Review
Biotechnology & Applied Microbiology
Yun-Feng Zhou, Di Zhang, Wan-Ting Yan, Kai Lian, Zheng-Zheng Zhang
Summary: This article reviews the therapeutic potential of multipotent stromal cells (MSCs) in repairing meniscal injuries and discusses the avenues for utilizing these cells. The current progress on biomaterial implants is also reviewed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Giuliana Minani Bertolino, Marie Maumus, Christian Jorgensen, Daniele Noel
Summary: Extracellular vesicles (EVs) isolated from induced pluripotent stem cells (iMSCs) show promise in regenerative medicine for the treatment of various diseases. However, the heterogeneity between MSC donors may lead to batch-to-batch variability in the use of EVs as cell-free therapeutic agents.
Review
Biochemistry & Molecular Biology
Vitale Miceli, Matteo Bulati, Gioacchin Iannolo, Giovanni Zito, Alessia Gallo, Pier Giulio Conaldi
Summary: MSCs are multipotent adult stem cells that support tissue regeneration, and their therapeutic effects are derived from the secretion of bioactive molecules. However, variables in clinical trials have led to inconsistent outcomes. Therefore, exploring the paracrine action of MSCs to enhance therapeutic benefits by modulating the composition of secretome is a promising approach for tissue regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Raphael Gorodetsky, Wilhelm K. Aicher
Summary: MSCs from different sources can release pro-regenerative and anti-inflammatory factors, with hPSCs from the fresh human placenta being a preferred source for abundant cell harvesting. The f-hPSCs from neonate tissues of the placenta can undergo extended expansion with low risk of senescence, making them competent cells for therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biology
Chih-Wei Zeng
Summary: Spinal cord injury (SCI) has a significant impact on quality of life, necessitating new treatment options. Multipotent mesenchymal stem cells (MSCs) have emerged as a promising candidate for SCI treatment due to their regenerative capabilities. This comprehensive review discusses the molecular mechanisms involved in MSC-mediated tissue repair in SCI. It also examines various clinical applications of MSCs in SCI treatment, and highlights the challenges associated with MSC-based therapies.
Review
Cell & Tissue Engineering
Hesham Soliman, Marine Theret, Wilder Scott, Lesley Hill, Tully Michael Underhill, Boris Hinz, Fabio M. Rossi
Summary: MSCs are essential for the development, maintenance, function, and regeneration of most tissues. They play a crucial role in responding to injury, promoting regeneration through secretion of trophic factors and ECM molecules, and contributing to fibrotic reparative processes. Through fate mapping and single cell omics, tissue-specific MSC identities and functions are being elucidated, providing unprecedented insights into the secret lives of tissue-resident MSCs.
Review
Cell Biology
Vadim I. Chechekhin, Konstantin Yu. Kulebyakin, Romesh I. Kokaev, Pyotr A. Tyurin-Kuzmin
Summary: Adipose tissue relies on the regulation of multipotent mesenchymal stromal cells (MSCs), which serve as both precursors for new adipocytes and key paracrine regulators of adipose tissue homeostasis. The activity of MSCs is tightly controlled, regulating aspects such as proliferation, differentiation, and signal molecule production through modulation of hormonal sensitivity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Immunology
Sophie Servais, Frederic Baron, Chantal Lechanteur, Laurence Seidel, Etienne Baudoux, Alexandra Briquet, Dominik Selleslag, Johan Maertens, Xavier Poire, Wilfried Schroyens, Carlos Graux, Ann De Becker, Pierre Zachee, Aurelie Ory, Julie Herman, Tessa Kerre, Yves Beguin
