Review
Oncology
Henry C. Y. Wong, Shing Fung Lee, Adrian Wai Chan, Saverio Caini, Peter Hoskin, Charles B. Simone Ii, Peter Johnstone, Yvette van der Linden, Joanne M. van der Velden, Emily Martin, Sara Alcorn, Candice Johnstone, Gustavo Nader Marta, Eva Oldenburger, Srinivas Raman, Agata Rembielak, Vassilios Vassiliou, Pierluigi Bonomo, Quynh-Nhu Nguyen, Edward Chow, Samuel Ryu
Summary: This study compared the efficacy of SBRT and cEBRT in treating spinal metastases through a systematic review and meta-analysis of randomized controlled trials. The results showed that SBRT may provide better complete pain response compared to cEBRT. However, there were no significant differences in overall pain response, local progression, and overall survival between the two treatments. Adverse events were similar, except for a lower incidence of radiation dermatitis in the SBRT group.
RADIOTHERAPY AND ONCOLOGY
(2023)
Review
Oncology
Chia Ching Lee, Yu Yang Soon, Timothy Cheo, Balamurugan Vellayappan, Jeremy Tey
Summary: The purpose of this study was to compare the efficacy and safety of SBRT and cEBRT in patients with previously unirradiated painful BM. The meta-analysis showed that SBRT significantly improved pain response and reduced local progression compared to cEBRT, but there were no differences in other outcomes.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Article
Biology
Yupeng Liu, Siyu Le, Yi Liu, Huinan Jiang, Binye Ruan, Yufeng Huang, Xuemei Ao, Xudong Shi, Xiaoyi Fu, Shuran Wang
Summary: This systematic review and meta-analysis examined the effects of calcium supplementation on bone mineral accretion in young populations. The findings suggest that calcium supplementation has a significant positive impact on bone density and mass, particularly in the femoral neck and total body. Interestingly, the improvement in bone mass at the femoral neck was more pronounced in the population aged 20-35 years.
Review
Integrative & Complementary Medicine
Qiangqiang Li, Guangpu Yang, Hongtao Xu, Shaowen Tang, Wayne Yuk-wai Lee
Summary: The study aimed to evaluate the effects of resveratrol supplementation on bone mineral density (BMD) and serum bone markers, but no significant effects were found based on the current evidence. Further investigation via well-organized multicentre randomized trials is needed.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2021)
Review
Rheumatology
Angelo Fassio, Alessandro Mantovani, Davide Gatti, Maurizio Rossini, Ombretta Viapiana, Irene Gavioli, Camilla Benini, Giovanni Adami
Summary: This study analyzed the efficacy of various pharmacological approaches for the treatment of complex regional pain syndrome type-I (CRPS-I) and found that parenteral bisphosphonates are recommended as the first-line treatment for CRPS-I.
Review
Endocrinology & Metabolism
Bai-Ru Cheng, Rou-Yan Wu, Qin-Yang Gao, Kai-Xin Jiang, Shuang-Sang Li, Shi-Hao Qi, Ming-Yi Yuan, Jian-Ping Liu
Summary: This systematic review suggests that XLGB capsule appears to be safe and has a beneficial effect on the quality of life and pain relief when used alone or in combination with conventional medications in osteoporosis patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Clinical Neurology
Michele Fornaro, Anna Maria Mondin, Martina Billeci, Andrea Fusco, Michele De Prisco, Claudio Caiazza, Fausta Micanti, Raffaella Calati, Andre Ferrer Carvalho, Andrea de Bartolomeis
Summary: This study conducted a systematic review and meta-analysis on the weight and affective psychopathology outcomes of major eating disorders. The results showed that different drugs have varying efficacy in different eating disorders, suggesting the need for further research.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Food Science & Technology
Yuqi Dou, Ying Wang, Zekun Chen, Xue Yu, Defu Ma
Summary: The systematic review and meta-analysis conducted indicated that n-3 PUFAs supplementation could slightly enhance bone mineral density (BMD), especially for postmenopausal women. However, there was no significant impact on bone-specific alkaline phosphatase (BALP) and osteocalcin. Alpha-linolenic acid supplementation form showed significant results in increasing BALP content compared to other forms. Moreover, the levels of bone resorption biomarkers, type I collagen cross-linked C-terminal peptide (CTX) and type I collagen cross-linked N-terminal peptide (NTX), were significantly decreased in participants who received n-3 PUFAs.
