Article
Chemistry, Analytical
Jianbo Liu, Jing Liu, Yonghui Shang, Jinqiong Xu, Xinyang Wang, Jianbin Zheng
Summary: A multiplex electrochemical immunosensor was developed for the simultaneous detection of two lung cancer markers, CEA and CA125, with high sensitivity and accuracy.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Engineering, Electrical & Electronic
Manish Rishi, Khairunnisa Amreen, Jaligam Murali Mohan, Arshad Javed, Satish Kumar Dubey, Sanket Goel
Summary: A highly sensitive, specific, and simple method of electrochemical detection of Escherichia coli (E. coli) was demonstrated in this study. The electrochemical system utilized a chemically modified glassy carbon electrode with graphitized mesoporous carbon as the working electrode, achieving interference-free and excellent sensitivity to E. coli detection.
SENSORS AND ACTUATORS A-PHYSICAL
(2022)
Article
Chemistry, Analytical
Akanksha Roberts, Subhasis Mahari, Deepshikha Shahdeo, Sonu Gandhi
Summary: A novel immunosensor for detecting the spike protein of the coronavirus was reported, showing high sensitivity and stability under optimized conditions for detecting very low levels of the virus protein in standard buffer. This immunosensor could serve as a rapid, specific, and sensitive diagnostic tool for detecting traces of the coronavirus spike antigen in clinical samples.
ANALYTICA CHIMICA ACTA
(2021)
Article
Engineering, Environmental
Navneet Chaudhary, Amit K. Yadav, Jai Gopal Sharma, Pratima R. Solanki
Summary: The study presents an electrochemical immunosensor based on lanthanum oxide nanoparticles for sensitive detection of trace amounts of ciprofloxacin antibiotic. The nanoparticles were synthesized via wet-chemical co-precipitation and characterized with various techniques before being used to enhance the electrochemical response of the immunosensor. The developed biosensor showed a wide linear detection range and good reproducibility, repeatability, sensitivity, and stability for detecting CPX in milk samples.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Immunology
Rishabh Anand Omar, Nishith Verma, Pankaj Kumar Arora
Summary: This study proposed a stable and reusable immunosensor for early tuberculosis diagnosis based on the detection and quantification of ESAT-6 via cyclic voltammetry. The physicochemical characterization of prepared materials was conducted using various analytical techniques, and electro-conductive PANI was successfully demonstrated as a polymeric substrate for Ni nanoparticles and rGO. The immunosensor showed a linear response towards ESAT-6 during CV measurements with a lower detection limit of approximately 1.0 ng mL(-1).
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Analytical
Guan-Cheng Chen, Chi-Hsien Liu, Wei-Chi Wu
Summary: An electrochemical platform based on a screen-printed carbon electrode (SPCE) was developed to detect parathyroid hormone (PTH). The nanocomposite of multi-walled carbon nanotube (MWCNT) and gold nanoparticles (AuNP) deposited on the SPCE improved the stability and conductivity of the immunosensor, while enhancing the electrochemical signal for enzyme-linked immunosensing.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Analytical
Le Zhao
Summary: A novel electrochemical immunosensor was fabricated for ultra-sensitive determination of Lactobacillus brevis, with gold nanoparticles electro-deposited on the electrode surface and ionic liquid used for improving the sensor's immobilization performance. After optimization, a linear regression equation was observed between the current increment and L. brevis concentration, with a detection limit estimated at 10^3 CFU/mL.
Article
Environmental Sciences
Haseena Onthath, Mostafa H. Sliem, Mithra Geetha, Kishor Kumar Sadasivuni, Aboubakr M. Abdullah, Bijandra Kumar
Summary: Electrochemical conversion of CO2 using a novel CuO nanocomposite has shown great potential in effectively reducing CO2 into useful fuels. The nanocomposite demonstrates high structural stability and durability, indicating its suitability for CO2 reduction.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Chemistry, Applied
Amit K. Yadav, Damini Verma, G. B. V. S. Lakshmi, Sergei Eremin, Pratima R. Solanki
Summary: This study presents a label-free immunosensing platform using molybdenum disulfide nanoparticles for electrochemical detection of ampicillin. The immunosensor showed high sensitivity, broad detection range, and excellent selectivity, stability, and reproducibility. Testing in milk, water, and orange juice confirmed the consistency and applicability of the immunosensor.
