Article
Microbiology
Shuying He, Shudan Cui, Wen Song, Yonghong Jiang, Hongsheng Chen, Dongjiang Liao, Xinpeng Lu, Jun Li, Xueqing Chen, Liang Peng
Summary: IL-17 plays a crucial role in nonalcoholic fatty liver disease (NAFLD) through the modulation of gut microbiota. T(H)17 cells restore the intestinal barrier, while dysbiosis of the microbiota leads to intestinal injury and disease progression.
Article
Multidisciplinary Sciences
Joshua B. R. White, Augustinas Silale, Matthew Feasey, Tiaan Heunis, Yiling Zhu, Hong Zheng, Akshada Gajbhiye, Susan Firbank, Arnaud Basle, Matthias Trost, David N. Bolam, Bert van den Berg, Neil A. Ranson
Summary: This study reveals the formation of stable glycan-utilizing machines, called utilisomes, which consist of glycoside hydrolases and bacterial outer membrane proteins in Bacteroides thetaiotaomicron. The structures of these utilisomes show the mechanism and function of the interactions between their components.
Article
Biochemistry & Molecular Biology
Dong-ha Kim, Yejin Sim, Jin-hyeon Hwang, In-Sook Kwun, Jae-Hwan Lim, Jihoon Kim, Jee-In Kim, Moon-Chang Baek, Mohammed Akbar, Wonhyo Seo, Do-Kyun Kim, Byoung-Joon Song, Young-Eun Cho
Summary: The study found that ellagic acid (EA) can be used as a dietary supplement for patients with alcoholic hepatitis. It can significantly reduce binge alcohol-induced gut barrier dysfunction, endotoxemia, and inflammatory liver injury by inhibiting gut dysbiosis and oxidative stress.
Article
Endocrinology & Metabolism
Xiaolin Ye, Yang Liu, Jiajin Hu, Yanyan Gao, Yanan Ma, Deliang Wen
Summary: This study investigated the effects of chlorogenic acid (CGA) found in coffee on obesity and metabolic endotoxemia. CGA was found to prevent weight gain, improve intestinal barrier function, and prevent metabolic disorders and endotoxemia through altering the gut microbiota composition. The study concludes that CGA-induced changes in the gut microbiota play a key role in inhibiting metabolic endotoxemia in high-fat diet-fed mice.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Evy Goossens, Jianhui Li, Chana Callens, Nathalie Van Rysselberghe, Hannele Kettunen, Juhani Vuorenmaa, Natalia Garcia Gonzalez, Claude Libert, Richard Ducatelle, Filip Van Immerseel
Summary: The acute stage of SIRS induces dysbiosis of the small intestinal and respiratory microbiome, which are associated with systemic inflammation and organ failure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Ozren Stojanovic, Jordi Altirriba, Dorothee Rigo, Martina Spiljar, Emilien Evrard, Benedek Roska, Salvatore Fabbiano, Nicola Zamboni, Pierre Maechler, Francoise Rohner-Jeanrenaud, Mirko Trajkovski
Summary: Intestinal surface changes in size and function are influenced by food excess and dietary lipids, with intestinal PPAR alpha playing a crucial role in adaptive increase of villi length and function. This research suggests that targeting intestinal PPAR alpha could be a potential strategy for treating obesity by improving lipid metabolism and reducing adiposity.
NATURE COMMUNICATIONS
(2021)
Article
Nutrition & Dietetics
Guojun Wu, Hiba R. Tawfeeq, Atreju I. Lackey, Yinxiu Zhou, Zoe Sifnakis, Sophia M. Zacharisen, Heli Xu, Justine M. Doran, Harini Sampath, Liping Zhao, Yan Y. Lam, Judith Storch
Summary: This study investigated the effects of LFABP and IFABP deficiency on the gut microbiota in mice, and found that these changes were associated with phenotypic changes induced by a high-fat diet.
Article
Nutrition & Dietetics
Huimin Zhang, Zhenxia Xu, Wenchao Chen, Fenghong Huang, Shouwen Chen, Xu Wang, Chen Yang
Summary: In this study, it was found that supplementation with algal oil could alleviate intestinal damage and inflammation induced by ceftriaxone sodium in mice. The algal oils inhibited the activity of pro-inflammatory cytokines TNF-alpha, IL-6, and MPO, increased the expression of tight junction protein ZO-1, and regulated the composition of gut microbiota.
