Structural Studies of Nicotinic Acetylcholine Receptors: Using Acetylcholine-Binding Protein as a Structural Surrogate

The role of alpha5 nicotinic acetylcholine receptors in mouse models of chronic inflammatory and neuropathic pain

(2015) Deniz Bagdas et al.   BIOCHEMICAL PHARMACOLOGY

Crystal structure of human glycine receptor-α3 bound to antagonist strychnine

(2015) Xin Huang et al.   NATURE

Glycine receptor mechanism elucidated by electron cryo-microscopy

(2015) Juan Du et al.   NATURE

Transcriptome Analysis of the Central and Peripheral Nervous Systems of the Spider Cupiennius salei Reveals Multiple Putative Cys-Loop Ligand Gated Ion Channel Subunits and an Acetylcholine Binding Protein

(2015) Päivi H. Torkkeli et al.   PLoS One

Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the α7 nicotinic acetylcholine receptor

(2015) Radovan Spurny et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

α7 Nicotinic Acetylcholine Receptor is a Novel Mediator of Sinomenine Anti-Inflammation Effect in Macrophages Stimulated by Lipopolysaccharide

(2015) Lang Yi et al.   SHOCK

Marine Macrocyclic Imines, Pinnatoxins A and G: Structural Determinants and Functional Properties to Distinguish Neuronal α7 from Muscle α12βγδ nAChRs

(2015) Yves Bourne et al.   STRUCTURE

Selective Ligand Behaviors Provide New Insights into Agonist Activation of Nicotinic Acetylcholine Receptors

(2014) Christopher B. Marotta et al.   ACS Chemical Biology

Structural and Functional Studies of the Modulator NS9283 Reveal Agonist-like Mechanism of Action at α4β2 Nicotinic Acetylcholine Receptors

(2014) Jeppe A. Olsen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of a human GABAA receptor

(2014) Paul S. Miller et al.   NATURE

X-ray structure of the mouse serotonin 5-HT3 receptor

(2014) Ghérici Hassaine et al.   NATURE

X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors

(2014) Thorsten Althoff et al.   NATURE

Molecular Recognition of the Neurotransmitter Acetylcholine by an Acetylcholine Binding Protein Reveals Determinants of Binding to Nicotinic Acetylcholine Receptors

(2014) Jeppe A. Olsen et al.   PLoS One

Structural basis for cooperative interactions of substituted 2-aminopyrimidines with the acetylcholine binding protein

(2014) K. Kaczanowska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insights into Cys-loop receptor function and ligand recognition

(2013) Mieke Nys et al.   BIOCHEMICAL PHARMACOLOGY

Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation

(2013) L. Sauguet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gating of Pentameric Ligand-Gated Ion Channels: Structural Insights and Ambiguities

(2013) Corrie J.B. daCosta et al.   STRUCTURE

Assembly of a π–π stack of ligands in the binding site of an acetylcholine-binding protein

(2013) Mariano Stornaiuolo et al.   Nature Communications

Identification of novel α7 nicotinic receptor ligands by in silico screening against the crystal structure of a chimeric α7 receptor ligand binding domain

(2012) Atilla Akdemir et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Functional α7β2 nicotinic acetylcholine receptors expressed in hippocampal interneurons exhibit high sensitivity to pathological level of amyloid β peptides

(2012) Qiang Liu et al.   BMC NEUROSCIENCE

Structural basis of ligand recognition in 5-HT3 receptors

(2012) Divya Kesters et al.   EMBO REPORTS

Molecular Determinants of Subtype-selective Efficacies of Cytisine and the Novel Compound NS3861 at Heteromeric Nicotinic Acetylcholine Receptors

(2012) Kasper Harpsøe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Characterization of Binding Mode of Smoking Cessation Drugs to Nicotinic Acetylcholine Receptors through Study of Ligand Complexes with Acetylcholine-binding Protein

(2012) Prakash Rucktooa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insights into the Structural Determinants Required for High-Affinity Binding of Chiral Cyclopropane-Containing Ligands to α4β2-Nicotinic Acetylcholine Receptors: An Integrated Approach to Behaviorally Active Nicotinic Ligands

(2012) Han-Kun Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, Pharmacology, and Biostructural Characterization of Novel α4β2 Nicotinic Acetylcholine Receptor Agonists

