Article
Chemistry, Multidisciplinary
Yingzheng Zhao, Lanzi Luo, Lantian Huang, Yingying Zhang, Mengqi Tong, Hanxiao Pan, Jianxun Shangguan, Qing Yao, Shihao Xu, Helin Xu
Summary: This study developed a new method, PNO gel, for treating diabetic foot ulcer. The results demonstrated that PNO can accelerate wound healing, reduce inflammation, and promote angiogenesis.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Materials Science, Biomaterials
Yu Wu, Tangzhao Liang, Ying Hu, Shihai Jiang, Yuansen Luo, Chang Liu, Guo Wang, Jing Zhang, Tao Xu, Lei Zhu
Summary: The study utilized 3D bioprinting to create 3D-ADSCs/NO hydrogel scaffolds, which enhanced migration and angiogenesis of HUVECs, accelerated burn wound healing in mice by promoting faster epithelialization and collagen deposition, and increased neovascularization through the VEGF signaling pathway, suggesting the scaffold as a promising strategy for treating severe burns.
REGENERATIVE BIOMATERIALS
(2021)
Article
Chemistry, Applied
Yuanping Hao, Wenwen Zhao, Hao Zhang, Weiping Zheng, Qihui Zhou
Summary: The BP/CS-bFGF hydrogel dressing prepared in this study shows great potential for diabetic chronic wound management. It has strong wet-tissue adhesion, self-mending, and antibacterial properties, and displays fast hemostasis capacity. The hydrogel dressing significantly accelerates full-thickness diabetic wound repair by increasing the production of Ki67, promoting the generation of epithelialization and collagen, inducing the formation of hair follicles, and enhancing neovascularization.
CARBOHYDRATE POLYMERS
(2022)
Article
Pharmacology & Pharmacy
Maya Ben-Yehuda Greenwald, Yu-Hang Liu, Weiye Li, Paul Hiebert, Maria Zubair, Hermann Tenor, Tobias Braun, Reto Naef, Daniel Razansky, Sabine Werner
Summary: Chronic non-healing wounds are a major health problem with limited therapeutic options. This study found that topical application of a nitric oxide-releasing drug in a hydrogel promoted wound repair and improved blood perfusion in mice.
Article
Biochemistry & Molecular Biology
Anna T. Hofmann, Paul Slezak, Sabine Neumann, James Ferguson, Heinz Redl, Rainer Mittermayr
Summary: In this study, the dose-dependent effects of rhVEGF(165) in fibrin sealant on ischemic and non-ischemic wounds were investigated. Lower doses of VEGF were found to promote angiogenesis and wound healing, and the use of fibrin sealant alone accelerated wound closure.
Article
Engineering, Multidisciplinary
Jiahui He, Zhenlong Li, Jiaxin Wang, Tongyang Li, Jueying Chen, Xianglong Duan, Baolin Guo
Summary: This study developed a multifunctional hydrogel with antibacterial, antioxidant, self-healing, and conductive properties. The hydrogel is capable of releasing nitric oxide (NO) under near-infrared (NIR) laser irradiation, which promotes the healing of diabetic wounds.
COMPOSITES PART B-ENGINEERING
(2023)
Article
Polymer Science
Jingying Zhang, Guannan Zhang, Yong Wang, Xiujun Qin, Ying Lu, Zhifang Wu, Chuxin Zhang, Li Xu, Jiali Han, Shuai Yang, Jianbo Song, Sijin Li
Summary: In this study, a hydrogel containing L-arginine-modified carboxymethyl cellulose and chitosan was developed, which exhibited antibacterial and nitric oxide-release properties and accelerated wound healing by promoting vascular reconstruction. The hydrogel showed good degradability and biocompatibility, as well as excellent inhibitory effects against Staphylococcus aureus. Furthermore, the hydrogel released nitric oxide, which benefited angiogenesis and promoted wound healing. This safe, antibacterial, and collaborative system has great potential for application in skin tissue engineering.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Shun Yao, Yuetong Wang, Junjie Chi, Yunru Yu, Yuanjin Zhao, Yuan Luo, Yongan Wang
Summary: A novel porous metal-organic framework (MOF) microneedle (MN) patch enabling photothermal-responsive nitric oxide (NO) delivery for promoting diabetic wound healing is presented. The NO-loadable copper-benzene-1,3,5-tricarboxylate (HKUST-1) MOF encapsulated with graphene oxide (GO) facilitates controlled release of NO molecules, resulting in accelerated vascularization, tissue regeneration, and collagen deposition in diabetic wound healing.
