Impact of host immunity on HTLV-1 pathogenesis: potential of Tax-targeted immunotherapy against ATL

Sensing of cell-associated HTLV by plasmacytoid dendritic cells is regulated by dense β-galactoside glycosylation

(2019) Sonia Assil et al.   PLoS Pathogens

Maintenance of long remission in adult T-cell leukemia by Tax-targeted vaccine: A hope for disease-preventive therapy

(2019) Mari Kannagi et al.   CANCER SCIENCE

CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer

(2019) Laura M. McLane et al.   Annual Review of Immunology

Human T-cell lymphotropic/leukemia virus type 1 (HTLV-1) Tax-specific T-cell exhaustion in HTLV-1-infected individuals

(2018) Ayako Masaki et al.   CANCER SCIENCE

Rapid Progression of Adult T-Cell Leukemia–Lymphoma after PD-1 Inhibitor Therapy

(2018) Lee Ratner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sporadic on/off switching of HTLV-1 Tax expression is crucial to maintain the whole population of virus-induced leukemic cells

(2018) Mohamed Mahgoub et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Switching and loss of cellular cytokine producing capacity characterize in vivo viral infection and malignant transformation in human T- lymphotropic virus type 1 infection

(2018) Huseini Kagdi et al.   PLoS Pathogens

Plasmacytoid dendritic cells control dengue and Chikungunya virus infections via IRF7-regulated interferon responses

(2018) Brian Webster et al.   eLife

PD-1 Inhibitor Therapy in Adult T-Cell Leukemia–Lymphoma

(2018)   NEW ENGLAND JOURNAL OF MEDICINE

Cytokine Networks Dysregulation during HTLV-1 Infection and Associated Diseases

(2018) Nicolas Futsch et al.   Viruses-Basel

HTLV-1 induces a Th1-like state in CD4+CCR4+ T cells that produces an inflammatory positive feedback loop via astrocytes in HAM/TSP

(2017) Yoshihisa Yamano et al.   JOURNAL OF NEUROIMMUNOLOGY

HTLV-1 bZIP Factor Enhances T-Cell Proliferation by Impeding the Suppressive Signaling of Co-inhibitory Receptors

(2017) Haruka Kinosada et al.   PLoS Pathogens

IL-10-mediated signals act as a switch for lymphoproliferation in Human T-cell leukemia virus type-1 infection by activating the STAT3 and IRF4 pathways

(2017) Leila Sawada et al.   PLoS Pathogens

HTLV-1 HBZ Viral Protein: A Key Player in HTLV-1 Mediated Diseases

(2017) Marco Baratella et al.   Frontiers in Microbiology

HTLV-1 Tax-Specific CTL Epitope–Pulsed Dendritic Cell Therapy Reduces Proviral Load in Infected Rats with Immune Tolerance against Tax

(2016) Satomi Ando et al.   JOURNAL OF IMMUNOLOGY

Suppression of Type I Interferon Production by Human T-Cell Leukemia Virus Type 1 Oncoprotein Tax through Inhibition of IRF3 Phosphorylation

(2016) Chun-Kit Yuen et al.   JOURNAL OF VIROLOGY

Aberrant PD-L1 expression through 3′-UTR disruption in multiple cancers

(2016) Keisuke Kataoka et al.   NATURE

HTLV-1 bZIP Factor Impairs Anti-viral Immunity by Inducing Co-inhibitory Molecule, T Cell Immunoglobulin and ITIM Domain (TIGIT)

(2016) Keiko Yasuma et al.   PLoS Pathogens

Treatment and survival among 1594 patients with ATL

(2015) H. Katsuya et al.   BLOOD

Clinical outcomes of a novel therapeutic vaccine with Tax peptide-pulsed dendritic cells for adult T cell leukaemia/lymphoma in a pilot study

(2015) Youko Suehiro et al.   BRITISH JOURNAL OF HAEMATOLOGY

Recent advances in the treatment of adult T-cell leukemia-lymphomas

(2015) Atae Utsunomiya et al.   CANCER SCIENCE

Systemic Cytokine Profiles in Strongyloides stercoralis Infection and Alterations following Treatment

(2015) Rajamanickam Anuradha et al.   INFECTION AND IMMUNITY

Integrated molecular analysis of adult T cell leukemia/lymphoma

(2015) Keisuke Kataoka et al.   NATURE GENETICS

Localization, quantification and interaction with host factors of endogenous HTLV-1 HBZ protein in infected cells and ATL

(2015) Goutham U Raval et al.   Retrovirology

Roles of HTLV-1 basic Zip Factor (HBZ) in Viral Chronicity and Leukemic Transformation. Potential New Therapeutic Approaches to Prevent and Treat HTLV-1-Related Diseases

(2015) Jean-Michel Mesnard et al.   Viruses-Basel

Involvement of double-stranded RNA-dependent protein kinase and antisense viral RNA in the constitutive NFκB activation in adult T-cell leukemia/lymphoma cells

(2015) S Kinpara et al.   LEUKEMIA

Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids

(2014) Jiaxi Wu et al.   Annual Review of Immunology

Cytotoxic T lymphocyte lysis of HTLV-1 infected cells is limited by weak HBZ protein expression, but non-specifically enhanced on induction of Tax expression

(2014) Aileen G Rowan et al.   Retrovirology

Host Restriction Factor SAMHD1 Limits Human T Cell Leukemia Virus Type 1 Infection of Monocytes via STING-Mediated Apoptosis

(2013) Alexandre Sze et al.   Cell Host & Microbe

Alpha Interferon Restricts Human T-Lymphotropic Virus Type 1 and 2 De Novo Infection through PKR Activation

