Article
Oncology
Britney M. Veal, Stacey B. Scott, Heather S. L. Jim, Brent J. Small
Summary: Subjective reports of cancer-related cognitive impairment often exceed objective findings from in-person neuropsychological assessments. This study examined the association between subjective cognition and real-time objective cognitive performance, as well as fatigue and depressed mood, in breast cancer survivors. The results showed that subjective cognition was consistently related to self-reported fatigue and depressed mood, while specific memory lapses were associated with both in-person and daily objective cognitive performance. Incorporating reports of memory lapses may help identify individuals with objectively measured cancer-related cognitive impairment.
Article
Oncology
Kelly M. Shaffer, Philip Chow, Jillian Glazer, Tri Le, Matthew J. Reilley, Mark J. Jameson, Lee M. Ritterband
Summary: This study demonstrated the feasibility of using EMA among cancer caregivers and found that higher caregiver depressive symptoms were related to overall higher reported negative affect and lower positive affect. The results suggest the importance of strategies to reduce negative affect and increase opportunities for positive affect in caregiving interventions.
Article
Psychology, Experimental
Janna N. Vrijsen, Nessa Ikani, Pierre Souren, Mike Rinck, Indira Tendolkar, Aart H. Schene
Summary: Cognitive theories of depression suggest that negative contextual triggers lead to negative mood and memories, and the context plays a crucial role in the onset of depressive episodes. This study used Experience Sampling Method to measure context, mood, and emotional memory in individuals with different depression statuses. The results showed that currently depressed individuals had the strongest negative processing style, while never-depressed individuals had the most positive, with remitted-depressed patients scoring in between.
Article
Oncology
Jacqueline H. Becker, Charlotte Ezratty, Nusrat Jahan, Mita Goel, Yael Tobi Harris, Jenny J. Lin
Summary: Breast cancer survivors with cognitive impairment tend to rely more on external sources of motivation to perform health behaviors, regardless of depression. Future studies and interventions should consider screening for cognitive impairment and involving caregivers to improve outcomes.
Article
Rehabilitation
Anna J. Neff, Yejin Lee, Christopher L. Metts, Alex W. K. Wong
Summary: This study found dynamic relationships between mood, social interactions, and somatic symptoms in individuals with mild stroke, with depressed mood negatively associated with social interactions, and fatigue negatively associated with social satisfaction and success. Additionally, stable mood and appropriate levels of social satisfaction, confidence, and success were related to lower levels of fatigue, anxiety, and depressed mood.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Medicine, General & Internal
Hunter Scott, Nashira I. Brown, Erica A. Schleicher, Robert A. Oster, Edward Mcauley, Kerry S. Courneya, Philip Anton, Diane K. Ehlers, Siobhan M. Phillips, Laura Q. Rogers
Summary: This study investigates the relationship between psychosocial symptoms and exercise barriers in breast cancer survivors. The results show that higher levels of anxiety, depression, and comorbidities are independently associated with specific exercise barriers. Health professionals should consider mood and comorbidities when evaluating survivors for exercise barriers and providing tailored exercise counseling.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Florien W. Boele, Patricia W. M. den Otter, Jaap C. Reijneveld, Philip C. de Witt Hamer, Hinke F. van Thuijl, Linda M. C. Lorenz, Pieter Wesseling, Frank J. Lagerwaard, Martin J. B. Taphoorn, Mathilde C. M. Kouwenhoven, Tom J. Snijders, Linda Douw, Martin Klein
Summary: HRQOL and NCF do not appear greatly impacted during long-term survivorship in LGG, but depressive symptoms and fatigue are persistent.
Article
Oncology
Martina E. Schmidt, Marvin Chong, Oliver Klassen, Joachim Wiskemann, Karen Steindorf
Summary: Cancer-related fatigue is still not well understood, leading to undifferentiated treatment. This study investigated the potential use of bioelectrical phase angle (PhA) as a marker to identify specific fatigue subtypes. PhA was measured in breast cancer patients, and its association with fatigue severity and response to strength training was analyzed. The results showed that a decrease in PhA was significantly associated with increased physical and emotional fatigue. The association was stronger in patients with normal BMI and low pre-diagnosis exercise level. Furthermore, PhA was related to chemotherapy and strength training. These findings indicate that PhA may be a useful marker in classifying fatigue subtypes and tailoring treatments accordingly.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Anne S. van Roozendaal, Melanie P. J. Schellekens, Rosalie A. M. van Woezik, Marije L. van der Lee
Summary: This study aimed to explore the complex relationships among fatigue, perpetuating factors, and protective factors in patients with CRF. By applying a multivariate network approach, self-efficacy and allowing rest were identified as key protective factors for CRF. Psychological interventions that enhance self-efficacy may be beneficial for patients with CRF to alleviate fatigue.
