期刊
BASIC RESEARCH IN CARDIOLOGY
卷 111, 期 4, 页码 -出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00395-016-0554-5
关键词
CD40; Macrophage; Atherosclerosis; Arteriogenesis; Neointima formation; Ischemic heart disease
资金
- AAA (alliance grant AMC/VUMC)
- Netherlands CardioVascular Research Initiative [CVON2011-19]
- Deutsche Forschungsgemeinschaft (DFG) [SFB1123-A5]
- European Research Council (ERC)
Coronary artery disease (CAD), also known as ischemic heart disease (IHD), is the leading cause of mortality in the western world, with developing countries showing a similar trend. With the increased understanding of the role of the immune system and inflammation in coronary artery disease, it was shown that macrophages play a major role in this disease. Costimulatory molecules are important regulators of inflammation, and especially, the CD40L-CD40 axis is of importance in the pathogenesis of cardiovascular disease. Although it was shown that CD40 can mediate macrophage function, its exact role in macrophage biology has not gained much attention in cardiovascular disease. Therefore, the goal of this review is to give an overview on the role of macrophage-specific CD40 in cardiovascular disease, with a focus on coronary artery disease. We will discuss the function of CD40 on the macrophage and its (proposed) role in the reduction of atherosclerosis, the reduction of neointima formation, and the stimulation of arteriogenesis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据