Article
Chemistry, Analytical
Yin Chen, Miao Zhang, Dai Lu, Jiaquan Yin, Wenli Gao, Xingbo Shi
Summary: An ingenious Halbach ring-mediated magnetic filter (HRMF) is developed for capture, sterilization, and detection of foodborne pathogenic bacteria. By synthesizing a composite material called MNP@PDA@PEI, which consists of magnetic nanoparticles (MNP) as the core coated with polydopamine (PDA) and polyethylenimine (PEI), HRMF can be formed under a Halbach ring. The HRMF can capture bacteria from solution via electrostatic adsorption and achieve sterilization through the photothermal effect of MNP@PDA@PEI. The proposed platform shows great potential for on-site real-time detection of foodborne pathogens and nondestructive sterilization in the food processing industry.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Review
Biochemical Research Methods
Fang Mi, Cunming Hu, Ying Wang, Li Wang, Fei Peng, PengFei Geng, Ming Guan
Summary: This article reviews the recent development of bio-recognition elements integrated on microfluidic chips and pathogen pretreatment in microfluidic chip technology. Furthermore, it summarizes and discusses the research progress of microfluidic technology based on optical and electrochemical sensors for the detection of foodborne pathogenic bacteria. Finally, the future prospects and challenges of microfluidic chips based on biosensors are presented.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Gaowa Xing, Nan Li, Haifeng Lin, Yuting Shang, Qiaosheng Pu, Jin-Ming Lin
Summary: In this paper, a one-step and wash-free microfluidic biosensor platform using a smartphone is presented for simultaneous detection of multiple foodborne bacteria DNA. The platform can detect four kinds of bacteria DNA within 5 minutes and has successfully detected trace amounts of foodborne bacteria DNA in milk and water samples.
Review
Chemistry, Analytical
Yuting Shang, Xinran Xiang, Qinghua Ye, Qingping Wu, Jumei Zhang, Jin-Ming Lin
Summary: This review provides an overview of the application of microfluidic chips in detecting foodborne bacteria using different nanomaterials. The combination of nanomaterials with microfluidics improves the detection efficiency and sensitivity. The challenges in translating scientific research into product development are discussed, along with perspectives on future technological directions and potential applications.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Houjuan Zhu, Zibiao Li, Enyi Ye, David Tai Leong
Summary: A biomineralization-assisted bottom-up strategy was developed to synthesize oxygenic hybrid ruthenium sulfide nanoclusters (RuSx NCs) with optimized photothermal therapy (PTT) by regulating oxygen amounts and sulfur defects. With increasing molar ratios of Ru to S, RuSx NCs demonstrated higher photothermal conversion efficiency (PCE) compared to most small-sized inorganic photothermal nanoagents. High PCE and superior photostability of RuSx NCs allowed for effective and complete cancer cell ablation, showing potential for future biomedical applications.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Yingjia Liu, Dong Jiang, Siyuan Wang, Gaozhe Cai, Li Xue, Yanbin Li, Ming Liao, Jianhan Lin
Summary: A microfluidic biosensor based on immunomagnetic separation, enzyme catalysis, and electrochemical impedance analysis was developed for rapid and sensitive detection of S. typhimurium. The biosensor could quantitatively detect S. typhimurium in 1 hour and demonstrated good feasibility for practical applications.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Applied
Jiaqi Wang, Lei Tan, Wenchao Bi, Haoyu Shen, Dengfeng Li, Zhenzhong Yu, Ning Gan
Summary: This study developed a microfluidic immunosensor for ultrasensitive detection of Staphylococcus aureus (S. aureus) using stir bar enrichment and DNAzyme-assisted click reaction. The method showed excellent sensitivity and simplicity, with satisfactory results in detecting real samples.