Summary: BM-derived MSC from a third-party donor appeared to improve hematological function after alloHCT, but comparative studies are needed to confirm these results.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Jayden A. Smith, Alexandra M. Nicaise, Rosana-Bristena Ionescu, Regan Hamel, Luca Peruzzotti-Jametti, Stefano Pluchino
Summary: Multiple sclerosis is a chronic inflammatory disease of the central nervous system characterized by demyelination and axonal degeneration. While current treatments for progressive MS are limited, stem cell transplantation shows promise in providing neurotrophic support, immunomodulation, and cell replacement to combat chronic neuroinflammation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Shiqi Xiang, Zixuan Lin, Meagan J. J. Makarcyzk, Kanyakorn Riewruja, Yiqian Zhang, Xiurui Zhang, Zhong Li, Karen L. Clark, Eileen Li, Silvia Liu, Tingjun Hao, Madalyn R. R. Fritch, Peter G. G. Alexander, Hang Lin
Summary: This study elucidates the difference between hiMPCs and hMSCs in response to TGF beta and presents a robust method for obtaining low hypertrophy hiMPCs-derived cartilage. The results also indicate the importance of activating both Smad2/3 and Smad1/5 in the initiation of chondrogenesis.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Cell & Tissue Engineering
Lydia J. Beeken, Darren S. J. Ting, Laura E. Sidney
Summary: Ocular surface inflammatory disorders are highly prevalent, heterogeneous diseases with a common factor of corneal inflammation. Current medications have limitations, and regenerative medicine cell therapies, particularly mesenchymal stem cells, show promise but require further investigation for successful clinical translation.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Editorial Material
Medicine, Research & Experimental
Jose Maria Lamo-Espinosa, Felipe Prosper, Juan F. Blanco, Fermin Sanchez-Guijo, Mercedes Alberca, Veronica Garcia, Margarita Gonzalez-Vallinas, Javier Garcia-Sancho
Summary: The study found that using 10, 40, and 100 million autologous cells for knee osteoarthritis treatment provided similar and long-lasting results, providing strong evidence for the efficacy of single-cell injection therapy.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Cell & Tissue Engineering
Alison J. Wilson, Emma Rand, Andrew J. Webster, Paul G. Genever
Summary: Many clinical trials involving mesenchymal stem/stromal cells lack comprehensive characterization data of the cellular population, including details on surface marker expression, viability, and differentiation. Functional assessment is very limited and does not always correlate with the likely mechanism of action.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Biotechnology & Applied Microbiology
Jehan J. El-Jawhari, Payal Ganguly, Elena Jones, Peter Giannoudis
Summary: This review discusses the application of bone marrow-derived mesenchymal stromal cells in treating osteonecrosis, including donor-related factors, the impact of aging on donor-related variability, and factors influencing the quantity and function of these cells.
BIOENGINEERING-BASEL
(2021)
Review
Cell Biology
Michal Szymoniuk, Jakub Litak, Leon Sakwa, Aleksandra Dryla, Wojciech Zezulinski, Wojciech Czyzewski, Piotr Kamieniak, Tomasz Blicharski
Summary: Spinal Cord Injury (SCI) is a common neurological disorder that causes permanent disability in most patients. Stem Cell Therapy (SCT) shows promise in regenerating the injured spinal cord through the use of various types of stem cells. Understanding the pathogenesis of SCI and the molecular mechanisms of stem cell action can improve the efficacy of SCT and lead to the development of new therapeutic approaches.