FOOD SCIENCE & NUTRITION
(2022)
Review
Food Science & Technology
Habib Yarizadeh, Sara Asadi, Hussein Baharlooi, Leila Setayesh, Nader Rahimi Kakavandi, Catherine Hambly, Kurosh Djafarian, Khadijeh Mirzaei
Summary: This study compared the effects of calorie restriction alone versus exercise-calorie restriction on bone mass in adults undergoing weight loss programs. The findings suggest that exercise can help preserve or increase bone mass at the hip and femoral neck during weight reduction, but did not significantly affect bone mineral density at the lumbar spine and total body.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Review
Geriatrics & Gerontology
B. A. Cedeno-Veloz, J. Erviti Lopez, M. Gutierrez-Valencia, L. Leache Alegria, L. C. Saiz, A. M. Rodriguez Garcia, M. Sanchez Latorre, R. Ramirez Velez, M. Izquierdo, N. Martinez-Velilla
Summary: Antiresorptive drugs have a statistically significant effect on preventing hip fractures in older adults, but with moderate quality of evidence and a high number needed to treat. There is no reduction in the risk of hip fractures in individuals aged 75 years and older. More randomized controlled trials are needed in very old osteoporotic adults.
JOURNAL OF NUTRITION HEALTH & AGING
(2022)
Review
Immunology
Yanfei Zheng, Zengliang Zhang, Ping Tang, Yuqi Wu, Anqi Zhang, Delong Li, Chong-Zhi Wang, Jin-Yi Wan, Haiqiang Yao, Chun-Su Yuan
Summary: Probiotics play a significant role in improving intestinal barrier function, immune function, inflammation, and microbiota composition, as evidenced by a systematic review and meta-analysis.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Shih-Yin Lin, Min-Chih Hung, Shih-Fu Chang, Fon-Yih Tsuang, Jenny Zwei-Chieng Chang, Jui-Sheng Sun
Summary: This network meta-analysis study compared the efficacy and safety of different drugs for the treatment of postmenopausal osteoporosis. Results showed that strontium ranelate, fluoride, and hormone replacement therapy were most effective in increasing bone mineral density, while parathyroid hormone was most effective in preventing new hip fractures. Bisphosphonate, monoclonal antibody, and fluoride had balanced efficacy in increasing BMD at all sites, with monoclonal antibody, bisphosphonate, and PTH being more favorable for overall effectiveness in increasing BMD and preventing hip fractures.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Oncology
Gustavo Nader Marta, Rachel Riera, Rafael Leite Pacheco, Ana Luiza Cabrera Martimbianco, Icro Meattini, Orit Kaidar-Person, Philip Poortmans
Summary: This study provides a critical assessment of the use of moderately hypofractionated irradiation for breast cancer patients. The results suggest that moderately hypofractionated irradiation is as effective and safe as conventional radiation doses, making it a suitable treatment option for most breast cancer patients.
Review
Food Science & Technology
Fatemeh Hajizadeh-Sharafabad, Elham Sharifi Zahabi, Mahsa Malekahmadi, Rasoul Zarrin, Mohammad Alizadeh
Summary: This study conducted a systematic review and meta-analysis of randomized controlled trials to investigate the effects of carotenoids on inflammatory parameters. The results showed significant effects of carotenoids on C-reactive protein and interleukin-6, but not on tumor necrosis factor-alpha. Individual carotenoids like astaxanthin, lutein/zeaxanthin, and beta-cryptoxanthin significantly decreased CRP levels, while only lycopene led to a significant decrease in IL-6. Overall, carotenoids may have protective effects on inflammatory biomarkers.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Cardiac & Cardiovascular Systems
Michelle Samuel, Jean-Claude Tardif, Nadia Bouabdallaoui, Paul Khairy, Marie-Pierre Dube, Lucie Blondeau, Marie-Claude Guertin
Summary: Low-dose colchicine has shown significant efficacy in reducing cardiovascular events among patients with coronary artery disease in randomized controlled trials, particularly in reducing the incidence of myocardial infarction, ischemic stroke, and urgent coronary revascularizations. Safety outcomes did not differ significantly between groups.
