期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 25, 期 12, 页码 2550-2554出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2015.04.049
关键词
Cytotoxicity; Haemolytic activity; Pulsatilla saponin A; Pulsatilla saponin D; Derivatives
资金
- National Natural Science Foundation of China [81302660]
- Provincial Universities of Jiangsu Province Natural Science Foundation [13KJB350006]
- Colleges and Universities in Jiangsu Province [CXZZ13_0842]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
The strong haemolytic activity of Pulsatilla saponin A (PSA), D (PSD) hampered their clinical development of antitumor agents. In order to solve this problem, C-28 position modification derivatives of PSA/PSD were synthesized. The cytotoxicity and haemolytic activity of these compounds were evaluated. Structure-activity relationship and structure-toxicity relationship had been observed. The mice acute toxicity of compound 11 was reduced greatly than that of PSA. This study indicates that compound 11 may represent an interesting class of potent antitumor agents from triterpenoid saponins avoiding the haemolysis problem. The present study has important significance for the development of antitumor saponins. (C) 2015 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据