Article
Nutrition & Dietetics
Xin Shu, Jiaqi Wu, Tao Zhang, Xiaoyu Ma, Zuoqin Du, Jin Xu, Jingcan You, Liqun Wang, Ni Chen, Mao Luo, Jianbo Wu
Summary: The study suggests that PCSK9 expression in adipose tissue may mediate statin-induced adipocyte insulin resistance. PCSK9 deficiency could protect against statin-induced impairments in insulin signaling.
Article
Cardiac & Cardiovascular Systems
Mario Luca Morieri, Valentina Perrone, Chiara Veronesi, Luca Degli Esposti, Margherita Andretta, Mario Plebani, Gian Paolo Fadini, Saula Vigili de Kreutzenberg, Angelo Avogaro
Summary: This study identified factors contributing to low achievement of LDL-cholesterol targets and underuse of lipid-lowering treatments in high- or very-high-cardiovascular risk patients. Gender, age, HDL-c, and triglyceride levels were found to delay statin prescriptions, indicating a need for modification to improve cardiovascular disease prevention. Late initiation of high-intensity treatments, especially in perceived low-risk patients, was highlighted as a key factor that needs to be addressed.
CARDIOVASCULAR DIABETOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Mateusz Matwiejuk, Hanna Mysliwiec, Olivia Jakubowicz-Zalewska, Adrian Chabowski, Iwona Flisiak
Summary: Psoriasis is a chronic inflammatory disease that affects various metabolic and immune processes, leading to lipid abnormalities, impaired glucose tolerance, metabolic disorders, and cardiovascular diseases. Statins and fibrates are commonly used drugs for treating lipid abnormalities in clinical practice. Statins reduce LDL, total cholesterol, and triglycerides, and stabilize atherosclerotic plaques, while fibrates lower triglycerides and LDL levels and increase HDL. New drugs like glitazones and GLP-1 receptor agonists have also shown potential in normalizing lipid profiles in psoriasis patients.
Review
Biochemistry & Molecular Biology
Adel Hajj Ali, Nour Younis, Rola Abdallah, Farah Shaer, Ali Dakroub, Mohammed Akli Ayoub, Rabah Iratni, Hadi Mohamad Yassine, Kazem Zibara, Alexander Orekhov, Ahmed Fawzy El-Yazbi, Ali H. Eid
Summary: Cardiovascular disease remains the primary cause of global morbidity and mortality, with atherosclerosis playing a key role in its pathogenesis. Along with traditional lipid-lowering therapies, recent molecular and genetic interventions such as PCSK9 monoclonal antibodies are gaining attention in the field of cardiovascular medicine.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Amanda J. Berberich, Alexandra M. Ouedraogo, Salimah Z. Shariff, Robert A. Hegele, Kristin K. Clemens
Summary: The incidence of severe and very severe hypertriglyceridemia in Canadian adults is 1 in 400 and 1 in 2500, respectively. Males, individuals with diabetes, obesity, and alcohol abuse are at highest risk for very severe hypertriglyceridemia. Increased surveillance is recommended for these high-risk groups.
LIPIDS IN HEALTH AND DISEASE
(2021)
Review
Medicine, General & Internal
Farzahna Mohamed, Brett Mansfield, Frederick J. Raal
Summary: Reducing LDL-C levels is crucial for preventing ASCVD, but many patients, especially those at high risk or with FH, don't achieve target levels with statin alone. The underutilization of novel LLT may be due to cost concerns or therapeutic inertia. Emerging approaches, including combination therapies and novel LLT strategies, offer potential for further LDL-C reduction and reduced ASCVD risk.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Satya Preetham Gunta, James H. O'Keefe, Evan L. O'Keefe, Carl J. Lavie
Summary: Statins are the first-line therapy for dyslipidemia, but many people cannot tolerate them, so alternative medications are needed to lower LDL-C levels and reduce cardiovascular events risk.
