RhCl3•3H2O-Catalyzed C7-Selective C-H Carbonylation of Indolines with CO and Alcohols

An attractive method for the synthesis of indoline-7-carboxylates through RhCl3-catalyzed C-H carbonylation of indolines with CO and alcohols was developed. The copper-based oxidant and removable pyrimidyl directing group played important roles in achieving high-level yields of the title products. Based on control experiments, a possible catalytic cycle was proposed.