Exploring genetic interaction manifolds constructed from rich single-cell phenotypes

A Genome-wide Framework for Mapping Gene Regulation via Cellular Genetic Screens

(2019) Molly Gasperini et al.   CELL

Global Genetic Networks and the Genotype-to-Phenotype Relationship

(2019) Michael Costanzo et al.   CELL

The Causes and Consequences of Genetic Interactions (Epistasis)

(2019) Júlia Domingo et al.   Annual Review of Genomics and Human Genetics

Mapping the Genetic Landscape of Human Cells

(2018) Max A. Horlbeck et al.   CELL

Massive mining of publicly available RNA-seq data from human and mouse

(2018) Alexander Lachmann et al.   Nature Communications

Genetic effects on gene expression across human tissues

(2017) François Aguet et al.   NATURE

Pooled CRISPR screening with single-cell transcriptome readout

(2017) Paul Datlinger et al.   NATURE METHODS

Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq

(2016) Diego Adhemar Jaitin et al.   CELL

Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens

(2016) Atray Dixit et al.   CELL

A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response

(2016) Britt Adamson et al.   CELL

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

Data Imputation in Epistatic MAPs by Network-Guided Matrix Completion

(2015) Marinka Žitnik et al.   JOURNAL OF COMPUTATIONAL BIOLOGY

Categorical Analysis of Human T Cell Heterogeneity with One-Dimensional Soli-Expression by Nonlinear Stochastic Embedding

(2015) Yang Cheng et al.   JOURNAL OF IMMUNOLOGY

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

(2014) Luke A. Gilbert et al.   CELL

The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

(2014) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Direct interaction of Plk4 with STIL ensures formation of a single procentriole per parental centriole

(2014) Midori Ohta et al.   Nature Communications

Establishment of Immortalized Human Erythroid Progenitor Cell Lines Able to Produce Enucleated Red Blood Cells

(2013) Ryo Kurita et al.   PLoS One

Dual-specificity MAP kinase phosphatases (MKPs)

(2012) Christopher J. Caunt et al.   FEBS Journal

Functional Overlap and Regulatory Links Shape Genetic Interactions between Signaling Pathways

(2010) Sake van Wageningen et al.   CELL

Hematopoiesis: An Evolving Paradigm for Stem Cell Biology

(2008) Stuart H. Orkin et al.   CELL

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH