Article
Engineering, Biomedical
Hao Wang, Dandan Su, Rufan Huang, Fan Shu, Fang Cheng, Gang Zheng
Summary: The study introduces a new therapy for treating psoriasis by functionalizing cell membranes with metabolic glycoengineering method, achieving targeted treatment effect to effectively reduce overproliferating keratinocytes and modulate immunity.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Physical
Chaoqiang Yan, Yanshuang Li, Endong Wang, Wen Wu Xu
Summary: Structural global searches with efficient algorithms have been widely used for studying molecules and clusters. However, determining the spatial conformation of thiolated gold nanoclusters (AuNCs) with code assistance has not been achieved due to the complex structural architecture of AuNCs, especially when only the chemical formula is known. This study successfully obtained the structure of the [Au-25(SR)(19)](0) cluster using minimal computations based on the grand unified model, and its reasonableness was verified through stability analysis and experimental absorption spectrum confirmation. The predicted [Au-25(SR)(19)](0) cluster, with a face-centered cubic kernel, has a considerably altered structure compared to the [Au-25(SR)(18)](-1) cluster. This study provides insights for decoding the chemical formulas of AuNCs and determining their spatial conformations.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Chemistry, Analytical
Hui Zhu, Yue Zhou, Yu Wang, Suying Xu, Tony D. James, Leyu Wang
Summary: We developed a new strategy to prepare stable and highly emissive near-infrared gold nanoclusters. These nanoclusters demonstrated bright and stable fluorescence imaging ability in tumors, as well as the capability of fluorine magnetic resonance imaging and computed tomographic imaging. These results indicate the potential of these nanoclusters in the field of biomedical research.
ANALYTICAL CHEMISTRY
(2022)
Article
Oncology
Zahra Rezaeivala, Armin Imanparast, Zahra Mohammadi, Bahareh Khalili Najafabad, Ameneh Sazgarnia
Summary: Conventional cancer treatments have limitations, so new nanotechnologies are being developed for cancer diagnosis and therapy. Phototherapy based on nanotechnology is a promising strategy. In this study, CoFe2O4 theranostic magnetic nanoparticles coated with spiky gold nanoparticles were designed and synthesized, and their photothermal effects were evaluated. The overlap of the emission spectrum of the light source and the absorption spectrum of the nanostructure amplified cell death.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Engineering, Environmental
Yihang Jiang, Wei Zhu, Zhourui Xu, Zhijun Zhang, Shuo Tang, Miaozhuang Fan, Zhengzheng Li, Jianyu Zhang, Chengbin Yang, Wing-Cheung Law, Ken-Tye Yong, Dong Wang, Gaixia Xu, Ben Zhong Tang
Summary: This study proposes a mitochondrion-targeting two-photon photodynamic therapy (TP-PDT) strategy based on a new type of photosensitizer with aggregation-induced emission (AIE) characteristics. It achieves efficient anti-tumor treatment in hypoxic-tolerant tumors.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Biotechnology & Applied Microbiology
Xin Jun Xu, Yi Li, Hao Hui, Chang Ling Liu, Yan Fu, Hong Yu Yang
Summary: This study successfully fabricated a multifunctional and dual-targeting nanoplatform based on hyaluronic acid-modified gold nanorods for combined photodynamic and photothermal therapy of cancer. The prepared nanoparticles exhibited high drug-loading capacity and excellent stability, and could enhance cellular uptake, escape from endo/lysosomes, and generate reactive oxygen species. In vitro experiments demonstrated that this combination therapy strategy had higher anticancer potential than photodynamic or photothermal therapy alone against MCF-7 tumor cells.
BIOTECHNOLOGY AND BIOENGINEERING
(2023)
Article
Chemistry, Analytical
Ke Li, Delai Kang, Yu Li, Weizhe Zhu, Lian Zhu, Juntao Zhang, Chengzhi Xu, Benmei Wei, Haibo Wang
Summary: In this study, a quantitative determination method for collagen triple helix integrity was developed using bovine skin collagen peptide-protected Au/Ag nanoclusters as a fluorescent probe.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Multidisciplinary
Paolo D'Agosta, Francesco Tumino, Valeria Russo, Andrea Li Bassi, Carlo S. Casari
Summary: In this work, the growth of WS2/MoS2 and MoS2/WS2 heterobilayers by pulsed laser deposition (PLD) under ultra-high vacuum conditions was studied. The heterobilayer morphology and structure at the nanoscale were investigated using in situ scanning tunneling microscopy. The experiments showed that the growth of the heterostructure can be controlled by tuning the number of laser pulses, achieving high coverage and thickness sensitivity. Raman spectroscopy revealed the effect of the interaction with the metallic substrate on the TMD vibrational properties and a strong interlayer coupling between the MoS2 and WS2 layers. The transfer of the heterobilayers onto a silica substrate confirmed that the interlayer coupling is not substrate-dependent. This work highlights the potential of PLD technique in growing TMD heterostructures and opens new perspectives in the synthesis of complex 2D layered materials.