CANADIAN JOURNAL OF CARDIOLOGY
(2021)
Article
Health Care Sciences & Services
Ronald Chow, Robert Bergner, Elizabeth Prsic
Summary: Current research suggests that music therapy can improve the physical and mental well-being of cancer patients, although the relationship between the duration of music therapy and its effectiveness requires further investigation.
BMJ SUPPORTIVE & PALLIATIVE CARE
(2023)
Review
Health Care Sciences & Services
Ronald Chow, Eduardo Bruera, Michael Sanatani, Leonard Chiu, Elizabeth Prsic, Gabriel Boldt, Michael Lock
Summary: This systematic review on pharmacologic interventions for cancer-related fatigue found that methylphenidate, modafinil, and paroxetine were more effective than placebo, with paroxetine being superior to both methylphenidate and modafinil. These findings provide guidance for future clinical trials.
BMJ SUPPORTIVE & PALLIATIVE CARE
(2023)
Review
Health Care Sciences & Services
Ronald Chow, Madison Novosel, Olivia W. So, Shreya Bellampalli, Jenny Xiang, Gabriel Boldt, Eric Winquist, Michael Lock, Maryam Lustberg, Elizabeth Prsic
Summary: This study conducted a systematic review and meta-analysis on the use of duloxetine in the prevention and treatment of chemotherapy-induced peripheral neuropathy (CIPN). The analysis of seven randomized controlled trials showed that duloxetine was statistically similar to placebo in terms of efficacy and safety for both the treatment and prevention of CIPN. However, the current evidence is limited and more comprehensive and higher-quality trials are needed to assess the use of duloxetine in CIPN.
BMJ SUPPORTIVE & PALLIATIVE CARE
(2023)
Article
Oncology
Maximilian C. Schmid, Jacob Lindegaard, Umesh Mahantshetty, Kari Tanderup, Ina Jurgenliemk-Schulz, Christine U. Haie-Meder, Lars Fokdal, Alina Sturdza, Peter Hoskin, Barbara Segedin, Kjersti Bruheim, Fleur Huang, Bhavana Rai, Rachel Cooper, Elzbieta van der Steen-Banasik, Erik R. Van Limbergen, Bradley Pieters, Primoz Petric, Dariga Ramazanova, Robin Ristl, Sadhana Kannan, Rohini Hawaldar, Stefan Ecker, Kathrin Kirchheiner, Li Tee Tan, Remi Nout, Nicole Nesvacil, Astrid de Leeuw, Richard Poetter, Christian Kirisits
Summary: This study reports the clinical and treatment characteristics, remission and failure patterns, and risk factors for local failure (LF) in patients with locally advanced cervical cancer. The study demonstrates the safety and validity of MR-IGABT and provides evidence for dose prescription and new risk factors for LF.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Oncology
Ronald Chow, Julie Midroni, Jagdeep Kaur, Gabriel Boldt, Geoffrey Liu, Lawson Eng, Fei-Fei Liu, Benjamin Haibe-Kains, Michael Lock, Srinivas Raman
Summary: The aim of this study is to provide a comprehensive understanding of the current landscape of artificial intelligence (AI) for cancer clinical trial enrollment and its predictive accuracy. The study found that AI demonstrated comparable or superior performance to manual screening for patient enrollment in cancer clinical trials, with accuracy, sensitivity, and specificity exceeding 80% in most datasets. AI is highly efficient and requires less time and human resources for screening patients.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Vicky Smith, Debayan Mukherjee, Anna Maria Tsakiroglou, Alexander Baker, Hitesh Mistry, Ananya Choudhury, Peter Hoskin, Timothy Illidge, Catharine M. L. West
Summary: Precision medicine is needed for muscle-invasive bladder cancer to improve survival rates. CD8 T cell counts show promise as a predictive biomarker for immune checkpoint inhibitors (ICIs). However, there is currently no biomarker to stratify patients for hypoxia-targeting or immune-targeting therapies.
Article
Oncology
Aleena Malik, Meghan P. Jairam, Ronald Chow, Seyed A. Mirshahvalad, Patrick Veit-Haibach, Charles B. Simone II
Summary: The aim of this meta-regression was to assess the impact of age, tumor size, percentage of males, and total sample size on the comparative effectiveness of radiofrequency ablation (RFA) and stereotactic body radiation therapy (SBRT). Ten studies reporting on overall survival and local control were included. Age showed a significant relationship with overall survival and local control for both RFA and SBRT, while tumor size had no significant relationship with overall survival or local control by SBRT.
