Article
Ophthalmology
Muhammad Yasir, Ajay Kumar Vijay, Mark Willcox
Summary: The study demonstrates that oxidative contact lens disinfecting solutions containing povidone iodine or hydrogen peroxide exhibit superior antiviral activity against a coronavirus surrogate of SARS-CoV-2, especially when the full regimen test is used.
CONTACT LENS & ANTERIOR EYE
(2022)
Article
Allergy
Susann Forkel, Caroline Beutner, Katharina Amschler, Silke Sabina Schroeder, Michael P. Schoen, Johannes Geier, Timo Buhl
Summary: Patch testing with PVP-I 2% aq. showed the lowest number of doubtful skin reactions while detecting the single allergic patient, suggesting it as the optimal preparation for iodine patch tests. Overestimation of iodine allergy was indicated, and positive patch test responses to iodine should be confirmed with ROATs before diagnosis.
CONTACT DERMATITIS
(2021)
Article
Ophthalmology
Pauline Cho, Maureen Valerie Boost, Sin Wan Cheung
Summary: This study aimed to determine whether the use of a povidone iodine (PI) disinfecting system in new orthokeratology (ortho-k) subjects is associated with changes in ocular symptoms and signs compared to before lens wear, and whether these changes are related to cleaning regimes. The results showed that the use of a PI-based solution did not increase the frequency or severity of ocular signs and symptoms observed before lens wear, indicating that the PI-based solution can adequately clean the lenses over a 6-month period.
CONTACT LENS & ANTERIOR EYE
(2023)
Article
Orthopedics
Ajay Premkumar, Sita Nirupama Nishtala, Joseph T. Nguyen, Mathias P. G. Bostrom, Alberto Carli
Summary: The study found that povidone-iodine 10% and a 1:1 solution of povidone-iodine 10% and 4% hydrogen peroxide were the only effective solutions against biofilm across all three surfaces and time points. Saline, vancomycin, and polymyxin-bacitracin were ineffective compared to other solutions for dispersing MSSA biofilm. Furthermore, the efficacy of commercial antibacterial solutions varied significantly, with a global decrease in efficacy as biofilm maturity increased.
JOURNAL OF ARTHROPLASTY
(2021)
Article
Public, Environmental & Occupational Health
Phat Tran, Jonathan Kopel, Keaton Luth, Huy Dong, Ameesh Dev, Dilip Mehta, Kelly Mitchell, Keith W. Moeller, Cameron D. Moeller, Ted Reid
Summary: This study aimed to determine if the combination of 5% betadine solution and silver colloidal gel is more effective than either substance alone in inhibiting the growth of gram-negative and gram-positive bacteria. The results showed that silver gel had complete inhibition on all the bacteria species examined except for the Klebsiella pneumoniae clinical isolate strain, while 5% betadine solution did not completely kill any of the tested bacteria. However, when 5% betadine solution and silver gel were used together, they were able to completely eliminate K. pneumoniae. The study concluded that the combination of 5% betadine solution and silver gel was superior at eliminating all tested bacteria.
AMERICAN JOURNAL OF INFECTION CONTROL
(2023)
Article
Medicine, General & Internal
Veronica Romano, Donato Di Gennaro, Anna Maria Sacco, Enrico Festa, Emanuela Roscetto, Morena Anna Basso, Tiziana Ascione, Giovanni Balato
Summary: This study evaluated the cytotoxicity of solutions containing povidone-iodine (PI) and hydrogen peroxide (H2O2), alone or in combination. The results showed that the toxicity of all tested solutions increased as exposure time increased, except for 0.3% PI solution, which exhibited the lowest toxicity. The combined solutions had lower cellular killing at 3 and 5 min compared to equal concentrations of H2O2, similar to PI solutions.
Article
Ophthalmology
Sin Wan Cheung, Maureen Valerie Boost, Pauline Cho
Summary: The study found that using a povidone iodine-based rigid lens disinfecting solution effectively reduced contamination rates of lenses and lens cases and conjunctival colonization. Regardless of the cleaning routine adopted, there were no significant differences observed in conjunctival colonization or contamination of lenses or cases.