Article
Pharmacology & Pharmacy
Amr Hassan, Dalia Elebeedy, Emadeldin R. Matar, Aly Fahmy Mohamed Elsayed, Ahmed I. Abd El Maksoud
Summary: This study fabricated green zinc oxide nanorods using albumin eggshell as a bio-template and investigated its angiogenic potential through experiments. The results demonstrated that zinc oxide nanorods induce angiogenesis through mechanisms such as inducing VEGF expression, providing a new approach for developing materials for wound healing.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Gina Tavares, Patricia Alves, Pedro Simoes
Summary: This article discusses the application of nitric oxide in wound healing, with hydrogels being studied as carriers for storing and delivering NO, showing promising results in improving wound healing, controlling and sustaining NO release, and bactericidal properties.
Article
Materials Science, Biomaterials
Jie Dou, Rong Yang, Xingxing Jin, Pengfei Li, Xiao Han, Lijuan Wang, Bo Chi, Jian Shen, Jiang Yuan
Summary: Nitric oxide plays a crucial role in wound healing, and the PU/KSNO biocomposite mats show excellent cytocompatibility and antibacterial properties, promoting the wound healing process.
REGENERATIVE BIOMATERIALS
(2022)
Review
Pharmacology & Pharmacy
Ugo D'Amora, Sawsan Dacrory, Mohamed Sayed Hasanin, Angela Longo, Alessandra Soriente, Samir Kamel, Maria Grazia Raucci, Luigi Ambrosio, Stefania Scialla
Summary: Graphene oxide (GO) and its reduced form (rGO) have attracted significant interest in the field of biomedical applications, particularly in wound healing, due to their unique physico-chemical properties. The large surface area and functional groups of GO and rGO enable their easy dispersion within various polymeric matrices, resulting in the development of advanced hybrid nanocomposites with tailored properties. These nanocomposites have demonstrated efficient antimicrobial and angiogenic properties, making them advantageous for wound care management. This review discusses the relationship between the structural and physico-chemical properties of GO or rGO/cellulose nanocomposites and their effects on antimicrobial and angiogenic mechanisms in wound healing.
Article
Chemistry, Multidisciplinary
Jie Yu, Ruili Zhang, Baihang Chen, Xuelan Liu, Qian Jia, Xiaofei Wang, Zuo Yang, Pengbo Ning, Zhongliang Wang, Yang Yang
Summary: This study establishes a system consisting of a degradable hydrogel dressing that reacts to reactive oxygen species, an encapsulated biosafe nitric oxide donor, and a low concentration of hydrogen peroxide as a disinfectant. This system promotes sustainable wound healing and disinfection by generating nitric oxide and mediating cell migration and collagen synthesis. It also demonstrates synergistic antibacterial properties against antibiotic-resistant bacteria.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Biotechnology & Applied Microbiology
Fei Fan, Sanjoy Saha, Donny Hanjaya-Putra
Summary: Hydrogels play a crucial role in wound healing by supporting a hydrated environment and promoting better healing outcomes through the incorporation of biomolecules and supporting cells. Various types of hydrogels have been developed and modified to match different stages of wound healing, with challenges related to adoption and future perspectives discussed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Jiafu Cao, Shwe Phyu Hlaing, Jihyun Kim, Eun Hee Lee, Seok Hee Kang, Suck Won Hong, In-Soo Yoon, Hwayoung Yun, Yunjin Jung, Jin-Wook Yoo, Juho Lee
Summary: In this study, researchers developed surface-modified nanoparticles that have enhanced antibacterial activity and wound healing capability. These nanoparticles can bind to bacterial surfaces and release nitric oxide, exhibiting high bactericidal activity against drug-resistant bacteria and promoting wound healing in an infected wound model.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Gastroenterology & Hepatology
Hsi-Chien Huang, Yun-Chieh Sung, Chung-Pin Li, Dehui Wan, Po-Han Chao, Yu-Ting Tseng, Bo-Wen Liao, Hui-Teng Cheng, Fu-Fei Hsu, Chieh-Cheng Huang, Yi-Ting Chen, Yu-Hui Liao, Hsin Tzu Hsieh, Yu-Chuan Shih, I-Ju Liu, Han-Chung Wu, Tsai-Te Lu, Jane Wang, Yunching Chen
Summary: This study aimed to develop a nanotherapy that delivers TRAIL and NO to PDAC to overcome stromal barriers and improve therapeutic efficacy. Results showed that delivering NO to the PDAC tumour stroma reprogrammed stellate cells, reduced desmoplasia, and enhanced TRAIL penetration, leading to significant antitumour effects.
