Article
Pharmacology & Pharmacy
Yaqian Li, Wenpeng Lu, Xuecheng Zheng, Linhui Zhang, Weichong Dong, Xiaoxiao Zhao, Zongmao Zhao, Zhiqing Zhang
Summary: This study demonstrates that combined intravenous and intrathecal administration can significantly shorten the treatment time of MRSA ventriculitis and increase the exposure of the drug in cerebrospinal fluid without an increased risk of adverse reactions.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Review
Clinical Neurology
Roland Nau, Fritz Sorgel, Helmut Eiffert
Summary: Antimicrobial resistance poses a growing threat to patients, including those with nosocomial central nervous system infections. Optimizing intravenous treatment to achieve sufficient concentrations of antibiotics in different CNS compartments is crucial when causative pathogens have reduced sensitivity to antibiotics or the blood-brain barrier is mildly impaired. Adjusting antibiotic doses and exploring new combinations have shown promise in addressing antimicrobial resistance in CNS infections.
CURRENT OPINION IN NEUROLOGY
(2021)
Article
Clinical Neurology
Finja Schweitzer, Yasemin Goereci, Christiana Franke, Steffi Silling, Fabian Bosl, Franziska Maier, Eva Heger, Birgit Deiman, Harald Pruss, Oezguer A. Onur, Florian Klein, Gereon R. Fink, Veronica Di Cristanziano, Clemens Warnke
Summary: The study found no evidence of SARS-CoV-2 in cerebrospinal fluid, and intrathecally produced anti-SARS-CoV-2 antibodies were not detected in post-COVID-19 syndrome patients. This suggests that a persistent central nervous system infection is unlikely to be the cause of neurological or neuropsychiatric post-COVID-19 syndrome.
ANNALS OF NEUROLOGY
(2022)
Article
Infectious Diseases
Guirong Wang, Ruixia Liang, Qing Sun, Xinlei Liao, Chenqian Wang, Hairong Huang
Summary: This study evaluated different methods for diagnosing central nervous system (CNS) involvement in patients with military tuberculosis (TB). The results showed that MRI had superior sensitivity and could be used as an initial diagnostic approach.
BMC INFECTIOUS DISEASES
(2022)
Article
Emergency Medicine
Ping Wang, Li-Ying Lin, Yuan-Qiang Lu
Summary: This article reports a case of diquat poisoning and highlights the importance of being aware of the development of pulmonary symptoms and neurological complications in patients. Interestingly, the study also found a correlation between the concentration of diquat in the cerebrospinal fluid and both the intracranial pressure and the severity of cerebral edema.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Biotechnology & Applied Microbiology
Ying Liu, Weiwei Zhu, Mengfan Jiao, Wenhu Guo, Yonggang Luo
Summary: The clinical value of metagenomic next-generation sequencing (mNGS) in central nervous system (CNS) infections was evaluated in this study. mNGS and routine examination of cerebrospinal fluid (CSF) samples were retrospectively analyzed and compared with clinical diagnosis. The results showed that mNGS had a higher detection rate and identified additional pathogens compared to conventional methods. The sensitivity and specificity of mNGS in the diagnosis of CNS infections were 89.5% and 44%, respectively.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Clinical Neurology
Fereshte Sheybani, Diederik van de Beek, Matthijs C. Brouwer
Summary: Half of the patients with suspected CNS infections are diagnosed with a CNS infection, and this was not related to CD4 counts. The best predictor for CNS infections was the CSF leukocyte count.
FRONTIERS IN NEUROLOGY
(2021)
Review
Medicine, General & Internal
Xue Chen, Min Huang, Zhenyuan Zhang, Huilan Jing, Yueli Zou, Hui Bu
Summary: This article reports a rare case of primary meningeal central nervous system lymphoma. The patient presented with progressive lower extremity motor dysfunction and blurred vision. Diagnosis was confirmed through cytology, immunohistochemistry, and flow cytometry of the cerebrospinal fluid. After treatment, the patient showed significant improvement and could walk and take care of herself after a 2-year follow-up.
