Article
Oncology
Jiuping Gao, Ting Yang, Xu Wang, Yi Zhang, Jing Wang, Beilei Zhang, Dihong Tang, Yanqiong Liu, Ting Gao, Qiuhui Lin, Jun Tang, Jingting Cai
Summary: The study found that CD133 may be a significant marker for cancer stem-like cells in ULMS and could be a potential therapeutic target.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Asmaa A. Zidan, Mohammed Al-Hawwas, Griffith B. Perkins, Ghada M. Mourad, Catherine J. M. Stapledon, Larisa Bobrovskaya, Xin-Fu Zhou, Plinio R. Hurtado
Summary: The study reveals that USC-derived extracellular vesicles (EVs) are a heterogeneous population ranging in size, with immunomodulatory functions that can promote B cell proliferation and IgM antibody secretion. Additionally, the EVs carry a variety of substances that play important roles in stimulating, differentiating, and immune functions of B cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Yingai Shi, Guihua Liu, Rongpei Wu, David L. Mack, Xiuzhi Susan Sun, Joshua Maxwell, Xuan Guan, Anthony Atala, Yuanyuan Zhang
Summary: This study highlights the regenerative significance of telomerase activity in human primary USCs, showing that telomerase-positive USCs have a robust regenerative potential in cell proliferation and multipotent differentiation capacity. The presence of telomerase activity is associated with maintaining cell surface marker expression, chromosomal stability, and in vivo tumorigenic transformation in USCs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell & Tissue Engineering
Elize Wolmarans, Juanita Mellet, Chrisna Durandt, Fourie Joubert, Michael S. Pepper
Summary: This exploratory study characterized the heterogeneity of freshly isolated hASCs after two population doublings (P2) using single-cell transcriptome analysis, identifying at least two subpopulations, with a major subpopulation identified as contractile cells likely to be pericytes and/or vascular smooth muscle cells (vSMCs) based on gene expression patterns.
STEM CELLS INTERNATIONAL
(2021)
Review
Pharmacology & Pharmacy
Xiya Yin, Qingfeng Li, Patrick Michael McNutt, Yuanyuan Zhang
Summary: Epithelial tissue injuries can have significant impacts on patients' quality of life, healthcare spending, and global economy. Urine-derived stem cells show versatile potential for tissue regeneration in repairing epidermal and urothelial injuries.
Article
Medicine, General & Internal
Yu-Hui Hao, Zhi-Zhen Liu, Hong Zhao, Lei Wang, Ajab Khan, Jian-Bin Mu, Yu-Fei Wang, Li-Hong Yang, Ran Zhou, Jun Xie
Summary: The study found that the CV8 acupoint is rich in adipose tissues containing abundant somatic stem cells with osteogenic, adipogenic, and neurogenic stem cell-like cell differentiation abilities. Cells derived from the CV8 acupoint showed enhanced cell proliferation and adipogenic, neurogenic differentiation compared to non-acupoint somatic stem cells, but weaker osteogenic differentiation capability.
CHINESE MEDICAL JOURNAL
(2021)
Article
Engineering, Biomedical
Ming Pei, Yixuan Amy Pei, Sheng Zhou, Elmira Mikaeiliagah, Christopher Erickson, Benjamin Giertych, Halima Akhter, Lei Wang, Amanda Stewart, Joshua Parenti, Bin Wang, Sijin Wen, Sotcheadt Sim, Eric Quenneville, Kirk C. Hansen, Steven Frisch, Gangqing Hu
Summary: Articular cartilage has limited self-healing capacity. Tissue-specific stem cells can be used for cartilage regeneration, but ex vivo expansion leading to cell senescence is a challenge. Cell-derived extracellular matrix (C-dECM) has been shown to rejuvenate stem cells and promote cartilage regeneration. In this study, the authors evaluated the rejuvenation of rabbit stem cells by C-dECM in both ex vivo and in vivo models, and identified potential cellular and molecular mechanisms involved.
