First High-Resolution Crystal Structures of the Glucocorticoid Receptor Ligand-Binding Domain–Peroxisome Proliferator-Activated γ Coactivator 1-α Complex with Endogenous and Synthetic Glucocorticoids

Development of Dihydrodibenzooxepine Peroxisome Proliferator-Activated Receptor (PPAR) Gamma Ligands of a Novel Binding Mode as Anticancer Agents: Effective Mimicry of Chiral Structures by Olefinic E/Z-Isomers

(2018) Keisuke Yamamoto et al.   JOURNAL OF MEDICINAL CHEMISTRY

A discontinuous autoinhibitory module masks the A1 domain of von Willebrand factor

(2017) W. Deng et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Structure and Dynamics of the Liver Receptor Homolog 1–PGC1 α Complex

(2017) Suzanne G. Mays et al.   MOLECULAR PHARMACOLOGY

Structural Analysis of the Glucocorticoid Receptor Ligand-Binding Domain in Complex with Triamcinolone Acetonide and a Fragment of the Atypical Coregulator, Small Heterodimer Partner

(2017) Emily R. Weikum et al.   MOLECULAR PHARMACOLOGY

Glucocorticoid receptor control of transcription: precision and plasticity via allostery

(2017) Emily R. Weikum et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Distinct Roles for Conformational Dynamics in Protein-Ligand Interactions

(2016) Xu Liu et al.   STRUCTURE

Structures and mechanism for the design of highly potent glucocorticoids

(2014) Yuanzheng He et al.   CELL RESEARCH

The ensemble nature of allostery

(2014) Hesam N. Motlagh et al.   NATURE

Conformation-independent structural comparison of macromolecules withProSMART

(2014) Robert A. Nicholls et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Glucocorticoid receptor signaling in health and disease

(2013) Mahita Kadmiel et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Deciphering Modern Glucocorticoid Cross-pharmacology Using Ancestral Corticosteroid Receptors

(2012) Jeffrey A. Kohn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Ligand and Receptor Dynamics Contribute to the Mechanism of Graded PPARγ Agonism

(2012) Travis S. Hughes et al.   STRUCTURE

Transcriptional integration of mitochondrial biogenesis

(2012) Richard C. Scarpulla et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Enhancing the Stability and Solubility of the Glucocorticoid Receptor Ligand-Binding Domain by High-Throughput Library Screening

(2010) Tobias Seitz et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular Switch in the Glucocorticoid Receptor: Active and Passive Antagonist Conformations

(2009) Guillaume A. Schoch et al.   JOURNAL OF MOLECULAR BIOLOGY

An epistatic ratchet constrains the direction of glucocorticoid receptor evolution

(2009) Jamie T. Bridgham et al.   NATURE

Stress and disorders of the stress system

(2009) George P. Chrousos   Nature Reviews Endocrinology

Protein Dynamism and Evolvability

(2009) N. Tokuriki et al.   SCIENCE

Structural and Biochemical Basis for the Binding Selectivity of Peroxisome Proliferator-activated Receptor γ to PGC-1α

(2008) Yong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY