Article
Environmental Sciences
Yizhu Mao, Qian Zhou, Jinhua Wang, Ruihuan Zhao, Xuefei Yang, Ya Shi, Jinyao Yin, Chenglan Jiang, Yuefeng He
Summary: This study investigates the role of circP50 in the proliferation and apoptosis of A549 cells under arsenic-induced conditions. The results suggest that circP50 mainly functions through the p53 pathway to mediate apoptosis in response to arsenic exposure.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Plant Sciences
Md Mahbubur Rahman, A. S. M. Ali Reza, Muhammad Ali Khan, Khaled Mahmud Sujon, Rokshana Sharmin, Mamunur Rashid, Md Golam Sadik, Md Abu Reza, Toshifumi Tsukahara, Raffaele Capasso, Ashik Mosaddik, Glenda C. Gobe, A. H. M. Khurshid Alam
Summary: Extracts from Tabebuia pallida possess significant anticancer activity by inducing apoptosis, enhancing antioxidant enzymes and caspases, and modulating the balance of pro-and anti-apoptotic genes to promote cell death.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Cell Biology
Claudio Urbani, Alessandro Mattiello, Gianmarco Ferri, Francesco Raggi, Dania Russo, Giulia Marconcini, Daniele Cappellani, Luca Manetti, Claudio Marcocci, Francesco Cardarelli, Fausto Bogazzi
Summary: This study demonstrated that PCB153 reduces apoptosis in pituitary cells through activation of the PI3K/Akt-mediated NF-κB pathway, while also inhibiting the expression of pro-apoptotic proteins like p38-MAPK, P53, and P21.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mathias S. Heltberg, Alessandra Lucchetti, Feng-Shu Hsieh, Duy Pham Minh Nguyen, Sheng-hong Chen, Mogens H. Jensen
Summary: This study investigates the dynamic signaling in the repair process of DNA damage in cells, revealing that the oscillatory dynamics of the transcription factor p53 optimize the repair efficiency by forming sub-compartments.
Article
Biochemistry & Molecular Biology
Jyoti B. Kaushal, Vinay Shukla, Pushplata Sankhwar, Rajesh K. Jha, Anila Dwivedi
Summary: The study uncovered the crucial role of TAK1 in mediating TGF beta 1-induced responses in endometriotic cells, influencing the activation of the NF kappa B-p65/Smad7 signaling cascade and subsequently affecting cell growth and inflammatory responses.
Article
Oncology
Douglas R. Green
Summary: Genetically identical cells in a tissue can exhibit different responses to environmental stress, influencing their decision to repair or die, and affecting surrounding cells. These responses play a role in controlling the health and fitness of individual cells and their competition with other genetically identical cells.
CANCER IMMUNOLOGY RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Zengxin Jiang, Guobin Qi, Wei Lu, Hao Wang, Defang Li, Weibin Chen, Lei Ding, Xiuying Yang, Hengfeng Yuan, Qingmin Zeng
Summary: This study found that omaveloxolone exerts antioxidative, anti-inflammatory, antiapoptotic and anti-ECM degradation effects via activation of the Nrf2/ARE signaling pathway and inhibition of the NF-kappa B signaling pathway in chondrocytes in vitro and attenuates osteoarthritis progression in vivo, suggesting its potential as a therapeutic agent for OA.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Shouye Hu, Yanqi Li, Bo Wang, Kan Peng
Summary: The study showed that TRIM38 can alleviate IL-1 beta-induced apoptosis and degeneration of chondrocytes by suppressing the NF-kappa B signaling pathway. This work suggests a potential role of TRIM38 in osteoarthritis and proposes it as a new therapeutic target for the disease.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mine Sulak, Gurbet Celik Turgut, Alaattin Sen
Summary: In this study, cerium oxide nanoparticles (CONPs) were synthesized using fresh green walnut shell extract in a microwave environment. The morphology and structure of the CONPs were characterized, and their mechanism of action in breast cancer cell lines (MCF7) was evaluated. The CONPs showed cytotoxic effects, induced apoptosis, and affected gene expression in the cancer cells.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Biochemistry & Molecular Biology
Marina Kolesnichenko, Nadine Mikuda, Uta E. Hoepken, Eva Kaergel, Bora Uyar, Ahmet Bugra Tufan, Maja Milanovic, Wei Sun, Inge Krahn, Kolja Schleich, Linda Hoff, Michael Hinz, Michael Willenbrock, Sabine Jungmann, Altuna Akalin, Soyoung Lee, Ruth Schmidt-Ullrich, Clemens A. Schmitt, Claus Scheidereit
Summary: The study reveals that DNA double-strand breaks elicit two subsequent phases of NF-kappa B activation, with the first phase controlling anti-apoptotic gene expression and the second phase driving expression of senescence-associated genes.