Article
Chemistry, Multidisciplinary
Hui Bian, Dandan Ma, Xinfu Zhang, Kai Xin, Youjun Yang, Xiaojun Peng, Yi Xiao
Summary: In this study, five novel NIR-II dyes were successfully developed with intense absorption ranging from 890 to 1206 nm, strong singlet oxygen generation capability, and fluorescence imaging ability triggered by a single NIR-II light. Among them, BH 1024 showed the best performance in singlet oxygen generation, moderate photothermal heating, and considerable fluorescence under 1064 nm laser irradiation. Encapsulating BH 1024 into folate-functionalized polymer demonstrated a synergetic PDT/PTT effect in vitro and in vivo, eventually achieving solid tumors elimination under NIR-II fluorescence guide. This is the first attempt to explore and design small molecular dyes for NIR-II PDT or NIR-II PDT/PTT.
Article
Chemistry, Multidisciplinary
Qiao-Ling Mo, Xiao-Cheng Dai, Yang Xiao, Fang-Xing Xiao
Summary: In this study, the photoinduced self-oxidative aggregation of metal nanoclusters (NCs) and their in-situ transformation to metal nanoparticles (NPs) were addressed. The charge transport capabilities of atomically precise metal NCs and plasmonic metal NPs were compared in photoelectrochemical (PEC) water splitting. The results showed that Au25 NCs exhibited superior performance in stimulating the interracial charge transport compared to plasmonic Au NPs, leading to enhanced PEC water splitting under visible light irradiation.
CHINESE CHEMICAL LETTERS
(2023)
Article
Oncology
Vinod Ravasaheb Shinde, Neeraja Revi, Sivasubramanian Murugappan, Surya Prakash Singh, Aravind Kumar Rengan
Summary: This article explores the use of therapeutic nanoparticles to exploit the enhanced permeability and retention (EPR) effect for passive targeting in tumor tissues, and summarizes its applications in cancer therapy.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Nanoscience & Nanotechnology
Yanan Tian, Dan Zhao, Xiaoyu Huang, Xiaomin Guan, Fu Wang, Xunbin Wei
Summary: In this study, carbon nitride nanoparticles (CN-NPs) were developed as a nanoplatform for efficient near-infrared photodynamic therapy (PDT) and photothermal therapy (PTT), guided by photoacoustic imaging (PAI). The CN-NPs exhibited enhanced absorption and efficient photothermal stability, and could inhibit tumor growth and recurrence under 1064 nm laser illumination. The accumulation and metabolism of CN-NPs in vivo could also be monitored in real time using PAI.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Yanan Tian, Dan Zhao, Xiaoyu Huang, Xiaomin Guan, Fu Wang, Xunbin Wei
Summary: The study introduces carbon nitride nanoparticles for efficient NIR-II PAI-guided photodynamic therapy (PDT)/photothermal therapy (PTT) with significant in vivo therapeutic effects.
With improved photothermal stability and high photo-to-heat conversion efficiency, CN-NPs exhibit efficient photothermal effects.
In vivo experiments demonstrate that CN-NPs can completely inhibit tumor growth and recurrence under 1064 nm.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Materials Science, Multidisciplinary
Shuxiao Yi, Qing Hu, Yajie Chi, Huijiao Qu, Yan Xiao
Summary: Real-time monitoring of kidney dysfunction in vivo is crucial for the diagnosis of renal diseases and the preservation of human health. This study synthesized renally clear gold nanoclusters (Au NCs) with both NIR-II excitation and emission, which enabled high-resolution fluorescence imaging and monitoring of kidney dysfunction. The developed Au NCs have significantly higher quantum yields and offer advantages of deep tissue penetration, high resolution, and high signal-to-background ratio compared to previous renal clearable NIR-II emitting materials. The findings provide new candidate materials for NIR-II fluorescence imaging and a powerful tool for kidney disease imaging.
