期刊
NEUROCHEMISTRY INTERNATIONAL
卷 128, 期 -, 页码 94-105出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuint.2019.04.010
关键词
Glucagon-like peptide-1; Bariatric surgery; Feeding behavior; Reward
资金
- NIDA NIH HHS [R21 DA043960] Funding Source: Medline
- NIDCD NIH HHS [R01 DC015388] Funding Source: Medline
- NIDDK NIH HHS [P30 DK058404, R01 DK105847] Funding Source: Medline
Meal ingestion provokes the release of hormones and transmitters, which in turn regulate energy homeostasis and feeding behavior. One such hormone, glucagon-like peptide-1 (GLP-1), has received significant attention in the treatment of obesity and diabetes due to its potent incretin effect. In addition to the peripheral actions of GLP-1, this hormone is able to alter behavior through the modulation of multiple neural circuits. Recent work that focused on elucidating the mechanisms and outcomes of GLP-1 neuromodulation led to the discovery of an impressive array of GLP-1 actions. Here, we summarize the many levels at which the GLP-1 signal adapts to different systems, with the goal being to provide a background against which to guide future research.
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