Article
Immunology
Ting-Ting Wu, Ying Pan, Ying-Ying Zheng, Yi Yang, Xian-Geng Hou, Chang-Jiang Deng, Yi-Tong Ma, Xiang Xie
Summary: The ABIC score is a potential prognostic model for patients with CAD who have undergone PCI, as it predicts high long-term mortality and cardiac death risk.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Liwei Liu, Ming Ying, Shiqun Chen, Qiang Li, Guanzhong Chen, Huanqiang Li, Ziling Mai, Yibo He, Bo Wang, Danyuan Xu, Zhidong Huang, Xiaoming Yan, Ning Tan, Zhujun Chen, Jin Liu, Yong Liu
Summary: This study suggests that high levels of PT-INR are associated with an increased risk of long-term mortality in patients with coronary artery disease.
BMC CARDIOVASCULAR DISORDERS
(2022)
Article
Medicine, General & Internal
Muhammet Onur Hanedan, Semiha Alkan Kayhan, Ebru Dizdar, Askin Kilic, Ali Kemal Arslan, Mehmet Ali Yuruk, Ufuk Sayar
Summary: This study compared the effects of face-to-face and telephone applications on patients' international normalized ratio (INR). The results showed that there was no significant difference in INR levels between patients monitored through telephone application and those monitored through face-to-face. Therefore, telephone application can be used for warfarin therapy management.
Article
Public, Environmental & Occupational Health
Yiyang Tang, Jing Sun, Zaixin Yu, Benhui Liang, Baohua Peng, Jing Ma, Xiaofang Zeng, Yilu Feng, Qin Chen, Lihuang Zha
Summary: This study found a positive correlation between prothrombin time-international normalized ratio (INR) and the risk of all-cause mortality in post-cardiac arrest (CA) patients. The findings suggest that an INR level exceeding 1.2 increases the risk of death in CA patients. High levels of INR are also associated with 30-day, 90-day, 1-year, and in-hospital mortalities. These results were consistent and validated in subgroup analyses, propensity score matching, and inverse probability of treatment analyses.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Pharmacology & Pharmacy
Xi Zhang, Fengwei Jiao, Guangrun Li, Xiaojia Yu, Yuqing Pei, Ying Zhang, Zihui Wang, Pengfei Li
Summary: Azvudine, a potential treatment for COVID-19, has drug interactions with anticoagulants warfarin and rivaroxaban that can increase the international normalized ratio (INR). Close monitoring of INR is necessary when these drugs are used together in COVID-19 patients.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Clinical Neurology
Yingjie Xu, Zhixin Huang, Pan Zhang, Jinghui Zhong, Wanqiu Zhang, Miaomiao Hu, Xianjun Huang, Zongyi Wu, Guoqiang Xu, Min Zhang, Wen Sun
Summary: This study analyzed the impact of international normalized ratio (INR) indicators on outcomes in patients with acute vertebrobasilar artery occlusion (VBAO) treated with endovascular treatment (EVT). The results showed that elevated INR and INR variability were associated with poor functional outcomes in VBAO patients. Further research is needed to confirm the findings and understand the underlying mechanisms.
TRANSLATIONAL STROKE RESEARCH
(2023)
Review
Medicine, Research & Experimental
Angelo Zinellu, Panagiotis Paliogiannis, Ciriaco Carru, Arduino A. Mangoni
Summary: Prolonged INR values were significantly associated with COVID-19 severity and mortality, suggesting its potential utility as a diagnostic and prognostic marker for COVID-19-associated coagulopathy.
ADVANCES IN MEDICAL SCIENCES
(2021)
Article
Hematology
Carmen B. Smith, Erin K. Hennessey, Caroline D. Crossey, Andrew J. Crannage
Summary: Limited studies have assessed the efficacy of vitamin K administration in patients with chronic liver disease (CLD). However, the results of this retrospective, single-center cohort study suggest that the administration of vitamin K in hospitalized patients with CLD may not have the intended benefit of reducing bleeding risk, as the change in international normalized ratio (INR) following vitamin K administration was minimal.