Article
Health Care Sciences & Services
Rohitashwa Sinha, Riccardo Masina, Cristina Morales, Katherine Burton, Yizhou Wan, Alexis Joannides, Richard J. Mair, Robert C. Morris, Thomas Santarius, Tom Manly, Stephen J. Price
Summary: Surgery for patients with glioblastoma poses high risks to cognitive function, and these risks may increase postoperatively. However, there is evidence of risk reduction in the early period after surgery, before radiotherapy. Future research could focus on personalized rehabilitation tools to aid the recovery process during this timeframe.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Oncology
Erica Schleicher, Edward McAuley, Kerry S. Courneya, Phillip Anton, Diane K. Ehlers, Siobhan M. Phillips, Robert A. Oster, Dorothy Pekmezi, Laura Q. Rogers
Summary: This study investigated moderators of response to a physical activity behavior change intervention for breast cancer survivors. The results showed that breast cancer survivors who received chemotherapy, were within 2 years of diagnosis, and were single were less likely to achieve moderate-to-vigorous physical activity of 150+ weekly minutes. Further research is needed to determine additional support and resources that may benefit these subgroups of breast cancer survivors.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Oncology
Shannen R. van der Kruk, Kate M. Gunn, Ilse Mesters, Brigid M. Lynch, Jeff K. Vallance, Terry Boyle
Summary: This study aimed to investigate the longitudinal associations between demographic, clinical, and lifestyle factors, and changes in patient-reported outcomes (PROs) in cancer survivors 6-9 years post-diagnosis in Western Australia. The results showed that a notable proportion of participants reported a negative minimal clinically important difference (MCID) in fatigue, depression, and health-related quality of life (HRQOL). Non-Caucasian individuals and those who had non-Hodgkin lymphoma (NHL) were associated with negative changes over time, while being obese and having received radiotherapy were related to improved outcomes.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Psychology, Clinical
Joyce Y. Zhu, Andre Plamondon, Abby L. Goldstein, Ivar Snorrason, Jasmin Katz, Throstur Bjorgvinsson
Summary: This study examined the dynamic interplay between affect and internalizing symptoms, and found that reducing negative affect may be more effective in alleviating internalizing symptoms compared to increasing positive affect. Additionally, individual differences in resistance to shifting affective states may serve as a useful marker for developing tailored interventions.
DEPRESSION AND ANXIETY
(2022)
Article
Clinical Neurology
Andrew J. Seidman, Charles J. George, Maria Kovacs
Summary: This study examined compliance and affective yield in ecological momentary assessment (EMA), finding that factors such as depression history, time-of-day, study duration, and social context can affect compliance and affective yield. Researchers and clinicians using EMA should take these factors into consideration.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Oncology
Alicia Duval, Christopher G. Davis, Eve-Ling Khoo, Heather Romanow, Yaadwinder Shergill, Danielle Rice, Andra M. Smith, Patricia A. Poulin, Barbara Collins
Summary: This study found that mindfulness training can alleviate subjective memory impairments in breast cancer survivors receiving chemotherapy, but has no effect on objective assessments.
Article
Oncology
Judith E. Carroll, Zev M. Nakamura, Brent J. Small, Xingtao Zhou, Harvey J. Cohen, Tim A. Ahles, Jaeil Ahn, Traci N. Bethea, Martine Extermann, Deena Graham, Claudine Isaacs, Heather S. L. Jim, Paul B. Jacobsen, Brenna C. McDonald, Sunita K. Patel, Kelly Rentscher, James Root, Andrew J. Saykin, Danielle B. Tometich, Kathleen Van Dyk, Wanting Zhai, Elizabeth C. Breen, Jeanne S. Mandelblatt
Summary: The study examined the longitudinal relationships between levels of C-reactive protein (CRP) and cognition in older breast cancer survivors and noncancer controls. The results showed that breast cancer survivors had higher levels of CRP, and increased CRP levels predicted lower cognitive function. This suggests that chronic inflammation may play a role in the development of cognitive problems.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
AnnaLynn M. Williams, Jeanne Mandelblatt, Mingjuan Wang, Gregory T. Armstrong, Nickhill Bhakta, Tara M. Brinkman, Wassim Chemaitilly, Matthew J. Ehrhardt, Daniel A. Mulrooney, Brent J. Small, Zhaoming Wang, Deokumar Srivastava, Leslie L. Robison, Melissa M. Hudson, Kirsten K. Ness, Kevin R. Krull
Summary: This study aimed to compare the accumulation of deficits in survivors of pediatric cancer with community controls and examine associations with host and treatment factors, neurocognition, and mortality. The results showed that pediatric cancer survivors experience clinically significant premature aging, with a DAI score of 0.16 at age 30 corresponding to age 63 in controls (33 years premature aging). Higher DAI scores were associated with increased risk of neurocognitive impairment and death.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Kelly A. Hyland, Sarah L. Eisel, Aasha I. Hoogland, James C. Root, Kris Bowles, Brian James, Ashley M. Nelson, Margaret Booth-Jones, Paul B. Jacobsen, Tim A. Ahles, Heather S. L. Jim, Brian D. Gonzalez
Summary: This controlled comparison study evaluated the cognitive function and symptoms of patients with chronic myeloid leukemia receiving tyrosine kinase inhibitors. The study found that patients had worse overall neuropsychological performance and verbal memory compared to controls. Patients also reported greater fatigue, insomnia, and depressive symptoms, which were associated with worse subjective cognition.
LEUKEMIA & LYMPHOMA
(2023)
Article
Oncology
Sylvia L. Crowder, Taylor L. Welniak, Aasha I. Hoogland, Brent J. Small, Yvelise Rodriguez, Kristen M. Carpenter, Stacy M. Fischer, Daneng Li, Anita Y. Kinney, Daniel Rotroff, Arshiya Mariam, Naomi Brownstein, Richard R. Reich, Tim Hembree, Mary C. Playdon, Anna E. Arthur, Christian AMaino Vieytes, Zonggui Li, Martine Extermann, Richard Kim, Donna L. Berry, Heather S. L. Jim
Summary: This study aimed to evaluate the association between pre-treatment diet quality indices and changes in cognitive function. The study found that a higher ratio of monounsaturated to saturated fat intake was associated with less decline in cognitive function 5 days after infusion. This suggests that consuming more monounsaturated fat and less saturated fat may have a protective effect against cancer-related cognitive decline during chemotherapy.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Psychology, Multidisciplinary
Danielle B. Tometich, Catherine E. Mosher, Melissa Cyders, Brenna C. McDonald, Andrew J. Saykin, Brent J. Small, Zhai Wanting, Zhou Xingtao, Heather S. L. Jim, Paul Jacobsen, Tim A. Ahles, James C. Root, Deena Graham, Sunita K. Patel, Jeanne Mandelblatt
Summary: Physical activity may improve cognitive function for older cancer survivors, and cognitive function may also affect the ability to organize oneself to be physically active. However, the expected prospective relationships between cognition and physical activity were not found in this study. The findings indicate that there is cross-sectional association between cognition and physical activity in survivors, but long-term predictive relationships were not observed. The study suggests that future research should consider the impact of cognitive function when older cancer survivors are attempting to increase their physical activity.
ANNALS OF BEHAVIORAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Sylvia L. Crowder, Heather S. L. Jim, Stephanie Hogue, Tiffany L. Carson, Doratha A. Byrd
Summary: There is a critical opportunity to improve cancer treatment outcomes and enhance anti-cancer immunity through dietary interventions aimed at modifying the gut microbiome with fermented foods. This review summarizes the current literature on the gut microbiome and response to immunotherapy and other cancer treatments, discusses the potential clinical implications of utilizing a fermented foods dietary approach, and highlights existing gaps in the literature regarding fermented food interventions in cancer patients. The review provides a compelling rationale for future research on fermented food dietary interventions for modulating the gut microbiome to reduce cancer burden.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Oncology
Kelly E. Rentscher, Traci N. Bethea, Wanting Zhai, Brent J. Small, Xingtao Zhou, Tim A. Ahles, Jaeil Ahn, Elizabeth C. Breen, Harvey Jay Cohen, Martine Extermann, Deena M. A. Graham, Heather S. L. Jim, Brenna C. McDonald, Zev M. Nakamura, Sunita K. Patel, James C. Root, Andrew J. Saykin, Kathleen Van Dyk, Jeanne S. Mandelblatt, Judith E. Carroll
Summary: This study aimed to investigate if older breast cancer survivors had higher levels of epigenetic aging and if it was related to functional outcomes. The study found that breast cancer survivors had higher levels of epigenetic aging compared to non-cancer controls, especially those who had undergone chemotherapy. Additionally, epigenetic aging was associated with worse cognitive and physical function.
