Article
Biochemistry & Molecular Biology
Bo-Ram Jin, Chae-Young Lim, Hyo-Jung Kim, Minho Lee, Hyo-Jin An
Summary: The study shows that MitoQ, a mitochondria-targeted antioxidant, has therapeutic effects in benign prostatic hyperplasia (BPH) models by inhibiting androgen receptor (AR) and NOD-like receptor family pyrin domain-containing 3 (NLRP3) signaling. Molecular modeling reveals the interaction between DHT, AR, NLRP3, and the inhibitory effects of MitoQ on AR and NLRP3. MitoQ administration alleviates prostate enlargement and exerts anti-proliferative and antioxidant effects in BPH rats by suppressing the AR and NLRP3 signaling pathways.
Article
Endocrinology & Metabolism
Mingxiao Feng, Sara Divall, Dustin Jones, Vaibhave Ubba, Xiaomin Fu, Ling Yang, Hong Wang, Xiaofeng Yang, Sheng Wu
Summary: The study found that the androgen receptor in the liver does not play a role in the reproductive dysfunction induced by high androgen levels, while DHT-treated LivARKO female mice still experienced reproductive issues.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kaitao Li, Yang Sun, Shizhao Liu, Yi Zhou, Qian Qu, Gaofeng Wang, Jin Wang, Ruosi Chen, Zhexiang Fan, Bingcheng Liu, Yuning Li, Xiaoyan Mao, Zhiqi Hu, Yong Miao
Summary: The study found that miR-221 significantly suppressed hair growth and proliferation in AGA patients. Mechanistic analysis revealed that AR directly promoted miR-221 transcription, leading to the inactivation of the MAPK pathway in DPCs and the PI3K/AKT pathway in DSCs. MiR-221 could serve as a novel biomarker and potential therapeutic target for treating AGA.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Oncology
Mazdak Jamshidi, Fatemeh Keshavarzi, Sabrieh Amini, Ismail Laher, Ali Gheysarzadeh, Kambiz Davari
Summary: The synthetic peptide used in this study inhibited AR transactivation in breast cancer cells and significantly promoted apoptosis in cancer cells, especially in those with high and low levels of AR expression.
Article
Biochemistry & Molecular Biology
Haoxin Zhan, Silin Zhang, Lirong Li, Zikai Chen, Yi Cai, Junjun Huang, Dan Wu, Biyun Huang, Bo Wu, Xiawen Liu
Summary: This study investigated the effects of two enantiomers of naftopidil (NAF) on the expression and activity of UGT2B15, and found that they can reduce intraprostatic and intracellular DHT levels, promoting apoptosis. Moreover, UGT2B15 played a crucial role in mediating the effects of the NAF enantiomers. The findings of this study could contribute to the expansion of clinical applications for NAF and support the development of new therapeutic strategies targeting the elimination of androgens for the treatment of BPH and other androgen-sensitive diseases.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Vaibhave Ubba, Serene Joseph, Olubusayo Awe, Dustin Jones, Milan K. Dsilva, Mingxiao Feng, Junjiang Wang, Xiaomin Fu, Razeen J. Akbar, Brittany H. Bodnar, Wenhui Hu, Hong Wang, Xiaofeng Yang, Ling Yang, Peixin Yang, Rexford Ahima, Sara Divall, Sheng Wu
Summary: This study investigates the metabolic impacts of androgen excess in females and the role of neuronal androgen receptor in the central nervous system. The findings suggest that excess androgens may partially alter calorie intake and energy expenditure in females via the neuronal androgen receptor, and also impact inflammation and microglia activation in the hypothalamus.
Article
Endocrinology & Metabolism
Nina M. M. Donaldson, Melanie Prescott, Amy Ruddenklau, Rebecca E. E. Campbell, Elodie Desroziers
Summary: PCOS patients often experience sexual dysfunction, and research has found that prenatally androgenized mouse models also show changes in sexual behavior. These findings suggest that androgen exposure may contribute to sexual dysfunction in PCOS patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Tuyen Thanh Tran, Keesook Lee
Summary: The study revealed that overexpression of JAG1's intracellular domain JICD in prostate cancer cells increased AR-Vs expression, enhanced AR activity in both androgen-independent and dependent conditions, raised the levels of the PCSC marker CD133, and altered components in PCSC-related signaling pathways. This suggests a critical role of JICD in promoting androgen independence and stem-like properties in PC cells.
Article
Oncology
Serina Cheung, Pallavi Jain, Jonathan So, Saeid Shahidi, Stephen Chung, Marianne Koritzinsky
Summary: Targeting the p38 MAPK protein kinase can inhibit growth and survival of castration-resistant prostate cancer cells, regardless of oxygen levels, and may prolong the survival of tumor-bearing mice. This demonstrates the potential of p38 MAPK inhibition as a therapeutic strategy for disrupting AR signaling in the heterogeneous CRPC tumor microenvironment.