(2012) Christine A. Ussing et al.   JOURNAL OF MEDICINAL CHEMISTRY

Gating Movement of Acetylcholine Receptor Caught by Plunge-Freezing

(2012) Nigel Unwin et al.   JOURNAL OF MOLECULAR BIOLOGY

Generation of Candidate Ligands for Nicotinic Acetylcholine Receptors via in situ Click Chemistry with a Soluble Acetylcholine Binding Protein Template

(2012) Neil P. Grimster et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Acetylcholine-Binding Protein in the Hemolymph of the Planorbid Snail Biomphalaria glabrata Is a Pentagonal Dodecahedron (60 Subunits)

(2012) Michael Saur et al.   PLoS One

Crystal Structure of Lymnaea stagnalis AChBP Complexed with the Potent nAChR Antagonist DHβE Suggests a Unique Mode of Antagonism

(2012) Azadeh Shahsavar et al.   PLoS One

Molecular actions of smoking cessation drugs at  4 2 nicotinic receptors defined in crystal structures of a homologous binding protein

(2012) B. Billen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines

(2012) R. Spurny et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the pentameric ligand-gated ion channel ELIC cocrystallized with its competitive antagonist acetylcholine

(2012) Jianjun Pan et al.   Nature Communications

Acetylcholine binding protein (AChBP) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors

(2011) Atilla Akdemir et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Creating an α7 Nicotinic Acetylcholine Recognition Domain from the Acetylcholine-binding Protein

(2011) Ákos Nemecz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intersubunit Bridge Formation Governs Agonist Efficacy at Nicotinic Acetylcholine α4β2 Receptors

(2011) Line Aagot Hede Rohde et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fragment Growing Induces Conformational Changes in Acetylcholine-Binding Protein: A Structural and Thermodynamic Analysis

(2011) Ewald Edink et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Principles of activation and permeation in an anion-selective Cys-loop receptor

(2011) Ryan E. Hibbs et al.   NATURE

Ligand-binding domain of an α7-nicotinic receptor chimera and its complex with agonist

(2011) Shu-Xing Li et al.   NATURE NEUROSCIENCE

A Structural and Mutagenic Blueprint for Molecular Recognition of Strychnine and d-Tubocurarine by Different Cys-Loop Receptors

(2011) Marijke Brams et al.   PLOS BIOLOGY

Crystal Structures of a Cysteine-modified Mutant in Loop D of Acetylcholine-binding Protein

(2010) Marijke Brams et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nicotinic pharmacophore: The pyridine N of nicotine and carbonyl of acetylcholine hydrogen bond across a subunit interface to a backbone NH

(2010) A. P. Blum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural determinants in phycotoxins and AChBP conferring high affinity binding and nicotinic AChR antagonism

(2010) Y. Bourne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal α7 nicotinic acetylcholine receptor

(2009) Ryan E Hibbs et al.   EMBO JOURNAL

Use of Acetylcholine Binding Protein in the Search for Novel α7 Nicotinic Receptor Ligands. In Silico Docking, Pharmacological Screening, and X-ray Analysis†

(2009) Chris Ulens et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification and Comparison of Amorphous Calcium Carbonate-Binding Protein and Acetylcholine-Binding Protein in the Abalone, Haliotis discus hannai

(2009) Jing Huang et al.   MARINE BIOTECHNOLOGY

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system

(2009) Antoine Taly et al.   NATURE REVIEWS DRUG DISCOVERY

Crystal structures of Lymnaea stagnalis AChBP in complex with neonicotinoid insecticides imidacloprid and clothianidin

(2008) Makoto Ihara et al.   INVERTEBRATE NEUROSCIENCE

Naturally Occurring Disulfide-bound Dimers of Three-fingered Toxins

(2008) Alexey V. Osipov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Ion Selectivity Filter in the Extracellular Domain of Cys-loop Receptors Reveals Determinants for Ion Conductance

(2008) Scott B. Hansen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel

(2008) Ricarda J. C. Hilf et al.   NATURE

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

(2008) Nicolas Bocquet et al.   NATURE

X-ray structure of a prokaryotic pentameric ligand-gated ion channel

(2008) Ricarda J. C. Hilf et al.   NATURE

Diversity of vertebrate nicotinic acetylcholine receptors

(2008) Neil S. Millar et al.   NEUROPHARMACOLOGY

Atomic interactions of neonicotinoid agonists with AChBP: Molecular recognition of the distinctive electronegative pharmacophore

(2008) T. T. Talley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA