Article
Chemistry, Inorganic & Nuclear
William K. Chu, Charles K. Rono, Banothile C. E. Makhubela
Summary: In this study, a series of nine novel cationic triazole-based complexes were synthesized and evaluated for their anticancer activity against different cancer cells. One ruthenium(II) complex, C7, showed good activity and selectivity against all cancer cell lines. These complexes demonstrated selectivity towards specific cancer cells and interacted with certain biomolecules, potentially serving as templates for targeted drug development.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Peter De'Ath, Mark R. J. Elsegood, Christopher A. G. Halliwell, Martin B. Smith
Summary: Three new carboxylic acid functionalized diphosphines were synthesized and their dinuclear ruthenium(II) complexes were successfully obtained. The cleavage of P-C-sp3 bond and characterization of the new compounds were achieved through a series of spectroscopic and analytical techniques.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Chad M. Bernier, Christine M. DuChane, Justin S. Martinez, Joseph O. Falkinham, Joseph S. Merola
Summary: A range of Rh-III and Ir(III) piano-stool complexes were synthesized and characterized, showing high antimicrobial activities against various microbes, particularly Mycobacterium smegmatis. Rh complexes were generally more potent than their Ir analogues, and activity increased with the hydrophobicity of the ligands.
Article
Chemistry, Multidisciplinary
Jesus E. Ceron-Castelan, Veronica Salazar-Pereda, Simplicio Gonzalez-Montiel, Daniel Mendoza-Espinosa, Jose A. Castro-Osma, Laura Lopez-Santos, Manuel A. Gomez-Bonilla, Cesar Sandoval-Chavez
Summary: Novel NNO-heteroscorpionate rhodium(III) and iridium(III) complexes were synthesized and their structures were characterized. These complexes exhibited efficient catalytic activity for the transfer hydrogenation of ketones and aldehydes under low catalyst loadings.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Marta Redrado, Andrea Benedi, Isabel Marzo, Angel L. Garcia-Otin, Vanesa Fernandez-Moreira, M. Concepcion Gimeno
Summary: A new class of emissive cyclometallated Ir-III-Au-I complexes with a bis(diphenylphosphino) methanide bridging ligand was synthesized successfully. These complexes showed different bioactivity in A549 lung carcinoma cells versus endothelial cells, mainly affecting the mitochondrial and lysosomal distribution within the cells.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Inorganic & Nuclear
Adhir Majumder, Tarak Nath Saha, Niladri Majumder, Rajat Naskar, Kuntal Pal, Ramananda Maity
Summary: Heterobimetallic complexes with NHC donor ligands show promising catalytic activity and selectivity in tandem catalysis, making them potential candidates for various organic transformations.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Luis Felipe Hernandez-Ayala, Cynthia Sinai Novoa-Ramirez, Miguel Reina, Lena Ruiz-Azuara
Summary: This study presents the synthesis, characterization, electrochemical studies, DFT calculations, and in vitro evaluation of four novel direct bonded ruthenium-selenium compounds, revealing the impact of intermediate properties and compound structure on cytotoxic activity, with 2c demonstrating the best inhibitory effect on cell proliferation.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Srividya Swaminathan, Jebiti Haribabu, Naveen Kumar Kalagatur, Maroli Nikhil, Nithya Balakrishnan, Nattamai S. P. Bhuvanesh, Krishna Kadirvelu, Ponmalai Kolandaivel, Ramasamy Karvembu
Summary: The synthesis of fourteen new Ru-II-arene complexes were characterized and found to exhibit high toxicity towards IMR-32 cancer cells, with two complexes showing the highest activity and the ability to induce apoptosis and cell cycle arrest. These complexes also demonstrated good binding affinity with receptors commonly overexpressed in cancer cells.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Inorganic & Nuclear
Sonia Infante-Tadeo, Vanessa Rodriguez-Fanjul, Cintia C. Vequi-Suplicy, Ana M. Pizarro
Summary: The passage describes the rapid hydrolysis and high basicity of complexes [Os(eta 6-arene)(C,N-phenylpyridine)Z] with chlorido or tethered oxygen as the ligand. It also reveals the structure-activity relationship between Os-CN and Os-NN complexes.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Urszula K. Komarnicka, Alessandro Niorettini, Sandra Koziel, Barbara Pucelik, Agata Barzowska, Daria Wojtala, Aleksandra Ziolkowska, Monika Lesiow, Agnieszka Kyziol, Stefano Caramori, Marina Porchia, Alina Bienko
Summary: In this study, two novel phosphine ligands and their corresponding metal complexes were synthesized and characterized. The copper(I) complexes were found to be highly unstable, while the ruthenium(II) and iridium(III) complexes showed promising cytotoxicity towards cancer cells. Further analysis revealed that these metal complexes effectively accumulated inside cancer cells, inducing apoptosis and altering the cell cycle. Additionally, the complexes exhibited low genotoxicity towards DNA and were able to generate reactive oxygen species. Furthermore, efficient anticancer action was demonstrated on multicellular tumor spheroids.
