Article
Chemistry, Multidisciplinary
Prashanth Ravishankar, Anna Daily
Summary: This study compared the genomic and proteomic profiles of tears and blood, revealing similarities and differences in protein and microRNA expression. Tears may serve as an alternative biofluid to blood.
APPLIED SCIENCES-BASEL
(2022)
Article
Ophthalmology
Hiroki Maehara, Koki Norikawa, Keiichiro Tanaka, Yutaka Kato, Akihito Kasai, Tomoko Omori, Takeshi Machida, Hideharu Sekine, Tetsuju Sekiryu
Summary: This study investigates the changes in tear film complement activation products (CAPs) and ocular surface after vitrectomy combined with cataract surgery. The results show that the levels of CAPs in tears increase after the surgery and suggest that a preoperative deficit in tear secretion may lead to prolonged complement activation and delayed recovery of ocular surface.
Article
Biochemistry & Molecular Biology
Katie D. Hunter, Robert W. E. Crozier, Jessica L. Braun, Val A. Fajardo, Adam J. MacNeil
Summary: In this study, the role of SARCA in allergen-activated mast cells was characterized. Treatment with the SARCA activating compound, CDN1163, was found to attenuate early phase mast cell degranulation, reactive oxygen species (ROS) production, and secretion of IL-6, IL-13, and CCL3. These protective effects may be driven by the suppression of p38 MAPK signaling. These findings suggest that SARCA is an important regulator of the mast cell response to allergens and may have therapeutic potential in targeting allergic pathologies.
Article
Orthopedics
Robert H. Brophy, Lei Cai, Qiang Zhang, R. Reid Townsend, Muhammad Farooq Rai
Summary: The proteomic profile of effusion resulting from ACL tears is associated with patient sex, injury pattern, and bone bruise location.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2022)
Review
Immunology
Nishelle D'souza, Milena Weber, Eszter Sarzsinszky, Susanne Vrtala, Mirela Curin, Mirjam Schaar, Victoria Garib, Margarete Focke-Tejkl, Yanqiu Li, Richard Jones, Hao Chen, Rudolf Valenta, Baoqing Sun
Summary: Approximately 30% of the global population suffers from IgE-mediated allergy, with China having the largest population and over 400 million allergic patients. Allergy prevention and treatment strategies include allergen avoidance, vaccination, and tolerance induction, requiring a detailed understanding of relevant allergen molecules affecting specific populations.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Ophthalmology
Arantxa Acera, Beatriz Abad, Xandra Pereiro, Francisco David Rodriguez, Noelia Ruzafa, Juan Antonio Duran, Elena Vecino
Summary: The tear film lipid layer (TFLL) plays a crucial role in maintaining high-quality vision, protecting the cornea, and promoting wound healing. Plasma rich in growth factor (PRGF) eye drops have emerged as a new treatment for aqueous deficient dry eye. This study compared the lipid profiles of PRGF eye drops with tears and found that the lipids in PRGF eye drops could be used as a supplement for altered tear lipid composition.
EXPERIMENTAL EYE RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Vanessza Emmert, Dominika Lendvai-Emmert, Kata Eklics, Viktoria Premusz, Gergely Peter Toth
Summary: Cow's milk protein allergy is a common pediatric food allergy that has a significant socioeconomic impact and affects the quality of life of individuals and their families. Various immunologic pathways contribute to the clinical symptoms, with some mechanisms well-known and others requiring further research. A comprehensive understanding of food allergy development and oral tolerance could lead to improved diagnostic tools and novel therapies for cow's milk protein allergy patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Ophthalmology
Marta Blanco-Vazquez, Amanda Vazquez, Itziar Fernandez, Andrea Novo-Diez, Elena Martinez-Plaza, Carmen Garcia-Vazquez, Maria J. Gonzalez-Garcia, Eva M. Sobas, Margarita Calonge, Amalia Enriquez-de-Salamanca
Summary: The purpose of this study was to analyze inflammation-and pain-related molecules in tears of patients suffering from chronic ocular pain associated with dry eye and/or a previous corneal refractive surgery. The study found that IL-10 and SP levels in tears were increased in patients with a history of corneal refractive surgery. IL-9 levels were associated with chronic ocular pain. These findings suggest that tear cytokines and neuromodulators could serve as biomarkers for chronic ocular pain, leading to improved therapeutic and disease management decisions.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Ophthalmology
Marta Blanco-Vazquez, Amanda Vazquez, Itziar Fernandez, Andrea Novo-Diez, Elena Martinez-Plaza, Carmen Garcia-Vazquez, Maria J. Gonzalez-Garcia, Eva M. Sobas, Margarita Calonge, Amalia Enriquez-de-Salamanca
Summary: The purpose of this study was to analyze inflammation- and pain-related molecules in tears of patients suffering from chronic ocular pain associated with dry eye and/or a previous corneal refractive surgery. The results showed that IL-9 tear levels were increased in patients with chronic ocular pain, IL-10, SP, MIP-1 alpha/CCL3, IL-2, and IFN-gamma were associated with previous surgery, and IL-8/CXCL8, MIP-1 alpha/CCL3, IL-2, and IFN-gamma were associated with DE-related inflammation. Higher NGF levels were related to chronic ocular pain and DE in patients with previous surgery. These findings are important for understanding biomarkers of chronic ocular pain and making better therapeutic and disease management decisions.
