Article
Biochemistry & Molecular Biology
Gang Li, Shijie Xu, Ung Gu Kang
Summary: Repeated administration of drugs of abuse leads to behavioral sensitization, which is also observed with MK-801, a NMDA receptor antagonist. This study investigated the characteristics of MK-801-induced behavioral sensitization and found that it occurred rapidly with only five consecutive treatments. The optimal dose for sensitization was identified, which corresponded to typical doses of abused NMDA antagonists. Changes were observed in the expression and phosphorylation of NMDA receptor subunits after MK-801-induced behavioral sensitization.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Neurosciences
Wenjuan Yu, Hongwei Fang, Lei Zhang, Miaowen Hu, Sidi He, Huafang Li, Hao Zhu
Summary: Treatment with MK-801 enhances proliferation of hippocampal astrocytes and upregulates BDNF mRNA expression. The NMDA, PI3K, and ERK1/2 signaling pathways may be involved in regulating MK-801-induced BDNF upregulation. These findings suggest that astrocytes may play a role in the acute neurological and behavioral response to MK-801 treatment.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Adel Kashefi, Carlos Tomaz, Shole Jamali, Ali Rashidy-Pour, Abbas Ali Vafaei, Abbas Haghparast
Summary: The study showed that CBD administration had a significant impact on extinction and reinstatement of MPH-induced conditioning place preference (CPP) in rats, suggesting its potential as a method to alleviate symptoms of drug addiction.
BRAIN RESEARCH BULLETIN
(2021)
Article
Neurosciences
Mandy Rita LeCocq, Priya Chander, Nadia Chaudhri
Summary: The involvement of the & mu;-opioid system in the reinstatement of responding evoked by alcohol-predictive cues is well-established, but its role in the delayed reinstatement is unclear. This study investigated the role of & mu;-opioid receptors (MORs) in the delayed reinstatement of an extinguished Pavlovian conditioned response. The results showed that inhibiting MORs attenuated reinstatement elicited by an alcohol cue, but not by a sucrose cue, indicating an alcohol-specific involvement. Furthermore, blocking MORs in the ventral hippocampus prevented reinstatement of alcohol cue-induced responding, highlighting the importance of MORs in this brain region.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Psychiatry
Tsung-Yu Pan, Yi-Ju Pan, Shih-Jen Tsai, Che-Wen Tsai, Feng-Yi Yang
Summary: This study investigated the efficacy of low-intensity pulsed ultrasound (LIPUS) in treating psychiatric symptoms and anxiety-like behaviors. The results showed that LIPUS stimulation improved deficits in locomotor activity and sensorimotor gating, improved anxiety-like behavior, and modulated the activity of NMDA receptors and c-Fos. Therefore, LIPUS may be a potentially valuable antipsychotic treatment for schizophrenia.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Neurosciences
Ying Peng, Dong Xu, Yuedi Ding, Xingqin Zhou
Summary: This study found that dietary supplementation of PQQ from pregnancy or postpartum could effectively prevent schizophrenia-like behaviors in mice induced by MK-801. Female mice responded better to PQQ supplementation than males. In vitro experiments showed that early supplementation of PQQ promoted neuronal growth and neurite development.
PSYCHOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yu-Hsien Chou, Chia Chun Hor, Ming Tatt Lee, Hsin-Jung Lee, Remo Guerrini, Girolamo Calo, Lih-Chu Chiou
Summary: The study reveals that NPS released during stress activates orexin neurons in the lateral hypothalamus, leading to the release of orexins in the ventral tegmental area (VTA) and reinstating cocaine seeking behavior through an endocannabinoid/CB(1) receptor-mediated signaling pathway.
Article
Neurosciences
Yao Q. Wang, Yanhua H. Huang, Saju Balakrishnan, Lidong Liu, Yu Tian Wang, Eric J. Nestler, Oliver M. Schluter, Yan Dong
Summary: This study elucidates the dynamic interactions between AMPARs and NMDARs during the generation and maturation of silent synapses in the NAc after cocaine experience. The findings provide a mechanistic basis for manipulating new synaptic contacts and potentially new neural network patterns created by these synapses for therapeutic benefit.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Neda Salmani, Masoumeh Nozari, Mahdieh Parvan, Sara Amini-Sardouei, Mohammad Shabani, Mohammad Khaksari, Massood Ezzatabadipour
Summary: This study examined the impact of environmental parameters on the severity of schizophrenia symptoms through an induced schizophrenia model in rats. The results suggest that environmental conditions play an important role in the development of schizophrenia and other neuropsychiatric disorders.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2022)
Article
Neurosciences
Jialing Cai, Xiaohang Che, Tianyu Xu, Yuanchao Luo, Meixue Yin, Xianda Lu, Chunfu Wu, Jingyu Yang
Summary: Repeated OXT treatment during abstinence inhibits both context-and restraint stress-induced METH-CPP reinstatement and promotes AHN in mice. Further evidence suggests that AHN is closely involved in mediating OXT's inhibitory effects on reinstatement induced by both triggers. This study provides valuable insights into the mechanisms underlying OXT's beneficial effects on METH addiction.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Behavioral Sciences
Prableen K. Singh, Kabirullah Lutfy
Summary: The study found differences in cocaine-induced conditioned place preference (CPP) between male and female mice lacking beta-endorphin, with gender-related distinctions in CPP reinstatement. The results suggest a functional role for beta-endorphin in cocaine-induced CPP and reinstatement.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Myrto Panopoulou, Oliver M. Schlueter
Summary: Frequent relapse hinders successful treatment of substance use disorders by triggering the retrieval of drug-associated memories. This study investigates the cellular and molecular mechanisms underlying drug-induced memory retrieval using a conditioned place preference (CPP) procedure in mice. The results suggest that Ca2+-permeable AMPA receptors (CP-AMPARs) in the nucleus accumbens (NAc) play a key role in regulating the threshold for drug-induced retrieval and behavioral expression of drug memories.