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2023)
Review
Cardiac & Cardiovascular Systems
Khalefa Althiab, Manal Aljohani, Sultan Alraddadi, Mohammed Algarni
Summary: Capecitabine is widely used as an antineoplastic agent due to its conversion to 5-fluorouracil in the liver and tumor tissues. Despite in vitro assays not showing interactions with warfarin, clinical evidence has shown potential for elevated INR and bleeding. This study reports a case of concurrent administration of capecitabine and warfarin resulting in sub- or supra-therapeutic INR without any adverse events, along with a review of management options.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mahmoud Mohamed, Maria Bosserdt, Viktoria Wieske, Benjamin Dubourg, Hatem Alkadhi, Mario J. Garcia, Sebastian Leschka, Elke Zimmermann, Abbas A. Shabestari, Bjarne L. Norgaard, Matthijs F. L. Meijs, Kristian A. Ovrehus, Axel C. P. Diederichsen, Juhani Knuuti, Bjrn A. Halvorsen, Vladymir Mendoza-Rodriguez, Yung-Liang Wan, Nuno Bettencourt, Eugenio Martuscelli, Ronny R. Buechel, Hans Mickley, Kai Sun, Simone Muraglia, Philipp A. Kaufmann, Bernhard A. Herzog, Jean-Claude Tardif, Georg M. Schuetz, Michael Laule, David E. Newby, Stephan Achenbach, Matthew Budoff, Robert Haase, Federico Biavati, Aldo Vasquez Mezquita, Peter Schlattmann, Marc Dewey
Summary: Combining coronary computed tomography angiography (CCTA) with coronary artery calcium (CAC) score can significantly improve the diagnosis of coronary artery disease (CAD). The addition of CAC score is particularly beneficial when CCTA alone is inconclusive.
EUROPEAN RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Sumaya Al Helali, Muhammad Abid Hanif, Ahmad Al Majed, Nura Alshugair, Abdullah Belfageih, Hamad Al Qahtani, Sameer Al Dulikan
Summary: The burden of plaques, especially calcified ones, is high in middle-aged Saudi patients without clinical CAD, with a higher prevalence in males. Abnormal blood lipids play an important role in plaque formation, highlighting the importance of assessing the risk of CAD in patients without clinical CAD.
BMC CARDIOVASCULAR DISORDERS
(2022)
Article
Medicine, General & Internal
Harry Gelissen, Harm-Jan de Grooth, Yvo Smulders, Evert-Jan Wils, Wouter de Ruijter, Roel Vink, Bob Smit, Jantine Rottgering, Leila Atmowihardjo, Armand Girbes, Paul Elbers, Pieter-Roel Tuinman, Heleen Oudemans-van Straaten, Angelique de Man
Summary: A multicenter randomized clinical trial in the Netherlands found that targeting a low-normal Pao(2) compared with a high-normal Pao(2) did not lead to a significant reduction in organ dysfunction among critically ill patients with systemic inflammatory response syndrome (SIRS). The study may have had limited power to detect a smaller treatment effect than was hypothesized.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Medicine, General & Internal
Rongrong Ding, Jianming Zheng, Dan Huang, Yanbing Wang, Xiufen Li, Xinlan Zhou, Li Yan, Wei Lu, Zongguo Yang, Zhanqing Zhang
Summary: The study aimed to investigate the impact of a new index, INPR, on determining liver fibrosis stage in patients with CHB. INPR was found to have good predictive efficacy and can be used as an accurate, inexpensive indicator for evaluating liver fibrosis.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Sebastian Heyne, Sascha Macherey, Max M. Meertens, Simon Braumann, Franz S. Niessen, Tobias Tichelbaecker, Stephan Baldus, Christoph Adler, Samuel Lee
Summary: This network meta-analysis aimed to evaluate the effect of early coronary angiography (CAG) compared with selective CAG (late and no CAG) for patients after out-of-hospital cardiac arrest without ST-elevation myocardial infarction (NSTE-OHCA). The meta-analyses showed that early CAG was associated with a statistically significant increase in overall survival compared to selective CAG. However, this effect was not observed in the subgroup analysis of randomized controlled trials (RCTs). The network meta-analysis based on non-randomized studies (NRS) indicated a significant increase in survival with late CAG compared to early CAG.
EUROPEAN HEART JOURNAL
(2023)
Article
Environmental Sciences
Manqing Luo, Xiaowei Xie, Jieyu Wu, Liwei Zhang, Xi Zheng, Mengying Xie, Na Lin, Huazhen Xiao, Jilang Zeng, Guohui Lan, Xiaoli Lu, Xiaoying Ye, Zelin Huang, Tingting Xu, Tinggui Wang, Kaiyang Lin, Yansong Guo, Xiaoxu Xie
Summary: This study investigated the association between long-term exposure to ambient particulate matter (PM10 and PM2.5) and coronary stenosis. The study found a significant correlation between chronic exposure to PM10 and PM2.5 and coronary stenosis. Each 10 μg/m3 increase in PM10 exposure was associated with a 33% increased risk of coronary stenosis, while each 10 μg/m3 increase in PM2.5 exposure was associated with an 87% increased risk. The study also identified potential mediators.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Cardiac & Cardiovascular Systems
Lingyao Zeng, Sylvain Moser, Nazanin Mirza-Schreiber, Claudia Lamina, Stefan Coassin, Christopher P. Nelson, Tarmo Annilo, Oscar Franzen, Marcus E. Kleber, Salome Mack, Till F. M. Andlauer, Beibei Jiang, Barbara Stiller, Ling Li, Christina Willenborg, Matthias Munz, Thorsten Kessler, Adnan Kastrati, Karl-Ludwig Laugwitz, Jeanette Erdmann, Susanne Moebus, Markus M. Noethen, Annette Peters, Konstantin Strauch, Martina Mueller-Nurasyid, Christian Gieger, Thomas Meitinger, Elisabeth Steinhagen-Thiessen, Winfried Maerz, Andres Metspalu, Johan L. M. Bjoerkegren, Nilesh J. Samani, Florian Kronenberg, Bertram Mueller-Myhsok, Heribert Schunkert
Summary: This study attempts to identify non-additive genetic effects associated with CAD, specifically epistatic interactions. A SNP pair located in cis at the LPA locus was found to be jointly associated with risk for CAD, peripheral arterial disease, aortic stenosis, hepatic lipoprotein(a) levels, and Lp(a) serum levels, while individual SNPs displayed no association. Further exploration revealed a strong dependency on a rare variant influencing risk through additive genetic as well as epistatic effects.
CARDIOVASCULAR RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Peter Stachon, Klaus Kaier, Philip Hehn, Alexander Peikert, Dennis Wolf, Vera Oettinger, Dawid Staudacher, Daniel Duerschmied, Andreas Zirlik, Manfred Zehender, Christoph Bode, Constantin von zur Muehlen
Summary: In a nationwide registry study in Germany, left main stenting was found to be a safe and effective treatment option for chronic coronary syndrome patients with left main coronary artery disease, showing reduced risks of bleeding, prolonged ventilation time, and postoperative delirium after risk adjustment, along with shorter hospital stay and lower costs.
CLINICAL RESEARCH IN CARDIOLOGY
(2022)
Letter
Cardiac & Cardiovascular Systems
Mika Hilvo, Mitja Laaperi, Antti Jylhae, Marcus E. Kleber, Reini Hurme, Hubert Scharnagl, Winfried Maerz, Juha Sinisalo, Reijo Laaksonen
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Sanjiv J. Shah, Barry A. Borlaug, Eugene S. Chung, Donald E. Cutlip, Philippe Debonnaire, Peter S. Fail, Qi Gao, Gerd Hasenfuss, Rami Kahwash, David M. Kaye, Sheldon E. Litwin, Philipp Lurz, Joseph M. Massaro, Rajeev C. Mohan, Mark J. Ricciardi, Scott D. Solomon, Aaron L. Sverdlov, Vijendra Swarup, Dirk J. van Veldhuisen, Sebastian Winkler, Martin B. Leon
Summary: This study suggests that placement of an interatrial shunt device does not reduce heart failure events or improve health status in patients with heart failure and preserved or mildly reduced ejection fraction.
Review
Chemistry, Analytical
Ursula Rohrer, Martin Manninger, Andreas Zirlik, Daniel Scherr
Summary: A wearable cardioverter-defibrillator (WCD) is a temporary treatment option for high-risk patients and those who are not suitable for an implantable cardioverter defibrillator (ICD). It is also increasingly important for the detection and treatment of heart failure (HF) and its arrhythmias. The WCD has evolved from a shock device to a monitoring device that captures physical activity and biomarkers for HF. In addition to preventing sudden cardiac death, the WCD could become an important tool in managing heart failure through remote monitoring and tracking therapy success.
Article
Hematology
Olivier Sanchez, Anais Charles-Nelson, Walter Ageno, Stefano Barco, Harald Binder, Gilles Chatellier, Daniel Duerschmied, Klaus Empen, Melanie Ferreira, Philippe Girard, Menno Huisman, David Jimenez, Sandrine Katsahian, Matija Kozak, Mareike Lankeit, Nicolas Meneveau, Piotr Pruszczyk, Antoniu Petris, Marc Righini, Stephan Rosenkranz, Sebastian Schellong, Branislav Stefanovic, Peter Verhamme, Kerstin de Wit, Eric Vicaut, Andreas Zirlik, Stavros Konstantinides, Guy Meyer
Summary: The PEITHO-3 study aims to compare the efficacy and safety of reduced-dose thrombolysis with standard anticoagulation in patients with intermediate-high-risk PE. The primary outcome is a composite of all-cause death, hemodynamic decompensation, or PE recurrence within 30 days, with key secondary outcomes including bleeding events. The study plans to enroll 650 patients and may impact future guideline recommendations for acute PE treatment.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Nutrition & Dietetics
Natascha Schweighofer, Caterina Colantonio, Christoph W. Haudum, Barbara Hutz, Ewald Kolesnik, Ines Mursic, Stefan Pilz, Albrecht Schmidt, Vanessa Stadlbauer, Andreas Zirlik, Thomas R. Pieber, Nicolas Verheyen, Barbara Obermayer-Pietsch
Summary: Sarcopenia is associated with increased risks of falls, osteoporosis, and mortality. However, there is no consensus on the gold standard DXA index for determining muscle mass in the diagnosis of sarcopenia. This study aimed to evaluate the prevalence, agreement, and reliability of sarcopenia diagnosis using various DXA-derived muscle mass indices, and examine the effects of different parameters, adjustments, and cut-off values on these outcomes. The results showed significant variation in sarcopenia prevalence depending on the index and cut-off values used. Height-adjusted parameters exhibited higher agreement in diagnosis, while unadjusted and adjusted indices showed lower agreement. The investigated indices demonstrated comparable reliability in follow-up examinations.