FRONTIERS IN NUTRITION
(2023)
Article
Environmental Sciences
Rili Hao, Xing Zhou, Xinyue Zhao, Xiaqing Lv, Xiangyang Zhu, NaNa Gao, Yang Jiang, Maoyu Wu, Dongxiao Sun-Waterhouse, Dapeng Li
Summary: In this study, it was demonstrated that the polysaccharide from Flammulina velutipes can alleviate CdCl2-induced intestinal damage by regulating intestinal inflammation and gut microbiota-related energy metabolism. This finding is of great significance for developing alternative strategies to prevent CdCl2-caused injury.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Biochemistry & Molecular Biology
Sebastian Stricker, Torsten Hain, Cho-Ming Chao, Silvia Rudloff
Summary: The intestinal and respiratory microbiota play a significant role in pediatric lung diseases, and the concept of the gut-lung axis has been established to describe their mutual influence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Chaima Ezzine, Lea Loison, Nadine Montbrion, Christine Bole-Feysot, Pierre Dechelotte, Moise Coeffier, David Ribet
Summary: Short chain fatty acids and branched chain fatty acids produced by the gut microbiota can increase protein SUMOylation, thus affecting intestinal physiology and reducing inflammation.
Article
Nutrition & Dietetics
Marta Calatayud, Rosa Aragao Boerner, Jonas Ghyselinck, Lynn Verstrepen, Jelle De Medts, Pieter Van den Abbeele, Claire L. Boulange, Sarah Priour, Massimo Marzorati, Sami Damak
Summary: This research investigated the effects of water kefir on gut microbiota, epithelial barrier function, and immunomodulation using in vitro tools. Water kefir increased beneficial short-chain fatty acid production and improved gut microbiota composition, showing potential health benefits for humans.
Article
Chemistry, Multidisciplinary
Boya Zhang, Xingpei Fan, Haining Du, Meimei Zhao, Ziyi Zhang, Ruijiao Zhu, Bo He, Yuxia Zhang, Xiaoyan Li, Jiaxin Li, Ning Gu
Summary: Foodborne carbon dots (CDs) are an emerging food nanocontaminant that pose an increasing risk of metabolic toxicity in mammals. Chronic CD exposure disrupts the gut-liver axis in mice, leading to glucose metabolism disorders. CD exposure alters the gut microbiota composition, increasing pro-inflammatory bacteria and inducing intestinal inflammation, systemic inflammation, and hepatic insulin resistance.
Article
Agriculture, Multidisciplinary
Yuxin Cheng, Yuting Huang, Kunyuan Liu, Siyi Pan, Zhiguo Qin, Ting Wu, Xiaoyun Xu
Summary: Selenium is an essential trace element with powerful antioxidant properties, and the Cardamine hupingshanensis aqueous extract (CE), rich in selenium, has the potential to improve intestinal redox status and regulate gut microbiota. The study shows that CE supplementation can enhance antioxidant enzyme activities, increase short-chain fatty acids concentration, and improve intestinal morphology in Se-deficient rats. Additionally, CE also leads to changes in intestinal microbiota composition, highlighting its potential in regulating gut health.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Biotechnology & Applied Microbiology
Cong He, Huan Wang, Chen Yu, Chao Peng, Xu Shu, Wangdi Liao, Zhenhua Zhu
Summary: Intestinal tuberculosis (ITB) and Crohn's disease (CD) have distinct gut microbiota profiles, with ITB showing a dominance of Proteobacteria and reduction of Firmicutes, as well as altered functional modules associated with inflammation. In contrast, CD is characterized by lower alpha diversity and increased abundance of specific bacteria, allowing for clear differentiation from ITB.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Food Science & Technology
Carolina de Weerth, Anna-Katariina Aatsinki, Meghan B. Azad, Frank F. Bartol, Lars Bode, Maria Carmen Collado, Amanda M. Dettmer, Catherine J. Field, Meagan Guilfoyle, Katie Hinde, Aniko Korosi, Hellen Lustermans, Nurul Husna Mohd Shukri, Sophie E. Moore, Shikha Pundir, Juan Miguel Rodriguez, Carolyn M. Slupsky, Sarah Turner, Johannes B. van Goudoever, Anna Ziomkiewicz, Roseriet Beijers