Review
Food Science & Technology
Bin Wang, Bosoon Park
Summary: The development of portable biosensors for field-deployable detections is increasingly important for controlling foodborne pathogens in regulatory environments and early outbreaks. Microfluidic methods offer advantages such as miniaturization, integration of multiple functions, and low cost. However, the sensitivity and specificity of portable biosensors are limited. This article introduces microfluidic devices for bacteria sampling and biosensing, with emphasis on particle-based sorting/enrichment methods and various biosensing applications. Future studies are needed to address challenges related to the small size and nonspherical shape of bacterial cells.
FOODBORNE PATHOGENS AND DISEASE
(2022)
Article
Food Science & Technology
Xiaoying Han, Yuanhui Liu, Juxin Yin, Min Yue, Ying Mu
Summary: The global burden of foodborne diseases is significant, with foodborne pathogens being the major cause of human illnesses. Microfluidic technology enables rapid, cost-effective, sensitive, and portable pathogen detection to meet on-site testing requirements. Multiplexed detection technology offers a new opportunity to ensure food safety by simultaneously detecting multiple pathogens.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Chemistry, Multidisciplinary
Kaili Yang, Weijun Xiu, Yuqing Li, Dou Wang, Qirui Wen, Lihui Yuwen, Xiao Li, Zhaowei Yin, Bin Liang, Lianhui Wang
Summary: In this study, a near-infrared responsive 2D nanozyme was developed for efficient treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections. The nanozyme exhibited effective antibacterial properties against MRSA through catalytic and photothermal effects. The results showed that the nanozyme had high bactericidal activity against MRSA under near-infrared light irradiation and promoted wound healing.
Article
Multidisciplinary Sciences
Kyoichi Oshiro, Yoshikazu Wakizaka, Masayo Takano, Takayuki Itoi, Hiroki Ohge, Kazumi Koba, Kyoko Yarimizu, So Fujiyoshi, Fumito Maruyama
Summary: This study developed a microfluidic DEP device for rapid cell separation and cell enumeration using microscopy. The device efficiently segregated bacterial cells and enriched target cell types without sample pretreatment, achieving all-in-one operation and requiring a small sample volume.
Review
Engineering, Biomedical
Hyunsoo Han, Bokyeong Sohn, Jihun Choi, Sangmin Jeon
Summary: The focus is on recent research advances and challenges in magnetic pretreatment of pathogenic bacteria using microfluidic devices, which utilize magnetic nanoparticles and emphasize the advantages of process automation and miniaturization.
BIOMEDICAL ENGINEERING LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Yuqiu Wang, Bingbing Gao, Bingfang He
Summary: This paper reports a three-dimensional origami microneedle (MN) patch inspired by the folded structure of insect wings, which has superfine miniature needle structures, microfluidic channels, and multiple functions. The MN patch with microfluidic channels was obtained by replicating silicone rubber molds patterned by a laser engraving machine. The MN patch has functional integration, including biomarker sensing, controllable drug release, and motion sensing. A mouse model experiment demonstrates the ability of the MN patch to accelerate wound healing.
Article
Chemistry, Analytical
Raul Fernandez-Mateo, Victor Calero, Hywel Morgan, Antonio Ramos, Pablo Garcia-Sanchez
Summary: This paper investigates stationary electroosmotic flows of electrolytes around insulating constrictions induced by low frequency AC electric fields, introducing the concept of concentration-polarization electroosmosis. Experimental results are in qualitative agreement with the model predictions, but trapping of particles in shallow channels is also observed.
ANALYTICAL CHEMISTRY
(2021)
Review
Chemistry, Analytical
Indrajit Patra, Mustafa M. Kadhim, Marwan Mahmood Saleh, Ghulam Yasin, Ali Abdulhussain Fadhil, Huda Sabah Jabr, Noora M. Hameed
Summary: This review provides an overview of the recent developments in aptasensors based on microfluidics for screening foodborne pathogenic bacteria and viruses. These sensors offer selectivity, sensitivity, portability, and affordability, and present a potential solution for improving on-site food safety detection platforms.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)