Article
Biochemistry & Molecular Biology
Lei Xu, Yangfan Ye, Zeqiang Tao, Tian Wang, Yutian Wei, Wanzhi Cai, Xin Wan, Pengzhan Zhao, Wei Gu, Bin Gu, Liuchao Zhang, Yufei Tian, Ning Liu, Yiming Tu, Jing Ji
Summary: This study elucidated the role of MLPH in GBM radiation resistance, showing that MLPH promotes radiotherapy resistance by regulating the NF-kappa B pathway. Additionally, O-GlcNAcylation of MLPH protects it from degradation and stabilizes its presence in cells. These findings provide insights into a potential mechanism of GBM radiation resistance and suggest a therapeutic strategy for GBM treatment.
Article
Cell Biology
Chenchen Zhou, Xueli Zhang, Cuiping Yang, Yuan He, Luo Zhang
Summary: The study reveals that PLEKHO2 acts as a novel inhibitor of apoptosis and necroptosis, playing a key role in regulating RIPK1 ubiquitination and activation. PLEKHO2 deficiency increases cell susceptibility to TNF-alpha induced apoptosis and necroptosis, affecting RIPK1 activation and NF-kappa B activation. Deficiency in PLEKHO2 leads to enhanced hepatotoxicity and lethality in mice after TNF alpha-induced hepatitis.
CELL DEATH & DISEASE
(2021)
Review
Oncology
Aneri Shah, Jonathan A. Lindquist, Lars Rosendahl, Ingo Schmitz, Peter R. Mertens
Summary: YB-1 is a RNA binding protein involved in various cellular processes, its activation is associated with NF-kappa B and can affect the inflammatory response and cell survival mechanisms.
Article
Biochemistry & Molecular Biology
Stephanie Nuan-Aliman, Didier Bordereaux, Catherine Thieblemont, Veronique Baud
Summary: RelB NF-κB subunit plays a role in controlling oxidative metabolism in DLBCL, inhibiting RelB reduces DLBCL mitochondrial ATP production and increases sensitivity to antimetabolic drugs.
Article
Clinical Neurology
Zhaohui Chai, Peidong Zheng, Jiesheng Zheng
Summary: The study found that ARPP21 expression was downregulated and miR-128 expression was upregulated in stroke patients. pc-ARPP21 promoted astrocyte proliferation, inhibited neuronal and astrocyte apoptosis, and reduced astrocyte inflammation. miR-128 targeted CREB1 and decreased BDNF secretion, reversing the effects of pc-ARPP21 on neurons and astrocytes.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)
Article
Cell Biology
Claudio Festuccia, Andrea Mancini, Giovanni Luca Gravina, Alessandro Colapietro, Antonella Vetuschi, Simona Pompili, Luca Ventura, Simona Delle Monache, Roberto Iorio, Andrea Del Fattore, William Fogler, John Magnani
Article
Ophthalmology
Roberto Iorio, Sabrina Petricca, Carla Luzi, Pierangelo Bellio, Loredana Cristiano, Claudio Festuccia, Gianfranco Amicosante, Giuseppe Celenza
Summary: The study investigates the regulatory effects of Lactobacillus sakei pro-Bio65 lysate on human conjunctival epithelial cells, showing that it does not affect cell proliferation but induces low levels of intracellular ROS and changes in mitochondrial membrane potential. Additionally, it upregulates antioxidant defense efficiency and reduces TNF-alpha expression, suggesting the potential application of L.SK paraprobiotic in promoting eye health and preventing oxidative stress-related conditions.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)
Article
Infectious Diseases
Lorenza Fagnani, Lisaurora Nazzicone, Fabrizia Brisdelli, Luisa Giansanti, Sara Battista, Roberto Iorio, Sabrina Petricca, Gianfranco Amicosante, Mariagrazia Perilli, Giuseppe Celenza, Pierangelo Bellio
Summary: The study indicates that combining antibiotics with amphoteric surfactants is a promising therapeutic option for infections caused by multidrug-resistant S. aureus. Among the compounds tested, L-prolinol amine-oxide C12NOX showed the most promising results. This research provides valuable insights into combating antibiotic resistance in pathogenic bacteria.
