期刊
AUTOPHAGY
卷 12, 期 5, 页码 900-904出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15548627.2016.1147673
关键词
autophagy; endocytosis; GTPase; intracellular trafficking; neurodegeneration; neuronal maintenance; RAB proteins; stress response
类别
资金
- Science and Engineering Research Board, Department of Science & Technology, Govt. of India
The RAB class of small GTPases includes the major regulators of intracellular communication, which are involved in vesicle generation through fusion and fission, and vesicular trafficking. RAB proteins also play an imperative role in neuronal maintenance and survival. Recent studies in the field of neurodegeneration have also highlighted the process of autophagy as being essential for neuronal maintenance. Here we review the emerging roles of RAB proteins in regulating macroautophagy and its impact in the context of neurodegenerative diseases.
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