Review
Chemistry, Multidisciplinary
Ajay S. Sharma, N. Vaibhavi, Binoy Kar, Utpal Das, Priyankar Paira
Summary: Metal complexes, especially rhenium-based complexes, have attracted global interest as potential cancer therapeutics due to their ability to detect and annihilate cancer cells.
Article
Biochemistry & Molecular Biology
Devesh S. Agarwal, Samrat Mazumdar, Kishan S. Italiya, Deepak Chitkara, Rajeev Sakhuja
Summary: A library of bile-acid-appended triazolyl aryl ketones was synthesized and evaluated for cytotoxicity against human breast adenocarcinoma and mouse mammary carcinoma cells. Two compounds, 6cf and 6af, showed potent anticancer activity with no toxicity to normal cells, making them potential candidates for the development of anticancer agents.
Review
Engineering, Chemical
Fredrik Lehmann, Johan Wennerberg
Summary: Despite significant advancements in anticancer drug development, there is a critical need for novel agents with unique but effective mechanisms to combat highly aggressive and drug-resistant tumors. Alkylating agents, particularly nitrogen-based ones, are commonly used for hematological and solid malignancies, exerting their antineoplastic effects throughout the cell cycle. Certain alkylating agents have been designed to enhance penetration into cells and increase their activity against tumors.
Review
Chemistry, Medicinal
Darshana Bora, Anjali Kaushal, Nagula Shankaraiah
Summary: Spirocompounds, an important class of organic frameworks, have shown promising anticancer potential, inspiring medicinal chemists to explore new derivatives with improved pharmacological properties. By investigating the anticancer activity and structure-activity relationships of various spirocompounds, this review may guide the design of novel spiromolecules with enhanced safety and efficacy in the future.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Saawan Kumar, Mie Riisom, Stephen M. F. Jamieson, Iman Kavianinia, Paul W. R. Harris, Nils Metzler-Nolte, Margaret A. Brimble, Christian G. Hartinger
Summary: Researchers conjugated a derivative of plecstatin-1 with peptides to enhance their targeting ability towards cancer cells. Metal-peptide conjugates were successfully synthesized and tested for their anticancer activity. Although the activity was relatively low, this study provides a potential strategy to design other metal complexes utilizing the targeting properties of peptides.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Noluthando V. Gamede, Tsitsi A. Kapfunde, Edward Ocansey, Denis M. Ngumbu, James Darkwa, Banothile C. E. Makhubela
TRANSITION METAL CHEMISTRY
(2020)
Article
Chemistry, Inorganic & Nuclear
Piwai Tshuma, Banothile C. E. Makhubela, Ndzondelelo Bingwa, Gift Mehlana
INORGANIC CHEMISTRY
(2020)
Article
Chemistry, Organic
Tommy F. Mabasa, Jackie Mabasa, Mthokozisi Simelane, Banele Vatsha, Banothile C. E. Makhubela, Henok H. Kinfe
Article
Chemistry, Medicinal
Zelinda Engelbrecht, Kim Elli Roberts, Ayesha Hussan, Gershon Amenuvor, Marianne Jaqueline Cronje, James Darkwa, Banothile C. E. Makhubela, Lungile Sitole
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2020)
Article
Chemistry, Inorganic & Nuclear
Pamela S. Moyo, Leah C. Matsinha, Banothile C. E. Makhubela
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2020)
Article
Dentistry, Oral Surgery & Medicine
Paloma Santos de Campos, Luiza Deitos Menti, Luise Pazutti, Natalia Angela Bortoli, Leonildo Alves Ferreira, Juanita Lizele van Wyk, James Darkwa, Henri Stephan Schrekker, Marcelo Lazzaron Lamers