MOLECULAR PSYCHIATRY
(2022)
Article
Neurosciences
Zheng-yu Sun, Li-hong Gu, Deng-lei Ma, Ming-yang Wang, Cui-cui Yang, Lan Zhang, Xin-min Li, Jie-wen Zhang, Lin Li
Summary: The novel mouse model induced by the combination of CPZ and MK-801 exhibited severe spatial and recognition memory deficits, hyperactivity, and anxiety disorder. The mice showed obvious demyelination and white matter damage, along with decreased expression levels of myelin basic protein (MBP) and 2',3'-cyclic nucleotide-3'-phosphodiesterase (CNPase) in the corpus callosum. Additionally, phosphorylation levels of Fyn and NMDA receptors were noticeably decreased in specific brain regions.
BRAIN RESEARCH BULLETIN
(2021)
Article
Neurosciences
Tom Macpherson, Claire I. Dixon, Jonathan Robertson, Marsha M. Sindarto, Patricia H. Janak, Delia Belelli, Jeremy J. Lambert, David N. Stephens, Sarah L. King
Summary: Extrasynaptic GABAA receptors in the nucleus accumbens play a crucial role in modulating behavioral responses to rewards and the effects of cocaine. Knockout or knockdown of a4 subunits of GABAARs leads to increased instrumental responding for reward-paired stimuli and attenuated potentiation of cocaine effects. These findings highlight the importance of GABAergic signaling in the nucleus accumbens in mediating the effects of cocaine.
Article
Clinical Neurology
Dongwoo Yu, Seul Ah Mun, Sang Woo Kim, Dae-Chul Cho, Chi Heon Kim, Inbo Han, Subum Lee, Sang -Woo Lee, Kyoung-Tae Kim
Summary: D-serine exacerbates neuropathic pain after traumatic spinal cord injury by mediating the NMDA receptor. NMDA receptor antagonists alleviate neuropathic pain after traumatic spinal cord injury.
Review
Psychiatry
Bethania Mongi-Bragato, Maria P. Avalos, Andrea S. Guzman, Flavia A. Bollati, Liliana M. Cancela
FRONTIERS IN PSYCHIATRY
(2018)
Article
Neurosciences
Bethania Mongi-Bragato, Maria Paula Avalos, Andrea S. Guzman, Constanza Garcia-Keller, Flavia A. Bollati, Liliana M. Cancela
Summary: This study investigated the role of endogenous enkephalin on adaptations in glutamate neurotransmission associated with repeated cocaine treatment using knockout proenkephalin mice. The results suggest a central role of enkephalin in regulating the glutamate mechanisms associated with cocaine sensitisation.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Andrea S. Guzman, Maria P. Avalos, Laura N. De Giovanni, Pia V. Euliarte, Marianela A. Sanchez, Bethania Mongi-Bragato, Daiana Rigoni, Flavia A. Bollati, Miriam B. Virgolini, Liliana M. Cancela
Summary: This study found that the involvement of CB1R in the NAcore can influence stress-induced reinstatement of cocaine-CPP by modulating glutamate release in a specific context.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Daiana Rigoni, Maria P. Avalos, Maria J. Boezio, Andrea S. Guzman, Gaston D. Calfa, Eduardo M. Perassi, Silvia M. Pierotti, Mariano Bisbal, Constanza Garcia-Keller, Liliana M. Cancela, Flavia Bollati
Summary: The study suggests that chronic stress can increase vulnerability to cocaine addiction by regulating the actin dynamics regulator cofilin, leading to changes in cocaine sensitization and self-administration. Reduced cofilin expression also affects synaptic morphology and function, and may prevent addiction to cocaine.
NEUROBIOLOGY OF STRESS
(2021)
Article
Immunology
Maria Paula Avalos, Andrea Susana Guzman, Daiana Rigoni, Ezequiel Axel Gorostiza, Marianela Adela Sanchez, Bethania Mongi-Bragato, Constanza Garcia-Keller, Eduardo Marcelo Perassi, Miriam Beatriz Virgolini, Javier Maria Peralta Ramos, Pablo Iribarren, Gaston Diego Calfa, Flavia Andrea Bollati, Liliana Marina Cancela
Summary: This study reveals the association between stressful experience-induced cocaine-related behaviors and the impairment of glutamatergic mechanisms in the NAcore. The imbalance of glutamate efflux and downregulation of GLT-1 in the NAcore caused by restraint stress disrupts glutamate homeostasis. Microglia play a role in the development of glutamatergic mechanisms underlying stress-induced vulnerability to cocaine addiction.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Physiology
Maria P. Avalos, Andrea S. Guzman, Constanza Garcia-Keller, Bethania Mongi-Bragato, Maria A. Esparza, Daiana Rigoni, Marianela A. Sanchez, Gaston D. Calfa, Flavia A. Bollati, Liliana M. Cancela
Summary: This study explores the neurobiological mechanisms underlying the sensitized response to the psychomotor-stimulating effects of cocaine following chronic restraint stress (CRS). The results show that enduring CRS-induced increase in psychostimulant response to cocaine is paralleled by an increase of extracellular dopamine levels in the NAcore, and that CRS induces an impairment of glutamate homeostasis in the NAcore. These findings emphasize the biological importance of GLT-1 in the comorbidity between chronic stress exposure and drug abuse.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)