ACS MATERIALS LETTERS
(2023)
Article
Biotechnology & Applied Microbiology
Xiao-Yan Yang, Jin-Guo Zhang, Qiao-Mei Zhou, Jie-Ni Yu, Yuan-Fei Lu, Xiao-Jie Wang, Jia-Ping Zhou, Xin-Fa Ding, Yong-Zhong Du, Ri-Sheng Yu
Summary: This study introduced a collagenase-functionalized biomimetic drug-loaded Au nanoplatform that efficiently targets PDAC tumors, degrades ECM, releases drugs under NIR light, and exerts synergistic antitumor effects.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Biochemical Research Methods
Jie Zhou, Shanshan Chen, Fang Sun, Pei Luo, Qiuzheng Du, Suzhen Zhao
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2015)
Article
Chemistry, Analytical
Jie Zhou, Lingchang Meng, Weiran Ye, Qiaolei Wang, Shizhen Geng, Chong Sun
ANALYTICA CHIMICA ACTA
(2018)
Article
Nanoscience & Nanotechnology
Jie Zhou, Lingchang Meng, Chong Sun, Weiran Ye, Chengqun Chen, Bin Du
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2018)
Article
Chemistry, Analytical
Jie Zhou, Ruhe Yang, Yiwen Sun, Fusui Luo, Jin Zhang, Huili Ma, Min Guan
Summary: The study presents the design of an interventional probe for the safe and effective imaging of foam cells in early atherosclerosis (AS) using methylene blue. The experimental results showed that the probe accumulated at the lesion site, enhanced fluorescence, and released niacin to inhibit the development of atherosclerosis.
Article
Nanoscience & Nanotechnology
Jie Zhou, Yiwen Sun, Jin Zhang, Fusui Luo, Huili Ma, Min Guan, Junfen Feng, Xiaomeng Dong
Summary: Finding a timely, sensitive, and noninvasive detection method for early diagnosis of Alzheimer's disease (AD) has become urgent. MicroRNA-193b (miR-193b) and Afl42 oligomers (AflO42) in neurogenic exosomes were identified as biomarkers reflecting pathological changes in the early stage of AD. A detection system based on the entropy-driven strand displacement reaction (ESDR) principle was developed, showing high specificity, sensitivity, and ease of operation, providing broad prospects for early diagnosis of AD.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Jie Zhou, Yiwen Sun, Jin Zhang, Fusui Luo, Huili Ma, Min Guan, Junfen Feng, Xiaomeng Dong
Summary: In this study, a detection system based on the entropy-driven strand displacement reaction (ESDR) principle was developed for the sensitive detection of miR-193b and AflO42, biomarkers for early stage AD. The system consisted of a dumbbell detection probe (H), an indicator probe (R), and graphene oxide (GO). GO adsorbed free R and quenched fluorescence, enhancing the sensitivity of the system. The detection limits for miR-193b and AflO42 were 77 pM and 53 pM, respectively.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Biomaterials
Jie Zhou, Qianwen Yin, Shengnan Li, Ruhe Yang, Rui Lou, Yiwen Sun, Bin Du
Summary: This study reports a new approach to increase tumor penetration using nanomedicines. By releasing specific substances, it reduces lactic acid accumulation in tumors and prevents tumor metastasis by decreasing extracellular matrix production. The results demonstrate that indirectly reducing extracellular matrix production enhances tumor penetration and inhibits deep tumor glycolysis.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Analytical
Qiaolei Wang, Rui Lou, Qianwen Yin, Ruhe Yang, Shengnan Li, Jie Zhou
Summary: This study utilized a fluorescent probe to detect cellular reactive oxygen species and prepared a nano-detection system for early detection of AS. Experimental results showed effective targeting in early AS rats and no acute biological toxicity, indicating promising application potential for early AS detection.
Article
Materials Science, Biomaterials
Shizhen Geng, Rui Lou, Qianwen Yin, Shengnan Li, Ruhe Yang, Jie Zhou
Summary: The study constructed a GOx/Dex@ZIF-TA nanosystem that utilized Dex to promote the penetration of GOx into the nucleus, inhibit collagen production, and suppress lung metastasis. In vivo and in vitro experiments yielded significant results, demonstrating the potential clinical benefits of this approach.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Materials Science, Biomaterials
Jie Zhou, Shizhen Geng, Qiaolei Wang, Qianwen Yin, Rui Lou, Liuliu Wei, Yuncong Wu, Bin Du, Hanchun Yao
JOURNAL OF MATERIALS CHEMISTRY B
(2020)
Article
Biochemistry & Molecular Biology
Jie Zhou, Chong Sun, Lingchang Meng, Weiran Ye, Pei Luo, Fang Sun, Shanshan Chen, Xia Xu
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2017)
Article
Chemistry, Medicinal
Jie Zhou, Hanchun Yao, Lingchang Meng, Chong Sun, Weiran Ye, Qiuzheng Du
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)