Article
Health Care Sciences & Services
Chia-Yi Lee, Tsai-Te Lu, Yaa-Jyuhn James Meir, Kuan-Jen Chen, Chun-Fu Liu, Chao-Min Cheng, Hung-Chi Chen
Summary: This study aimed to determine the timing of Nd:YAG laser capsulotomy on CDVA, IOP, and SE in patients with PCO. The results showed that Nd:YAG laser capsulotomy performed within one year after cataract surgery may lead to significant hyperopic change, in which ACD alteration affects the hyperopic shift significantly.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Engineering, Environmental
Priya Vijayaraghavan, Yen-Yun Wang, Sathyadevi Palanisamy, Li-Yun Lee, Yuk-Kwan Chen, Shey-Cherng Tzou, Shyng-Shiou F. Yuan, Yun-Ming Wang
Summary: A highly efficient electrochemical impedimetric immunosensor is developed for the detection of oral squamous cell carcinoma. The immunosensor, based on amino-functionalized FeCo metal-organic frameworks grown on porous nickel foam solid supports, exhibits excellent selectivity and sensitivity. It is capable of detecting oral cancer in real human blood samples using electrochemical impedance spectroscopy and shows good correlation with the standard method.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Inorganic & Nuclear
Vladimir Pelmenschikov, Chien-Hong Chen, I-Jui Hsu, Ulf-Peter Apfel, Giorgio Caserta, Lars Lauterbach, Tsai-Te Lu, Yu-Ting Tseng, Linda Iffland-Mu''hlhaus, Donato Calabrese, Yu-Che Chang, Konstantin Laun, Chih-Wen Pao, Ilya Sergueev, Yoshitaka Yoda, Wen-Feng Liaw
Summary: Efforts are being made to develop earth-abundant metal catalysts for dehydrogenation/hydrolysis of amine boranes. In this study, complex 3-K-crown was explored as a pre-catalyst for the dehydrogenation of DMAB, and the transformation of 3-K-crown into intermediate A during H-2 generation was supported by experimental and computational results. The substrate-gated transformation of pre-catalyst 3 into intermediate A was also observed in the reaction of complex 4-Na-crown with CO as an alternative synthetic route.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Tsung-Ying Lee, Hung-Hsun Lu, Hui-Teng Cheng, Hsi-Chien Huang, Yun-Jen Tsai, I-Hsiang Chang, Chao-Peng Tu, Chieh-Wei Chung, Tsai-Te Lu, Chi-How Peng, Yunching Chen
Summary: A stimuli-responsive drug carrier was developed to deliver nitric oxide (NO) for the treatment of kidney fibrosis. The nanoparticles effectively inhibited the activation of myofibroblasts and collagen I synthesis, resulting in a significant reduction in fibrotic area in a mouse model. This strategy holds therapeutic potential for the treatment of renal fibrosis and requires further investigation.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Microbiology
Cheng-Han Chen, Yu-Hsiang Liao, Michael Muljadi, Tsai-Te Lu, Chao-Min Cheng
Summary: To ensure clean drinking water, a colorimetric assay for rapid microorganism detection using a metabolism-based approach was developed. The assay leveraged the reaction between viable microorganisms and a combination of reagents, resulting in a color change. This novel assay demonstrated its potential for practical and medical use for microorganism detection.