PROGRESS IN CARDIOVASCULAR DISEASES
(2023)
Review
Pharmacology & Pharmacy
Laura Alvarez-Jimenez, Felix Morales-Palomo, Alfonso Moreno-Cabanas, Juan F. Ortega, Ricardo Mora-Rodriguez
Summary: This study provides an update on the diabetogenic effect of statins by analyzing randomized-controlled trials. The results show that statin therapy increases glycated hemoglobin levels and insulin resistance regardless of the glycemic control status. The diabetogenic effect is not influenced by the type or dosage of statin prescribed.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Wen-Yu Ho, Chieh-Li Yen, Cheng-Chia Lee, Yi-Ran Tu, Chao-Yu Chen, Ching-Chung Hsiao, Pao-Hsien Chu, Hsiang-Hao Hsu, Ya-Chun Tian, Chih-Hsiang Chang
Summary: This study investigated the cardiovascular protective effects of fibrates in patients with end-stage renal disease (ESRD). The results showed that fibrates, whether used alone or in combination with statins, did not reduce mortality or cardiovascular risks in ESRD patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
Ziwei Zhu, Kai Wang, Xingjie Hao, Liangkai Chen, Zhonghua Liu, Chaolong Wang
Summary: This study systematically investigated the causal relationships among HDL cholesterol, LDL cholesterol, triglycerides, fasting insulin, and glycated hemoglobin A(1c). The results suggest that insulin resistance is a strong causal factor of high triglycerides and low HDL cholesterol, highlighting the importance of early control of insulin resistance to prevent type 2 diabetes, dyslipidemia, and cardiovascular complications.
Review
Cardiac & Cardiovascular Systems
Angelos D. Karagiannis, Anurag Mehta, Devinder S. Dhindsa, Salim S. Virani, Carl E. Orringer, Roger S. Blumenthal, Neil J. Stone, Laurence S. Sperling
Summary: LDL-C is a causative factor for atherosclerotic cardiovascular disease, and pharmacological interventions can lower LDL-C levels. More patients are achieving very low LDL-C levels, with cardiovascular event reduction increasing log linearly in association with lowering LDL-C.
EUROPEAN HEART JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Imre Juhasz, Szilvia Ujfalusi, Ildiko Seres, Hajnalka Lorincz, Viktoria Evelin Varga, Gyoergy Paragh, Sandor Somodi, Mariann Harangi, Gyoergy Paragh
Summary: This study found that in non-diabetic, obese patients, Afamin levels were significantly higher and correlated with markers of metabolic syndrome. After multiple regression analysis, HbA1c levels and small HDL subfractions were identified as independent predictors of Afamin.
Review
Medicine, Research & Experimental
Grzegorz Grzesk, Bednarska Dorota, Lukasz Wolowiec, Anna Wolowiec, Joanna Osiak, Mariusz Kozakiewicz, Joanna Banach
Summary: 4 million people die from cardiovascular diseases annually in Europe due to atherosclerosis. Lowering LDL cholesterol level is the main therapeutic goal, but only 43% of statin-taking patients achieved their targets. PCSK9 inhibitors are a new group of lipid-lowering drugs that can reduce LDL-C level.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medical Laboratory Technology
Junji Kobayashi, Takuya Minamizuka, Masaya Koshizaka, Yoshiro Maezawa, Hiraku Ono, Koutaro Yokote
Summary: The study found that serum HDL-C is an extremely useful marker for discriminating LPL deficiency from SHTG in the Japanese population, with high sensitivity and specificity, which can serve as an important indicator of the type of disease in patients.