Article
Cell Biology
Roberto Iorio, Giuseppe Celenza, Sabrina Petricca
Summary: Mitochondria are critical organelles for cellular energy balance and cell death. Mitophagy, the selective removal of dysfunctional mitochondria by autophagy, plays important roles in maintaining mitochondrial health. Both impaired and excessive mitophagy are involved in various ageing-associated diseases. Recent advances have explored the molecular mechanisms and signaling pathways that regulate mitophagy, including the early role and spatial specificity of the AMPK/ULK1 axis.
Editorial Material
Pharmacology & Pharmacy
Luca D'andrea, Marina Montemagni, Giuseppe Celenza, Roberto Iorio, Ciro Costagliola
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sabrina Petricca, Giuseppe Celenza, Carla Luzi, Benedetta Cinque, Anna Rita Lizzi, Nicola Franceschini, Claudio Festuccia, Roberto Iorio
Summary: Triazole and imidazole fungicides, as emerging pollutants with endocrine-disrupting properties, have been found to have adverse effects on male reproductive cells. This study specifically demonstrates that ketoconazole and miconazole, alone or in combination with prochloraz, significantly impair the functions of Sertoli cells and cause oxidative stress. However, fluconazole shows no cytotoxic effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Valentina Di Nisio, Sevastiani Antonouli, Pauliina Damdimopoulou, Andres Salumets, Sandra Cecconi
Summary: This paper is an updated review on the consequences of postovulatory aging (POA) on oocyte quality, either in vivo or in vitro, with a focus on the modifications caused by POA on oocyte nuclear, cytoplasmic, genomic, and epigenetic maturation, as well as embryo development. The research highlights the importance of considering the effects of POA in assisted reproductive technologies, particularly when the fertilization of mature oocytes is delayed due to unforeseen circumstances.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Pharmacology & Pharmacy
Alessandro Colapietro, Peiying Yang, Alessandra Rossetti, Andrea Mancini, Flora Vitale, Sharmistha Chakraborty, Stefano Martelluci, Francesco Marampon, Vincenzo Mattei, Giovanni Luca Gravina, Roberto Iorio, Robert A. Newman, Claudio Festuccia
Summary: The study demonstrates that PBI-05204 enhances the sensitivity of GBM cells to radiation therapy by promoting the transition from autophagy to apoptosis, enhancing DNA damage, and reducing DNA repair. The combination of PBI-05204 with radiotherapy reduces tumor progression and enhances antitumor activity.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Jacopo Di Gregorio, Sabrina Petricca, Roberto Iorio, Elena Toniato, Vincenzo Flati
Summary: Metabolic alterations, including enhanced aerobic glycolysis, oxidative phosphorylation, gluconeogenesis, and fatty acid beta-oxidation, play crucial roles in the development and survival of cancers.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Roberto Iorio, Giuseppe Celenza, Sabrina Petricca
Summary: Inflammation and oxidative stress are closely related in chronic diseases, and targeting inflammatory pathways may be a potential therapeutic strategy. Phytochemicals extracted from edible plants, such as ss-caryophyllene and carnosic acid, have demonstrated anti-inflammatory, antioxidant, and neuroprotective effects in various experimental models. These compounds have the potential to maintain mitochondrial homeostasis and ameliorate glia-mediated neuroinflammation in the treatment of neurodegenerative diseases.
Article
Chemistry, Medicinal
Lorenza Fagnani, Lisaurora Nazzicone, Pierangelo Bellio, Nicola Franceschini, Donatella Tondi, Andrea Verri, Sabrina Petricca, Roberto Iorio, Gianfranco Amicosante, Mariagrazia Perilli, Giuseppe Celenza
Summary: This study investigated the inhibitory activity of protocetraric and salazinic acids against SARS-CoV-2 3CL(pro). The results showed that both compounds are slow-binding inactivators of 3CL(pro) with a competitive inhibition mechanism. In cellular experiments, these compounds did not show cytotoxicity. Molecular modeling predicted the binding mechanism of these compounds with 3CL(pro).
