期刊
STEM CELLS
卷 38, 期 1, 页码 34-44出版社
OXFORD UNIV PRESS
DOI: 10.1002/stem.3069
关键词
Adult stem cells; Cell surface receptors; Cancer; Signal transduction; Cell death
资金
- NIH [R01-CA201148, R01-NS107857]
Multiple stem cell types exhibit inherent tropism for cancer, and engineered stem cells have been used as therapeutic agents to specifically target cancer cells. Recently, stem cells have been engineered to target multiple surface receptors on tumor cells, as well as endothelial and immune cells in the tumor microenvironment. In this review, we discuss the rationales and strategies for developing multiple receptor-targeted stem cells, their mechanisms of action, and the promises and challenges they hold as cancer therapeutics. Stem Cells 2019
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