Article
Endocrinology & Metabolism
Kuldeep Shrivastava, Thaarini Swaminathan, Alessandro Barlotta, Vikshar Athreya, Hassan Choudhry, Mark A. Rossi
Summary: Maternal overnutrition during gestation and lactation leads to increased body weight in offspring, which normalizes after weaning but predisposes them to diet-induced obesity in adulthood. This is associated with altered synaptic strength in an extended amygdala-lateral hypothalamic pathway, which is influenced by developmental growth rate.
MOLECULAR METABOLISM
(2023)
Article
Neurosciences
Minghua Li, Jessica L. Kinney, Yu-Qiu Jiang, Daniel K. Lee, Qiwen Wu, Daehoon Lee, Wen-Cheng Xiong, Qian Sun
Summary: A key mode of neuronal communication between distant brain regions is through excitatory synaptic transmission mediated by long-range glutamatergic projections. However, we found that the glutamatergic projection from the hypothalamic supramammillary nucleus (SuM) largely avoids pyramidal neurons in hippocampal CA3 region and instead targets interneurons to provide feedforward inhibition. This novel long-range glutamatergic pathway suppresses the activity of principal neurons and reveals a new means by which SuM regulates hippocampal activity.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Biology
Mengru Liang, Tingliang Jian, Jie Tao, Xia Wang, Rui Wang, Wenjun Jin, Qianwei Chen, Jiwei Yao, Zhikai Zhao, Xinyu Yang, Jingyu Xiao, Zhiqi Yang, Xiang Liao, Xiaowei Chen, Liecheng Wang, Han Qin
Summary: The hypothalamic supramammillary nucleus (SuM) plays a crucial role in controlling wakefulness, and the projection of SuM neurons to the medial septum (MS) is involved in regulating wakefulness.
COMMUNICATIONS BIOLOGY
(2023)
Review
Neurosciences
Mark A. Rossi
Summary: The lateral hypothalamic area (LHA) regulates energy balance through complex connections with other brain regions, leveraging distinct neuron populations. Recent studies have identified at least 30 different LHA neuron types, some of which influence specific aspects of energy homeostasis. This review highlights the emerging evidence from cell-type-specific investigations and proposes outstanding questions for future research.
TRENDS IN NEUROSCIENCES
(2023)
Article
Neurosciences
Joel D. Hahn, Lei Gao, Tyler Boesen, Lin Gou, Houri Hintiryan, Hong-Wei Dong
Summary: This study investigated the neuronal connections of the lateral preoptic area (LPO) and the caudally adjacent lateral hypothalamic area anterior region (LHAa) in mice. The results showed highly diverse connections of these hypothalamic regions with over 200 gray matter regions spanning the forebrain, midbrain, and rhombicbrain. These connections are associated with various functions including reward prediction, innate survival behaviors, and affect.
JOURNAL OF COMPARATIVE NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Song-Yu Li, Jing-Juan Cao, Kang Tan, Liu Fan, Ya-Qian Wang, Zi-Xuan Shen, Shuai-Shuai Li, Chao Wu, Hui Zhou, Hua-Tai Xu
Summary: Food cues play a pivotal role in triggering physiological responses and have a critical impact on obesity risk. This study revealed the crucial role of corticotropin-releasing hormone (CRH)-expressing neurons in the lateral hypothalamic area in promoting feeding behaviors in mice. The research also identified downstream targets and emphasized the involvement of CRH neuropeptide in orchestrating this regulatory network.
Article
Endocrinology & Metabolism
Moonsun Sa, Eun-Seon Yoo, Wuhyun Koh, Mingu Gordon Park, Hyun-Jun Jang, Yong Ryoul Yang, Mridula Bhalla, Jae-Hun Lee, Jiwoon Lim, Woojin Won, Jea Kwon, Joon-Ho Kwon, Yejin Seong, Byungeun Kim, Heeyoung An, Seung Eun Lee, Ki Duk Park, Pann-Ghill Suh, Jong-Woo Sohn, C. Justin Lee
Summary: The study identifies GABRA5 neurons in the lateral hypothalamus as important regulators of energy balance. Inhibiting these neurons leads to increased weight gain and lipid accumulation, which is dependent on astrocytic GABA release.