Article
Biochemistry & Molecular Biology
Sabrina Petricca, Giuseppe Celenza, Ciro Costagliola, Fausto Tranfa, Roberto Iorio
Summary: This study evaluated the in vitro effects of preservative-free bimatoprost (BIM) 0.03% vs. 0.01% on human conjunctival epithelial (HCE) cells. The results showed that long-term exposure to BIM 0.03% resulted in a significant decrease in cell proliferation and viability, as well as alterations in cell cycle and mitochondrial function. BIM 0.01% did not exhibit cytotoxicity or negative influence on conjunctival cell growth and viability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Gianna Rossi, Valentina Di Nisio, Alessandro Chiominto, Sandra Cecconi, Mauro Maccarrone
Summary: This study aimed to investigate the expression levels of the main receptors and metabolic enzymes of the endocannabinoid system in the ovaries, oviducts, and uteri of mice at different reproductive stages. The results showed that TRPV1 receptor had the highest expression and significantly increased during aging, while NAPE-PLD, FAAH, and DAGL-beta enzymes were the most expressed in these organs and increased with age. Immunohistochemistry revealed the distribution of these proteins in specific cells in each organ. These findings provide new insights into the role of the endocannabinoid system in female reproduction and its therapeutic potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Valentina Di Nisio, Sevastiani Antonouli, Sabrina Colafarina, Osvaldo Zarivi, Gianna Rossi, Sandra Cecconi, Anna Maria Giuseppina Poma
Summary: Controlled ovarian stimulation (COS) is a common procedure in assisted reproductive technologies, but it can lead to an unbalanced hormonal and molecular environment that affects cellular mechanisms. This study found changes in mitochondrial DNA fragmentation, antioxidant enzymes, apoptotic proteins, and pro-survival proteins in the oviducts of mice that underwent repeated hyperstimulation. The results show that while the antioxidant machinery is activated, apoptosis is not induced due to the activation of pro-survival proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Valentina Di Nisio, Gianna Rossi, Alessandro Chiominto, Ezio Pompili, Sandra Cecconi
Summary: This study investigates the effects of aging and parity on VEGF-A/VEGFR protein content and signaling in mouse ovaries. The results show that the protein content of VEGF-A and phosphorylated VEGFR2 significantly decreases in post-reproductive (PM) ovaries, but remains unchanged in other groups. Additionally, the downstream signaling pathways and protein content of markers related to angiogenesis and cell cycle progression are modulated in an age- and parity-dependent manner.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Reproductive Biology
Patrycja Kurowska, Ewa Mlyczynska, Julia Wajda, Konrad Krol, Karolina Pich, Patrycja Guzman, Aleksandra Greggio, Oliwia Szkraba, Malgorzata Opydo, Joelle Dupont, Agnieszka Rak
Summary: This study investigated the expression of PNX-14 and GPR173 in ovarian tissue and the effects of PNX-14 on granulosa cell function. The results showed that PNX-14 can influence ovarian follicle growth by promoting granulosa cell proliferation, hormone secretion, and cell cycle progression.
REPRODUCTIVE BIOLOGY
(2024)
Article
Reproductive Biology
Sonia Srivastava, Swarnima Mishra, Gyan Babu, Banalata Mohanty
Summary: This study aimed to investigate the efficacy of PD149163 in preventing/ameliorating LPS-induced inflammation in the female reproductive system of mice. The results showed that PD149163 reduced/prevented the inflammation in the ovary and uterine horn, restored the balance of inflammatory cytokines and oxidative stress, and recovered the levels of reproductive hormones and corticosterone.
REPRODUCTIVE BIOLOGY
(2024)
Article
Reproductive Biology
Chen Zhang, Hongyan Cheng, Xue Ye, Heng Cui, Yi Li, Honglan Zhu, Xiaohong Chang
Summary: Extracellular matrix protein 1 (ECM1) is significantly upregulated in endometriosis tissues. Blocking ECM1 attenuates cell migration and invasion. ECM1 regulates cell migration, invasion, and cytoskeleton reorganization via the RhoC/ROCK1 signaling pathway.
REPRODUCTIVE BIOLOGY
(2024)