Article
Microbiology
Yunqi Zhu, Wenxuan Zhao, Xihong Yang, Yuanyuan Zhang, Xiaoling Lin, Xing Weng, Yali Wang, Cong Cheng, Yun Chi, Hongxia Wei, Zhihang Peng, Zhiliang Hu
Summary: This study found that mNGS has a high sensitivity for detecting common opportunistic CNS pathogens in HIV-infected patients, although its performance in CNS tuberculosis is unsatisfactory. EBV and CMV are commonly detected by CSF mNGS, but the threshold for clinically significant detection still needs to be defined.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Maria Thastrup, Hanne Vibeke Marquart, Kjeld Schmiegelow
Summary: Despite the good prognosis of acute lymphoblastic lymphoma in children and adolescents, involvement of the central nervous system (CNS) remains a therapeutic challenge. The current method for detecting CNS involvement has low sensitivity, while flow cytometric analysis of cerebrospinal fluid (CSF) offers a novel and sensitive approach. Prospective studies have shown that flow cytometry detects CNS involvement at a higher rate than conventional methods and is particularly sensitive in detecting low-level CNS disease. Flow cytometry-detected CNS involvement is linked to a higher risk of relapse and poor outcomes in childhood ALL.
Article
Oncology
Jiayan Gu, Xin Huang, Yi Zhang, Chenhui Bao, Ziyang Zhou, Hongyan Tong, Jie Jin
Summary: This study evaluated the correlation between cerebrospinal fluid (CSF) cytokine levels and central nervous system (CNS) involvement in adult acute myeloid leukemia (AML). The results showed that CSF IL-6 is a promising marker for the diagnosis of adult AML with CNS involvement and is also associated with therapeutic response.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Shanshan Zhang, Gang Wu, Yuru Shi, Ting Liu, Liangfei Xu, Yuanyuan Dai, Wenjiao Chang, Xiaoling Ma
Summary: In this study, metagenomic next-generation sequencing (mNGS) identified a wide variety of pathogens in CA-CNS infections, many of which were undetectable by conventional methods.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Clinical Neurology
Lara M. Fahmy, Yongsheng Chen, Stephanie Xuan, E. Mark Haacke, Jiani Hu, Quan Jiang
Summary: This study utilized MRI to map the distribution of cerebrospinal fluid (CSF) within all peri-neural and peri-vascular spaces in humans. The findings indicated that all neural and vascular communication channels within the central nervous system are surrounded by CSF, suggesting implications for cerebral waste clearance and immunity that require further investigation.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medical Laboratory Technology
Yao Hu, Jin Xiang, Xiao Luo, Meijuan Lu, Dongwen Xu, Bobin Chen, Ming Guan
Summary: This study assessed the potential application of CSF FLC ratios in diagnosing PCNSL and monitoring treatment efficacy, and found that CSF FLC is a novel biomarker for diagnosis and chemotherapy efficacy monitoring in PCNSL.
CLINICA CHIMICA ACTA
(2022)
Article
Oncology
Soeren Buesker, Walter Jaeger, Stefan Poschner, Lisa Mayr, Valentin Al Jalali, Johannes Gojo, Amedeo A. Azizi, Sami Ullah, Muhammad Bilal, Lobna El Tabei, Uwe Fuhr, Andreas Peyrl
Summary: This study aimed to investigate the penetration of temozolomide into cerebrospinal fluid (CSF) in pediatric patients. The results showed that metronomic oral temozolomide could penetrate into CSF in pediatric patients, with even higher concentration levels compared to adults.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2022)
Article
Neurosciences
Adi Cymerblit-Sabba, Adam S. Smith, Sarah K. Williams Avram, Michelle Stackmann, Austin C. Korgan, Maria C. Tickerhoof, W. Scott Young
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2020)
Article
Neurosciences
W. Scott Young, June Song
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2020)
Letter
Endocrinology & Metabolism
Balazs Mayer, Krisztian Nemeth, Miklos Krepuska, Vamsee D. Myneni, Dragan Maric, John F. Tisdale, Matthew M. Hsieh, Naoya Uchida, Heon-Jin Lee, Michael J. Nemeth, Kenn Holmbeck, Constance Tom Noguchi, Heather Rogers, Soumyadeep Dey, Arne Hansen, Jeffrey Hong, Ian Chow, Sharon Key, Ildiko Szalayova, Jerome Pagani, Karoly Marko, Ian MacClain-Caldwell, Lynn Vitale-Cross, W. Scott Young, Michael J. Brownstein, Eva Mezey
CLINICAL ENDOCRINOLOGY
(2021)
Article
Neurosciences
Jerome Wahis, Angel Baudon, Ferdinand Althammer, Damien Kerspern, Stephanie Goyon, Daisuke Hagiwara, Arthur Lefevre, Lara Barteczko, Benjamin Boury-Jamot, Benjamin Bellanger, Marios Abatis, Miriam Da Silva Gouveia, Diego Benusiglio, Marina Eliava, Andrei Rozov, Ivan Weinsanto, Hanna Sophie Knobloch-Bollmann, Matthew K. Kirchner, Ranjan K. Roy, Hong Wang, Marie Pertin, Perrine Inquimbert, Claudia Pitzer, Jan Siemens, Yannick Goumon, Benjamin Boutrel, Christophe Maurice Lamy, Isabelle Decosterd, Jean-Yves Chatton, Nathalie Rouach, W. Scott Young, Javier E. Stern, Pierrick Poisbeau, Ron Stoop, Pascal Darbon, Valery Grinevich, Alexandre Charlet
Summary: This study reveals a morphologically distinct subpopulation of astrocytes expressing OT receptors in the central amygdala of mice and rats, mediating the anxiolytic and positive reinforcement effects of OT. It challenges the traditional belief that OT exclusively acts on neurons, highlighting the essential role of astrocytes in modulating emotional states under normal and chronic pain conditions.