Article
Oncology
Jeanne S. Mandelblatt, Brent J. Small, Xingtao Zhou, Zev M. Nakamura, Harvey J. Cohen, Tim A. Ahles, Jaeil Ahn, Traci N. Bethea, Martine Extermann, Deena Graham, Claudine Isaacs, Paul B. Jacobsen, Heather S. L. Jim, Brenna C. McDonald, Sunita K. Patel, Kelly E. Rentscher, James C. Root, Andrew J. Saykin, Danielle B. Tometich, Kathleen Van Dyk, Wanting Zhai, Elizabeth C. Breen, Judith E. Carroll
Summary: Immune activation/inflammation markers were found to explain differences in neurocognition between breast cancer survivors and noncancer controls. Breast cancer survivors had significantly higher IL-6 levels before and after systemic therapy, and IL-6 partially explained the neurocognitive differences between survivors and controls.
Article
Oncology
Kelly Nudelman, Kwangsik Nho, Michael Zhang, Brenna C. McDonald, Wanting Zhai, Brent J. Small, Claire E. Wegel, Paul B. Jacobsen, Heather S. L. Jim, Sunita K. Patel, Deena M. A. Graham, Tim A. Ahles, James C. Root, Tatiana Foroud, Elizabeth C. Breen, Judith E. Carroll, Jeanne S. Mandelblatt, Andrew J. Saykin
Summary: This study found that genetics may play an important role in modifying risk for cognitive decline in older female breast cancer survivors. Several genetic variants and genes were identified to be associated with differences in patterns of cognitive decline in cancer patients compared to controls. Further research and validation of these findings in other cancer populations is necessary to inform therapeutic research and evaluations of risk for cognitive decline in older cancer survivors.
Review
Oncology
Rina S. S. Fox, Grace E. E. Armstrong, Julia S. S. Gaumond, Taylor F. D. Vigoureux, Corinne H. H. Miller, Stacy D. D. Sanford, John M. M. Salsman, Emmanuel Katsanis, Terry A. A. Badger, Damon R. R. Reed, Brian D. D. Gonzalez, Heather S. L. Jim, Echo L. L. Warner, David E. E. Victorson, Laura B. B. Oswald
Summary: This review evaluated the prevalence, correlates, and psychosocial implications of social isolation and connectedness among young adult cancer survivors aged 18-39 years. The results showed that social isolation was similarly prevalent among young adults, older cancer survivors, and noncancer populations. Social isolation was related to worse psychological well-being, whereas social connectedness was often, but not always, related to better psychological well-being.
Article
Oncology
Dana E. Rollison, Brian D. Gonzalez, Kea Turner, Heather S. L. Jim, Yayi Zhao, Rossybelle P. Amorrortu, Rachel Howard, Kavita M. Ghia, Bryan Ngo, Phillip Reisman, Colin Moore, Randa Perkins, Robert J. Keenan, David A. Sallman, Cristina M. Naso, Edmondo J. Robinson, Susan T. Vadaparampil, Vani N. Simmons, Matthew B. Schabath, Scott M. Gilbert
Summary: Patient-reported data can improve healthcare quality and patient outcomes. This study investigated the completion rates of an Electronic Patient Questionnaire (EPQ) used to collect demographics, sexual orientation, and gender identity data, and found associations with demographic and cancer characteristics. The findings are important for improving data acquisition methods and identifying potential disparities in data completeness that may impact clinical care quality and generalizability of self-reported data.
Article
Oncology
Aasha I. Hoogland, Brent J. Small, Laura B. Oswald, Crystal Bryant, Yvelise Rodriguez, Brian D. Gonzalez, Xiaoyin Li, Michelle C. Janelsins, Hailey W. Bulls, Brian W. James, Bianca Arboleda, Claudia Colon-Echevarria, Mary K. Townsend, Shelley S. Tworoger, Paulo C. Rodriguez, Julienne E. Bower, Sachin M. Apte, Robert M. Wenham, Heather S. L. Jim
Summary: Treatment-related symptoms such as fatigue, depression, and disruptions in sleep and physical activity are common in gynecologic cancer patients. Higher levels of inflammation, particularly C-reactive protein, are associated with worse symptomatology, specifically depression and disrupted physical activity. However, inflammation may not be significantly related to fatigue or sleep disturbance.
Meeting Abstract
Oncology
Traci N. Bethea, Wanting Zhai, Xingtao Zhou, Tim A. Ahles, Jaeil Ahn, Harvey J. Cohen, Asma A. Dilawari, Deena Graham, Heather Jim, Brenna C. McDonald, Zev M. Nakamura, Sunita K. Patel, Kelly E. Rentscher, James C. Root, Andrew J. Saykin, Brent J. Small, Kathleen Van Dyk, Jeanne S. Mandelblatt, Judith E. Carroll
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