Summary: Human milk is a complex liquid food that is customized to meet the needs of infants. The non-nutrient bioactives in milk have an impact on child cognitive and behavioral development, a process known as 'Lactocrine Programming'. This review discusses the links between human milk composition and child cognitive and behavioral development, and provides recommendations for future studies.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lihua Sun, Richard Aarnio, Erika Atencio Herre, Salli Karna, Senthil Palani, Helena Virtanen, Heidi Liljenback, Jenni Virta, Aake Honkaniemi, Vesa Oikonen, Chunlei Han, Sanna Laurila, Marco Bucci, Semi Helin, Emrah Yatkin, Lauri Nummenmaa, Pirjo Nuutila, Jing Tang, Anne Roivainen
Summary: Photoperiod affects the availability of mu-opioid receptors (MOR) in brown adipose tissue (BAT), and sympathetic innervation may regulate thermogenesis via the peripheral MOR system.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Sport Sciences
Tanja Sjoros, Saara Laine, Taru Garthwaite, Henri Vaha-Ypya, Eliisa Loyttyniemi, Mikko Koivumaki, Noora Houttu, Kirsi Laitinen, Kari K. Kalliokoski, Harri Sievanen, Tommi Vasankari, Juhani Knuuti, Ilkka H. A. Heinonen
Summary: This study aimed to investigate whether a reduction in daily sedentary behavior improves insulin sensitivity in adults with metabolic syndrome. The results showed that reducing sedentary behavior by 40 minutes per day, while increasing moderate-to-vigorous physical activity by 20 minutes per day, resulted in slightly decreased fasting insulin levels, but had no effects on insulin sensitivity or body adiposity.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Nutrition & Dietetics
Carles Lerin, Maria Carmen Collado, Elvira Isganaitis, Erland Arning, Brandi Wasek, Ellen W. Demerath, David A. Fields, Teodoro Bottiglieri
Summary: The concentration of S-adenosylmethionine (SAM) is higher in breast milk compared to other biofluids and is absent in infant milk formulas. This may suggest a strong demand for this metabolic nutrient during infant early growth.
Article
Biochemistry & Molecular Biology
Serena Manara, Marta Selma-Royo, Kun D. Huang, Francesco Asnicar, Federica Armanini, Aitor Blanco-Miguez, Fabio Cumbo, Davide Golzato, Paolo Manghi, Federica Pinto, Mireia Valles-Colomer, Loredana Amoroso, Maria Valeria Corrias, Mirco Ponzoni, Roberta Raffaeta, Raul Cabrera-Rubio, Mari Olcina, Edoardo Pasolli, Maria Carmen Collado, Nicola Segata
Summary: Findings reveal that modern westernized lifestyles have an impact on mother-infant microbiome sharing, with differences in composition and diversity observed in newborns compared to non-westernized populations.
Article
Radiology, Nuclear Medicine & Medical Imaging
Lihua Sun, Sanna Laurila, Minna Lahesmaa, Eleni Rebelos, Kirsi A. Virtanen, Katharina Schnabl, Martin Klingenspor, Lauri Nummenmaa, Pirjo Nuutila
Summary: This study reveals that secretin can induce satiation by modulating the metabolic communication between brown adipose tissue and the brain. Secretin regulates the brain response to appetite-inducing stimuli and improves inhibitory control, leading to increased feelings of fullness.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Multidisciplinary Sciences
Christine Bauerl, Joao Zulaica, Luciana Rusu, Alicia Rodriguez Moreno, Francisco J. Perez-Cano, Carles Lerin, Desiree Mena-Tudela, Laia Aguilar-Camprubi, Anna Parra-Llorca, Cecilia Martinez-Costa, Ron Geller, Maria Carmen Collado
Summary: Breastmilk contains antibodies that can neutralize SARS-CoV-2, with higher neutralizing titers in milk from naturally infected women and positive correlation with immunoglobulin A levels. There are differences in neutralizing antibody production between mRNA-based vaccines and the ChAdOx1 COVID-19 vaccine. These findings suggest that breastmilk from vaccinated or naturally infected women may provide protection against SARS-CoV-2 infection to breastfed infants.
Review
Pediatrics
Anna Parra-Llorca, Alejandro Pinilla-Gonzlez, Laura Torrejon-Rodriguez, Inmaculada Lara-Canton, Julia Kuligowski, Maria Carmen Collado, Maria Gormaz, Marta Aguar, Maximo Vento, Eva Serna, Maria Cernada
Summary: This narrative review discusses the mechanisms of bacterial sepsis in preterm infants, a prevalent and serious illness. It examines the role of the innate immune response and oxidative stress in the pathogenesis and their potential as early biomarkers. Furthermore, it addresses the impact of sepsis-induced mechanisms on dysbiosis and changes in neonatal microbiota.