CLINICA CHIMICA ACTA
(2021)
Article
Medicine, General & Internal
Pedro Romero-Aroca, Raquel Verges, Jordi Pascual-Fontanilles, Aida Valls, Josep Franch, Joan Barrot, Xavier Mundet, Alex La Torre, Antonio Moreno, Ramon Sagarra, Josep Basora, Eugeni Garcia-Curto, Marc Baget-Bernaldiz
Summary: This study found that arterial hypertension, high HbA1c levels, microalbuminuria, high LDL-cholesterol, high TC/HDL-C index, high non-HDL-C/HDL-C index, the use of statins, and high body mass index are the main factors influencing the development of diabetic retinopathy. Conversely, high HDL-cholesterol levels and the use of fibrates have a protective effect.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Environmental Sciences
Eran Manes, Anat Tchetchik, Yosef Tobol, Ronen Durst, Gabriel Chodick
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2019)
Article
Cell Biology
Katelynn A. Toomer, Mengyao Yu, Diana Fulmer, Lilong Guo, Kelsey S. Moore, Reece Moore, Ka'la D. Drayton, Janiece Glover, Neal Peterson, Sandra Ramos-Ortiz, Alex Drohan, Breiona J. Catching, Rebecca Stairley, Andy Wessels, Joshua H. Lipschutz, Francesca N. Delling, Xavier Jeunemaitre, Christian Dina, Ryan L. Collins, Harrison Brand, Michael E. Talkowski, Federica del Monte, Rupak Mukherjee, Alexander Awgulewitsch, Simon Body, Gary Hardiman, E. Starr Hazard, Willian A. da Silveira, Baolin Wang, Maire Leyne, Ronen Durst, Roger R. Markwald, Solena Le Scouarnec, Albert Hagege, Thierry Le Tourneau, Peter Kohl, Eva A. Rog-Zielinska, Patrick T. Ellinor, Robert A. Levine, David J. Milan, Jean-Jacques Schott, Nabila Bouatia-Naji, Susan A. Slaugenhaupt, Russell A. Norris
SCIENCE TRANSLATIONAL MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Michael Winther, Shoshi Shpitzen, Or Yaacov, Jakob Landau, Limor Oren, Linda Foroozan-Rosenberg, Naama Lev Cohain, Daniel Schurr, Vardiela Meiner, Auryan Szalat, Shai Carmi, Michael R. Hayden, Fran Leitersdorf, Ronen Durst
JOURNAL OF LIPID RESEARCH
(2019)
Article
Cardiac & Cardiovascular Systems
Alexander P. Nissen, Van Thi Thanh Truong, Bader A. Alhafez, Jyothy J. Puthumana, Anthony L. Estrera, Simon C. Body, Siddharth K. Prakash
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2020)
Review
Radiology, Nuclear Medicine & Medical Imaging
Dan Gilon, David Leibowitz, Ronen Durst, Zaza Iakobishvili
JOURNAL OF THORACIC IMAGING
(2020)
Article
Multidisciplinary Sciences
Joshua Stokar, David Leibowitz, Ronen Durst, Dorith Shaham, Donna R. Zwas
Article
Medicine, General & Internal
A. Elis, M. Leventer-Roberts, A. Bachrach, N. Lieberman, R. Durst, H. Knobler, R. Balicer
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2020)
Letter
Endocrinology & Metabolism
Kobi Gorin, Mordechai Golomb, Shoshi Spitzen, Eran Leitersdorf, Daniel Schurr, Arin Haj-Yahia, Ram Weiss, Gil Leibowitz, Ronen Durst
CLINICAL ENDOCRINOLOGY
(2020)
Article
Medicine, General & Internal
M. D. Cappellini, V. Viprakasit, A. T. Taher, P. Georgiev, K. H. M. Kuo, T. Coates, E. Voskaridou, H. -K. Liew, I. Pazgal-Kobrowski, G. L. Forni, S. Perrotta, A. Khelif, A. Lal, A. Kattamis, E. Vlachaki, R. Origa, Y. Aydinok, M. Bejaoui, P. J. Ho, L. -P. Chew, P. -C. Bee, S. -M. Lim, M. -Y. Lu, A. Tantiworawit, P. Ganeva, L. Gercheva, F. Shah, E. J. Neufeld, A. Thompson, A. Laadem, J. K. Shetty, J. Zou, J. Zhang, D. Miteva, T. Zinger, P. G. Linde, M. L. Sherman, O. Hermine, J. Porter, A. Piga
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
Article
Medicine, General & Internal