Article
Materials Science, Ceramics
Akbar Mohammad, Mohammad Ehtisham Khan, Md Rezaul Karim, Moo Hwan Cho, Taeho Yoon
Summary: An Ag@SnO2-g-C3N4-based electrochemical sensor was developed for the successful detection of the carcinogenic substance hydrazine. The sensor showed good sensitivity and low detection limit, enabling efficient monitoring of hydrazine concentration under various conditions.
CERAMICS INTERNATIONAL
(2021)
Article
Chemistry, Inorganic & Nuclear
S. B. Arpitha, B. E. Kumara Swamy, J. K. Shashikumara
Summary: In this study, a ZnO/Co3O4 nanocomposite modified carbon paste electrode (MCPE) was synthesized using a simple co-precipitation method. The MCPE was used as an electrochemical sensor for the simultaneous determination of Hydroquinone (HQ) and Resorcinol (RS) at pH 7.4. The obtained nanoparticles were characterized by SEM, XRD, and EDS analysis. The ZnO/Co3O4 MCPE showed good selectivity, stability, and successful detection of HQ and RS using CV and DPV techniques.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Chemistry, Analytical
Omer Saltuk Bolukbasi, Bahar Bankoglu Yola, Ceren Karaman, Necip Atar, Mehmet Lutfi Yola
Summary: This study successfully developed an electrochemical AFP immunosensor based on nanomaterials, which demonstrated high sensitivity and detection limit. The results showed that this sensor can be effectively used for cancer diagnosis.
Article
Biophysics
Maitri Shah, Pratik Kolhe, Akanksha Roberts, Narlawar Sagar Shrikrishna, Sonu Gandhi
Summary: The uncontrolled use of antibiotics in animals has led to antibiotic-resistant bacteria in humans. To investigate antibiotic contamination in animal origin food products, a reduced graphene oxide-based immunosensor was developed for the sensitive detection of Penicillin G. The sensor showed excellent detection capabilities and was able to detect antibiotics in milk, eggs, and meat samples. The in-house developed antibodies displayed better sensitivity compared to commercial antibodies.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Inorganic & Nuclear
K. G. Manjunatha, B. E. Kumara Swamy, G. K. Jayaprakash, H. D. Madhuchandra, K. A. Vishnumurthy
Summary: Strontium ferrate nanoparticles were synthesized and combined with multi-walled carbon nanotubes to modify the carbon paste electrode. The modified electrode showed higher electrocatalytic activity and sensitivity for the detection of paracetamol.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Viktorija Liustrovaite, Dovydas Karoblis, Benediktas Brasiunas, Anton Popov, Arturas Katelnikovas, Aivaras Kareiva, Arunas Ramanavicius, Roman Viter, Maria Teresa Giardi, Donats Erts, Almira Ramanaviciene
Summary: ZnO nanostructures with different morphologies and particle sizes were evaluated and applied for the development of an immunosensor. The nanostructures included spherical polydisperse structures, compact rod-like spherical structures, and rod-shaped particles. These ZnO nanostructures were mixed with Nafion solution and drop-casted onto screen-printed carbon electrodes, followed by immobilization of prostate-specific antigen (PSA). The affinity interaction of PSA with monoclonal antibodies against PSA was evaluated using the differential pulse voltammetry technique. The detection and quantification limits for anti-PSA were determined for different ZnO nanostructures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Qingguo Bai, Ivan Shupyk, Laetitia Vauriot, Jerome Majimel, Christine Labrugere, Marie-Helene Delville, Jean-Pierre Delville
Summary: By synthesizing well-controlled nanoheterodimers using lasers focused inside microfluidic reactors, the growth of metallic dots can be effectively controlled and is more efficient compared to using UV lamps.
