期刊
MOVEMENT DISORDERS
卷 34, 期 11, 页码 1728-1734出版社
WILEY
DOI: 10.1002/mds.27853
关键词
deep brain stimulation; directional; Parkinson's disease; stimulation-induced dyskinesia; subthalamic nucleus
BackgroundAcute dyskinesias elicited by STN-DBS, here referred to as stimulation-induced dyskinesias, predict optimal clinical outcome in PD. However, it remains elusive whether stimulation-induced dyskinesias can guide DBS programming. ObjectivesHere, we characterized stimulation-induced dyskinesias clinically and anatomically. We then tested whether dyskinesia-inducing contacts could be effectively programmed using independent current source technology. MethodsWe characterized stimulation-induced dyskinesias with directional and ring stimulation retrospectively in 20 patients. We then localized dyskinesia-inducing contacts by imaging coregistration and eventually programmed those contacts. ResultsWe elicited dyskinesias in half of our patients. Dyskinesia-inducing contacts were mainly directional and were all located ventrally within the dorsolateral motor STN. When these dyskinesia-inducing contacts were programmed using independent current source technology, dyskinesia disappeared and robust antibradykinetic effects were obtained. ConclusionWe confirm that stimulation-induced dyskinesias are helpful clinical observations, which may guide programming of directional STN-DBS in PD. (c) 2019 International Parkinson and Movement Disorder Society
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