Letter
Oncology
Aleena Malik, Meghan P. Jairam, Ronald Chow, Seyed A. Mirshahvalad, Patrick Veit-Haibach, Charles B. Simone II
Article
Biochemistry & Molecular Biology
Vicky Smith, Dave Lee, Mark Reardon, Rekaya Shabbir, Sudhakar Sahoo, Peter Hoskin, Ananya Choudhury, Timothy Illidge, Catharine M. L. West
Summary: Hypoxia and suppressive TME are negative prognostic factors for MIBC. Transcriptomic analyses show that hypoxia increases immune signalling and infiltrates in bladder cancer. This study investigates the relationship between HIF-1 and -2, hypoxia, immune signalling, and infiltrates in MIBC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Ronald Chow, Jean J. Mathews, Emily YiQin Cheng, Samantha Lo, Joanne Wong, Sorayya Alam, Breffni Hannon, Gary Rodin, Rinat Nissim, Sarah Hales, Dio Kavalieratos, Kieran L. Quinn, George Tomlinson, Camilla Zimmermann
Summary: This study examined the effectiveness of interventions offering support for caregivers of patients with advanced cancer on caregiver quality of life (QOL) and mental health outcomes. The findings suggest that interventions targeting caregivers, dyads, or patients and families can lead to improvements in caregiver QOL and mental health.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Michael J. Dubec, David L. Buckley, Michael Berks, Abigael Clough, John Gaffney, Anubhav Datta, Damien J. McHugh, Nuria Porta, Ross A. Little, Susan Cheung, Christina Hague, Cynthia L. Eccles, Peter J. Hoskin, Robert G. Bristow, Julian C. Matthews, Marcel van Herk, Ananya Choudhury, Geoff J. M. Parker, Andrew McPartlin, James P. B. O'Connor
Summary: The study aimed to develop oxygen-enhanced MRI (OE-MRI) in head and neck cancer patients and translate the technique onto an MR Linac system. The results showed that OE-MRI was feasible and had good repeatability, and it has the potential to guide future clinical trials of biology guided adaptive radiotherapy.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Health Care Sciences & Services
James H. B. Im, Ronald Chow, Madison Novosel, Jenny Xiang, Michael Strait, Vinay Rao, Jennifer Kapo, Camilla Zimmermann, Elizabeth Prsic
Summary: This study aimed to explore the association between receiving an inpatient palliative care consultation and hospital outcomes, including in-hospital death, ICU use, discharge to hospice, 30-day readmissions, and 30-day ED visits. A retrospective chart review was conducted on medical oncology admissions at Yale New Haven Hospital, with and without palliative care consultations. The results showed that receiving more palliative care consultations was associated with higher odds of hospital death and discharge to hospice, and lower odds of ICU admission, but had no significant association with 30-day readmissions or ED visits.
BMJ SUPPORTIVE & PALLIATIVE CARE
(2023)
Article
Oncology
Martin Swinton, Neethu Billy Graham Mariam, Jean Ling Tan, Katherine Murphy, Thiraviyam Elumalai, Manjusha Soni, Alexandra Ferrera, Charlotte Richardson, Richard Walshaw, Hitesh Mistry, Vijay Ramani, Yeepei Song, Alison Birtle, Ann Henry, Joachim Chan, Peter Hoskin, Ananya Choudhury
Summary: This study analyzed the survival outcomes of node-positive bladder cancer patients and found that there was no significant difference in survival rates between surgery and radiation therapy. Bladder-sparing treatment should be considered as an option for patients with poor survival rates.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Health Care Sciences & Services
Denis Qeska, Ronald Chow, Tracy A. Balboni, Jennifer Kapo, Camilla Zimmermann, Elizabeth Prsic
Summary: This study aimed to assess the association between advance care planning (ACP) and outcomes of in-hospital mortality, 30-day hospital readmission, and 30-day emergency department visits among patients with cancer. The study found that patients with documented ACP had lower rates of readmission and ED visits within 30 days. This association was independent of hospice utilization.