Article
Endocrinology & Metabolism
Moonsun Sa, Eun-Seon Yoo, Wuhyun Koh, Mingu Gordon Park, Hyun-Jun Jang, Yong Ryoul Yang, Mridula Bhalla, Jae-Hun Lee, Jiwoon Lim, Woojin Won, Jea Kwon, Joon-Ho Kwon, Yejin Seong, Byungeun Kim, Heeyoung An, Seung Eun Lee, Ki Duk Park, Pann-Ghill Suh, Jong-Woo Sohn, C. Justin Lee
Summary: The authors identify a role for GABRA5 neurons in the lateral hypothalamus for energy balance regulation. Inhibiting these neurons increases weight gain and lipid accumulation through a process dependent on astrocytic GABA release.
Article
Neurosciences
Mark A. Rossi, Marcus L. Basiri, Yuejia Liu, Yoshiko Hashikawa, Koichi Hashikawa, Lief E. Fenno, Yoon Seok Kim, Charu Ramakrishnan, Karl Deisseroth, Garret D. Stuber
Summary: The lateral hypothalamic area (LHA) contains distinct populations of glutamatergic neurons that project to different brain regions, with neurons projecting to the lateral habenula (LHb) or ventral tegmental area (VTA) showing anatomical, transcriptional, electrophysiological, and functional differences. Neurons projecting to the LHb are particularly sensitive to satiety state and feeding hormones, indicating differential processing of reward and aversion stimuli in divergent efferent pathways.
Article
Neurosciences
Chong Song, Wei Wei, Tong Wang, Min Zhou, Yunshi Li, Bing Xiao, Dongyi Huang, Junwei Gu, Linyong Shi, Junjie Peng, Dianshi Jin
Summary: This study explored the mechanism of cognitive dysfunction in rats with hypothalamic obesity, finding that microglial infiltration and synapse loss mediated by the LHA in the hypothalamic-hippocampal circuit may be the underlying mechanism for memory impairments in these rats.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Md Tarikul Islam, Florian Rumpf, Yusuke Tsuno, Shota Kodani, Takeshi Sakurai, Ayako Matsui, Takashi Maejima, Michihiro Mieda
Summary: PVHAVP neurons in the paraventricular nucleus of the hypothalamus play a role in promoting wakefulness by interacting with orexin/hypocretin neurons in the lateral hypothalamus. These neurons also receive inputs from brain regions involved in sleep-wakefulness regulation, stress response, and energy metabolism, and mediate arousal induced by novelty stress and melanocortin receptor agonist.
Article
Neurosciences
Kseniia Prokofeva, Yuki C. Saito, Yasutaka Niwa, Seiya Mizuno, Satoru Takahashi, Arisa Hirano, Takeshi Sakurai
Summary: To understand the regulation of sleep-wakefulness cycles, it is important to study the relationship between the preoptic area (POA) and lateral hypothalamic area (LHA), which have opposing roles in sleep-wakefulness regulation. This study revealed the direct connection between GABA- and galanin-producing neurons in the ventrolateral preoptic nucleus (VLPO) and orexin-producing neurons in the LHA. It also discovered that the VLPOGABA-LHA pathway plays a previously unknown role in the regulation of sleep and wakefulness.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Anatomy & Morphology
Maria G. Bilbao, Daniel Garrigos, Marta Martinez-Morga, Angel Toval, Yevheniy Kutsenko, Rosario Bautista, Alberto Barreda, Bruno Ribeiro Do-Couto, Luis Puelles, Jose Luis Ferran
Summary: In this study, a prosomeric immunohistochemical mapping of hypothalamic cells expressing tyrosine hydroxylase (TH) in rats was conducted. The results showed that TH-positive cells were predominantly located in the periventricular stratum of the paraventricular and subparaventricular alar domains, as well as in the acroterminal arcuate nucleus and the terminal periventricular stratum in the tuberal region. The prosomeric model proved useful for determining the precise location of TH-positive cells relative to morphogenetic signals and provided potential causal explanation for the specification of this hypothalamic cell type.
