemporal representation structure for facial video-based blood volume pulse (BVP) signal measurement. The structure strengthens the generation of BVP-related features and enhances BVP signal period pattern learning through global-local association. Experimental results show that the proposed structure outperforms state-of-the-art methods in BVP signal measurement with significant reductions in mean absolute error and root mean squared error. This structure has potential applications in telemedical and non-contact heart health monitoring.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2023)
Article
Nanoscience & Nanotechnology
Sai Krishna Katla, Wan Zhou, Hamed Tavakoli, Elvia Lilia Padilla Mendez, Xiujun Li
Summary: A low-cost microfluidic platform with a flexible heater was developed for real-time temperature-dependent spectroscopic measurement in healthcare settings. After confirming its performance through comparing on-chip spectroscopic measurement with conventional spectroscopy using methylene blue, its application for temperature-dependent absorption spectroscopy of a model biomolecule, curcumin, was demonstrated. The system is portable, battery-powered, and requires minimal sample volumes, making it highly suitable for point-of-care characterization.
Article
Chemistry, Multidisciplinary
Yulin Liu, Junjie Zhang, Yabei Li, Yuxiang Zhao, Shuake Kuermanbayi, Jian Zhuang, Hua Zhang, Feng Xu, Fei Li
Summary: This study constructed an in vitro mechanical-inflammatory coupled microenvironment model for microglia and demonstrated that lipopolysaccharide treatment induced activation of microglia on a stiff matrix, leading to disruption of redox balance and increased susceptibility to ROS production. The respiratory activity and migration behavior of microglia were closely associated with their activation process, with the most pronounced changes observed in stiff matrix-LPS-induced microglia. The findings provide valuable insights into the mechanisms underlying neuroinflammatory processes in the CNS.
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).