Article
Endocrinology & Metabolism
Tanja Sjoeros, Saara Laine, Taru Garthwaite, Henri Vaha-Ypya, Mikko Koivumaki, Olli Eskola, Eliisa Loyttyniemi, Noora Houttu, Kirsi Laitinen, Kari K. Kalliokoski, Harri Sievanen, Tommi Vasankari, Juhani Knuuti, Ilkka H. A. Heinonen
Summary: Interventions aimed at reducing sedentary behavior for 1 hour per day can improve insulin sensitivity in the weight-bearing thigh muscles of sedentary adults with metabolic syndrome. However, this intervention does not have a significant impact on overall muscle and whole body insulin sensitivity.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Chemistry, Applied
Min Wang, Jianjun Zhou, Noelia Pallares, Juan Manuel Castagnini, Maria Carmen Collado, Francisco J. Barba
Summary: The recovery of antioxidants and minerals, as well as the content of contaminants, in rainbow trout and sole side streams extracts obtained by pressurized liquid extraction (PLE) were evaluated and the effect of gastrointestinal digestion was tested. No mycotoxins were detected in the extracts, and heavy metals were found to be below maximum legislated limits. PLE significantly increased the antioxidant capacity recovery and the contents of certain minerals in the extracted samples. The bioaccessibility of Mg, Ca, and Fe was lower in sole extracts compared to rainbow trout.
Article
Endocrinology & Metabolism
Eleni Rebelos, Aino Latva-Rasku, Kalle Koskensalo, Laura Pekkarinen, Ekaterina Saukko, Jukka Ihalainen, Miikka-Juhani Honka, Jouni Tuisku, Marco Bucci, Sanna Laurila, Johan Rajander, Paulina Salminen, Lauri Nummenmaa, Jacobus F. A. Jansen, Ele Ferrannini, Pirjo Nuutila
Summary: The study found that in individuals with obesity, there was a decrease in total N-acetylaspartate compared to lean controls. Additionally, the increase in brain myo-inositol in response to hyperinsulinemia was similar in both lean participants and those with obesity. The study suggests that insulin signaling and glucose metabolism are closely associated with the changes in brain metabolites that occur in obesity.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Endocrinology & Metabolism
Laura Pekkarinen, Tatu Kantonen, Vesa Oikonen, Merja Haaparanta-Solin, Richard Aarnio, Alex M. Dickens, Annie von Eyken, Aino Latva-Rasku, Prince Dadson, Anna K. Kirjavainen, Johan Rajander, Kari Kalliokoski, Tapani Roennemaa, Lauri Nummenmaa, Pirjo Nuutila
Summary: This study aimed to investigate CB1R availability in peripheral tissue and brain in young men with overweight versus lean men. The results suggest endocannabinoid dysregulation already in the preobesity state, as CB1R availability in abdominal adipose tissue was lower in the high-risk group and correlated with insulin sensitivity and unfavorable lipid profile.
Review
Microbiology
Silvia Saturio, Alejandra Rey, Anna Samarra, Maria Carmen Collado, Marta Suarez, Laura Mantecon, Gonzalo Solis, Miguel Gueimonde, Silvia Arboleya
Summary: The development of the neonate's intestinal microbiome begins at birth when the mother provides the initial microbial inoculum. This microbiome contains antibiotic resistance genes, which are affected by different perinatal factors. Antibiotics, commonly used in pediatrics, can disrupt the early microbiota and increase the levels of antibiotic resistance genes. Understanding the factors influencing the development of the resistome in early life is crucial due to the emergence of antibiotic-resistant microorganisms.
Article
Nutrition & Dietetics
Laxmi Yeruva, Bharat Kumar Mulakala, Dhivyaa Rajasundaram, Sonia Gonzalez, Raul Cabrera-Rubio, Cecilia Martinez-Costa, Maria Carmen Collado
Summary: The study found that maternal dietary source affects the expression profile of milk miRNA, and miRNA is associated with maternal dietary nutrients, milk microbiota, infant gut microbiota, and infant growth and development.
CLINICAL NUTRITION
(2023)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Lihua Sun, Pirjo Nuutila
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)