Article
Neurosciences
Konstantin G. Heimrich, Tino Prell
Summary: PD-MCT is a multidisciplinary inpatient treatment option increasingly applied in Germany, with data showing improvements in motor function for patients. Factors such as age, severity, and depression levels may impact the efficacy of the treatment. Further research is needed to explore the effectiveness of different treatment durations.
Article
Clinical Neurology
Thomas Payne, Toby Burgess, Stephen Bradley, Sarah Roscoe, Matilde Sassani, Mark J. Dunning, Dena Hernandez, Sonja Scholz, Alisdair McNeill, Rosie Taylor, Li Su, Iain Wilkinson, Thomas Jenkins, Heather Mortiboys, Oliver Bandmann
Summary: This study characterized bioenergetic dysfunction in Parkinson's disease using a multimodal approach, and found impaired mitophagy and mitochondrial uncoupling in patient-derived fibroblasts. The study also revealed abnormal phosphocreatine levels and implicated a link between impaired mitophagy and impaired striatal energy homeostasis in early Parkinson's disease.
Article
Nursing
Soontareeporn Meepring, Richard Gray, Yan Li, Grace Ho, Wai-Tong Chien, Daniel Bressington
Summary: People diagnosed with schizophrenia have poor cardiometabolic health, with elevated 10-year cardiovascular disease risk (CVD-R) scores and low quality of life (QOL). This study quantified individual 10-year CVD-R of people diagnosed with early psychosis using the QRISK(R)3 calculator and explored relationships between QOL, CVD-R, and lifestyle factors. Despite positive lifestyle behaviours, participants had elevated CVD-R scores and poor physical health-related QOL.
JOURNAL OF PSYCHIATRIC AND MENTAL HEALTH NURSING
(2022)
Article
Nutrition & Dietetics
Chee Wai Ku, Rachael Si Xuan Loo, Michelle Mei Ying Tiong, Sing Yee Clara Eng, Yin Bun Cheung, Lay See Ong, Kok Hian Tan, Mary Foong-Fong Chong, Jerry Kok Yen Chan, Fabian Yap, See Ling Loy
Summary: This study found associations between nocturnal behaviors and sleep quality in pregnant women. Nocturnal eating and artificial light exposure at night were associated with poor sleep quality, while nocturnal physical activity and screen viewing before bedtime were not related to sleep quality.
Article
Medicine, General & Internal
Laura Heath, Susan A. Jebb, Paul Aveyard, Carmen Piernas
Summary: Controversial evidence suggests that obesity may not pose a risk to health if a person leads a healthy lifestyle and does not have any metabolic complications. This study aimed to investigate the relationship between adherence to healthy lifestyle recommendations and the absence of metabolic complications in relation to cardiovascular disease and mortality rates based on different body mass index (BMI) categories. The findings suggest that meeting healthy lifestyle recommendations or not having metabolic complications can partially offset the risk of developing cardiovascular disease and premature mortality in overweight or obese individuals. Therefore, offering support to achieve and maintain a healthy weight and adopt healthy behaviors is crucial in preventive healthcare.
Article
Nutrition & Dietetics
Raissa Dias Fernandez, Graziela Maria Benevenuto Bezerra, Lane Viana Krejcova, Daniela Lopes Gomes
Summary: This study evaluated the correlation between anthropometric variables and the quality of life in individuals with Parkinson's disease. The results showed that quality of life was worse in terms of body discomfort, social support, and mobility, and it deteriorated with advanced age. There were also correlations between the worst scores in quality of life dimensions and nutritional status.
Article
Medicine, General & Internal
Ling-Yu Qi, Jing-Wen Yang, Shi-Yan Yan, Jian-Feng Tu, Yan-Fen She, Ying Li, Li-Li Chi, Bang-Qi Wu, Cun-Zhi Liu
Summary: Acupuncture is a promising therapy for irritable bowel syndrome (IBS), and this pilot study demonstrates clinically meaningful improvement in IBS symptoms with acupuncture treatment. However, there were no significant differences in efficacy among different acupuncture methods.
Article
Clinical Neurology
Claudio Liguori, Valentino De Franco, Rocco Cerroni, Matteo Spanetta, Nicola Biagio Mercuri, Alessandro Stefani, Mariangela Pierantozzi, Alessandra Di Pucchio
Summary: This study aimed to investigate the impact of sleep problems on the health-related quality of life in patients with Parkinson's Disease, and its correlation with motor impairment and anti-PD therapy. The results showed that sleep problems significantly affect HRQoL and worsen with disease progression.