Antonio J. Vallejo-Vaz, Christophe A. T. Stevens, Alexander R. M. Lyons, Kanika I. Dharmayat, Tomas Freiberger, G. Kees Hovingh, Pedro Mata, Frederick J. Raal, Raul D. Santos, Handrean Soran, Gerald F. Watts, Marianne Abifadel, Carlos A. Aguilar-Salinas, Khalid F. Alhabib, Mutaz Alkhnifsawi, Wael Almahmeed, Fahad Alnouri, Rodrigo Alonso, Khalid Al-Rasadi, Ahmad Al-Sarraf, Nasreen Al-Sayed, Francisco Araujo, Tester F. Ashavaid, Maciej Banach, Sophie Beliard, Marianne Benn, Christoph J. Binder, Martin P. Bogsrud, Mafalda Bourbon, Krzysztof Chlebus, Pablo Corral, Kairat Davletov, Olivier S. Descamps, Ronen Durst, Marat Ezhov, Dan Gaita, Jacques Genest, Urh Groselj, Mariko Harada-Shiba, Kirsten B. Holven, Meral Kayikcioglu, Weerapan Khovidhunkit, Katarina Lalic, Gustavs Latkovskis, Ulrich Laufs, Evangelos Liberopoulos, Marcos M. Lima-Martinez, Jie Lin, Vincent Maher, A. David Marais, Winfried Maerz, Erkin Mirrakhimov, Andre R. Miserez, Olena Mitchenko, Hapizah Nawawi, Borge G. Nordestgaard, Andrie G. Panayiotou, Gyorgy Paragh, Zaneta Petrulioniene, Belma Pojskic, Arman Postadzhiyan, Katarina Raslova, Ashraf Reda, Zeljko Reiner, Fouzia Sadiq, Wilson Ehidiamen Sadoh, Heribert Schunkert, Aleksandr B. Shek, Mario Stoll, Erik Stroes, Ta-Chen Su, Tavintharan Subramaniam, Andrey V. Susekov, Myra Tilney, Brian Tomlinson, Thanh Huong Truong, Alexandros D. Tselepis, Anne Tybjaerg-Hansen, Alejandra Vazquez Cardenas, Margus Viigimaa, Luya Wang, Shizuya Yamashita, Lale Tokgozoglu, Alberico L. Catapano, Kausik K. Ray
Summary: This study characterized the adult population with heterozygous familial hypercholesterolaemia using data from the FHSC global registry, highlighting the challenges in prevention and management of the condition. Early detection and greater use of combination therapies are needed to reduce the global burden of familial hypercholesterolaemia.
Article
Cardiac & Cardiovascular Systems
Idit Tessler, Moshe Leshno, Amir Shmueli, Shoshana Shpitzen, Ronen Durst, Dan Gilon
Summary: The study found that echocardiographic screening for first-degree relatives of BAV index cases is not only clinically important but also cost-effective and cost-saving. Sensitivity analysis supported the model's robustness, suggesting its generalization.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2021)
Article
Cardiac & Cardiovascular Systems
Idit Tessler, Guillaume Goudot, Juliette Albuisson, Noga Reshef, Donna R. Zwas, Shai Carmi, Shoshana Shpitzen, Galina Levin, Guy Kelman, Charles Cheng, Jean-Michael Mazzella, Yonatan Levin, Emmanuel Messas, Dan Gilon, Ronen Durst
Summary: The study revealed intrafamilial variability in the morphology of bicuspid aortic valve (BAV), indicating that morphology is determined by factors other than Mendelian genetics. As prognosis differs by morphology, clinical outcomes may vary even between first-degree relatives.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Tycho R. Tromp, Merel L. Hartgers, G. Kees Hovingh, Antonio J. Vallejo-Vaz, Kausik K. Ray, Handrean Soran, Tomas Freiberger, Stefano Bertolini, Mariko Harada-Shiba, Dirk J. Blom, Frederick J. Raal, Marina Cuchel
Summary: Patients with homozygous familial hypercholesterolaemia (HoFH) globally face issues of late diagnosis, under-treatment, and high risk of premature ASCVD. The use of multiple lipid-lowering therapy regimens is associated with lower LDL cholesterol levels and better outcomes. Significant global disparities exist in treatment regimens, control of LDL cholesterol levels, and cardiovascular event-free survival.
Review
Cardiac & Cardiovascular Systems
Idit Tessler, Noga Reshef, Shoshana Shpitzen, Dan Gilon, Ronen Durst
Summary: Mitral valve prolapse (MVP) is the most common primary valvular abnormality, associated with various degrees of incompetent function and sequelae, including heart failure and sudden cardiac death. Recent advancements in echocardiographic techniques and understanding of mitral valve anatomy and physiology have improved the accuracy and reliability of MVP diagnosis.
KARDIOLOGIA POLSKA
(2022)
Article
Rheumatology
O. Shamriz, Y. Tal, R. Durst, A. Pollak, A. E. Moses, D. Mevorach
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2019)
