Asymmetric Inverse-Electron-Demand Diels-Alder Reaction of β,γ-Unsaturated Amides through Dienolate Catalysis

Reported herein is an inverse-electron-demand oxa-Diels-Alder reaction that is remotely beta,gamma-regioselective with beta,gamma-unsaturated amides and beta,gamma-unsaturated-alpha-ketoesters using a bifunctional catalyst. It can provide different kinds of dihydropyrans bearing three subsequent chiral carbon centers in good to high yield (61-99%) and with complete enantioselectivity (99 to >99% ee). Furthermore, a larger-scale experiment confirmed the reliability of the current reaction, and further effective transformation of the product has been realized.