(2013) A. Cachat et al.   JOURNAL OF VIROLOGY

Interferon-α (IFN-α) suppresses HTLV-1 gene expression and cell cycling, while IFN-α combined with zidovudin induces p53 signaling and apoptosis in HTLV-1-infected cells

(2013) Shuichi Kinpara et al.   Retrovirology

Blockade of Chronic Type I Interferon Signaling to Control Persistent LCMV Infection

(2013) E. B. Wilson et al.   SCIENCE

Persistent LCMV Infection Is Controlled by Blockade of Type I Interferon Signaling

(2013) J. R. Teijaro et al.   SCIENCE

Human T-cell leukemia virus type 1: replication, proliferation and propagation by Tax and HTLV-1 bZIP factor

(2013) Masao Matsuoka et al.   Current Opinion in Virology

Polycomb-Mediated Loss of miR-31 Activates NIK-Dependent NF-κB Pathway in Adult T Cell Leukemia and Other Cancers

(2012) Makoto Yamagishi et al.   CANCER CELL

Tax is a potential molecular target for immunotherapy of adult T-cell leukemia/lymphoma

(2012) Susumu Suzuki et al.   CANCER SCIENCE

Systems Biology Approaches Reveal a Specific Interferon-Inducible Signature in HTLV-1 Associated Myelopathy

(2012) Sonja Tattermusch et al.   PLoS Pathogens

HTLV-1 uveitis

(2012) Koju Kamoi et al.   Frontiers in Microbiology

HTLV-1 bZIP factor enhances TGF-  signaling through p300 coactivator

(2011) T. Zhao et al.   BLOOD

HTLV-1 bZIP factor impairs cell-mediated immunity by suppressing production of Th1 cytokines

(2011) K. Sugata et al.   BLOOD

Kinetics and intracellular compartmentalization of HTLV-1 gene expression: nuclear retention of HBZ mRNAs

(2011) F. Rende et al.   BLOOD

Bronchiectasis Is Associated With Human T-Lymphotropic Virus 1 Infection in an Indigenous Australian Population

(2011) Lloyd Einsiedel et al.   CLINICAL INFECTIOUS DISEASES

Programmed death-1 (PD-1)/PD-1 ligand pathway–mediated immune responses against human T-lymphotropic virus type 1 (HTLV-1) in HTLV-1-associated myelopathy/tropical spastic paraparesis and carriers with autoimmune disorders

(2011) Tomohiro Kozako et al.   HUMAN IMMUNOLOGY

Oral tolerance

(2011) Howard L. Weiner et al.   IMMUNOLOGICAL REVIEWS

In vivo Expression of Human T-lymphotropic Virus Type 1 Basic Leucine-Zipper Protein Generates Specific CD8+ and CD4+ T-Lymphocyte Responses that Correlate with Clinical Outcome

(2011) Silva Hilburn et al.   JOURNAL OF INFECTIOUS DISEASES

Functional impairment of Tax-specific but not cytomegalovirus-specific CD8+ T lymphocytes in a minor population of asymptomatic human T-cell leukemia virus type 1-carriers

(2011) Ayako Takamori et al.   Retrovirology

Orf-I and Orf-II-Encoded Proteins in HTLV-1 Infection and Persistence

(2011) Dustin Edwards et al.   Viruses-Basel

Transplantation of allogeneic hematopoietic stem cells for adult T-cell leukemia: a nationwide retrospective study

(2010) M. Hishizawa et al.   BLOOD

Meta-Analysis on the Use of Zidovudine and Interferon-Alfa in Adult T-Cell Leukemia/Lymphoma Showing Improved Survival in the Leukemic Subtypes

(2010) Ali Bazarbachi et al.   JOURNAL OF CLINICAL ONCOLOGY

HTLV-1 Evades Type I Interferon Antiviral Signaling by Inducing the Suppressor of Cytokine Signaling 1 (SOCS1)

(2010) Stéphanie Olière et al.   PLoS Pathogens

Free HTLV-1 induces TLR7-dependent innate immune response and TRAIL relocalization in killer plasmacytoid dendritic cells

(2009) R. Colisson et al.   BLOOD

HBZ is an immunogenic protein, but not a target antigen for human T-cell leukemia virus type 1-specific cytotoxic T lymphocytes

(2009) K. Suemori et al.   JOURNAL OF GENERAL VIROLOGY

Stromal Cell-Mediated Suppression of Human T-Cell Leukemia Virus Type 1 Expression In Vitro and In Vivo by Type I Interferon

(2009) S. Kinpara et al.   JOURNAL OF VIROLOGY

Involvement of TORC2, a CREB co-activator, in the in vivo-specific transcriptional control of HTLV-1

(2009) Shiwen Jiang et al.   Retrovirology

In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)

(2009) Mineki Saito et al.   Retrovirology

Overexpressed NF- B-inducing kinase contributes to the tumorigenesis of adult T-cell leukemia and Hodgkin Reed-Sternberg cells

(2008) Y. Saitoh et al.   BLOOD

Correlation between polymorphisms at interleukin-6 but not at interleukin-10 promoter and the risk of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis in Brazilian individuals

(2008) Sandra Rocha Gadelha et al.   JOURNAL OF MEDICAL VIROLOGY

PD-1/PD-L1 expression in human T-cell leukemia virus type 1 carriers and adult T-cell leukemia/lymphoma patients

(2008) T Kozako et al.   LEUKEMIA

Human T-cell leukemia virus type 1 Tax modulates interferon-α signal transduction through competitive usage of the coactivator CBP/p300

(2008) Jing Zhang et al.   VIROLOGY

Human T-cell leukemia virus type 1 blunts signaling by interferon alpha

(2008) Xuan Feng et al.   VIROLOGY