NATURE NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Jackob Moskovitz, Adam Smith
Summary: Methionine oxidation and reduction commonly occur in biological systems, with levels of MetO dependent on the redox status impacting protein function and toxicity accumulation. The Msr system plays a crucial role in regulating the effects of MetO.
Editorial Material
Endocrinology & Metabolism
Adam S. Smith, Benjamin Jurek, Valery Grinevich, Michael T. Bowen
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Neurosciences
Luanne H. Hale, Maria C. Tickerhoof, Adam S. Smith
Summary: This study investigated the effects of chronic oxytocin (OXT) and selective serotonin reuptake inhibitor (SSRI) treatment on social defeat stress in male and female socially monogamous prairie voles. Results showed that chronic intranasal OXT treatment had a negative impact on sociability in non-defeated females but promoted social engagement in defeated females. Moreover, SSRI treatment had only modest effects on social behaviors compared to OXT.
Article
Neurosciences
Kyle R. Gossman, Benjamin Dykstra, Byron H. Garcia, Arielle P. Swopes, Adam Kimbrough, Adam S. Smith
Summary: This study assessed the organization and functional connectivity models of the social decision-making network (SDMN) using c-Fos in prairie voles during specific social interactions. The results showed distinct patterns of c-Fos activity in different brain regions during social encounters, leading to the formation of discrete network modules. The partner functional connectivity network resembled the theoretical SDMN model, while stranger networks demonstrated different architecture with connections associated with threat and aggressive behaviors.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Yousuke Tsuneoka, Chihiro Yoshihara, Ryuko Ohnishi, Sachine Yoshida, Eri Miyazawa, Masanobu Yamada, Kazuhiko Horiguchi, W. Scott Young, Katsuhiko Nishimori, Tadafumi Kato, Kumi O. Kuroda
Summary: The study illustrates the relationship between oxytocin and parental care, genetic mutations can affect parental behaviors in mice, and the behavior performance towards pups showed no significant difference among mice with different genotypes under minimal stress conditions.
Review
Behavioral Sciences
Erika M. Vitale, Adam S. Smith
Summary: Social interaction and maintaining social bonds are essential for mental and physical health in social species. Loneliness in humans involves physical isolation as well as negative perceptions about social interactions and connectedness. Loneliness and social isolation are associated with dysfunction in brain regions regulating motivation and stress responsiveness. Both humans and animal models display physiological symptoms and altered behavior as a result of social isolation.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Adam S. Smith, Kyle R. Gossman, Benjamin Dykstra, Fei Philip Gao, Jackob Moskovitz
Summary: The brain in AD undergoes severe oxidative attack, leading to methionine oxidation. This study shows that immunization of AD mice with a methionine sulfoxide-rich protein induces the production of anti-MetO antibody, resulting in improved memory capabilities, reduced A beta levels, and enhanced antioxidant capabilities in the brain. These findings suggest that active immunization could delay or prevent the onset of AD.
Editorial Material
Neurosciences
Adam S. Smith
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2022)
Article
Behavioral Sciences
Erika M. Vitale, Adrianna Kirckof, Adam S. Smith
Summary: The death of a loved one is a major stressor in life, with a significant proportion of bereaved individuals experiencing prolonged grief. In this study, male prairie voles showed increased investigation of partner odor following the loss of their bonded female partner, suggesting a reunion-seeking behavior. Additionally, dopamine receptor expression in specific brain regions was affected by the loss of a high-quality opposite-sex relationship, indicating a potential role of neurocircuits in motivation and social loss.
GENES BRAIN AND BEHAVIOR
(2023)