Synthesis of β3-Amino Esters by Iridium-Catalyzed Asymmetric Allylic Alkylation Reaction

A method to prepare chiral beta(3)-amino esters from methyl 3-aminopropanoate was described. This method capitalized on a sequence involving an Ir-catalyzed asymmetric allylation of 2-azaallyl anions and a 2-aza-Cope rearrangement. beta(3)-Amino esters containing a versatile alkene group were prepared.