BMJ SUPPORTIVE & PALLIATIVE CARE
(2023)
Review
Respiratory System
Ronald Chow, Olivia W. So, James H. B. Im, Kenneth R. Chapman, Ani Orchanian-Cheff, Andrea S. Gershon, Robert Wu
Summary: This review examined significant predictors and prediction scores for readmission among patients with chronic obstructive pulmonary disease (COPD). The study identified several factors, including patient characteristics, hospitalization details, investigation results, and discharge characteristics, that were significantly associated with readmission risk.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2023)
Article
Oncology
Derek A. Mumaw, Allison J. Hazy, Aleksander Vayntraub, Thomas J. Quinn, Kamran Salari, John H. Chang, Noah Kalman, Sanford Katz, James Urbanic, Robert H. Press, Arpi Thukral, Henry Tsai, George E. Laramore, Jason Molitoris, Carlos Vargas, Samir H. Patel, Craig Stevens, Rohan L. Deraniyagala
Summary: This study evaluated contralateral recurrences in patients with oropharyngeal squamous cell carcinoma who received unilateral proton beam therapy. The results showed a favorable contralateral neck failure rate that was comparable to photon irradiation.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Kangpyo Kim, Dongryul Oh, Jae Myoung Noh, Yang Won Min, Hong Kwan Kim, Yong Chan Ahn
Summary: This study suggests that hypofractionated radiation therapy alone is a feasible option for early stage esophageal squamous cell carcinoma patients. Particularly, in patients with tumor length < 3 cm, this treatment scheme shows favorable local control rates with low incidence of esophageal toxicities.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Lin Chen, Jing Li, Kunpeng Li, Jiang Hu, Qingjie Li, Chenglong Huang, Gaoyuan Wang, Na Liu, Linglong Tang
Summary: This study analyzed the probability of hearing impairment after radiotherapy for nasopharyngeal carcinoma and developed a predictive model, providing dose limitation suggestions to improve patients' quality of life.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yiwei Yang, Jianxin Wang, Feng Gao, Zhen Liu, Tangzhi Dai, Haowen Zhang, Hongyu Zhu, Tingting Wang, Dexin Xiao, Kui Zhou, Zheng Zhou, Dai Wu, Xiaobo Du, Sen Bai
Summary: This paper provides a comprehensive description of the current status of PARTER, which is the first experimental FLASH platform utilizing megavoltage X-rays. It showcases the reliable performance and stability of the dosimeters and monitors used in PARTER, as well as the satisfactory dose distribution and characteristics of the FLASH X-rays. The platform effectively meets the requirements of preclinical research on megavoltage X-ray FLASH and undergoes continuous upgrades.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Maria Thor, Kelly Fitzgerald, Aditya Apte, Jung Hun Oh, Aditi Iyer, Otasowie Odiase, Saad Nadeem, Ellen D. Yorke, Jamie Chaft, Abraham J. Wu, Michael Offin, Charles B. Simone Ii, Isabel Preeshagul, Daphna Y. Gelblum, Daniel Gomez, Joseph O. Deasy, Andreas Rimner
Summary: The purpose of this study was to identify predictors of disease progression in early-stage non-small cell lung cancer (NSCLC) patients after receiving definitive stereotactic body radiation therapy (SBRT). The results showed that tumor diameter and SUVmax were the most frequently reported features associated with progression/survival, and a re-fitted model including these two features had the best performance.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yong-Qiao He, Tong-Min Wang, Da-Wei Yang, Wen-Qiong Xue, Chang-Mi Deng, Dan-Hua Li, Wen-Li Zhang, Ying Liao, Ruo-Wen Xiao, Lu-Ting Luo, Hua Diao, Xia-Ting Tong, Yan-Xia Wu, Xue-Yin Chen, Jiang-Bo Zhang, Ting Zhou, Xi-Zhao Li, Pei-Fen Zhang, Xiao-Hui Zheng, Shao-Dan Zhang, Ye-Zhu Hu, Guan-Qun Zhou, Jun Ma, Ying Sun, Wei-Hua Jia
Summary: In this study, researchers aimed to establish a predictive model for radiation-induced brain injury (RBI) in nasopharyngeal carcinoma (NPC) patients by incorporating clinical factors and newly developed genetic variants. They conducted a large-scale retrospective study and a genome-wide association study to develop a polygenic risk score (PRS) for RBI risk prediction. The results showed that the PRS, combined with clinical factors, improved the accuracy of RBI risk stratification and suggested personalized radiotherapy.
