期刊
SCIENCE
卷 365, 期 6449, 页码 140-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aau4735
关键词
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资金
- Bill AMP
- Melinda Gates Foundation as part of the Breast Milk, Gut Microbiome, and Immunity (BMMI) Project
- Washington University School of Medicine Physician Scientist Training Program
- NIH [AI043596, DK30292]
- Russian Science Foundation [19-14-00305]
- Thought Leader award from Agilent Technologies
- Russian Science Foundation [19-14-00305] Funding Source: Russian Science Foundation
Characterizing the organization of the human gut microbiota is a formidable challenge given the number of possible interactions between its components. Using a statistical approach initially applied to financial markets, we measured temporally conserved covariance among bacterial taxa in the microbiota of healthy members of a Bangladeshi birth cohort sampled from I to 60 months of age. The results revealed an ecogroup of 15 covarying bacterial taxa that provide a concise description of microbiota development in healthy children from this and other low-income countries, and a means for monitoring community repair in undernourished children treated with therapeutic foods. Features of ecogroup population dynamics were recapitulated in gnotobiotic piglets as they transitioned from exclusive milk feeding to a fully weaned state consuming a representative Bangladeshi diet.
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