Article
Clinical Neurology
Alexander Fidao, George Jelinek, Steve Simpson-Yap, Sandra Neate, Nupur Nag
Summary: People with multiple sclerosis (pwMS) have reduced quality of life, and engaging in healthy lifestyle behaviors such as a healthy diet and regular physical activity can improve their quality of life. This study aims to assess the benefits of individual lifestyle behaviors on quality of life, and whether engaging in multiple healthy behaviors concurrently has additive benefits.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Carolin Gabbert, Inke R. Koenig, Theresa Lueth, Meike Kasten, Anne Gruenewald, Christine Klein, Joanne Trinh
Summary: Using generalized linear models, this study found that coffee drinking was associated with reduced swallowing problems, while the dosage and duration of coffee intake were not related to motor or non-motor symptoms. Aspirin intake correlated with increased tremor, problems getting up, light-headedness, and problems remembering. Smoking directly correlated with symptoms such as drooling, swallowing difficulties, and freezing, as well as potentially mood-related symptoms like unexplained pains, memory problems, and feeling sad. Confirmatory and longitudinal studies are needed to further investigate these clinical correlations over time.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Ann Finnimore, Deborah Theodoros, Anna Rumbach
Summary: The impact of PD Check-In on QoL of people with PD is investigated, showing significant treatment effects on DIP, VHI, and VHI-P. However, self-reported outcome measures may not fully capture changes in QoL for people with PD.
Article
Medicine, General & Internal
Shima Gholamalishahi, Seyed Ali Hosseini, Evaristo Ettorre, Alice Mannocci, Chidiebere Emmanuel Okechukwu, Mohamad Javad Keshavarz, Giuseppe La Torre
Summary: There is an association between the levels of physical activity and the lifestyle, life expectancy, and quality of life in patients with Alzheimer's disease.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Konstantin G. Heimrich, Tino Prell
Summary: This article presents demographic and detailed clinical data from 159 patients with Parkinson's disease or atypical Parkinsonian syndromes treated in the Parkinson's disease multimodal complex treatment (PD-MCT) in Germany. The dataset allows determination of the effect of PD-MCT and identification of predictors of a beneficial treatment. The dataset can be used by clinicians and academia for further research and as reference.
Article
Clinical Neurology
Lei Wu, Shiyu Li, Yilin Tang, Xiaoniu Liang, Zhiheng Xu, Tianyu Hu, Xiaoli Liu, Miao Cai, Xuedong Liu
Summary: This study found that there is seasonal fluctuation in the quality of life of patients with Parkinson's disease, with higher scores in the spring and lower scores in the autumn. The determinants of quality of life also vary by season, suggesting that clinicians may need to consider specific factors for different seasons before initiating therapy.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Raphael Scherbaum, Andreas Moewius, Judith Oppermann, Johanna Geritz, Clint Hansen, Ralf Gold, Walter Maetzler, Lars Toenges
Summary: This study found that wearable device-based parameters (DBP) can objectively describe gait and balance impairment in Parkinson's disease (PD) and are correlated with clinical scores. PD-MCT significantly improves gait velocity and stride length and has a positive impact on other DBP. Motor complications and fear of falling may influence the response to PD-MCT. The results of this study suggest that a DBP-based assessment can provide more individualized therapy and improve outcomes for PD patients.
JOURNAL OF NEUROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Nupur Nag, Lavinia Tran, Kathy Fotis, Julian A. Smith, Gilbert C. Shardey, Robert A. Baker, Christopher M. Reid
HEART LUNG AND CIRCULATION
(2019)
Article
Environmental Sciences
Xin Lin, Maggie Yu, George A. Jelinek, Steve Simpson-Yap, Sandra Neate, Nupur Nag
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Clinical Neurology
Jing Wu, George A. Jelinek, Tracey Weiland, Anna Karin Hedstrom, Lars Alfredsson, Sandra Neate, Alysha De Livera, Nupur Nag, Steve Simpson-Yap
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2020)
Article
Clinical Neurology
Alexander Fidao, Alysha De Livera, Nupur Nag, Sandra Neate, George A. Jelinek, Steve Simpson-Yap
Summary: Depression plays a major mediating role in the relationship between fatigue and mental quality of life in people with multiple sclerosis, while physical activity has a minor role. These findings may contribute to the development of treatments to reduce the impacts of fatigue and improve mental quality of life in pwMS.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Article
Health Care Sciences & Services
Nupur Nag, Xin Lin, Maggie Yu, Steve Simpson-Yap, George A. Jelinek, Sandra L. Neate, Michele Levin
Summary: The study found that physical activity was inversely associated with most neurological disorders, while smoking was positively associated with MND and stroke. Additionally, cognitive engagement, face-to-face social interaction, and stress-reducing activities were significantly linked to AD and stroke, while online social interaction and stress reduction activities were associated with MS.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Editorial Material
Clinical Neurology
W. Bevens, K. Gray, S. L. Neate, N. Nag, T. J. Weiland, G. A. Jelinek, S. Simpson-Yap
Summary: The management of multiple sclerosis (MS) has seen significant advancements with the rise of mHealth technologies, but the uptake of mHealth apps among MS patients outside of North America remains unclear. This study, based on the HOLISM cohort, provides insights into mHealth app usage and the characteristics of adopters within a global MS population. Overall, 3.1% of respondents reported using mHealth apps, mainly concentrated in Australasia and North America.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Article
Health Care Sciences & Services
Sandra L. Neate, Angela Donald, George A. Jelinek, Nupur Nag
Summary: This study explored the perspectives of people with multiple sclerosis (pwMS) on lifestyle modification for disease management. Participants faced practical challenges and psychological barriers, but also experienced positive outcomes and personal transformations through engagement in healthy lifestyle behaviors. These findings may lead to more focused qualitative explorations of lifestyle modification experiences and outcomes in MS in the future.
