Article
Pharmacology & Pharmacy
Hongyan Ma, Baoyi Yang, Lu Yu, Yang Gao, Xiangmei Ye, Ying Liu, Zhengtian Li, Hulun Li, Enyou Li
Summary: Sevoflurane protects the liver from ischemia-reperfusion injury by regulating the Nrf2/HO-1 pathway, reducing tissue damage and cell apoptosis, and promoting Nrf2 nucleation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biology
Vennila Ponnusamy, Richard T. H. Ip, Moumin A. E. K. Mohamed, Paul Clarke, Eva Wozniak, Charles Mein, Leslie Schwendimann, Akif Barlas, Philippa Chisholm, Ela Chakkarapani, Adina T. Michael-Titus, Pierre Gressens, Ping K. Yip, Divyen K. Shah
Summary: Ponnusamy et al identified let-7b-5p as an elevated microRNA in neonates with moderate to severe encephalopathy using next generation sequencing of dried blood spots. They demonstrated that let-7b-5p exerts its effects through the Hippo-YAP pathway in cell culture and murine models of perinatal brain injury, indicating the need for validation in larger neonate cohorts to confirm its role as a biomarker for neonatal encephalopathy.
COMMUNICATIONS BIOLOGY
(2021)
Article
Environmental Sciences
Sujuan Zhao, Jiayi Xu, Weiyun Zhang, Wei Yan, Guangyu Li
Summary: Microcystin-LR (MCLR) exposure induced impairment to the male reproductive system in zebrafish and potentially affected offspring through transgenerational toxicity. Paternal MCLR exposure may significantly impact gene-specific DNA methylation patterns in the testis, leading to developmental neurotoxicity in the offspring.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Immunology
Liang Wen, Qing-Hui Yang, Xiao-Lei Ma, Ting Li, Sa Xiao, Chao-Feng Sun
Summary: The study demonstrates that inhibition of TNFAIP1 plays a crucial role in ameliorating myocardial I/R injury by reducing cardiomyocyte apoptosis, oxidative stress, and inflammatory response via activation of the Nrf2 signaling pathway. knockdown of TNFAIP1 potentiates Nrf2 signaling through the modulation of the Akt/GSK-3 beta pathway, highlighting TNFAIP1 as a potential therapeutic target for myocardial I/R injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Seyong Chung, Si Yeong Kim, Kyubae Lee, Sewoom Baek, Hyun-Su Ha, Dae-Hyun Kim, Suji Park, Chan Hee Lee, Hye-Seon Kim, Young Min Shin, Seung Eun Yu, Hak-Joon Sung
Summary: This study explores the liposomal targeting of splenic CD11b(+) cells and the induction of in situ reprogramming through the use of hypoxic-mimetic agent-loaded liposomes. The reprogrammed cells show enhanced vasculogenic potential, leading to accelerated regeneration in inflamed tissues. Advanced tools such as intravital multiphoton microscopy, F-19 2D/3D MRI, and microchannel hydrogel chips are used to validate the strategy.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Environmental Sciences
Jesus Ibarluzea, Mikel Subiza-Perez, Ane Arregi, Amaia Molinuevo, Enrique Arranz-Freijo, Manuel Sanchez-de Miguel, Ana Jimenez, Ainara Andiarena, Loreto Santa-Marina, Aitana Lertxundi
Summary: This study investigated the association between prenatal maternal urinary fluoride levels and symptoms of attention-deficit/hyperactivity disorder (ADHD) in children aged 8 and 11 years. The results showed no association between maternal urinary fluoride levels during pregnancy and cognitive problems-inattention symptoms at 8 or 11 years old. However, at age 11, there was a significant inverse association between maternal urinary fluoride levels and being categorized as a cognitive problems-inattention case. These findings contradict previous studies and highlight the need for further population-based research to confirm or challenge these results.
ENVIRONMENTAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Michelle Z. L. Kee, Ai Ling Teh, Andrew Clappison, Irina Pokhvisneva, Julie L. MacIssac, David T. S. Lin, Katia E. Ramadori, Birit F. P. Broekman, Helen Chen, Mary Lourdes Daniel, Neerja Karnani, Michael S. Kobor, Peter D. Gluckman, Yap Seng Chong, Jonathan Y. Huang, Michael J. Meaney
Summary: This study found an association between prenatal maternal depressive symptoms and inter-individual genome-wide DNA methylation, specifically in mothers carrying female fetuses. It also revealed sex-dependent associations with depression-related genes and signaling pathways, suggesting the potential role of maternal-fetal interactions in intergenerational transmission.
Article
Environmental Sciences
Dennis Khodasevich, Nina Holland, Alan Hubbard, Kim Harley, Julianna Deardorff, Brenda Eskenazi, Andres Cardenas
Summary: This study investigated the impact of prenatal exposure to 11 phthalate metabolites on epigenetic aging in children. The results suggest that certain phthalates are associated with epigenetic aging in children, and the effect may vary depending on sex and timing of measurement.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Lina Bai, Junhua Yang, Hong Zhang, Wei Liao, Yunguang Cen
Summary: The study found that the knockdown of APPL1 in myocardial ischemia leads to increased apoptosis and inflammation, while overexpression of APPL1 can inhibit myocardial ischemia/hypoxia-reperfusion injury by inactivating the APAF-1/Caspase9 signaling pathway. The findings suggest that APPL1 may be a promising target for the treatment of myocardial ischemia.
Article
Immunology
Kerstin Muelling, Alexa Josephine Fischer, Elena Siakaeva, Mathis Richter, Sharareh Bordbari, Ilona Spyra, Christian Koester, Dirk M. Hermann, Matthias Gunzer, Ursula Felderhoff-Mueser, Ivo Bendix, Jadwiga Jablonska, Josephine Herz
Summary: This study found that neutrophils in the neonatal brain are rapidly activated after experimental hypoxia-ischemia, producing reactive oxygen species and showing an increased proportion of hyperactivated/aged cells compared to peripheral neutrophils. Delayed neutrophil depletion led to reduced cellular neurodegeneration and decreased microglial and astroglial activation, offering new possibilities for therapeutic approaches in post-hypoxic brain injury.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Cardiac & Cardiovascular Systems
Dino A. Giussani
Summary: The article explores the impact of chronic fetal hypoxia during pregnancy on the development of cardiovascular disease in offspring and potential therapeutic approaches, with a focus on molecular-level research and potential targets for clinical intervention.
Article
Endocrinology & Metabolism
Prabhas Chaudhari, Ankush Madaan, Jose Carlos Rivera, Iness Charfi, Tiffany Habelrih, Xin Hou, Mohammad Nezhady, Gregory Lodygensky, Graciela Pineyro, Thierry Muanza, Sylvain Chemtob
Summary: Lactate acts through GPR81 to participate in brain angiogenesis and attenuate hypoxic/ischemic injury.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Review
Cell Biology
Nariaki Nakamura, Xiaobing Shi, Radbod Darabi, Yong Li
Summary: Cellular reprogramming is a crucial topic in stem cell and molecular biology research, involving aspects such as cell proliferation, determination of cell fate, and stem cell renewal. Factors like hypoxia and epigenetics play significant roles in tissue and organ development during this process.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Camilo Lopez-Aguirre, Suzanne J. Hand, Daisuke Koyabu, Vuong Tan Tu, Laura A. B. Wilson
Summary: Fluctuating asymmetry, as an index of both developmental instabilities and homeostatic capabilities of organisms, was studied in prenatal development of bats focusing on the humerus bone. Results showed relatively stable magnitudes of fluctuating asymmetry throughout ontogeny, with significant differences in cross-sectional asymmetry across developmental stages. Developmental patterns of longitudinal and cross-sectional asymmetry did not correspond, indicating independent processes controlling symmetric bone elongation and thickening.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, General & Internal
Zhenxian Jia, Hongling Zhang, Ling Yu, Feng Qiu, Yiqing Lv, Jing Guan, Huiqing Gang, Jingwen Zuo, Tongzhang Zheng, Hongxiu Liu, Wei Xia, Shunqing Xu, Yuanyuan Li
Summary: This prospective cohort study found an association between prenatal lead exposure and increased risk of cognitive developmental delay (CDD) in children with high genetic risk. These findings suggest that prenatal lead exposure and genetic background may jointly contribute to an increased risk of CDD in children, indicating the possibility for an integrated strategy to assess CDD risk and improve children's cognitive ability.
Article
Behavioral Sciences
Valerie S. Knopik, Kristine Marceau, Rohan H. C. Palmer, Taylor F. Smith, Andrew C. Heath
Article
Substance Abuse
William V. Lechner, Valerie S. Knopik, John E. McGeary, Nichea S. Spillane, Jennifer W. Tidey, Sherry A. McKee, Jane Metrik, Adam M. Leventhal, Damaris J. Rohsenow, Christopher W. Kahler
NICOTINE & TOBACCO RESEARCH
(2016)
Article
Genetics & Heredity
Valerie S. Knopik, Kristine Marceau, L. Cinnamon Bidwell, Rohan H. C. Palmer, Taylor F. Smith, Alexandre Todorov, Allison Schettini Evans, Andrew C. Heath
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
(2016)
Article
Behavioral Sciences
Kristine Marceau, Rohan H. C. Palmer, Jenae M. Neiderhiser, Taylor F. Smith, John E. McGeary, Valerie S. Knopik
Article
Behavioral Sciences
Ziada Ayorech, Saskia Selzam, Emily Smith-Woolley, Valerie S. Knopik, Jenae M. Neiderhiser, John C. DeFries, Robert Plomin
Review
Neurosciences
Valerie S. Knopik, Kristine Marceau, L. Cinnamon Bidwell, Emily Bolan
NEUROTOXICOLOGY AND TERATOLOGY
(2019)
Article
Clinical Neurology
Leslie A. Brick, Marisa E. Marraccini, Lauren Micalizzi, Chelsie E. Benca-Bachman, Valerie S. Knopik, Rohan H. C. Palmer
JOURNAL OF AFFECTIVE DISORDERS
(2019)
Article
Psychology, Developmental
Valerie S. Knopik, Lauren Micalizzi, Kristine Marceau, Amy M. Loviska, Li Yu, Alexandra Bien, Emily Rolan, Allison S. Evans, Rohan H. C. Palmer, Andrew C. Heath
Summary: This research suggests that maternal smoking during pregnancy may be associated with poorer performance in some aspects of executive function, particularly in working memory and inhibition tasks. However, familial transmission of risk for low executive function appears to be more important.
DEVELOPMENT AND PSYCHOPATHOLOGY
(2022)
Article
Psychology, Developmental
Kristine Marceau, Li Yu, Valerie S. Knopik, Jody M. Ganiban, Jenae M. Neiderhiser
Summary: This study examines the intergenerational transmission of internalizing and externalizing symptom severity in twin families, finding that genetic and environmental influences play a role and there is modest correlation between symptom severity in parents and children.
DEVELOPMENT AND PSYCHOPATHOLOGY
(2022)
Article
Psychology, Developmental
Max Owens, Ashley J. Harrison, Katie L. Burkhouse, John E. McGeary, Valerie S. Knopik, Rohan H. C. Palmer, Brandon E. Gibb
DEVELOPMENT AND PSYCHOPATHOLOGY
(2016)
Article
Psychology, Developmental
Kristine Marceau, Valerie S. Knopik, Jenae M. Neiderhiser, Paul Lichtenstein, Erica L. Spotts, Jody M. Ganiban, David Reiss
DEVELOPMENT AND PSYCHOPATHOLOGY
(2016)
Article
Psychology, Experimental
Katie L. Burkhouse, Mary L. Woody, Max Owens, John E. McGeary, Valerie S. Knopik, Brandon E. Gibb
COGNITION & EMOTION
(2016)
Article
Psychology, Experimental
Mary L. Woody, Anastacia Y. Kudinova, John E. McGeary, Valerie S. Knopik, Rohan H. C. Palmer, Brandon E. Gibb
COGNITION & EMOTION
(2016)
Article
Psychology, Multidisciplinary
Robert Plomin, John C. DeFries, Valerie S. Knopik, Jenae M. Neiderhiser
PERSPECTIVES ON PSYCHOLOGICAL SCIENCE
(2016)