EXPERIMENTAL EYE RESEARCH
(2022)
Review
Allergy
Mariona Pascal, Carmen Moreno, Ignacio Davila, Ana Tabar, Joan Bartra, Moises Labrador, Olga Luengo
Summary: The introduction of molecular diagnosis has greatly improved the diagnosis and management of allergic patients. However, accurately interpreting the results of molecular assays can be challenging due to limited evidence. A panel of experts reviewed scientific evidence and developed recommendations on using ratio analysis in allergy diagnosis to better define patients' sensitization profiles.
CLINICAL AND TRANSLATIONAL ALLERGY
(2021)
Article
Biochemistry & Molecular Biology
Juan Torrent-Burgues, Javier Hoyo, Tzanko Tzanov
Summary: The study found that there were no significant differences in the behavior of lipid tear products at the air/liquid interface, despite differences in applications. Sodium chloride, glucose, albumin, and lysozyme were observed to have a notable influence on the surface properties of the lipid Langmuir films.
CHEMISTRY AND PHYSICS OF LIPIDS
(2021)
Article
Orthopedics
Hanwook Kim, Jong-Min Kim, Seong-Il Bin, Bum-Sik Lee
Summary: Radial tears in the anterior third of the lateral meniscus are more likely to be accompanied by horizontal tears. The incidence of complex tears is significantly higher in the anterior group compared to the comparison group.
ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH
(2022)
Article
Immunology
I-Hui Lin, Ming-Chin Tsai, Jun-Peng Chen, Lin-Shien Fu
Summary: The study found that for two thirds of atopic children, a specific allergen could be identified during follow-up tests. Specific allergens could be identified through MAST tests and further assist in treatment options.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Ophthalmology
Yohannes Abere Ambaw, Dhayan Parresh Timbadia, Manfred Raida, Federico Torta, Markus R. Wenk, Louis Tong
Summary: Human tears, a biological fluid rich in lipids, provide insights into fatty acid metabolism and physiology of the ocular surface. The changes in tear lipid mediators can assess inflammation severity and serve as diagnostic tools in personalized medicine.
Article
Immunology
Xin Liu, Yufei Zhang, Xu Cui, Ting Fan, Jin Shu, Hui Li, Xiaojing Huo, Chao Lu
Summary: Gd-DTPA induced severe allergic reactions and mast cells activation, leading to histamine, tryptase, and cytokines release in both mice serum and LAD2 cells supernatant. RNAseq analysis showed changes in mRNA levels related to inflammation signaling pathways after Gd-DTPA activated MCs.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Ophthalmology
Soufiane Souissi, Christophe Baudouin, Antoine Labbe, Pascale Hamard
Summary: The standardized micropulse transscleral diode laser cyclophotocoagulation procedure can lead to a mild decrease in intraocular pressure with a low rate of complications, thereby achieving a relatively good risk-benefit profile, especially for moderately hypertensive refractory glaucoma patients.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Hussam El Chehab, Damien Gatinel, Christophe Baudouin, Marc Muraine, Louis Hoffart, Pascal Rozot, Chadi Mehanna, Clemence Bonnet, Jean-Philippe Nordmann, Pierre-Yves Santiago, Carole Burillon, Stephanie Baillif, Pierre Jean Pisella, Michel Weber, Antoine Robinet-Perrin, Danielle Deidier, Aurelien Hay, Max Villain, Georges Baikoff, Anne Sophie Gauthier, Thibaud Mathis, Corinne Dot
JOURNAL OF CATARACT AND REFRACTIVE SURGERY
(2020)
Review
Ophthalmology
Leying Wang, Kai Cao, Zhenyu Wei, Christophe Baudouin, Antoine Labbe, Qingfeng Liang
OPHTHALMIC RESEARCH
(2020)
Article
Ophthalmology
Chloe Chamard, Max Villain, Alain Bron, Alexandre Causse, Yacine Bentaleb, Francois Pelen, Christophe Baudouin, Vincent Daien
OPHTHALMIC RESEARCH
(2020)
Review
Cell Biology
Stephane Melik Parsadaniantz, Annabelle Reaux-le Goazigo, Anais Sapienza, Christophe Habas, Christophe Baudouin
Article
Ophthalmology
Chloe Chamard, Sophie Larrieu, Christophe Baudouin, Alain Bron, Max Villain, Vincent Daien
ACTA OPHTHALMOLOGICA
(2020)
Article
Ophthalmology
Sihem Lazreg, Marc Labetoulle, Didier Renault, Christophe Baudouin
Summary: The study demonstrated that combined corneal scrubbing and matrix regenerating therapy can lead to rapid healing and successful resolution of persisting corneal ulcers, including large and deep corneal ulcers.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2021)