Article
Medicine, General & Internal
Dmytro Sirokha, Olexandra Gorodna, Dmytro Lozhko, Ganna Livshyts, Nataliya Zelinska, Liudmyla Livshits
Summary: Including the newly identified missense mutation c.2507T>G in the list of AIS-causing mutations can improve the diagnostic informativity of AR gene mutation analysis in patients with AIS.
CLINICAL CASE REPORTS
(2021)
Article
Urology & Nephrology
Julie Suan-Wei Yang, Chen Qian, Sungyong You, Mirja Rotinen, Edwin M. Posadas, Stephen J. Freedland, Dolores Di Vizio, Jayoung Kim, Michael R. Freeman
Summary: SAFB1 acts as an important regulator of androgen catabolism in prostate cancer, affecting intracrine androgen levels through UGT gene regulation, with potential implications for AR inhibitor resistance.
AMERICAN JOURNAL OF CLINICAL AND EXPERIMENTAL UROLOGY
(2021)
Review
Urology & Nephrology
Ankit Desai, Musaab Yassin, Axel Cayetano, Tharu Tharakan, Channa N. Jayasena, Suks Minhas
Summary: The use of testosterone replacement therapy and anabolic-androgenic steroids has increased, posing challenges for infertility and hypogonadism patients. The recovery time for spermatogenesis after stopping these drugs is variable, and hormonal stimulation or assisted reproductive techniques may be required. Counselling and further research on the long-term effects of these agents are important considerations.
THERAPEUTIC ADVANCES IN UROLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Dong-Xu Qiu, Jian Li, Jin-Wei Zhang, Min-Feng Chen, Xiao-Mei Gao, Yong-Xiang Tang, Ye Zhang, Xiao-Ping Yi, Hong-Ling Yin, Yu Gan, Gui-Lin Wang, Xiong-Bing Zu, Shuo Hu, Yi Cai
Summary: This study aimed to compare the efficiency of different biopsy strategies for prostate cancer diagnosis. Results showed that dual-tracer PET/CT-TB achieved a higher PCa detection rate and could avoid unnecessary biopsies. Dual-tracer PET/CT-TB plus SB is a more effective and promising strategy for the definite diagnosis of clinically significant PCa than mpMRI-TB.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Cell Biology
Yang Yang, Jindong Sheng, Shuai Hu, Yun Cui, Jing Xiao, Wei Yu, Jing Peng, Wenke Han, Qun He, Yu Fan, Yuanjie Niu, Jun Lin, Ye Tian, Chawnshang Chang, Shuyuan Yeh, Jie Jin
Summary: This study identified the histopathological characteristics and molecular mechanisms underlying accelerated progression of benign prostatic hyperplasia (BPH). Increased stromal components and prostatic fibrosis, accompanied by higher myofibroblast accumulation and collagen deposition, were found to be the main features of accelerated progressive BPH tissues. Mechanism dissection revealed that higher expression of CYP19 and G protein-coupled estrogen receptor (GPER) with higher estrogen biosynthesis contribute to the progression of BPH. Targeting the CYP19/estrogen/GPER/G alpha i signaling axis may provide new personalized therapeutics for better suppressing the progression of BPH.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Xufeng Lu, Dazhuan E. Xin, Juanjuan K. Du, Quanli C. Zou, Qian Wu, Yanan S. Zhang, Wenhai Deng, Jicheng Yue, Xing S. Fan, Yuanyuan Zeng, Xiaju Cheng, Xue Li, Zhaoyuan Hou, Man Mohan, Ting C. Zhao, Xiaomei Lu, Zhijie Chang, Liyan Xu, Yu Sun, Xiongbing Zu, Yu Zhang, Y. Eugene Chinn
Summary: In this study, LOXL2 was found to play a role in the epigenetic regulation of tumorigenesis and cancer progression, specifically in the female reproductive system. LOXL2 restricts cancer development through the deacetylation of H3K36ac. LOXL2 loss promotes uterine cancer initiation and progression, and represses the efficacy of anti-PD-1 immunotherapy.
