期刊
AUTOIMMUNITY REVIEWS
卷 15, 期 5, 页码 477-483出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.autrev.2016.01.017
关键词
Autoantibody; Autoantibody production; Biomarker; Cancer; Immune surveillance; Humoral immune response
类别
资金
- Inspiring Minds scholarship at Edith Cowan University
A link between autoimmune responses and cancer via autoantibodies was first described in the 1950s. Since, autoantibodies have been studied for their potential use as cancer biomarkers, however the exact causes of their production remain to be elucidated. This review summarizes current theories of the causes of autoantibody production in cancer, namely: 1) defects in tolerance and inflammation, 2) changes in protein expression levels, 3) altered protein structure, and 4) cellular death mechanisms. We also highlight the need for further research into this field to improve our understanding of autoantibodies as biomarkers for cancer development and progression. (C) 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据