Article
Biochemistry & Molecular Biology
Wen-Han Chuang, Yu-Ting Chou, Yi-Hong Chen, Ting-Han Kuo, Wen-Feng Liaw, Tsai-Te Lu, Chih-Fei Kao, Yun-Ming Wang
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive impairment, memory loss, and behavioral deficits. The aggregation of β-amyloid(1-42) (Aβ(1-42)) is a significant cause of AD pathogenesis. Despite extensive research, current treatment efficacy for AD remains insufficient. Nitric oxide (NO) has a neuroprotective role in the central nervous system by inhibiting Aβ aggregation and rescuing memory and learning deficits through the NO signaling pathway. Targeting the NO pathway may be a therapeutic option, but the limited half-life of NO in the biological system poses a challenge. This study explored a biomimetic dinitrosyl iron complex (DNIC-COOH) that can stably deliver NO to address this issue. Adding DNIC-COOH to neuron-like cells and primary cortical neurons along with Aβ(1-42) demonstrated its ability to protect neuronal cells, enhance neuronal functions, and facilitate Aβ(1-42) degradation through the NO-sGC-cGMP-AKT-GSK3β-CREB/MMP-9 pathway.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Biochemical Research Methods
Tarik Abdelkareem Mostafa Amer, Sathyadevi Palanisamy, Pamela Berilyn So, Priya Vijayaraghavan, Shey-Cherng Tzou, Tsai-Te Lu, Chia-Her Lin, Yun-Ming Wang
Summary: The use of MOF-based nanomaterials in bioapplications has increased due to their biocompatibility, drug degradation, tunable porosity, and intrinsic biodegradability. Bimetallic MOFs embedded with and without folic acid were synthesized and used for tissue sealing and repairing incisional wound sites in mice models. These materials displayed antibacterial properties and enhanced wound healing rates, and also showed potential for cell migration and angiogenesis.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Cheng-Jhe Liao, Yu-Ting Tseng, Yu-An Cheng, Loise Ann Dayao, Linda Iffland-Muehlhaus, Leland B. Gee, Ryan D. Ribson, Ting-Shan Chan, Ulf-Peter Apfel, Tsai-Te Lu
Summary: This study discovered low-molecular-weight/protein-bound dinitrosyl iron complexes (DNICs) as a metallocofactor assembled under inflammatory conditions with elevated levels of nitric oxide (NO) and superoxide (O-2(-)). The study found that the supporting/bridging ligands in DNICs control the selective monooxygenation of NO and redox interconversion between O-2(-) and O-2.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Yi-Chieh Chan, Ya-Hui Lin, Hsiu-Ching Liu, Ru-Siou Hsu, Min-Ren Chiang, Li-Wen Wang, Tsu-Chin Chou, Tsai-Te Lu, I-Chi Lee, Li-An Chu, Shang-Hsiu Hu
Summary: A magnetoelectric massager strategy is proposed for brain function restoration in traumatic brain injury through alternating magnetic field-triggered nitric oxide release and electrical stimulation. NO release from an NO donor (GSNO) through electrical stimulation significantly promotes neural stem cell (NSC) synapse differentiation and growth. In combination with in vivo traumatic brain injury, this strategy allows for the inhibition of inflammation, angiogenesis, and neuronal interrogation mediated by NO and electrical stimulation.
Article
Dentistry, Oral Surgery & Medicine
Shyng-Shiou F. Yuan, Chang-Wei Su, Leong-Perng Chan, Hieu D. H. Nguyen, Yuk-Kwan Chen, Je-Kang Du, Kuang-Hung Cheng, Yen-Yun Wang
Summary: The expression of IL17RB in oral cancer tissues is higher than in normal tissues and is positively correlated with tumor characteristics and poor prognosis. In vitro studies show that IL17RB expression is positively correlated with cell migration ability in OSCC cell lines.
Article
Oncology
Terutsugu Koya, Kenichi Yoshida, Misa Togi, Yo Niida, Sumihito Togi, Hiroki Ura, Shuichi Mizuta, Tomohisa Kato Jr, Sohsuke Yamada, Takeo Shibata, Yi-Chang Liu, Shyng-Shiou Yuan, Deng-Chyang Wu, Hirohito Kobayashi, Taiju Utsugisawa, Hitoshi Kanno, Shigetaka Shimodaira
Summary: This study developed highly potent human platelet lysate-induced antigen-presenting cells (HPL-APCs) and aimed to verify the safety, tolerability, and immunoinducibility of HPL-APCs loaded with cancer candidate antigens. Interim analysis confirmed safety and tolerability in three patients and immune response in two completed cases. This study demonstrates the feasibility and immunoinducibility of personalized cancer vaccines using HPL-APCs and highlights the potential for further antitumor activity through optimized combination therapies.
Article
Materials Science, Biomaterials
Shih-Hao Chang, Hui-Yi Hsiao, Yi-Hong Chen, Ming-Huei Cheng, Jia-Wei Liu, Hsiao-Jo Huang, Yu-Ting Chou, Tarik Abdelkareem Mostafa Amer, Priya Vijayaraghavan, Sathyadevi Palanisamy, Yun-Ming Wang, Tsai-Te Lu
Summary: Craniofacial/jawbone deformities pose a significant challenge in facial/dental restoration. To improve bone regeneration, a study explored the functional conjugation of nitric oxide (NO)-delivery dinitrosyl iron complex (DNIC) with bone graft materials. The results showed that DNIC-COOH, with its steady kinetics for cellular uptake and intracellular release of NO, exhibited favorable biocompatibility and proliferation effects on osteoblasts and endothelial cells. In an in vivo model, DNIC-DBBM/DNIC-TCP enhanced bone and blood vessel formation, indicating its potential for clinical application in regenerative medicine.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