HEALTH EXPECTATIONS
(2022)
Article
Health Care Sciences & Services
Nupur Nag, Maggie Yu, George A. Jelinek, Steve Simpson-Yap, Sandra L. Neate, Hollie K. Schmidt
Summary: This study found that lifestyle behaviors are associated with quality of life in multiple sclerosis patients, and they appear to differ based on MS phenotype; diet, wellness, and physical activity have positive effects on QoL, while vitamin D and omega-3 supplements were not associated with QoL.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Clinical Neurology
Nupur Nag, Xirun Yang, George Jelinek, Sandra Neate, Steve Simpson-Yap
Summary: Undertaking stress-reducing activities or meditation may help reduce depression, fatigue, and enhance mastery in patients with multiple sclerosis. Physical and relaxation activities are associated with lower frequencies of depression, while meditation is associated with lower frequency of depression and higher mastery.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Nutrition & Dietetics
Vivienne Guan, Steve Simpson-Yap, Nupur Nag, George Jelinek, Sandra Neate, Yasmine Probst
Summary: Understanding the dietary characteristics of people living with multiple sclerosis (plwMS) is important for planning nutrition interventions. This study validated the psychometric properties of the Dietary Habits Questionnaire (DHQ) and compared it with repeated 24-hour recall assessments. The DHQ was found to be appropriate for screening participants with relapsing-remitting MS, and five dietary patterns were identified.
Article
Clinical Neurology
Alexander Fidao, George Jelinek, Steve Simpson-Yap, Sandra Neate, Nupur Nag
Summary: People with multiple sclerosis (pwMS) have reduced quality of life, and engaging in healthy lifestyle behaviors such as a healthy diet and regular physical activity can improve their quality of life. This study aims to assess the benefits of individual lifestyle behaviors on quality of life, and whether engaging in multiple healthy behaviors concurrently has additive benefits.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Jeanette C. Reece, Sandra L. Neate, Rebekah A. Davenport, Elasma Milanzi, Nupur Nag, William Bevens, Maggie Yu, George A. Jelinek, Steve Simpson-Yap
Summary: This study aims to investigate the relationship between stressful life events and fatigue and depressive symptoms in people living with multiple sclerosis (plwMS). The findings suggest that the number and load of stressful life events are not associated with higher prevalence of fatigue or depressive symptoms, except for those events with a perceived negative emotional impact.
ACTA NEUROLOGICA BELGICA
(2023)
Article
Clinical Neurology
Steve Simpson-Yap, Sandra L. Neate, Nupur Nag, Yasmine C. Probst, Maggie Yu, George A. Jelinek, Jeanette C. Reece
Summary: This study aimed to examine the relationship between diet quality and subsequent disability in people with MS. The results showed that higher diet quality was associated with lower disability risk, while meat and dairy consumption was associated with increased disability risk.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Health Care Sciences & Services
Muskan Yadav, Sandra Neate, Craig Hassed, Richard Chambers, Sherelle Connaughton, Nupur Nag
Summary: The goal of this research was to identify elements that aided in course completion and implementation of teachings in a digital mindfulness course. The study found that benefits from a virtual community, appeal of content, enablers to participation and implementation, and personal benefits were key themes. Some novel findings include growing together, repeating the course, evidence-based teaching, and immediate benefits on physical and mental well-being.
JMIR FORMATIVE RESEARCH
(2022)