Article
Medicine, General & Internal
David Zweiker, Lukas Fiedler, Gabor G. Toth, Andreas Strouhal, Georg Delle-Karth, Guenter Stix, Harald Gabriel, Ronald K. Binder, Martin Rammer, Michael Pfeffer, Paul Vock, Brigitte Lileg, Clemens Steinwender, Kurt Sihorsch, Florian Hintringer, Silvana Mueller, Fabian Barbieri, Martin Martinek, Wolfgang Tkalec, Nicolas Verheyen, Klemens Ablasser, Andreas Zirlik, Daniel Scherr
Summary: This study aimed to evaluate the relationship between baseline characteristics and acute procedural outcomes during left atrial appendage closure (LAAC). The results showed that the major complication rate was low in this high-risk patient population, but end-stage kidney disease and low baseline haemoglobin were independently associated with a higher major complication rate.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Guenther Silbernagel, Yan Q. Chen, Martin Rief, Marcus E. Kleber, Michael M. Hoffmann, Tatjana Stojakovic, Andreas Stang, Mark A. Sarzynski, Claude Bouchard, Winfried Maerz, Yue-Wei Qian, Hubert Scharnagl, Robert J. Konrad
Summary: Apolipoprotein C-II (ApoC-II) has an inverse J-shaped relationship with cardiovascular mortality, with the lowest risk observed in the middle quintile. Increasing low circulating ApoC-II levels may reduce cardiovascular risk.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Nicolas Verheyen, Angelika Batzner, David Zach, Andreas Zirlik, Brenda Gerull, Stefan Frantz, Christoph Maack, Stefan Stoerk, Hubert Seggewiss, Caroline Morbach
Summary: This study aimed to investigate whether echocardiography-derived parameters obtained at rest can aid in determining the presence of left ventricular outflow tract obstruction (LVOTO) in hypertrophic cardiomyopathy (HCM) patients. Among 142 HCM patients, the distance between the mitral leaflet tip and ventricular septum (TIS) in the apical three-chamber view was found to be independently associated with LVOTO. A TIS value of <= 14 mm had a sensitivity of 97% and specificity of 57% in identifying LVOTO.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Meeting Abstract
Medicine, General & Internal
A. Eberl, M. Manninger, U. Rohrer, M. Benedikt, S. Kurath-Koller, B. Pratl, S. Loibnegger, L. Andrecs, A. Zirlik, D. Scherr
WIENER KLINISCHE WOCHENSCHRIFT
(2022)
Meeting Abstract
Medicine, General & Internal
J. Gollmer, L. Potter, I Vosko, T. Tomin, R. Birner-Gruneberger, D. von Lewinski, S. Sedej, D. Scherr, A. R. Wende, P. Rainer, A. Zirlik, H. Bugger
WIENER KLINISCHE WOCHENSCHRIFT
(2022)
Meeting Abstract
Medicine, General & Internal
L. Herold, G. Toth-Gayor, F. Fruhwald, S. Paetzold, S. Altmanninger-Sock, S. Harb, A. Schmidt, E. Buschmann, H. Bugger, K. Ablasser, T. Glantschnig, E. Bisping, C. Stoffel, S. Knopper, R. Weixler, W. Muckenauer, R. Zweiker, R. Gasser, A. Zirlik, D. von Lewinski
WIENER KLINISCHE WOCHENSCHRIFT
(2022)
Meeting Abstract
Medicine, General & Internal
P. Hochegger, L. Moser, Kanoun S. S. Schnur, R. Pranevicius, A. Schmidt, K. Ablasser, N. Verheyen, R. Maier, O. Luha, A. Zirlik, G. Toth-Gayor
WIENER KLINISCHE WOCHENSCHRIFT
(2022)
Meeting Abstract
Medicine, General & Internal
M. Manninger, U. Rohrer, A. Eberl, B. Pratl, S. Loibnegger, L. Andrecs, A. Zirlik, D. Scherr
WIENER KLINISCHE WOCHENSCHRIFT
(2022)