Editorial Material
Medicine, Legal
Noemie Bonneau, Christophe Baudouin, Francoise Brignole-Baudouin
Summary: The OECD is urging the scientific community to develop and validate alternative methods to reduce the need for animal testing, and proposes combining models and tests into integrated approaches to testing to obtain robust data.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Juliette Buffault, Francoise Brignole-Baudouin, Elodie Reboussin, Karima Kessal, Antoine Labbe, Stephane Melik Parsadaniantz, Christophe Baudouin
Summary: Comparing the effects of latanoprost and a Rho-kinase inhibitor on TGF-beta 2-induced glaucoma-like model revealed that the ROCKi was able to reverse the TGF-beta 2-induced cytoskeletal and ECM rearrangements, while latanoprost only affected the extracellular matrix.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Xin Zhang, Stephane Melik-Parsadaniantz, Christophe Baudouin, Annabelle Reaux-Le Goazigo, Nathan Moreau
Summary: The cornea, a crucial part of the eye, requires constant renewal and efficient healing to maintain ocular homeostasis. The Hedgehog signaling pathway plays a vital role in corneal wound healing, promoting cell proliferation, migration, and maintenance of the corneal epithelial barrier.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Elodie Reboussin, Juliette Buffault, Francoise Brignole-Baudouin, Annabelle Reaux-Le Goazigo, Luisa Riancho, Celine Olmiere, Jose-Alain Sahel, Stephane Melik Parsadaniantz, Christophe Baudouin
Summary: This study demonstrated the neuroprotective and immunomodulatory effects of MSCs on RGCs in an ex vivo neuroretina explant model. However, co-culture with MSCs led to explant edema and the formation of an epiretinal membrane-like phenotype. The use of MSC secretome may offer the beneficial effects of MSCs without their potential adverse effects through paracrine signaling.
JOURNAL OF NEUROINFLAMMATION
(2022)
Review
Ophthalmology
Marc Labetoulle, Andrea Leonardi, Pierre-Jean Pisella, Christophe Baudouin
Summary: Dry eye disease is a chronic inflammatory disease of the ocular surface that requires long-term therapy. Treatment with ciclosporin A 0.1% cationic emulsion can improve clinical signs and symptoms as early as 4 weeks after treatment initiation.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Review
Ophthalmology
Juliette Buffault, Francoise Brignole-Baudouin, Antoine Labbe, Christophe Baudouin
Summary: The purpose of this article is to provide an overview of the existing alternative models for studying the trabecular meshwork (TM). The TM is a complex tissue that regulates aqueous humor outflow and dysfunction of the TM is a major contributor to open-angle glaucoma. Traditional animal models have limitations, leading to a focus on developing alternative in vitro models. These models have shown promise in reducing reliance on animal experimentation in glaucoma research.
CURRENT EYE RESEARCH
(2023)
Article
Ophthalmology
Jason Bacharach, Iqbal Ike K. Ahmed, Elizabeth Sharpe, Michael S. Korenfeld, Steven Zhang, Christophe Baudouin
Summary: This study evaluated the safety and efficacy of a preservative-free formulation of latanoprost (T2345) compared to benzalkonium chloride-preserved latanoprost in patients with primary open-angle glaucoma or ocular hypertension. The results showed that both formulations effectively controlled intraocular pressure, with T2345 demonstrating better safety profile.
CLINICAL OPHTHALMOLOGY
(2023)
Article
Sport Sciences
Morten Carstens Moe, Emin Ozmert, Christophe Baudouin, Abhinav Binadra, Sven Crafoord, Young Jo, Hayyam Kiratli, Melita Moore, Yannis P. Pitsiladis, Udo Rolle, Ben Tan, Ozge Yanik, Richard Budgett, Ugur Erdener, Kathrin Steffen, Lars Engbretsen
Summary: Vision plays a crucial role in athletes' success, with 80% of perceptual input being visual. Eye health and sports medicine are closely intertwined, as the physical nature of sports makes athletes more prone to eye injuries. In addition to injuries, vision problems such as blurred vision and light sensitivity can also affect athletes' performance. Collaboration between sports medicine professionals and ophthalmologists is necessary to provide athletes with appropriate eye care and guidance on eye protection.
BMJ OPEN SPORT & EXERCISE MEDICINE
(2023)