Summary: The study found that C(16)MImCl has a better inhibitory effect on proliferation and cell-cell adhesion of oral squamous cell carcinoma, showing stronger effects on more aggressive tumor cells but minimal effects on keratinocytes. Compared to cisplatin, C(16)MImCl has similar effects on inducing cell death.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2021)
Article
Chemistry, Inorganic & Nuclear
Edward Ocansey, James Darkwa, Banothile C. E. Makhubela
Summary: Bimetallic catalytic systems, particularly heterogeneous ones, have been found to be effective for CO2 hydrogenation due to synergistic effects. These systems can catalyze the reduction of CO2 to formate selectively. Ir-Sn catalysts can effectively hydrogenate CO2 directly or bicarbonate ions formed in solution during the catalytic cycle.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Materials Science, Multidisciplinary
Raynold Techie-Menson, Charles K. Rono, Anita Etale, Gift Mehlana, James Darkwa, Banothile C. E. Makhubela
Summary: Monomers derived from renewable sources, such as bio-based furfural, glycerol and lactic acid, were used to prepare methacrylate monomers with high yield and purity via transesterification reactions. The resulting co-polymers had considerable molecular weights and thermal properties, with some crystalline regions identified. Reinforced with cellulose triacetate and polysulfone, the polymer composites showed hydrolytic degradation and were applied as coatings and water filtration membranes.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Fiona M. Nermark, Mmilili M. Mapolelo, James Darkwa, Ola F. Wendt, Charlotta Turner
Summary: The optimal conditions for extracting sulfur from sub-bituminous coal involve using ethanol/water (90/10, v/v %) at 129 degrees C (105 bars) for 10 minutes. However, this method is not efficient in removing ash.
Article
Chemistry, Multidisciplinary
Oluwasegun E. Olaoye, Olayinka Oyetunji, Banothile C. E. Makhubela, Apollinaire Muyaneza, Gopendra Kumar, James Darkwa
Summary: The study prepared various complexes by reacting different pyrazole-based compounds with palladium and nickel compounds, which were then used as catalysts in the hydrogenation of sorbic acid. The active catalysts showed significant activities and selectivity in reducing sorbic acid, indicating a sequential hydrogenation process with preference for less hindered C=C bonds.
SOUTH AFRICAN JOURNAL OF CHEMISTRY-SUID-AFRIKAANSE TYDSKRIF VIR CHEMIE
(2021)
Article
Chemistry, Multidisciplinary
Divambal Appavoo, Lara C. Spencer, Ilia A. Guzei, Carlos J. Gomez-Garcia, Juanita L. van Wyk, James Darkwa
Summary: In this study, four copper complexes were synthesized and characterized, showing the ability to catalyze the ring opening polymerization of ε-caprolactone and d,l-lactide to obtain polymers with low molecular weights and polydispersity indices. The end group analysis revealed the presence of benzoate, hydroxyl, methoxy, and cyclic end groups in the polymers.
Article
Chemistry, Inorganic & Nuclear
Anelisa Matiwane, Collins Obuah, James Darkwa
Article
Chemistry, Multidisciplinary
Pamela N. Sekoto, Tseliso M. Magengenene, Leah C. Matsinha, Richard Tia, James Darkwa, Banothile C. E. Makhubela
NEW JOURNAL OF CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Christian K. Adokoh, Frankline K. Keter, Henok H. Kinfe, Robert Tshikhudo, James Darkwa
RSC MEDICINAL CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Piwai Tshuma, Banothile C. E. Makhubela, Lars Ohrstrom, Susan A. Bourne, Nabanita Chatterjee, Isaac N. Beas, James Darkwa, Gift Mehlana