期刊
BEHAVIOURAL BRAIN RESEARCH
卷 296, 期 -, 页码 118-124出版社
ELSEVIER
DOI: 10.1016/j.bbr.2015.09.005
关键词
Physical activity; Sedentary behavior; Brain atrophy; Elderly; MRI
资金
- NIA [N01-AG-1-2100]
- NIA Intramural Research Program, Hjartavernd (the Icelandic Heart Association)
- Althingi (the Icelandic Parliament)
- National Science Foundation Graduate Research Fellowship [DGE-0940903]
- National Institutes of Health Intramural Research Program [Z01 DK071013, Z01 DK071014]
Many studies have examined the hypothesis that greater participation in physical activity (PA) is associated with less brain atrophy. Here we examine, in a sub-sample (n = 352, mean age 79.1 years) of the Age, Gene/Environment Susceptibility-Reykjavik Study cohort, the association of the baseline and 5-year change in magnetic resonance imaging (MRI)-derived volumes of gray matter (GM) and white matter (WM) to active and sedentary behavior (SB) measured at the end of the 5-year period by a hip-worn accelerometer for seven consecutive days. More GM (beta = 0.11; p = 0.044) and WM (beta = 0.11; p = 0.030) at baseline was associated with more total physical activity (TPA). Also, when adjusting for baseline values, the 5-year change in GM (beta = 0.14; p = 0.0037) and WM (beta = 0.11; p = 0.030) was associated with TPA. The 5-year change in WM was associated with SB (p = 0.11; p = 0.0007). These data suggest that objectively measured PA and SB late in life are associated with current and prior cross-sectional measures of brain atrophy, and that change over time is associated with PA and SB in expected directions. (C) 2015 Elsevier B.V. All rights reserved.
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