期刊
NEUROIMAGE
卷 204, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2019.116202
关键词
Lactate; Bicarbonate; Hyperpolarized 13C MRI; Metabolism; ANLS; Aerobic glycolysis
资金
- Canadian Cancer Society [705246]
- Canadian Institutes of Health Research [PJT-152928]
Lactate is now recognized as an important intermediate in brain metabolism, but its role is still under investigation. In this work we mapped the distribution of lactate and bicarbonate produced from intravenously injected C-13-pyruvate over the whole brain using a new imaging method, hyperpolarized C-13 MRI (N = 14, ages 23 to 77). Segmenting the C-13-lactate images into brain atlas regions revealed a pattern of lactate that was preserved across individuals. Higher lactate signal was observed in cortical grey matter compared to white matter and was highest in the precuneus, cuneus and lingual gyrus. Bicarbonate signal, indicating flux of [1-C-13]pyruvate into the TCA cycle, also displayed consistent spatial distribution. One-way ANOVA to test for significant differences in lactate among atlas regions gave F = 87.6 and p < 10(-6). This report of a lactate topography in the human brain and its consistent pattern is evidence of region-specific lactate biology that is preserved across individuals.
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