Editorial Material
Urology & Nephrology
Meng Gao, Zhiyong Chen, Jinbo Chen
Article
Immunology
Huihuang Li, Xiongbing Zu, Jiao Hu, Zicheng Xiao, Zhiyong Cai, Ning Gao, Jinbo Chen
Summary: This study found that different cuproptosis patterns in bladder cancer patients are associated with tumor microenvironment phenotypes and immunotherapy efficacy. By constructing a cuproptosis risk score and signature, it is possible to accurately predict patient prognosis and immunotherapy efficacy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Zicheng Xiao, Zhiyong Cai, Dingshan Deng, Shiyu Tong, Xiongbing Zu
Summary: In this study, the comprehensive correlation between epithelial mesenchymal transition (EMT) and prognosis, tumor microenvironment (TME), and molecular subtypes of bladder cancer (BLCA) was investigated. EMT-related genes were found to play an important role in tumor progression and immunity in BLCA. An EMT risk score was developed and validated, which accurately predicted the prognosis and immunophenotype of a single patient. The findings could guide more effective precision medical strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Letter
Urology & Nephrology
Chao Quana, Jinbo Chena, Jiao Hua
Article
Chemistry, Multidisciplinary
Zhiyong Cai, Jinbo Chen, Zhengzheng Yu, Huihuang Li, Zhi Liu, Dingshan Deng, Jinhui Liu, Chunliang Chen, Chunyu Zhang, Zhenyu Ou, Minfeng Chen, Jiao Hu, Xiongbing Zu
Summary: In order to improve the response rate of immune checkpoint blockade monotherapy (ICB), it is important to identify a potential target for combination therapy. Based on the analysis of tumor microenvironment (TME)-related indicators, it is confirmed that BCAT2 plays a role in shaping a noninflamed TME in bladder cancer. Multiomics analysis reveals that BCAT2 inhibits the recruitment of cytotoxic lymphocytes by suppressing proinflammatory cytokine/chemokine-related pathways and the T-cell-chemotaxis pathway. Immunoassays demonstrate a negative correlation between the secretion of CD8(+)T-cell-related chemokines and BCAT2, resulting in a decrease in the number of CD8(+)T cells around BCAT2(+) tumor cells. The combination of BCAT2 deficiency and anti-PD-1 antibody shows a synergistic effect in vivo, suggesting the potential of BCAT2 in combination therapy. Furthermore, the predictive value of BCAT2 in immunotherapy efficacy is validated in multiple immunotherapy cohorts.
Article
Cell Biology
Jiao Hu, Jinbo Chen, Zhenyu Ou, Haige Chen, Zheng Liu, Minfeng Chen, Ruiyun Zhang, Anze Yu, Rui Cao, Enchong Zhang, Xi Guo, Bo Peng, Dingshan Deng, Chunliang Cheng, Jinhui Liu, Huihuang Li, Yihua Zou, Ruoping Deng, Gang Qin, Wenze Li, Lue Wang, Tao Chen, Xiaming Pei, Guanghui Gong, Jiansheng Tang, Belaydi Othmane, Zhiyong Cai, Chunyu Zhang, Zhi Liu, Xiongbing Zu
Summary: This study compares the efficacy of different neoadjuvant treatments in patients with MIBC and suggests that neoadjuvant combination therapy based on tislelizumab provides the best results. The development of an efficacy prediction model helps identify patients who are suitable for neoadjuvant combination therapy. The study also indicates that patients achieving pathological complete response may be candidates for bladder preservation therapy.
CELL REPORTS MEDICINE
(2022)
Review
Urology & Nephrology
Jinbo Chen, Chi-Ping Huang, Chao Quan, Xiongbing Zu, Zhenyu Ou, Yu-Chieh Tsai, Edward Messing, Shuyuan Yeh, Chawnshang Chang
Summary: In this review, the roles of androgen receptor (AR) in bladder cancer development and progression are summarized, along with the clinical applications. Bladder cancer is the ninth most common cancer, with noticeable gender differences. Evidence suggests that AR may promote the development, progression, and recurrence of bladder cancer, contributing to these differences. Targeting androgen-AR signaling has potential as therapy for bladder cancer and has implications for the identification of new therapeutic targets. The success of targeted-AR therapies in clinical trials will aid in the development of improved treatments.
NATURE REVIEWS UROLOGY
(2023)
Article
Chemistry, Multidisciplinary
Huihuang Li, Jinbo Chen, Zhenghao Li, Minfeng Chen, Zhenyu Ou, Miao Mo, Ruizhe Wang, Shiyu Tong, Peihua Liu, Zhiyong Cai, Chunyu Zhang, Zhi Liu, Dingshan Deng, Jinhui Liu, Chunliang Cheng, Jiao Hu, Xiongbing Zu
Summary: A systematic multi-omics analysis identified S100A5 as a novel immunosuppressive target for bladder cancer. The expression of S100A5 inhibits CD8(+) T cell recruitment and cytotoxicity, leading to resistance to immune checkpoint blockade therapy. Targeting S100A5 enhances the infiltration and cytotoxicity of CD8(+) T cells, thereby enhancing the efficacy of immune checkpoint blockade therapy in bladder cancer.
Article
Medicine, Research & Experimental
Peihua Liu, Benyi Fan, Belaydi Othmane, Jiao Hu, Huihuang Li, Yu Cui, Zhenyu Ou, Jinbo Chen, Xiongbing Zu
Summary: This study establishes the critical oncogenic axis of METTL14/IncDBET/FABP5 in BCa, revealing the important role of m(6)A modification in the malignant progression of BCa.