期刊
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
卷 286, 期 1909, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rspb.2019.1263
关键词
spermatozoa; embryogenesis; microvesicles; retrotransposons; transgenerational inheritance; Weismann barrier
The active uptake of exogenous nucleic acids by spermatozoa of virtually all animal species is a well-established phenomenon whose significance has long been underappreciated. A growing body of published data demon that extracellular vesicles released from mammalian somatic tissues pass an RNA-based flow of information to epididymal spermatozoa, thereby crossing the Weismann barrier. That information is delivered to oocytes at fertilization and affects the fate of the developing progeny. We propose that this essential process of epigenetic transmission depends upon the documented ability of epididymal spermatotoa to bind and internalite foreign nucleic acids in their nuclei. In other words, spermatotoa are not passive vectors of exogenous molecules but rather active participants in essential somatic communication across generations.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据