Mode-of-action profiling reveals glutamine synthetase as a collateral metabolic vulnerability of M. tuberculosis to bedaquiline
出版年份 2019 全文链接
标题
Mode-of-action profiling reveals glutamine synthetase as a collateral metabolic vulnerability of M. tuberculosis to bedaquiline
作者
关键词
-
出版物
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 116, Issue 39, Pages 19646-19651
出版商
Proceedings of the National Academy of Sciences
发表日期
2019-09-10
DOI
10.1073/pnas.1907946116
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- The NMR solution structure of Mycobacterium tuberculosis F-ATP synthase subunit ε provides new insight into energy coupling inside the rotary engine
- (2018) Shin Joon et al. FEBS Journal
- Ionophoric effects of the antitubercular drug bedaquiline
- (2018) Kiel Hards et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- High-throughput metabolomic analysis predicts mode of action of uncharacterized antimicrobial compounds
- (2018) Mattia Zampieri et al. Science Translational Medicine
- Cardiac safety of bedaquiline: a systematic and critical analysis of the evidence
- (2017) Emanuele Pontali et al. EUROPEAN RESPIRATORY JOURNAL
- Differential inhibition of adenylylated and deadenylylated forms of M. tuberculosis glutamine synthetase as a drug discovery platform
- (2017) A. Theron et al. PLoS One
- Nontargeted Metabolomics Reveals the Multilevel Response to Antibiotic Perturbations
- (2017) Mattia Zampieri et al. Cell Reports
- Turning the respiratory flexibility of Mycobacterium tuberculosis against itself
- (2016) Dirk A. Lamprecht et al. Nature Communications
- Network analysis identifies Rv0324 and Rv0880 as regulators of bedaquiline tolerance in Mycobacterium tuberculosis
- (2016) Eliza J. R. Peterson et al. Nature Microbiology
- Bactericidal mode of action of bedaquiline
- (2015) K. Hards et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Systematic discovery of drug interaction mechanisms
- (2015) G. Chevereau et al. Molecular Systems Biology
- Antibiotic efficacy is linked to bacterial cellular respiration
- (2015) Michael A. Lobritz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Bactericidal Antibiotics Induce Toxic Metabolic Perturbations that Lead to Cellular Damage
- (2015) Peter Belenky et al. Cell Reports
- Tuberculosis Drug Development: History and Evolution of the Mechanism-Based Paradigm : Figure 1.
- (2015) Sumit Chakraborty et al. Cold Spring Harbor Perspectives in Medicine
- Beta-Lactam Antibiotics Induce a Lethal Malfunctioning of the Bacterial Cell Wall Synthesis Machinery
- (2014) Hongbaek Cho et al. CELL
- Inhibition of Glutamine Synthetase: A Potential Drug Target in Mycobacterium tuberculosis
- (2014) Sherry Mowbray et al. MOLECULES
- Delayed bactericidal response of Mycobacterium tuberculosis to bedaquiline involves remodelling of bacterial metabolism
- (2014) Anil Koul et al. Nature Communications
- Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis
- (2014) Madhumitha Nandakumar et al. Nature Communications
- Advances in the development of new tuberculosis drugs and treatment regimens
- (2013) Alimuddin Zumla et al. NATURE REVIEWS DRUG DISCOVERY
- Approval of Novel TB Drug Celebrated--With Restraint
- (2013) J. Cohen SCIENCE
- In VitroCombination Studies of Benzothiazinone Lead Compound BTZ043 against Mycobacterium tuberculosis
- (2012) Benoit Lechartier et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors
- (2012) Johan Gising et al. JOURNAL OF MEDICINAL CHEMISTRY
- Para-Aminosalicylic Acid Acts as an Alternative Substrate of Folate Metabolism in Mycobacterium tuberculosis
- (2012) S. Chakraborty et al. SCIENCE
- The challenge of new drug discovery for tuberculosis
- (2011) Anil Koul et al. NATURE
- Nutrient-starved, non-replicating Mycobacterium tuberculosis requires respiration, ATP synthase and isocitrate lyase for maintenance of ATP homeostasis and viability
- (2009) M. Gengenbacher et al. MICROBIOLOGY-SGM
- Synergistic drug combinations tend to improve therapeutically relevant selectivity
- (2009) Joseph Lehár et al. NATURE BIOTECHNOLOGY
- The Diarylquinoline TMC207 for Multidrug-Resistant Tuberculosis
- (2009) Andreas H. Diacon et al. NEW ENGLAND JOURNAL OF MEDICINE
- Is resistance useless? Multidrug resistance and collateral sensitivity
- (2009) Matthew D. Hall et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Diarylquinolines Are Bactericidal for Dormant Mycobacteria as a Result of Disturbed ATP Homeostasis
- (2008) Anil Koul et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis
- (2008) S. P. S. Rao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Crystal Structures of Mammalian Glutamine Synthetases Illustrate Substrate-Induced Conformational Changes and Provide Opportunities for Drug and Herbicide Design
- (2007) Wojciech W. Krajewski et al. JOURNAL OF MOLECULAR BIOLOGY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started