FRONTIERS IN NEUROANATOMY
(2022)
Article
Neurosciences
Yuejin Zhang, Guangpin Chu, Yangming Leng, Xueling Lin, Hong Zhou, Yisheng Lu, Bo Liu
Summary: The activation of parvalbumin (PV) neurons in the contralateral medial vestibular nucleus (MVN) after unilateral labyrinthectomy (UL) is detrimental to vestibular compensation. However, regulating the activity of bilateral MVN PV neurons can promote vestibular compensation, with commissural inhibition from the ipsilateral MVN PV neurons playing an important role.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Patricia Seoane-Collazo, Amparo Romero-Pico, Eva Rial-Pensado, Laura Linares-Pose, Anxela Estevez-Salguero, Johan Ferno, Ruben Nogueiras, Carlos Dieguez, Miguel Lopez
Summary: Nicotine exerts a marked negative energy balance through regulation of brown adipose tissue and white adipose tissue, mainly controlled at the central level by modulation of hypothalamic neuropeptide systems and AMPK. The study reveals that the kappa opioid receptor signaling plays a crucial role in mediating the effects of nicotine on body weight loss.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Neurosciences
Gonzalo Alvarez-Bolado, Marco R. Celio
JOURNAL OF COMPARATIVE NEUROLOGY
(2016)
Review
Neurosciences
Elise Wattendorf, Birgit Westermann, Martin Lotze, Klaus Fiedler, Marco R. Celio
JOURNAL OF COMPARATIVE NEUROLOGY
(2016)
Article
Neurosciences
F. Girard, J. Venail, B. Schwaller, M. R. Celio
Article
Neurosciences
Alessandro Bilella, Gonzalo Alvarez-Bolado, Marco R. Celio
Editorial Material
Neurosciences
Carlo Calanchini, Claudio Bassetti, Marco R. Celio
JOURNAL OF COMPARATIVE NEUROLOGY
(2016)
Article
Neurosciences
Alessandro Bilella, Gonzalo Alvarez-Bolado, Marco R. Celio
JOURNAL OF COMPARATIVE NEUROLOGY
(2016)
Article
Neurosciences
Federica Filice, Marco R. Celio, Alexandre Babalian, Walter Blum, Viktoria Szabolcsi
JOURNAL OF COMPARATIVE NEUROLOGY
(2017)
Article
Neurosciences
Viktoria Szabolcsi, Gioele W. Albisetti, Marco R. Celio
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2017)
Article
Behavioral Sciences
Diana M. Roccaro-Waldmeyer, Franck Girard, Daniele Milani, Elisabetta Vannoni, Laurent Pretot, David P. Wolfer, Marco R. Celio
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2018)
Article
Anatomy & Morphology
Alexandre Babalian, Simone Eichenberger, Alessandro Bilella, Franck Girard, Viktoria Szabolcsi, Diana Roccaro, Gonzalo Alvarez-Bolado, Chun Xu, Marco R. Celio
BRAIN STRUCTURE & FUNCTION
(2019)
Article
Neurosciences
Elise Wattendorf, Birgit Westermann, Klaus Fiedler, Simone Ritz, Annetta Redmann, Joerg Pfannmoeller, Martin Lotze, Marco R. Celio
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2019)
Article
Multidisciplinary Sciences
C. Gutierrez Herrera, F. Girard, A. Bilella, T. C. Gent, D. M. Roccaro-Waldmeyer, A. Adamantidis, M. R. Celio
NATURE COMMUNICATIONS
(2019)
Article
Clinical Neurology
Franck Girard, Michelle von Siebenthal, Fred P. Davis, Marco R. Celio
Article
Anatomy & Morphology
Siri Leemann, Alexandre Babalian, Franck Girard, Fred Davis, Marco R. Celio
Summary: The PV2 cluster is a group of parvalbumin-positive neurons located in the ventromedial region of the periaqueductal gray (PAG). It has unique connections and gene expression patterns. PV2 receives inputs from the orbitofrontal cortex and ventrolateral hypothalamus, and projects to various regions involved in autonomic control. It expresses peptides and receptors, indicating its inhibitory nature. PV2 may play a role in regulating the activity of specific nuclei in the hypothalamus and PAG.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)