Article
Chemistry, Multidisciplinary
Johann Mignolet, Albertus Viljoen, Marion Mathelie-Guinlet, Felipe Viela, Claire Valotteau, Yves F. Dufrene
Summary: Bacterial pili play various functional roles in surface adherence, motion, and virulence. The type IVc pilus in Caulobacter crescentus is crucial for surface colonization but has not been thoroughly investigated at the molecular level. Through fluorescence-based screening, atomic force microscopy, and genetic manipulation, researchers found that the type IVc pilus exhibits high stickiness due to multiple hydrophobic interactions and has nanospring mechanical properties, contributing to a better understanding of bacterial pilus nanomachines.
Article
Biology
Albertus Viljoen, Felipe Viela, Marion Mathelie-Guinlet, Dominique Missiakas, Giampiero Pietrocola, Pietro Speziale, Yves F. Dufrene
Summary: Through force spectroscopy studies on living bacteria, Viljoen et al. characterise the binding of S. aureus to host von Willebrand factor (vWF). They propose that S. aureus vWF-binding protein triggers an ultra-strong interaction between the adhesin clumping factor A and vWF.
COMMUNICATIONS BIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Claire Michelet, Zhuxin Li, H. Jalenques, Sebastien Incerti, Philippe Barberet, Guillaume Deves, Marie-Helene Delville, Herve Seznec
Summary: The purpose of this study is to quantify the accuracy of a specific correction method for thick samples in proton computed micmtomography, and assess the accuracy of reconstructed densities using Geant4 simulations. The results demonstrate the successful application of the correction method in thick sample tomographic reconstruction, improving the accuracy for phosphorus to <= 4%.
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2022)
Article
Plant Sciences
Estelle Deboever, Geraldine Van Aubel, Valeria Rondelli, Alexandros Koutsioubas, Marion Mathelie-Guinlet, Yves F. Dufrene, Marc Ongena, Laurence Lins, Pierre Van Cutsem, Marie-Laure Fauconnier, Magali Deleu
Summary: This study investigates the potential of fatty acid hydroperoxides (HPOs) as plant defense elicitors and their mechanism of action. The results show that HPOs enhance Arabidopsis thaliana's resistance to Botrytis cinerea and activate early immune-related defense responses. Biophysical analysis reveals that HPO insertion into plant plasma membranes impacts their structure.
PLANT CELL AND ENVIRONMENT
(2022)
Article
Microbiology
Shanice S. Webster, Marion Mathelie-Guinlet, Andreia F. Verissimo, Daniel Schultz, Albertus Viljoen, Calvin K. Lee, William C. Schmidt, Gerard C. L. Wong, Yves F. Dufrene, George A. O'Toole
Summary: Pseudomonas aeruginosa uses force-induced changes mediated by the PilY1 protein to sense surfaces and regulate biofilm formation. The study provides insights into the mechanosensing mechanism of type IV pili and its role in surface colonization strategies.
Article
Chemistry, Physical
Adeline Perro, Noemie Coudon, Jean-Paul Chapel, Nicolas Martin, Laure Beven, Jean-Paul Douliez
Summary: The use of templates in materials chemistry is a well-established approach for producing membrane bounded hollow spheres. Water-in-water emulsion droplets have emerged as promising alternative templates to produce capsules in solvent-free conditions, offering practical importance in materials chemistry.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Analytical
Zeineb Ben Abdallah, Halim Sghaier, Ibtissem Gammoudi, Fabien Morote, Sebastien Cassagnere, Lena Romo, Laure Beven, Christine Grauby-Heywang, Touria Cohen-Bouhacina
Summary: This work describes the development of an immunosensor for detecting fungal B1 aflatoxin (AFB1). The sensor consists of three screen-printed electrodes (SPEs) made of gold, silver/silver chloride, and carbon pastes. A cheap electronic system was designed to control the sensor and measure the current variations. The gold working electrode of the sensor was functionalized with an antibody specific to AFB1. The sensor successfully detected AFB1 in a buffer and in rice milk samples.
Article
Chemistry, Physical
Noemie Coudon, Laurence Navailles, Frederic Nallet, Isabelle Ly, Ahmed Bentaleb, Jean-Paul Chapel, Laure Beven, Jean-Paul Douliez, Nicolas Martin
Summary: All-aqueous microdroplets produced by liquid-liquid phase separation have been used as promising models of artificial cells and offer new methods for solvent-free encapsulation of fragile solutes. In this study, stable and impermeable water-in-water emulsions were constructed by the interfacial self-assembly of mixed sodium oleate/1-decanol bilayers on dextran-rich droplets. The lipid-based membrane was shown to be impermeable to oligonucleotides, proteins, and a low molecular weight dye.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Toxicology
Eloise Colnot, Laura Cardoit, Marie-Jeanne Cabirol, Lydia Roudier, Marie-Helene Delville, Anne Fayoux, Muriel Thoby-Brisson, Laurent Juvin, Didier Morin
Summary: This study found that prenatal exposure to titanium dioxide nanoparticles (NPs) affects the normal development and operation of the respiratory centers in offspring, leading to abnormally elevated breathing rates.
PARTICLE AND FIBRE TOXICOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Antoine Amestoy, Aarushee Rangra, Vincent Mansard, Daisuke Saya, Emilie Pouget, Estelle Mazaleyrat, Fabrice Severac, Christian Bergaud, Reiko Oda, Marie-Helene Delville
Summary: Flexible strain sensors based on silica nanohelix (NH) arrays grafted with gold nanoparticles (AuNPs) showed improved stability and sensitivity compared to sensors containing only nanoparticles. These sensors have great potential for applications such as electronic skin and flexible touchscreens.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Multidisciplinary
Fenghuan Zhao, Qingguo Bai, Chenghui Xia, Junjie Hao, Marion Gayot, Jean-Pierre Delville, Marie-Helene Delville
Summary: We propose a method for synthesizing well-controlled core-shell nanoheterodimers (NHDs) based on single bimetallic Au@M (M = Au, Ag, Pd, Pt) nanodots (BNDs) grown on TiO2 nanoparticles (NPs). The process involves a two-step laser-assisted deposition. The first step uses a focused UV laser to nucleate and grow a single core nanodot (ND) with quantitatively controlled size. In the second step, a new metal precursor is added to the Au-TiO2 NHDs and a second laser deposition takes place on the first gold NDs. The synthesized NHDs exhibit different growth patterns depending on the metals involved.
MATERIALS ADVANCES
(2023)
Article
Nanoscience & Nanotechnology
Minh-Thanh Do, Kevin Zimny, Abhishek Singh Dahiya, Jinkai Yuan, Rajaoarivelo Mbolotiana, Eric Lebraud, Cedric Lambin, Francois Lagugne-Labarthet, Wilfrid Neri, Mario Maglione, Annie Colin, Marie-Helene Delville, Philippe Poulin
Summary: This study directly observes a single-phase ferroelectric structure stabilized by size-induced thermal residual stress in NaNbO3 nanowires and demonstrates their excellent efficiency for lead-free piezoelectric nanocomposites. This contradicts the performance of BaTiO3 nanowires and is explained by structure modifications at the nanoscale.
ACS APPLIED NANO MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Junjie Hao, Junzi Li, Meijuan Chen, Xijian Duan, Bing Xu, Yiwen Li, Tingchao He, Xiao Wei Sun, Marie-Helene Delville, Jiaji Cheng
Summary: This article introduces a top-down chemical etching process that allows for precise control of nanocrystal solutions with identical concentrations, enabling the study of ligand-induced chiral conduction mechanisms. The results indicate a negative correlation between the shell layer and the chirality of the first exciton peak, but a positive correlation with the chirality of the CdS shell absorption. The integrity of the core is essential for maintaining high circular dichroism and circularly polarized luminescence signals.
MATERIALS CHEMISTRY FRONTIERS
(2022)
Article
Microbiology
Shanice S. Webster, Marion Mathelie-Guinlet, Andreia F. Verissimo, Daniel Schultz, Albertus Viljoen, Calvin K. Lee, William C. Schmidt, Gerard C. L. Wong, Yves F. Dufrene, George A. O'Toole
Summary: The study reveals that a single cysteine residue in the vWA domain of PilY1 plays a key role in force-induced changes necessary for surface sensing by TFP in biofilm formation. Mutation of this cysteine affects surface adhesion forces, sustained conformational changes, and c-di-GMP signaling, providing insights into the different surface colonization strategies observed in P. aeruginosa strains PA14 and PAO1.
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