BIOACTIVE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Martina Culenova, Andreas Nicodemou, Zuzana Varchulova Novakova, Michaela Debreova, Veronika Smolinska, Sona Bernatova, Dana Ivanisova, Olga Novotna, Jaromir Vasicek, Ivan Varga, Stanislav Ziaran, Lubos Danisovic
Summary: The study successfully isolated UDSCs and analyzed their morphological, surface marker, cell doubling time, and cell shape characteristics. The results showed that UDSCs have the potential for regenerating damaged tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Emergency Medicine
Wenqian Zhang, Jungen Hu, Yizhou Huang, Chenyu Wu, Huiqi Xie
Summary: This review provides an up-to-date overview of the biological characteristics and applications of urine-derived stem cells (USCs) in tissue engineering and regenerative medicine, particularly in skin, bone, and articular cartilage repair. The underlying repair mechanisms and application modes of USCs are summarized, along with potential concerns and perspectives.
Article
Veterinary Sciences
Dongsheng Li, Huina Luo, Huimin Ruan, Zhisheng Chen, Shengfeng Chen, Bingyun Wang, Yong Xie
Summary: This study successfully isolated and characterized exosomes from different types of feline samples, demonstrating that the use of differential centrifugation is a feasible method for exosome isolation. These exosomes can be further utilized for diagnosis and therapeutics in veterinary pre-clinical and clinical studies.
BMC VETERINARY RESEARCH
(2021)
Article
Materials Science, Multidisciplinary
Yongjin Sun, Juntao Zhang, Bi Chen, Yunlong Yang, Haiyan Li, Xin Niu, Qing Li, Weidong Wu, Zongping Xie, Yunfeng Chen, Fuyue Wu, Yang Wang
Summary: This study demonstrates the effectiveness of USC-sEVs in accelerating wound healing in aged mice by ameliorating cellular senescence and reducing SASP secretion. USC-sEVs loaded in HAAM can effectively accelerate wound healing by controlling release and locating the sEVs in the wound site.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Tianyuan Shi, Martin Cheung
Summary: Using rodents for modeling neurological diseases has limitations due to differences in genetics, neural development, and physiology between humans and rodents. In the past decade, induced pluripotent stem cells and induced neural stem cells generated through reprogramming somatic cells have offered a powerful alternative for studying disease pathogenesis and testing regenerative medicines. Urine-derived stem cells are an ideal cell source for reprogramming due to their proliferation, multipotency, epithelial nature, and ease of reprogramming.
CELL AND BIOSCIENCE
(2021)
Review
Genetics & Heredity
Qian Zhou, Yiyu Cheng, Fang Sun, Jie Shen, M. I. Nasser, Ping Zhu, Xueyan Zhang, Yuxiang Li, Guangming Yin, Yuequn Wang, Xiushan Wu, Mingyi Zhao
Summary: Urine-derived stem cells (USCs), a newly discovered type of stem cells, possess regenerative powers and multidirectional differentiation potential, and play an important role in disease treatment and basic medical research. USCs have characteristics similar to mesenchymal stromal cells (MSCs), can be readily obtained from urine and steadily cultured.
FRONTIERS IN GENETICS
(2022)
Article
Cell Biology
Mark Jakob, Mario Hambrecht, Jennifer L. Spiegel, Julia Kitz, Martin Canis, Ralf Dressel, Katrin Streckfuss-Bomeke
Summary: A multimodal therapeutic approach involving radiotherapy is essential for treating head and neck squamous cell carcinoma, but its use is limited due to the risk of damaging surrounding healthy tissue. Mesenchymal stem cells show promising therapeutic potential in cell-based tissue engineering and regenerative medicine due to their immunomodulatory properties. Generating induced pluripotent stem cell-derived mesenchymal stem cells in an autologous manner could be a novel personalized treatment option in regenerative medicine.
Article
Multidisciplinary Sciences
P. Olof Olsson, Jeong Yeonwoo, Kyumi Park, Yeong-Min A. Yoo, W. S. A. Hwang
Summary: The successful cloning of canine pups from urine-derived cells (UDCs) has been reported. UDCs are easily obtainable and noninvasive, and can be cultured and transfected with plasmids. These cells can be used as a source material for noninvasive recovery of breeding capacity in genetically important or infertile animals, as well as for human and animal studies.