RADIOTHERAPY AND ONCOLOGY
(2024)
Review
Oncology
Xiaoyong Xiang, Zhe Ji, Jing Jin
Summary: A review of studies suggests that brachytherapy as a salvage therapy for recurrent glioblastoma shows acceptable safety and good post-treatment clinical efficacy for selected patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
M. Berbee, C. T. Muijs, F. E. M. Voncken, L. Wee, M. Sosef, B. van Etten, J. W. van Sandick, F. A. R. M. Warmerdam, J. J. de Haan, E. Oldehinkel, J. M. van Dieren, L. Boersma, J. A. Langendijk, A. van der Schaaf, J. B. Reitsma, E. Schuit
Summary: This study externally validated a model for predicting 2-year total mortality in lung cancer patients in esophageal cancer patients. The intercept and/or slope of the original model needed adjustment to achieve good performance in esophageal cancer patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominique Reijtenbagh, Jeremy Godart, Joan Penninkhof, Sandra Quint, Andras Zolnay, Jan-Willem Mens, Mischa Hoogeman
Summary: This study compared the performance of the current PotD strategy with non-adaptive and fully online-adaptive techniques in the treatment of cervical cancer patients. The findings show that the PotD protocol is effective in improving normal tissue sparing compared to no adaptation, while fully online-adaptive approaches can further reduce target volume but come with a more complex workflow.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Albrecht Weiss, Steffen Loeck, Ting Xu, Zhongxing Liao, Aswin L. Hoffmann, Esther G. C. Troost
Summary: Traditional models for predicting radiation pneumonitis may not be applicable to non-small cell lung cancer patients treated with passively-scattered proton therapy. The use of effective alpha/beta parameter can predict the occurrence of radiation pneumonitis in these patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Z. A. R. Gouw, J. Jeong, A. Rimner, N. Y. Lee, A. Jackson, A. Fu, J-j. Sonke, J. O. Deasy
Summary: This study investigates the effectiveness of non-uniform fractionation schedules in radiotherapy for early-stage non-small cell lung cancer. Through modeling, optimized schedules are proposed to minimize local failures and toxicity risk. The results suggest that non-standard primer shot fractionation can reduce hypoxia-induced radioresistance and improve treatment outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Sara Ronchi, Alessandro Cicchetti, Maria Bonora, Rossana Ingargiola, Anna Maria Camarda, Stefania Russo, Sara Imparato, Paolo Castelnuovo, Ernesto Pasquini, Piero Nicolai, Mohssen Ansarin, Michele Del Vecchio, Marco Benazzo, Ester Orlandi, Barbara Vischioni
Summary: This study evaluates the efficacy and toxicity of carbon ion radiotherapy (CIRT) in locally advanced head and neck mucosal melanoma patients. The results show that CIRT is safe and effective in treating the local region, and immunotherapy after relapse can improve overall survival. However, further prospective trials are needed to assess the role of targeted/immune- systemic therapy in this disease.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominik Wawrzuta, Justyna Klejdysz, Marzanna Chojnacka
Summary: This study analyzed articles about radiation oncology published in The New York Times since its inception in 1851, and identified changes in media sentiment and prevalent themes related to radiotherapy. The findings suggest an increasing negative sentiment in media coverage towards radiotherapy, with a shift towards reporting treatment errors, toxicity, and ineffectiveness.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Elaine Limkin, Pierre Blanchard, Benjamin Lacas, Jean Bourhis, Mahesh Parmar, Lisa Licitra, Quynh-Thu Le, Sue S. Yom, Catherine Fortpied, Johannes Langendijk, Jan B. Vermorken, Jacques Bernier, Jens Overgaard, Jonathan Harris, Jean-Pierre Pignon, Anne Auperin
Summary: This study investigated the impact of season of radiotherapy on the outcomes of head and neck squamous cell cancer patients. The results showed that the season of radiotherapy did not have any significant effect on patient outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Fabio L. Cury, Gustavo A. Viani, Andre G. Gouveia, Camila V. S. Freire, Gabriel de A. Grisi, Fabio Y. Moraes
Summary: In limb-sparing treatment of soft tissue sarcoma patients, a 5-day course of preoperative radiotherapy results in high local control and favorable R0 margins, with acceptable complication rates, particularly for patients receiving higher biological equivalent doses.
RADIOTHERAPY AND ONCOLOGY
(2024)