CONTACT LENS & ANTERIOR EYE
(2021)
Article
Reproductive Biology
Juan E. Romano, Renato G. Zanoni, Beatrice Mislei, Diego Bucci, Domenico Mion, Gaetano Mari
Summary: The study estimated the number of colonies forming units (CFU) in penile mucosa and semen and compared the effect of two antiseptic solutions used to reduce bacterial counts in those areas. The results showed that flushing the preputial cavity with 0.05% chlorhexidine digluconate or 1% povidone-iodine solution reduced the CFU counts in penile mucosa and semen.
Article
Surgery
Rod J. Rohrich, Jasson T. Abraham, Brendan Alleyne, Justin Bellamy
Summary: This article describes simple preventative strategies during rhinoplasty procedures to minimize the risk of disease transmission, particularly discussing the use of povidone-iodine in prophylaxis during the perioperative period.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Polymer Science
Mark D. Eddleston, Levente Raduly, Tristan T. Tapper, Reece J. Hughes, Gareth M. Browne, Martin J. Conway
Summary: Fluorine-free analogues of three commercially available rigid contact lens materials were prepared and compared to evaluate their performance. The replacement of hexafluoroisopropyl methacrylate with non-fluorinated monomers resulted in reduced oxygen permeabilities and inadequate hardness, dimensional stability, and lipid deposit resistance. The best overall properties were achieved with a 1:1 mixture of methyl methacrylate and 3-methacryloxypropyltris-(trimethylsiloxy)silane, but they still exhibited lower oxygen permeability and lipid deposition resistance. These findings highlight the challenges in developing rigid lens polymers without the use of fluorinated species and the potential negative impact on safety and eye health.
JOURNAL OF POLYMER ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Yanling You, Ya-Xuan Zhu, Junjie Jiang, Zhixin Chen, Chenyao Wu, Zhimin Zhang, Han Lin, Jianlin Shi
Summary: In this study, a new two-dimensional iodine nanomaterial called iodinene was proposed for the treatment of infectious diseases in vivo. Iodinene demonstrated enhanced antibacterial efficacy against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa by in situ production of active HIO and I2 molecules via allotropic transformation. The in vivo results further confirmed the desirable antibacterial efficacy of iodinene in treating bacterial wound infection and pneumonia.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Ophthalmology
Katsuhide Yamasaki, Yohei Mizuno, Yoshiyuki Kitamura, David J. McCanna, William Ngo, Lyndon W. Jones
Summary: All three solutions significantly reduced P. aeruginosa on direct-contact surfaces. The PVP-I system was more effective against P. aeruginosa on non-contact surfaces than the hydrogen peroxide system or the chemical multipurpose system, and capable of inhibiting regrowth of P. aeruginosa for at least 7 days post-disinfection.
CONTACT LENS & ANTERIOR EYE
(2021)
Article
Biochemistry & Molecular Biology
Celine Abueva, Hyun Seok Ryu, Jun Won Min, Phil Sang Chung, Hyeon Sook You, Myung Suk Yang, Seung Hoon Woo
Summary: The study synthesized a quaternary ammonium chitosan derivative, which when complexed with povidone-iodine showed increased effectiveness against multidrug-resistant bacteria and fungi, with no cytotoxic effects and promoting wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Otorhinolaryngology
Christian A. Lux, Kristi Biswas, Michael W. Taylor, Richard G. Douglas
Summary: This study aimed to evaluate the in vitro antimicrobial efficacy of neutral electrolysed water (NEW) and povidone-iodine (PVI) against Staphylococcus aureus biofilms associated with chronic rhinosinusitis (CRS). Results showed that PVI demonstrated promising antibiofilm activity at physiological concentrations, while NEW was ineffective. Further investigation is needed to determine the in vivo efficacy of PVI as a potential treatment for refractory CRS.
Article
Materials Science, Biomaterials
Yingmin Ye, Yanmin Wang, Kai Zhang, Wei Guo, Tianyu Kong, Xiaokang Ding, Nana Zhao, Fujian Xu
Summary: In this study, a simple method is reported to prepare two-dimensional iodine nanosheets (2D iodine NSs) with good stability and high biocompatibility using an aqueous solvent-assisted ultrasonic route. Due to the large specific surface area of the 2D morphology, iodine NSs effectively interact with bacterial membranes, leading to the destruction of bacterial integrity and further damage to intracellular DNA. Consequently, the iodine NSs exhibit significant antibacterial activity against S. aureus both in vitro and in vivo.
BIOMATERIALS SCIENCE
(2023)