Article
Cell & Tissue Engineering
Adrien Moya, Nathanael Larochette, Marianne Bourguignon, Hanane El-Hafci, Esther Potier, Herve Petite, Delphine Logeart-Avramoglou
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2018)
Article
Cell & Tissue Engineering
Adrien Moya, Joseph Paquet, Mickael Deschepper, Nathanael Larochette, Karim Oudina, Cyprien Denoeud, Morad Bensidhoum, Delphine Logeart-Avramoglou, Herve Petite
Article
Orthopedics
G. E. Salazar-Noratto, N. De Nijs, Y. Stevens, G. Gibson, R. E. Guldberg
OSTEOARTHRITIS AND CARTILAGE
(2019)
Article
Cell & Tissue Engineering
David S. Reece, Olivia A. Burnsed, Kaley Parchinski, Elizabeth E. Marr, Roger M. White, Giuliana E. Salazar-Noratto, Angela S. P. Lin, Nick J. Willett, Robert E. Guldberg
TISSUE ENGINEERING PART A
(2020)
Article
Pharmacology & Pharmacy
Pinpin Wang, Federico Perche, Delphine Logeart-Avramoglou, Chantal Pichon
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2019)
Article
Engineering, Biomedical
Pinpin Wang, Delphine Logeart-Avramoglou, Herve Petite, Cristine Goncalves, Patrick Midoux, Federico Perche, Chantal Pichon
ACTA BIOMATERIALIA
(2020)
Article
Engineering, Biomedical
Nathanael Larochette, Hanane El-Hafci, Esther Potier, Niclas Setterblad, Morad Bensidhoum, Herve Petite, Delphine Logeart-Avramoglou
ACTA BIOMATERIALIA
(2020)
Article
Chemistry, Multidisciplinary
Pinpin Wang, Federico Perche, Patrick Midoux, Catia S. D. Cabral, Virginie Malard, Ilidio J. Correia, Hanane EI-Hafci, Herve Petite, Delphine Logeart-Avramoglou, Chantal Pichon
Summary: Dual mRNA system for osteogenesis was developed, and RAMs were prepared using LPR for sustained mRNA release and prolonged transgene expression, leading to significant new bone tissue induction in mice. The results suggest that the BMP2/NS1 dual mRNA system is suitable for osteogenic engagement, and RAM-BMP2/NS1 could be promising off-the-shelf products for clinical orthopedic practice.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Cell & Tissue Engineering
Guotian Luo, Pauline Wosinski, Giuliana E. Salazar-Noratto, Morad Bensidhoum, Rena Bizios, Sayed-Amir Marashi, Esther Potier, Puyi Sheng, Herve Petite
Summary: This article summarizes past efforts in the clinical use of MSCs and reports the latest findings that identify glucose metabolism as a crucial parameter in MSC survival and functions related to tissue regeneration. These findings justify further research and the development of new strategies for MSC-based therapies.
TISSUE ENGINEERING PART B-REVIEWS
(2023)
Article
Medicine, Research & Experimental
Aysegul Atasoy-Zeybek, Michael J. Coenen, Gresin P. Hawse, Delphine Logeart-Avramoglou, Christopher H. Evans, Rodolfo E. De La Vega
Summary: Bone morphogenetic protein-2 (BMP-2) is used clinically to enhance bone healing but requires high doses and has adverse side effects. Gene transfer of transgenic BMP-2 shows that it is more effective than rhBMP-2 in signaling. The transferred cells can induce signaling in a paracrine fashion, but the secreted BMP-2 cannot affect distant cells.
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2023)
Article
Cell & Tissue Engineering
Manon Maroquenne, Marianne Bourguignon, Nathanael Larochette, Hanane El-Hafci, Morgane Margottin, Esther Potier, Delphine Logeart-Avramoglou
Summary: This study investigated the mechanisms underlying the differences in osteogenicity between adipose tissue-derived mesenchymal stem cells (ATSCs) and bone marrow-derived mesenchymal stem cells (BMSCs) in ceramic constructs, focusing on the impact of inflammation. The results showed that BMSC constructs consistently induced bone formation, while ATSC-containing constructs did not. Gene expression analysis revealed that BMSCs differentiated into osteogenic lineage early post-implantation, while ATSCs differentiated later. The upregulation of inflammatory genes and the presence of immune cells in the ATSC constructs correlated with impaired osteogenic differentiation. The importance of this study is rated 6 out of 10.
STEM CELL REVIEWS AND REPORTS
(2023)
Article
Engineering, Biomedical
Giuliana E. Salazar-Noratto, Catriana C. Nations, Hazel Y. Stevens, Robert E. Guldberg
REGENERATIVE ENGINEERING AND TRANSLATIONAL MEDICINE
(2019)
